Download or read book Functional Annotation of Farm Animal Genomes written by Hans Cheng and published by Frontiers Media SA. This book was released on 2021-12-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Animal Genomics written by Sukanta Mondal and published by Academic Press. This book was released on 2020-11-25 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. - Integrates basic and advanced concepts of animal biotechnology and presents future developments - Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production - Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock - Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Download or read book Assessment of State specific Dna Methylation Patterns to Improve Functional Annotation of Farm Animal Genomes written by Ryan James Corbett and published by . This book was released on 2021 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past several decades, genetic advancements in the domestic pig (Sus scrofa) and other farm animal species have resulted in increased economic output and expanded use of these organisms as biomedical models to study human disease. However, limited functional annotation of the porcine genome-particularly in non-coding regulatory regions-hinders both identification of causal genes for complex traits and translational research capabilities. The Functional Annotation of Animal Genomes consortium seeks to map functional elements in domesticated animal genomes in part by performing sequencing assays to characterize the animal epigenome, as specific chromatin modifications have been shown to be predictive of regulatory regions. DNA methylation is the most ubiquitous epigenetic modification made to the DNA molecule, and in mammals occurs almost exclusively at cytosines in CpG dinucleotides. DNA methylation exerts regulatory effects through numerous mechanisms, including the occlusion of transcription factors at activating regulatory regions, and as such has been shown to play important roles in establishing spatiotemporal gene expression. Furthermore, differential methylation has been associated with genomic imprinting and stress-induced physiological changes in mammals. Assessment of DNA methylation in the pig and other farm animal species has thus far been limited in scope. In this dissertation, I have characterized state-specific DNA methylation patterns in farm animal genomes across a diverse collection of cell types, developmental stages, and environmental conditions, to enhance understanding of epigenetic gene regulation in livestock and poultry. First, I demonstrate that sorted porcine immune cells exhibit unique DNA methylation landscapes that are strongly correlated with local and distal gene expression as well as binding sites for transcription factors regulating immune cell-specific functions. The co-localization of immune cell differentially methylated regions with GWAS SNPs for immune-related traits supports the use of epigenomics assays to increase functional annotation of economically relevant genomic regions. Second, I show that development of four porcine fetal tissues (whole brain, liver, loin muscle, and placenta) is associated with increased differentiation of DNA methylation profiles that likely contributes to tissue-specific transcriptomes and transcription factor regulatory potential. I also report widespread allele-biased methylation in fetal tissues associated with breed-specific gene regulation as well as putative regions of genomic imprinting events. Third, I characterize associations between environmental stimuli and DNA methylation patterns in two studies. I show that piglet weaning correlates with changes in peripheral blood mononuclear cell DNA methylation, and that increased weaning stress is associated with increased methylation and decreased expression of T cell-enriched genes, suggesting a diminished adaptive immune response. Lastly, I assess the impact of broiler chick incubation parameters on cardiac DNA methylation and observe significant temperature-associated differential methylation of genes involved in heart morphogenesis. I identified differentially methylated and expressed genes between temperature treatments that may influence environment-driven differences in cardiovascular development. In conclusion, I have performed the most expansive survey of whole-genome DNA methylation in farm animal species to date and have identified thousands of putative regulatory elements influencing state-specific gene and phenotype expression. These data will be a valuable resource for future functional annotation efforts seeking to identify mechanistic links between genetic and phenotypic variation in animal species.

Download or read book Exploring Horizons for Domestic Animal Genomics written by National Research Council and published by National Academies Press. This book was released on 2002-08-27 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the important contributions that genomic analysis can make to agriculture, production and companion animal science, evolutionary biology, and human health with respect to the creation of models for genetic disorders, the National Academies convened a group of individuals to plan a public workshop that would: (1) assess these contributions; (2) identify potential research directions for existing genomics programs; and (3) highlight the opportunities of a coordinated, multi-species genomics effort for the science and policymaking communities. Their efforts culminated in a workshop sponsored by the U.S. Department of Agriculture, Department of Energy, National Science Foundation, and the National Institutes of Health. The workshop was convened on February 19, 2002. The goal of the workshop was to focus on domestic animal genomics and its integration with other genomics and functional genomics projects.

