Download or read book FUNCTIONAL IMAGING BIOMARKERS PREDICTING UPPER LIMB RECOVERY FROM SEVERE MOTOR IMPAIRMENT AFTER STROKE written by Yun-Hee Kim and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: IntroductionUnderstanding recovery mechanism and predicting recovery outcome after stroke are important to implicate individually-tailored rehabilitation strategy. In case of recovery of upper extremity (UE) motor function, most biomarkers demonstrate low predictive power in severe stroke. This study focused on investigation of functional imaging biomarkers optimally predicting recovery of UE motor function in severe stroke patients.MethodsForty-two subacute ischemic stroke patients (24 males, mean age 57.2u00b112.4 years) with severe motor impairment participated. They underwent T1-weighted, diffusion tensor imaging, resting-state functional MRI at 2 weeks after stroke. Motor function was assessed using the Fugl-Meyer Assessment scale at 2 weeks and 3 months after stroke. Participants were divided into the Fitter and Non-fitter groups according to whether the UE motor recovery achieves 70% of initial impairment based on proportional recovery. Important neuroimaging measures were investigated; fractional anisotropy (FA) values of the corticospinal tract (CST), corpus callosum (CC), superior cerebellar peduncle (SCP), lesion load of the CST, and interhemispheric connectivity were extracted. ResultsFA value of the SCP was considered as a significant predictive biomarker for UE motor recovery in the Fitter group. FA value of the CC and strength of functional connectivity between visual and auditory areas were predictive biomarkers in the Non-fitter group.ConclusionsDomains of predictive biomarkers were different according to the recovery pattern in severe stroke. Especially, non-motor domains were considered as predictive biomarkers for UE recovery in Non-fitter group. This study implies the need to develop different strategy for UE motor recovery in severe stroke patients with highly unpredictable individuals. AcknowledgementThis study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP; NRF-2017R1A2A1A05000730, NRF-2017R1D1A1B03034109, NRF-2017M3A9G5083690) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C1501).

Download or read book Stroke Recovery and Rehabilitation written by Richard L. Harvey, MD and published by Demos Medical Publishing. This book was released on 2008-11-20 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title 2012 Stroke Recovery and Rehabilitation is the new gold standard comprehensive guide to the management of stroke patients. Beginning with detailed information on risk factors, epidemiology, prevention, and neurophysiology, the book details the acute and long-term treatment of all stroke-related impairments and complications. Additional sections discuss psychological issues, outcomes, community reintegration, and new research. Written by dozens of acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, Stroke Recovery and Rehabilitation features: The first full-length discussion of the most commonly-encountered component of neurorehabilitation Multi-specialty coverage of issues in rehabilitation, neurology, PT, OT, speech therapy, and nursing Focus on therapeutic management of stroke related impairments and complications An international perspective from dozens of foremost authorities on stroke Cutting edge, practical information on new developments and research trends Stroke Recovery and Rehabilitation is a valuable reference for clinicians and academics in rehabilitation and neurology, and professionals in all disciplines who serve the needs of stroke survivors.

Download or read book Dynamics of Neurological and Behavioural Recovery After Stroke written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is one of the main causes of serious adult disability in Europe. Around 80% of stroke survivors suffer from motor impairment, typically affecting unilateral motor control of the face, arm, and leg. Especially upper limb impairments limit patient’s activities of daily living. While the majority of patients shows some level of spontaneous neurological recovery, about 20-30% do not recover at all. Most of the observed improvements in upper limb function occur in the first 10 weeks after stroke. However, the mechanisms underlying motor recovery are poorly understood. While primary and secondary prevention measures aim to reduce the number of stroke patients and to detect and treat the stroke as soon as possible, investing in tertiary prevention is important to predict, accelerate, and enhance post-stroke recovery. Chapter 1 discusses two issues. First, the inability to monitor neurological recovery after stroke due to the absence of adequate quantification of neurological state. Secondly, the demand for additional prognostic biomarkers of motor recovery in more severely affected stroke patients. Adequate quantification of neurological recovery is required to investigate whether neurorehabilitation interventions can induce neurological motor recovery after stroke. Unfortunately, neurological motor recovery cannot be measured directly. Therefore, derivatives of neurological state associated with behavioural recovery should be identified, referred to as biomarkers. In this thesis, we investigate biomarkers derived from observed behaviour and biomarkers derived from brain activity. A clinical assessment which is often used in scientific research to monitor behavioural recovery after stroke is the Fugl-Meyer motor assessment of the upper extremity (FM-UE). The FM-UE reflects the ability to perform movements dissociated from abnormal muscle synergies and originates from the different stages of motor recovery after stroke.

