Download or read book Function and Regulation of Eye Gone in Drosophila Eye Development written by 趙如蘭 and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2002-03-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book Regulation of Drosophila Eye Development by the Transcription Factors written by Jennifer Colleen Jemc and published by . This book was released on 2007 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) First, we characterized the eye phenotypes arising from overexpression of nito. Overexpression of nito perturbs eye development and in contrast to spen, which has been shown to act as a positive effector of EGFR signaling, appears to be a negative effector of EGFR signaling during eye development. Further genetic analysis of the relationship between spen and nito in the eye suggests they function antagonistically, possibly by targeting a common set of genes for transcriptional regulation. Further analysis of SPOC family mutants and study of the functions of these proteins at a molecular level will be necessary to understand the relationship of small and large SPOC proteins and the roles of the proteins in development and disease.
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in the Drosophila Eye written by Amit Singh and published by Springer Science & Business Media. This book was released on 2013-09-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in Drosophila Eye written by Amit Singh and published by Springer Nature. This book was released on 2020-05-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.
Download or read book Identifying a Role for Retinoblastoma in Regulation of Differentiation During Drosophila Eye Development written by Latishya Janine Steele and published by . This book was released on 2009 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Slingshot and the Regulation of Hedgehod in Drosophila Eye Development written by Edward M. Rogers and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Dynamics in the Developing Drosophila Eye written by Daisuke Yamamoto and published by Landes Bioscience. This book was released on 1996 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Genetic and Hormonal Regulation of Drosophila Eye Development written by Catherine Anne Brennan and published by . This book was released on 1999 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Development of Drosophila Melanogaster written by Michael Bate and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Download or read book Using Transcriptomics to Identify Targets of Eyeless and Signaling Pathways in Drosophila Eye Development written by Nfsonsam Landry Ewongkem and published by . This book was released on 2012 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue-specific transcription factors cooperate with signaling pathways to promote specification, in part by co-regulating transcription. The Drosophila melanogaster Pax6 homolog Eyeless forms a complex, incompletely understood regulatory network with signaling pathways to control eye-specific gene expression. I employed mRNAseq and microarray approaches to identify targets co-regulated by Eyeless and Hedgehog, Decapentaplegic or Notch signals, to further understand the Drosophila eye network. The gene encoding the neprilysin family peptidase 'Abnormally blistered and morphologically misshapen eyes', Abams and the Drosophila class II 'Myosin heavy chain' protein, Mhc, were expressed at higher levels in the eye tissues versus wing tissues, and were highly expressed in eye tissues in response to Ey+N. Thus, both abams and Mhc were predicted to have roles in eye development. Whereas wild type eyes have a regular array of ommatidia interspersed with regularly occurring sensory bristles, using RNA interference (RNAi), I showed that reduction of abams function resulted in smaller eyes that consisted of patches of individual ommatidia surrounded by numerous bristles. Photoreceptor development was disrupted when abams function was reduced in eye precursors. Loss of function analyses and RNAi of Mhc revealed disruptions in the eye lattice and the mispositioning of photoreceptor nuclei within the eye precursor epithelium. My results suggest that Abams is involved in cell-cell signaling while Mhc regulates cell morphology and/or cell-cell adhesion during eye development. Transcription factor binding site (BS) analyses using computational modeling revealed [greater than or equal to] 94 other candidate genes as potential direct targets of Ey or Ey+Hh, Dpp or N. These included genes with already known roles in Drosophila eye development, as well as genes with unknown function, thus providing potential new directions to pursue to further understand the mechanism of interaction between Ey and Hh, Dpp or Notch during Drosophila eye development. Given the similarity between D. melanogaster and vertibrate eye development, further study of Abams and Mhc in Drosophila eye development will provide novel insights into our understanding of eye development in D. melanogaster and humans.
Download or read book Functional Dissection of Eyes Absent and Sine Oculis in Drosophila Eye Development written by Barbara Jusiak and published by . This book was released on 2012 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Behavioral Genetics of the Fly Drosophila Melanogaster written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Download or read book Developmental Systems Insects written by S. J. Counce and published by . This book was released on 1972 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The causal analysis of insect embryogenesis; The development of spatial patterns in the integument of insects; The imaginal discs of drosophila; Role of hormones in insect development; The morphogenesis of patterns in drosophila.
Download or read book Drosophila melanogaster written by Farzana Khan Perveen and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
