Download or read book Structural and Functional Characterization of Circular RNAs written by Amaresh Chandra Panda and published by Frontiers Media SA. This book was released on 2022-01-04 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book Lessons in Immunity written by Loriano Ballarin and published by Academic Press. This book was released on 2016-04-08 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool. - Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context - Focuses on both cells and humoral components of a variety of non-classical model organisms - Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla - Presents a valuable holistic cross-sectional approach for teaching immunology and its applications

Download or read book Amphioxus Immunity written by An-Long Xu and published by Elsevier. This book was released on 2015-12-31 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: - Amphioxus as a model for understanding the evolution of vertebrates - basic knowledge of immunology - immune organs and cells of amphioxus - a genomic and transcriptomic view of the Amphioxus immunity - pattern recognition system in Amphioxus - transcription factors in Amphioxus - the complement system of Amphioxus - the oxidative burst system in Amphioxus - immune effectors in Amphioxus - lipid signaling of immune response in Amphioxus - apoptosis in amphioxus; primitive adaptive immune system of Amphioxus - and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. - Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms - Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity - Includes much pioneering work, from the molecular, genomic, and cellular to the individual level

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Download or read book Identification of Therapeutic Targets and Novel Biomarkers in Prostate Cancer written by Shashwat Sharad and published by Frontiers Media SA. This book was released on 2023-02-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Experimental Hepatocarcinogenesis written by M.B. Roberfroid and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The meeting on experimental hepatocarcinogenesis which took place in Spa, Belgium at the end of May 1987 was the Second European Meeting. About 100 scientists, mostly from Europe but also from the United States, met there for three days in a very friendly atmosphere to exchange knowledge and ideas on experimental and human liver carcinogenesis. The main topics discussed during the meeting included general reviews on hepatocarcinogenesis, experimental models of hepa tocarcinogenesis, biology of hepatocarcinogenesis, and in vitro studies in hepatocarcinogenesis. They are all covered by the various chapters of this proceedings volume, which reflects the present state of knowledge in this important field of cancer research. The final aim of that research is to understand the basic mechanisms of carcinogenesis. The liver offers a parti cularly interesting tool to reach such a goal. Indeed, its biochemistry, its morphology, and its physiology are very diverse, but relatively well known. Various protocols have been developed to produce hepatocellular carcinomas or other malignant tumors. Their appearance is most often preceded by phenotypically altered foci and nodules which have been isolated and characterized. The major cell populations of normal, neoplastic, and malignant livers have been cultivated.

Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Download or read book Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease written by Reinhold G. Erben and published by Frontiers Media SA. This book was released on 2019-04-05 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology of diseases such as chronic kidney disease, left ventricular hypertrophy, myocardial infarction, hypertension, and disorders characterized by impaired bone mineralization. The 11 articles compiled in this Research Topic consist of three Original Research articles and 8 Reviews or Mini Reviews, and are an excellent source of information about the state of the art in the FGF23/αKlotho field, covering almost all aspects of FGF23/αKlotho biology.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress and challenges with therapeutic targeting of chemokine receptors written by Vadim Gaponenko and published by Frontiers Media SA. This book was released on 2023-10-18 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Leong s Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.

Download or read book Endocrine FGFs and Klothos written by Makoto Kuro-o and published by Springer Science & Business Media. This book was released on 2012-03-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Download or read book Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research Volume II written by Lixin Cheng and published by Frontiers Media SA. This book was released on 2023-09-05 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.

Download or read book The Evolution of the Immune System written by Davide Malagoli and published by Academic Press. This book was released on 2016-05-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. - Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms - Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology - Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization - Brings concepts and ideas on the evolution of the immune system to a wide readership