Download or read book Niedermeyer s Electroencephalography written by Donald L. Schomer and published by Lippincott Williams & Wilkins. This book was released on 2012-10-18 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on electroencephalography since 1982, Niedermeyer's Electroencephalography is now in its thoroughly updated Sixth Edition. An international group of experts provides comprehensive coverage of the neurophysiologic and technical aspects of EEG, evoked potentials, and magnetoencephalography, as well as the clinical applications of these studies in neonates, infants, children, adults, and older adults. This edition's new lead editor, Donald Schomer, MD, has updated the technical information and added a major new chapter on artifacts. Other highlights include complete coverage of EEG in the intensive care unit and new chapters on integrating other recording devices with EEG; transcranial electrical and magnetic stimulation; EEG/TMS in evaluation of cognitive and mood disorders; and sleep in premature infants, children and adolescents, and the elderly. A companion website includes fully searchable text and image bank.

Download or read book Broken Movement written by John W. Krakauer and published by MIT Press. This book was released on 2022-06-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair. Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.

Download or read book Subcortical Stroke written by Geoffrey Donnan and published by OUP Oxford. This book was released on 2002-04-11 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subcortical Stroke is a new and fully revised edition of Lacunar and Other Subcortical Infarctions (OUP, 1995). Stroke is one of the most common causes of death and subcortical stroke accounts for 20-30% of all cerebrovascular infarctions. Our understanding of stroke processes in general, and subcortical stroke in particular, has advanced considerably in recent years. Research findings from the fields of neurochemistry, imaging and genetics have provided insight and input to our understanding of this condition, and this new edition provides an opportunity to describe these advances, and to relate the findings to the clinical expression, neural mechanism, prognosis and treatment of subcortical stroke. In addition, new subcortical syndromes such as CADASIL are covered, as is subcortical haemorrhage. This book presents a comprehensive and authoritative review of the field with contributions from the leading international experts. Subcortical Stroke is for stroke physicians, neurologists and those researching cerebrovascular diseases.

Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

Download or read book Clinical Pathways in Stroke Rehabilitation written by Thomas Platz and published by Springer Nature. This book was released on 2021-01-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when and in which settings to provide rehabilitation over the course of recovery post stroke. Each chapter starts with a description of the clinical problem encountered. This is followed by a systematic, but concise review of the evidence (RCTs, systematic reviews and meta-analyses) that is relevant for clinical decision-making, and comments on assessment, therapy (training, technology, medication), and the use of technical aids as appropriate. Based on these summaries, clinical algorithms / pathways are provided and the main clinical-decision situations are portrayed. The book is invaluable for all neurorehabilitation team members, clinicians, nurses, and therapists in neurology, physical medicine and rehabilitation, and related fields. It is a World Federation for NeuroRehabilitation (WFNR) educational initiative, bridging the gap between the rapidly expanding clinical research in stroke rehabilitation and clinical practice across societies and continents. It can be used for both clinical decision-making for individuals and as well as clinical background knowledge for stroke rehabilitation service development initiatives.

Download or read book Hand Function written by Mehmet Tuncay Duruöz and published by Springer Science & Business Media. This book was released on 2014-03-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate assessment of hand function is critical to any treatment regimen of the hand compromised patient. Hand Function is a practical, clinical book which provides the knowledge needed to distinguish the different dimensions of hand function, particularly impairment, disability and handicap. Beginning with an overview of basic principles and examination, subsequent chapters evaluate the hand function in specific afflicted populations, including the rheumatoid patient, the stroke patient, the trauma patient, the geriatric patient and the pediatric patient, as well as special populations such as diabetes mellitus patients and musicians. An appendix containing hand function scales essential to the assessment of disability is also included. Rheumatologists, physiatrists, hand surgeons, orthopedists, occupational therapists and physical therapists will all find Hand Function a useful and valuable addition to their clinical references.

