Download or read book Functional Polypeptides for Biomedical Applications written by Jessica R. Kramer and published by . This book was released on 2012 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic polypeptides have shown great promise as materials for biotechnology and medicine, with applications in tissue engineering, drug delivery, and as therapeutics. Despite significant advances in the preparation of well-defined polypeptides and the development of self-assembling materials, a need remains for a broader scope of polypeptides with functionalities that mimic the complexity and function of post-translationally modified natural proteins. The display of functionalities that have therapeutic effects, target materials to specific tissues, passivate the immune response, or have stimuli responsive behavior, are highly desirable yet generally require complex and inefficient synthetic approaches. This dissertation reports several distinct advances in the preparation of a wide variety of highly functional polypeptide materials. Progress in both the polymerization of functionalized NCA monomers and the post-polymerization modification of polypeptides is described. A new method of NCA purification was developed, and has allowed access to diverse monomers with functionalities previously unattainable due to impurities that impeded polymerization. This purification technique was applied to the synthesis of glycosylated NCAs, which yielded the first living polymerizations of glycosylated NCAs and gave access to glycopolypeptides with unique properties and conformations. The display of sugar functionalities from synthetic polymers is an area of great interest due to the many attractive properties imparted upon the parent material, such as non-ionic water solubility, biological targeting, and shielding of the polypeptide from proteases. These glycopolypeptides were used to explore the effect of conformation on self-assembly and ligand binding, and to develop vesicles with potential medical applications in targeted drug delivery. In addition, a new conjugation technique for facile post-polymerization modification of polypeptides is described. This conjugation utilizes the unique chemistry of the natural amino acid methionine to allow chemoselective introduction of a wide variety of functional groups via alkylation. We investigated the stability of various alkylated methionines to thiolysis, and developed a simple method to attach and later remove different groups. Finally, work performed during an NSF-IGERT funded internship at HRL Laboratories Inc. is described. Surface modification of carbon foam anodes for microbial fuel cell applications was explored, and the use of thermogravimetric analysis as technique to evaluate biofilm formation was developed.

Download or read book Peptides and Peptide based Biomaterials and their Biomedical Applications written by Anwar Sunna and published by Springer. This book was released on 2017-10-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

Download or read book Peptide Applications in Biomedicine Biotechnology and Bioengineering written by Sotirios Koutsopoulos and published by Woodhead Publishing. This book was released on 2017-11-16 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Download or read book Biophysical Characterization of Functional Peptides written by Vibin Ramakrishnan and published by Springer Nature. This book was released on 2023-08-02 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This protocol book presents reproducible and step-by-step procedures for the peptide synthesis, their characterization and applications. The volume includes an introductory section on in silico modelling of new peptide molecules, Molecular Dynamics Simulations, Docking, Electrostatic fingerprinting of peptides, and other modelling tools for peptide designing and optimization. Further, it covers protocols for the solid phase peptide synthesis, chromatographic and mass spectrometric characterization of peptides. Importantly, it covers methods for biophysical characterizations of peptides for their potential applications as drug delivery vehicles, peptide nano-assembly, bionanocatalysis, protein aggregation diseases, and peptide-based anti-bacterial. ​

Download or read book Folded Synthetic Peptides for Biomedical Applications written by Alessandro Contini and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.

Download or read book Biomedical Applications of Peptide Glyco and Glycopeptide Dendrimers and Analogous Dendrimeric Structures written by Jaroslav Sebestik and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.

Download or read book Peptide Bionanomaterials written by Mohamed A. Elsawy and published by Springer Nature. This book was released on 2023-08-28 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach. This book gives the reader an overview on the design rules for de novo self-assembling peptide and reviews the diverse range of bioinspired peptide nanostructures such as β-sheet and β-hairpin, α-helical and coiled coil, self-assembling short peptides and peptidomimetics, collagen-based and elastin-like peptides, silk peptides, peptide amphiphiles, peptides co-polymers and others. The book also covers the wide variety of responsive and functional biomaterials that have been innovated based on those nanostructures for various applications ranging from tissue engineering, therapeutics and drug delivery to antimicrobial nanomaterials and biosensors. Finally, the book also discusses the peptide bionanomaterials global market and the future of the emerging industry. Chapter “Characterization of Peptide-Based Nanomaterials” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Peptide Self Assembly and Engineering written by Xuehai Yan and published by John Wiley & Sons. This book was released on 2024-02-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.