Download or read book GO FAANG Gathering on Functional Annotation of Animal Genomes Workshop written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Animal Genetics and Diseases Advances in Farming and Livestock Systems written by Mark S. Fife and published by Frontiers Media SA. This book was released on 2020-02-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new Animal Genetics and Disease 2017 conference committee organized a Research Topic for the proceedings of this inaugural conference. The meeting brought together specialists working on the interface between genomics, genetic engineering, and infectious disease, with the aims of improving animal and human health and welfare. This conference was funded by Advanced Courses and Scientific Conference at the Wellcome Genome Campus, Hinxton, UK. The conference will highlight breakthroughs in genomic technologies that are rapidly increasing our understanding of the fundamental role that host and pathogen genetics play in infections and epidemics. This Research Topic focuses on how infections spread and how they further affect the productivity of livestock systems and food supply chains. Thanks to technological advances, we now have the tools for real-time surveillance of zoonoses affecting wildlife, farm animals and animal-to-human disease transmission.

Download or read book Genome Mapping and Genomics in Domestic Animals written by Noelle E. Cockett and published by Springer Science & Business Media. This book was released on 2008-10-31 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics research on animals has generated huge databases and several new concepts and strategies, which are used to elucidate origin, evolution and phylogeny of species. Genetic and physical maps of genomes give details on chromosomal location, function, expression and regulation of genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on selected animal systems contributed by leading scientists from around the world. This volume offers information on gene mapping and genomics research in domesticated and farmed animals including cattle, water buffalo, sheep, deer, poultry, turkeys, rabbits, dogs and pigs. While the genome maps for some species are very limited, full genome sequences are available for cattle, chickens and dogs. Genomic research contributes to the identification of genetic regions that control the functionality and well-being of animals. Several farmed species are also used as models for biomedical studies.

Download or read book Animal Genomics written by Bhanu P. Chowdhary and published by S. Karger AG (Switzerland). This book was released on 2003 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication provides an update on the current status of gene maps in different livestock and pet/companion animal species. The findings summarized in species specific commentaries and original articles testify the rapid advances made in the field of animal genomics. Of significant interest is the fact that current investigations are providing headways for two important and exciting research fronts: targeted high-resolution mapping leading to the application of genomic information in addressing questions of economic and biological significance in animals, and the initiation of whole genome sequencing projects for some of the animal species. Like in humans and mice, this will set the stage for a new level of research and real time complex analysis of the genomes of these species. Animal Genomics signifies the beginning of a new era in this field and celebrates the achievements of the past 20 years of genomics research. It will be of special interest to researchers involved in genome analysis - both gross chromosomal as well as molecular - in various animal species, and to comparative and evolutionary geneticists.

Download or read book Why Livestock Genomics for Developing Countries offers Opportunities for Success written by Farai Catherine Muchadeyi and published by Frontiers Media SA. This book was released on 2020-12-14 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Advances in Genomics of Crossbred Farm Animals written by Xiao-Lin Wu and published by Frontiers Media SA. This book was released on 2021-09-24 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genome Analysis in Domestic Animals written by Hermann Geldermann and published by Wiley-Blackwell. This book was released on 1990-09-11 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of review articles presents the first comprehensive treatment of the impact of modern molecular biology on an important and rapidly growing field in animal breeding: the analysis of the genome. The contributions, ranging from descriptions of basic knowledge to application-oriented reports, cover topics such as * the organization of animal genomes * the screening and cloning of genes * the analysis of gene functions * the molecular mechanisms of diseases * the patentability of genetic inventions Due to its broad scope, the book will stimulate progress in breeding technology and improve the interaction between researchers, practical breeders and government authorities within farm animal technology.

Download or read book Farm Animals Advances in Genomics written by Johann Casini and published by States Academic Press. This book was released on 2021-11-16 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of genomes of organisms which incorporates the principles of genetics is referred to as genomics. DNA sequencing, bioinformatics and recombinant DNA are some of the techniques studied under this discipline. Humans depend on farm animals for various products such as meat, milk, fur, leather, egg, etc. The study of farm animals' genome aims to make use of the understanding of genomics and proteomics for the purpose of increasing livestock productivity, sustainable breeding and xenotransplantation. Increased disease resistance and inheritance of desired characteristics are some of the prominent applications of animal genetics and genome study. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this field have been included in this book. It is a compilation of chapters that discuss the most vital concepts and emerging trends in the field of farm animal genomics. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.