Download or read book Stroke Rehabilitation written by Leeanne M. Carey and published by Oxford University Press. This book was released on 2012-06-28 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke Rehabilitation: Insights from Neuroscience and Imaging informs and challenges neurologists, rehabilitation therapists, imagers, and stroke specialists to adopt more restorative and scientific approaches to stroke rehabilitation based on new evidence from neuroscience and neuroimaging literatures. The fields of cognitive neuroscience and neuroimaging are advancing rapidly and providing new insights into human behavior and learning. Similarly, improved knowledge of how the brain processes information after injury and recovers over time is providing new perspectives on what can be achieved through rehabilitation. Stroke Rehabilitation explores the potential to shape and maximize neural plastic changes in the brain after stroke from a multimodal perspective. Active skill based learning is identified as a central element of a restorative approach to rehabilitation. The evidence behind core learning principles as well as specific learning strategies that have been applied to retrain lost functions of movement, sensation, cognition and language are also discussed. Current interventions are evaluated relative to this knowledge base and examples are given of how active learning principles have been successfully applied in specific interventions. The benefits and evidence behind enriched environments is reviewed with examples of potential application in stroke rehabilitation. The capacity of adjunctive therapies, such as transcranial magnetic stimulation, to modulate receptivity of the damaged brain to benefit from behavioral interventions is also discussed in the context of this multimodal approach. Focusing on new insights from neuroscience and imaging, the book explores the potential to tailor interventions to the individual based on viable brain networks.

Download or read book Imaging Acute Neurologic Disease written by Massimo Filippi and published by Cambridge University Press. This book was released on 2014-09-11 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of best practice in using diagnostic imaging in acute neurologic conditions. The symptom-based approach guides the choice of the available imaging tools for efficient, accurate, and cost-effective diagnosis. Effective examination algorithms integrate neurological and imaging concepts with the practical demands and constraints of emergency care.

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Download or read book Oxford Textbook of Neurorehabilitation written by Volker Dietz and published by Oxford University Press. This book was released on 2020-05-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurorehabilitation is an expanding field with an increasing clinical impact due to an ageing population. During the last 20 years, neurorehabilitation has developed from a discipline with little scientific background, separated from other medical centers, to a medical entity largely based on the principles of 'evidenced based medicine' with strong ties to basic research and clinical neurology. Today neurorehabilitation is still a work in progress and treatment standards are not yet established for all aspects of the field. There are very few books that address contemporary neurorehabilitation from this perspective. This new edition of the Oxford Textbook of Neurorehabilitation provides an understanding of the theoretical underpinnings of the subject as well as a clear perspective on how (and why) to approach treatment decisions on an individualized basis. The book has been thoroughly updated to reflect novel important developments in the field and includes new chapters on vocational rehabilitation, self-management strategies in neurorehabilitation, and music supported therapy in neurorehabilitation. This indispensable book will be of great interest to rehabilitation physicians, neurologists, and allied health care professionals who look after patients requiring neurorehabilitation.

Download or read book Diffusion of Innovations in Health Service Organisations written by Sir Trisha Greenhalgh and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a systematic review on how innovations in health service practice and organisation can be disseminated and implemented. This is an academic text, originally commissioned by the Department of Health from University College London and University of Surrey, using a variety of research methods. The results of the review are discussed in detail in separate chapters covering particular innovations and the relevant contexts. The book is intended as a resource for health care researchers and academics.

Download or read book Understanding Stroke Recovery to Improve Outcomes From Acute Care to Chronic Rehabilitation written by Adriana Bastos Conforto and published by Frontiers Media SA. This book was released on 2022-11-09 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Systems Neuroscience written by Kenji Kansaku and published by Springer. This book was released on 2015-01-28 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impaired brain has often been difficult to rehabilitate owing to limited knowledge of the brain system. Recently, advanced imaging techniques such as fMRI and MEG have allowed researchers to investigate spatiotemporal dynamics in the living human brain. Consequently, knowledge in systems neuroscience is now rapidly growing. Advanced techniques have found practical application by providing new prosthetics, such as brain–machine interfaces, expanding the range of activities of persons with disabilities, or the elderly. The book’s chapters are authored by researchers from various research fields such as systems neuroscience, rehabilitation, neurology, psychology and engineering. The book explores the latest advancements in neurorehabilitation, plasticity and brain–machine interfaces among others and constitutes a solid foundation for researchers who aim to contribute to the science of brain function disabilities and ultimately to the well-being of patients and the elderly worldwide.

Download or read book Textbook of Stroke Medicine written by Michael Brainin and published by Cambridge University Press. This book was released on 2014-09-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.