Download or read book Biologically Active Peptides written by David B. Weiner and published by CRC Press. This book was released on 1993-11-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Download or read book Nanoscale Assembly written by Wilhelm T.S. Huck and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has received tremendous interest over the last decade, not only from the scientific community but also from a business perspective and from the general public. Although nanotechnology is still at the largely unexplored frontier of science, it has the potential for extremely exciting technological innovations that will have an enormous impact on areas as diverse as information technology, medicine, energy supply and probably many others. The miniturization of devices and structures will impact the speed of devices and information storage capacity. More importantly, though, nanotechnology should lead to completely new functional devices as nanostructures have fundamentally different physical properties that are governed by quantum effects. When nanometer sized features are fabricated in materials that are currently used in electronic, magnetic, and optical applications, quantum behavior will lead to a set of unprecedented properties. The interactions of nanostructures with biological materials are largely unexplored. Future work in this direction should yield enabling technologies that allows the study and direct manipulation of biological processes at the (sub) cellular level.

Download or read book Biomimetic Protein Based Elastomers written by Namita Roy Choudhury and published by Royal Society of Chemistry. This book was released on 2022-04-20 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastomeric proteins are ubiquitous in nature, where they have evolved precise structures and properties that are necessary to perform specific biological roles and functions. This book emphasizes the impact of amino acid sequence on modulating protein structure, properties, and function. Examples include conformational ensemble dynamics, environmental responsiveness, self-assembly, physico-mechanical properties, morphology, and properties tailored for biomedical applications. This foundational framework is not only critical to advance scientific understanding and knowledge on elastomeric proteins but also enables the conceptualization, rational design, and development of biosynthetic elastomers and their analogous polypeptides for a variety of applications. Edited and contributed by pioneering researchers in the field, the book provides a timely overview of the materials, along with the synthesis techniques, the unique characteristics of elastomeric proteins, and biomedical and industrial applications. The book will provide a reference for graduate students and researchers interested in designing biomimetic proteins tailored for various functions.

Download or read book Biologically Active Peptides written by David B. Weiner and published by CRC Press. This book was released on 2023-07-28 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Download or read book Protection of Functional Groups in Peptide Synthesis written by Erhard Gross and published by Elsevier. This book was released on 2014-05-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups. This volume is recommended for specialists and researchers concerned with peptide and protein research.

Download or read book Proteome Research written by Marc R. Wilkins and published by Springer Science & Business Media. This book was released on 1997 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Download or read book Self assembly of Peptide polymer Conjugates for the Formation of Functional Biomaterials Via Molecular Dynamics Simulations written by Iris Wing Yin Fu and published by . This book was released on 2015 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide-polymer conjugates are versatile molecular building blocks that can self-assemble into well-defined nanostructures with customizable biofunctionality and tunable physical properties for a wide range of biomedical applications. In this dissertation, two structural analogues of peptide-polymer conjugates are discussed: peptide amphiphiles and block copolymers with the difference between their respective domains tailored for specific applications. Self-assembly process of these peptide-polymer conjugates into different nanostructure morphologies is examined via molecular dynamics simulations using our recently developed integrated simulation package, called BioModi (Biomolecular Multiscale Models at UC Irvine). This simulation package consists of coarse-grained models that mimic realistic molecules and molecular interactions of amino acids, nucleic acids, and polymers, yet are simplified enough to allow molecular simulation of large systems over long time scales. For peptide amphiphiles, emphasis is placed on achieving a fine balance between the two distinct hydrophobic and hydrophilic domains to attain a supramolecular architecture that can serve as a biomimetic hydrogel scaffold for tissue engineering. The role of different environmental factors (e.g. temperature, pH, solvent) on the self-assembly behavior of peptide amphiphiles is elucidated in detail. Our simulations show that under optimal conditions, spontaneously self-assembly results in the formation of cylindrical nanofibers that can switch into spherical micelles in response to a small pH range as similarly observed by in vitro experiments. Moreover, phase diagrams are constructed to identify morphological transitions, and unique self-assembly kinetic mechanisms are characterized. Chemical modification of the peptide amphiphile sequence is investigated and contrasting structural characteristics are observed to correlate with differences in mechanical behavior of the resulting gel. For block copolymers, the inherent design utilizes a cationic polypeptide conjugated to a synthetic polymer that promotes favorable electrostatic interactions with nucleic acid fragments upon the formation of a polyionic complex as an effective gene carrier. Efficient complexation of block polymers with siRNA is determined via molecular dynamics simulations to be a function of the length of the polymer and the charge density of the system. Implementation of our newly developed coarse-grained models, BioModi, and insight gained from our simulations will provide key parameters to advance computer-aided design and development of innovative smart biomaterials.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advanced Functional Polymers for Biomedical Applications written by Masoud Mozafari and published by Elsevier. This book was released on 2019-06-14 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Functional Polymers for Biomedical Applications presents novel techniques for the preparation and characterization of functionalized polymers, enabling researchers, scientists and engineers to understand and utilize their enhanced functionality in a range of cutting-edge biomedical applications. Provides systematic coverage of the major types of functional polymers, discussing their properties, preparation techniques and potential applications Presents new synthetic approaches alongside the very latest polymer processing and characterization methods Unlocks the potential of functional polymers to support ground-breaking techniques for drug and gene delivery, diagnostics, tissue engineering and regenerative medicine