Download or read book Functional Imaging of the Mammalian Spinal Cord written by Michael Adam Moffitt and published by . This book was released on 2004 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vivo Three photon Excited Fluorescence Functional Imaging of the Spinal Cord in Health and Disease written by Yu-Ting Cheng and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in in vivo optical imaging have enabled observation of diverse biological phenomena across different organs and organisms at single cell resolution. In the central nervous system (CNS), such imaging can be used to explore the connection between cell-resolved neural activity and behavior, a key capability for gaining insight on CNS function and dysfunction.The spinal cord of vertebrates serves as the conduit that shuttles sensory and motor information back and forth between the brain and the periphery that governs fundamental behaviors across species such as locomotion and somatosensory function. Because dense myelin covers the dorsal aspect of the spinal cord, imaging neuronal, vascular, and immune function deep inside the grey matter is challenging. The focus of my thesis is to utilize three-photon excited fluorescence (3PEF) microscopy to overcome this imaging challenge and investigate neuronal function, blood flow, and inflammatory cell behavior at an unprecedented depth in the spinal cord of awake and behaving mice. Here, I present using 3PEF microscopy combined with adaptive optics as a promising tool to image patterns of neuronal activity from deep spinal cord layers in an awake, locomoting mice. These tools also enabled measurement of blood flow in individual vessels across the vascular hierarchy and vessel types, as well as neuronal dieback and microglial dynamics after focal spinal cord ischemia, opening the door to cell-resolved studies of structure and function of the spinal cord in health and disease.
Download or read book In Vivo Optical Imaging of Brain Function written by Ron D. Frostig and published by CRC Press. This book was released on 2009-05-06 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques a
Download or read book The Mammalian Spinal Cord written by Charles Watson and published by Academic Press. This book was released on 2021-12-22 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mammalian Spinal Cord provides a comprehensive account of the anatomy and histology of the spinal cord. The text covers the cytoarchitecture, chemoarchitecture, motor neuron distribution, long tracts, autonomic outflow, and gene expression in the spinal cord. A feature of the book is the inclusion of segment-by-segment atlases of the spinal cords of rat, mouse, newborn mouse, marmoset, rhesus monkey, and human. This book is an essential reference for researchers studying the spinal cord. Includes full-color photographic images of Nissl-stained sections from every spinal cord segment in each of two rodent and three primate species, over 160 Nissl plates Contains comprehensively labeled diagrams to accompany each Nissl-stained section, over 160 diagrams Provides more than 500 photographic images of sections stained for AChE, ChAT, parvalbumin, NADPH- diaphorase, calretinin, or other markers to supplement the Nissl-stained images
Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by Cambridge University Press. This book was released on 2005-06-08 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.
Download or read book The Mammalian Spinal Cord written by Charles Watson and published by Academic Press. This book was released on 2022-04-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mammalian Spinal Cord provides a comprehensive account of the anatomy and histology of the spinal cord. The text covers the cytoarchitecture, chemoarchitecture, motor neuron distribution, long tracts, autonomic outflow, and gene expression in the spinal cord. A feature of the book is the inclusion of segment-by-segment atlases of the spinal cords of rat, mouse, newborn mouse, marmoset, rhesus monkey, and human. This book is an essential reference for researchers studying the spinal cord.
Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by Cambridge University Press. This book was released on 2012-04-26 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of human movement have proliferated in recent years. This greatly expanded and thoroughly updated reference surveys the literature on the corticospinal control of spinal cord circuits in human subjects, showing how different circuits can be studied, their role in normal movement and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks and changes in patients with CNS lesions. Each chapter concludes with a helpful résumé that can be used independently of the main text to provide practical guidance for clinical studies. The final four chapters bring together the changes in transmission in spinal and corticospinal pathways during movement and how they contribute to the desired movement. This book is essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.
Download or read book Introduction to Functional Magnetic Resonance Imaging written by Richard B. Buxton and published by Cambridge University Press. This book was released on 2009-08-27 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a useful introductory book on a technique that has revolutionized neuroscience, specifically cognitive neuroscience. Functional magnetic resonance imaging (fMRI) has now become the standard tool for studying the brain systems involved in cognitive and emotional processing. It has also been a major factor in the consilience of the fields of neurobiology, cognitive psychology, social psychology, radiology, physics, mathematics, engineering, and even philosophy. Written and edited by a clinician-scientist in the field, this book remains an excellent user's guide to t
Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Download or read book Microscopic Magnetic Resonance Imaging written by Luisa Ciobanu and published by CRC Press. This book was released on 2017-09-08 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, significant advances in magnetic resonance microscopy (MRM) have been made possible by a combination of higher magnetic fields and more robust data acquisition technologies. This technical progress has enabled a shift in MRM applications from basic anatomical investigations to dynamic and functional studies, boosting the use of MRM in biological and life sciences. This book provides a simple introduction to MRM emphasizing practical aspects relevant to high magnetic fields. It focuses on biological applications and presents a number of selected examples of neuroscience applications. The text is mainly intended for those who are beginning research in the field of MRM or are planning to incorporate high-resolution MRI in their neuroscience studies.
Download or read book Quantitative MRI of the Spinal Cord written by Julien Cohen-Adad and published by Academic Press. This book was released on 2014-01-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. Chapters authored by international experts in the field of MRI of the spinal cord Contains “cooking recipes —examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice Ideal for clinical settings
Download or read book Brain Energy Metabolism written by Johannes Hirrlinger and published by Humana Press. This book was released on 2014-09-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
Download or read book Ultrafast Ultrasound Imaging written by Hideyuki Hasegawa and published by MDPI. This book was released on 2018-09-21 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Ultrafast Ultrasound Imaging" that was published in Applied Sciences
Download or read book Atlas of the Spinal Cord written by Gulgun Sengul and published by Academic Press. This book was released on 2012-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Atlas of the Spinal Cord is the first comprehensive atlas of rodent and primate spinal cords. This atlas features histological images and labeled drawings of every segment from rat, mouse, marmoset monkey, rhesus monkey, and human spinal cords. Nissl-stained section images and matching drawings for each segment are supplemented by up to four histochemical or immunohistochemical images on a facing page. The neuron groups supplying major limb muscles are identified in each species. Constructed by the established leaders in neuroanatomical atlas development, this new atlas will be the indispensible resource for scientists who work on rodent or primate spinal cord.
Download or read book The Spinal Cord written by Charles Watson and published by Academic Press. This book was released on 2009-11-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN). The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN) All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply
Download or read book Spinal Cord Injury SCI Repair Strategies written by Giuseppe Perale and published by Woodhead Publishing. This book was released on 2019-10-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
