Download or read book Function and Flexibility Friend or Foe written by Kris Pauwels and published by Frontiers Media SA. This book was released on 2016-10-06 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.
Download or read book Function and Flexibility Friend Or Foe written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that "form follows function". When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that "function follows form" as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original "1 gene - 1 protein structure - 1 function" relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan's quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.
Download or read book Weak Interactions in Molecular Machinery written by Irene Díaz-Moreno and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse cellular processes depend on weak interactions between biological components. In this volume, we bring together a wealth of recent information on this topic, combining original research articles with up-to-date reviews, organized under four separate themes. In our first section on nucleic acid regulation, we include a study of the PII-NAGK-PipX-NtcA regulatory axis of cyanobacteria and discover much about the role of RNA binding protein regulation and cross-talk in the control of AU-rich mRNA. Peptide-mediated weak interactions are our second theme in which we review weak molecular interactions in clathrin-mediated endocytosis, investigate the selectivity of the G7-18NATE inhibitor peptide for the Grb7-SH2 domain target and present new structure and interactions of the TPR domain of Sgt2 with yeast chaperones and Ybr137wp. Our third part focuses on carbohydrates and includes a thorough review of how to use NMR to study transient carbohydrate - protein binding and a structural and functional study of lysostaphin - substrate interaction. In our final section, we look at functional sensors driving weak interactions by presenting the molecular basis of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX alongside a review of intramolecular fuzzy interactions involving intrinsically disordered domains. Taken together, our eBook chapters offer some recent insight into this area of scientific understanding which is still expanding exponentially.
Download or read book CD4 T cells in HIV A friend or foe written by Sunil Kannanganat Sidharthan and published by Frontiers Media SA. This book was released on 2023-07-26 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Flexible Work Arrangements Conceptualizations and International Experiences written by Isik U. Zeytinoglu and published by Springer. This book was released on 2002-12-18 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the effect of flexible work arrangements on individusls' career, family, health and well-being, as well as effects on the workplace and the society.
Download or read book Functions and Basic Doctrine of the United States Air Force written by and published by . This book was released on 1984 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of the Mind written by Harold Pashler and published by SAGE. This book was released on 2013-01-14 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's hard to conceive of a topic of more broad and personal interest than the study of the mind. In addition to its traditional investigation by the disciplines of psychology, psychiatry, and neuroscience, the mind has also been a focus of study in the fields of philosophy, economics, anthropology, linguistics, computer science, molecular biology, education, and literature. In all these approaches, there is an almost universal fascination with how the mind works and how it affects our lives and our behavior. Studies of the mind and brain have crossed many exciting thresholds in recent years, and the study of mind now represents a thoroughly cross-disciplinary effort. Researchers from a wide range of disciplines seek answers to such questions as: What is mind? How does it operate? What is consciousness? This encyclopedia brings together scholars from the entire range of mind-related academic disciplines from across the arts and humanities, social sciences, life sciences, and computer science and engineering to explore the multidimensional nature of the human mind.
Download or read book Enemies to Friends written by Jessa James and published by KSA Publishing Consultants. This book was released on with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our story began as an arranged marriage. It started with a lie. To love and to cherish, till death do we part. Those are the words that I whispered to him at the altar. He is a Leone, tall and mighty, heir to the family fortune. I’m a De Rose, the only daughter of a rival family. We both have our reasons for agreeing to that. Neither of us expects it to last. Two sworn enemies, brokering peace. Paying the price with our own lives. Our marriage is heavy with secrets and ripe for betrayal. Yet something warm grows out of that cold place, a fierce love blooming between us… To love and to cherish, till death do we part...
Download or read book Friends and Enemies written by J.L. Granatstein and published by University of Toronto Press. This book was released on 2024-03-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Friends and Enemies presents a collection of essays on Canadian foreign policy written by J.L. Granatstein, one of the leading political and military historians in the country. The essays cover a period primarily from the Second World War through to the early 2000s and examine policy under prime ministers Mackenzie King, Louis St. Laurent, John Diefenbaker, Lester Pearson, and Pierre Trudeau. Based on interviews and extensive archival research, the essays reveal how Granatstein’s views shifted as he reacted to altered conditions in Canada, Canadian alliances, and the world situation.