Download or read book Animal Genomics for Animal Health written by Marie-Hélène Pinard and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: "It includes a review of the state of the art in animal genomics and its applications to animal health. The contributions describe the new tools available, such as HapMaps for chicken and cattle, and show how the understanding of gene structure and function can be successfully applied to delineate the molecular mechanisms of disease and determine complex phenotypes associated with health traits. A critical evaluation of future needs and future applications of animal genomics is also presented. The integration of animal genomics in animal health research is likely to revolutionize the way scientists approach the challenges of discovering highly effective drugs and vaccines for animal diseases."--BOOK JACKET.

Download or read book Genomic Selection in Animals written by Joel Weller and published by John Wiley & Sons. This book was released on 2016-01-04 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of whole genome selection has quickly developed into the breeding methodology of the future. As efforts to map a wide variety of animal genomes have matured and full animal genomes are now available for many animal scientists and breeders are looking to apply these techniques to livestock production. Providing a comprehensive, forward-looking review of animal genomics, Genomic Selection in Animals provides coverage of genomic selection in a variety of economically important species including cattle, swine, and poultry. The historical foundations of genomic selection are followed by chapters that review and assess current techniques. The final chapter looks toward the future and what lies ahead for field as application of genomic selection becomes more widespread. A concise, useful summary of the field by one of the world’s leading researchers, Genomic Selection in Animals fills an important gap in the literature of animal breeding and genomics.

Download or read book Gene Regulation Explored by Systems Biology in Livestock Science written by Andressa Oliveira De Lima and published by Frontiers Media SA. This book was released on 2022-04-27 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Integrative Genomics and Network Biology in Livestock and other Domestic Animals written by David E. MacHugh and published by Frontiers Media SA. This book was released on 2020-09-11 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Advances in Farm Animal Genomic Resources written by Stéphane Joost and published by Frontiers Media SA. This book was released on 2016-01-28 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of livestock started with the domestication of their wild ancestors: a restricted number of species allowed to be tamed and entered a symbiotic relationship with humans. In exchange for food, shelter and protection, they provided us with meat, eggs, hides, wool and draught power, thus contributing considerably to our economic and cultural development. Depending on the species, domestication took place in different areas and periods. After domestication, livestock spread over all inhabited regions of the earth, accompanying human migrations and becoming also trade objects. This required an adaptation to different climates and varying styles of husbandry and resulted in an enormous phenotypic diversity. Approximately 200 years ago, the situation started to change with the rise of the concept of breed. Animals were selected for the same visible characteristics, and crossing with different phenotypes was reduced. This resulted in the formation of different breeds, mostly genetically isolated from other populations. A few decades ago, selection pressure was increased again with intensive production focusing on a limited range of types and a subsequent loss of genetic diversity. For short-term economic reasons, farmers have abandoned traditional breeds. As a consequence, during the 20th century, at least 28% of farm animal breeds became extinct, rare or endangered. The situation is alarming in developing countries, where native breeds adapted to local environments and diseases are being replaced by industrial breeds. In the most marginal areas, farm animals are considered to be essential for viable land use and, in the developing world, a major pathway out of poverty. Historic documentation from the period before the breed formation is scarce. Thus, reconstruction of the history of livestock populations depends on archaeological, archeo-zoological and DNA analysis of extant populations. Scientific research into genetic diversity takes advantage of the rapid advances in molecular genetics. Studies of mitochondrial DNA, microsatellite DNA profiling and Y-chromosomes have revealed details on the process of domestication, on the diversity retained by breeds and on relationships between breeds. However, we only see a small part of the genetic information and the advent of new technologies is most timely in order to answer many essential questions. High-throughput single-nucleotide polymorphism genotyping is about to be available for all major farm animal species. The recent development of sequencing techniques calls for new methods of data management and analysis and for new ideas for the extraction of information. To make sense of this information in practical conditions, integration of geo-environmental and socio-economic data are key elements. The study and management of farm animal genomic resources (FAnGR) is indeed a major multidisciplinary issue. The goal of the present Research Topic was to collect contributions of high scientific quality relevant to biodiversity management, and applying new methods to either new genomic and bioinformatics approaches for characterization of FAnGR, to the development of FAnGR conservation methods applied ex-situ and in-situ, to socio-economic aspects of FAnGR conservation, to transfer of lessons between wildlife and livestock biodiversity conservation, and to the contribution of FAnGR to a transition in agriculture (FAnGR and agro-ecology).