Download or read book An Introduction to Human Resource Management written by Nick Wilton and published by SAGE Publications. This book was released on 2010-10-04 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting new introductory text in human resource management moves beyond a prescriptive approach to provide a holistic overview of the role of HRM in its contemporary context. Acknowledging and reflecting upon key trends in HRM, the labour market and the broader economy, the author offers critical discussion of the theoretical and practical issues surrounding HRM. Includes accessible learning features to help you best explore the material, including: - 'research', 'ethics' and 'international' insight boxes; - chapter summaries and objectives; - self-test questions; - recommended reading; - end of chapter case studies. An accompanying companion website (www.sagepub.co.uk/wilton) provides you with full-text journal articles, extended case studies, weblinks and a glossary. The website also provides an instructor's manual, PowerPoint slides and a multiple-choice test bank for lecturers. This book is essential reading for undergraduate, postgraduate and MBA students, as well as those studying for their CIPD qualifications. Nick Wilton is Senior Lecturer in HRM at Bristol Business School at the University of the West of England. "Well-researched, well-written, and is clearly signposted and structured for the reader. The learning objectives at the outset of every chapter act as a clear guide for each topic explored. Additional references and further reading are also offered to the student seeking deeper knowledge. Case studies, throughout the book, bring the HRM theories to life and demonstrably link these with practice. Wilton's book is an extremely useful core text for students of HRM and a welcome addition to HRM resources" - Denise Bagley, Principal Lecturer in Human Resource Management, London South Bank University
Download or read book What the Body Commands written by Colin Klein and published by MIT Press. This book was released on 2015-08-14 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel theory of pain, according to which pains are imperatives—commands issued by the body, ordering you to protect the injured part. In What the Body Commands, Colin Klein proposes and defends a novel theory of pain. Klein argues that pains are imperative; they are sensations with a content, and that content is a command to protect the injured part of the body. He terms this view “imperativism about pain,” and argues that imperativism can account for two puzzling features of pain: its strong motivating power and its uninformative nature. Klein argues that the biological purpose of pain is homeostatic; like hunger and thirst, pain helps solve a challenge to bodily integrity. It does so by motivating you to act in ways that help the body recover. If you obey pain's command, you get better (in ordinary circumstances). He develops his account to handle a variety of pain phenomena and applies it to solve a number of historically puzzling cases. Klein's intent is to defend the imperativist view in a pure form—without requiring pain to represent facts about the world. Klein presents a model of imperative content showing that intrinsically motivating sensations are best understood as imperatives, and argues that pain belongs to this class. He considers the distinction between pain and suffering; explains how pain motivates; addresses variations among pains; and offers an imperativist account of maladaptive pains, pains that don't appear to hurt, masochism, and why pain feels bad.
Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1984 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Work and Family Allies or Enemies written by Stewart D. Friedman and published by Oxford University Press. This book was released on 2000-06-22 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: We've come a long way since the classic book The Organization Man first introduced the "ideal" 2-person career--a full-time male breadwinner and a stay-at-home wife. What typified the '50s good life is in stark contrast to contemporary reality: 63% of all married women with children under six years old are in the workforce and 40% of all workers are part of a dual-earner couple. Work and Family--Allies or Enemies? offers a fresh new lens for viewing the real struggles that business professionals face in their daily battle to find ways of "getting a life" and "having it all." Based on a pioneering study that surveyed more than 800 business professionals, this volume will help readers understand and deal with the effects of gender, professional culture, and social expectations, on the evolving roles of men and women in crafting an integrated life. A rich, inspiring, and at times disturbing look at how work and family affect the lives of men and women trying to manage the complexities of modern living, the authors argue that it is critical to learn how to manage the boundaries between work and family, to handle ambiguity, to manage multiple tasks simultaneously, and to build networks of support at work and in the community. Work and Family--Allies or Enemies? offers a prescription for success that requires that all parties--individuals, employers, and society--clarify what is important, recognize and support the whole person, and continually experiment with new ways to achieve meaningful goals.
Download or read book Computerworld written by and published by . This book was released on 1977-05-16 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 40 years, Computerworld has been the leading source of technology news and information for IT influencers worldwide. Computerworld's award-winning Web site (Computerworld.com), twice-monthly publication, focused conference series and custom research form the hub of the world's largest global IT media network.
Download or read book Computational Toxicology written by Sean Ekins and published by John Wiley & Sons. This book was released on 2007-06-30 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.
Download or read book Crohn s Disease and Ulcerative Colitis written by Daniel C. Baumgart and published by Springer. This book was released on 2017-03-01 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.
Download or read book Total Integrated Marketing written by James M. Hulbert and published by Kogan Page Publishers. This book was released on 2005 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on their combined experience of over half a century of advising companies, the authors argue that marketing has lost its way. Companies cannot win in today's highly competitive markets by leaving marketing up to the marketing department. Success in the new marketplace demands integration of the firm's entire set of capabilities into a seamless system that delivers exemplary customer satisfaction, if not delight. Integrating marketing is imperative, from the top down, and with every major function: finance, operations, sales, R&D, customer service and HR. Only by creating Total Integrated Marketing, ensuring that everyone in the organization has one paramount goal to get and keep customers can success be achieved. The authors provide a wealth of marketing tips and innovations that readers can easily adapt to their own businesses and revealing cases that lift the lid on good and bad practice around the world.
