Download or read book Function and Dysfunction of Complement Factor H written by Mihály Józsi and published by Frontiers Media SA. This book was released on 2022-02-21 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Complement FactsBook written by Bernard J. Morley and published by Academic Press. This book was released on 2000 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complement system is a protein system that combines with antibodies to form a defense against bugs and viruses. This book contains entries on all its components, including C1q and lectins, serine proteases, and terminal pathway proteins.
Download or read book An Investigation Into the Role of Complement Factor H in the Retina written by J. A. E. Williams and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the UK. In 2005, the first publication of a genome-wide associated study identified a single nucleotide polymorphism in complement factor H (CFH) as a genetic risk factor for AMD. CFH is a secreted regulator of the alternative complement pathway and therefore key to controlling the inflammatory response. Prior to 2005, little was known about the role of CFH in the retina. This study addresses this question in order to understand how this protein could contribute towards AMD pathology. Initial experiments confirmed that retinal pigment epithelial (RPE) cells are capable of secreting detectable levels of CFH, and that RPE cells were able to enhance the secretion of CFH in response to inflammatory stimuli. The main focus of this study was to characterise the effect of loss of CFH on young and aged retina in Cfh-/- mice. Immunohistochemical studies revealed that signs of stress and re-distribution of complement proteins appear at one year of age. Genome-wide microarray analysis of the RPE and choroid or neuroretina, showed that loss of CFH has little effect on gene expression in young mice but that the impact of CFH loss increases with age. The largest group of genes to change were involved in antigen presentation and immunity suggesting that CFH has an important role in immune regulation in the eye. Analysis of visual function using electoretinograms revealed that dysfunction seen at two years was not present at one year, indicating that age-related gene expression changes are likely to be involved in the pathogenic process in these mice. This study reveals the importance of CFH in maintaining retinal health and good visual function with age.
Download or read book Pediatric Allergy Principles and Practice E Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Download or read book Mechanism and Function of Complement Factor H written by Nicola McIntosh and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Complement Therapeutics written by John D. Lambris and published by Springer Science & Business Media. This book was released on 2012-09-19 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials. The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system.
Download or read book Structure and Function of the Central Part of Complement Factor H written by Christoph Schmidt (Ph.D.) and published by . This book was released on 2009 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ocular Vascular Occlusive Disorders written by Sohan Singh Hayreh and published by Springer. This book was released on 2015-02-18 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive account of the pathogenesis, clinical features, and management of ocular vascular occlusive disorders, with the focus very much on the scientific evidence. This offers a sound basis for addressing the many controversies that surround these disorders, which collectively constitute the most common cause of visual impairment or blindness. The book is divided into two sections, the first of which addresses the basic science and encompasses vascular anatomy, blood supply and flow, and retinal tolerance time to acute ischemia. The second, clinical, section covers the presentation, clinical features, diagnosis, and treatment of the full range of vascular occlusive disorders of the retina, the choroid, the anterior segment of the eye, ophthalmic manifestations of carotid artery disease and the optic nerve. Ocular Vascular Occlusive Disorders, written by a distinguished world leader in the field, will be invaluable for general ophthalmologists, and particularly for retina specialists, neuro-ophthalmologists, and researchers.
Download or read book Role of the Complement Factor H related Protein 5 in Renal Disease by Protein Expression and Molecular Solution Structural Studies written by Nilufar Kadkhodayi-Kholghi and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Is Complement Factor H a Shared Risk Factor for Age related Macular Degeneration and Cardiovascular Disease written by R. Sofat and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background and Aims: Inflammation is implicated in common disorders of ageing including atherosclerosis and age-related macular degeneration (AMD), although the link between inflammation and cardiovascular disease (CVD) is the more studied. The recent finding that susceptibility to AMD is increased substantially by common single nucleotide polymorphisms (SNPs) in the gene that encodes complement factor H (CFH; a circulating inhibitor of complement activation) provides evidence that inflammation in general, and complement in particular, maybe causally involved in AMD. Since AMD and atherosclerosis share similar pathological features and risk factors, including a link with inflammation, an important question arises: is complement factor H (fH) a shared risk factor for both AMD and CHD? One SNP in particular, which has the most replicated association in AMD, rs1061170, which encodes a putative functional tyrosine to histidine change (Y402H), and has been studied in both AMD and coronary heart disease (CHD). I hypothesised that genetic variants in CFH, in particular rs1061170 is associated with risk of both AMD and CHD and that this association may be mediated through changes in circulating fH concentration. I addressed this hypothesis by: (i) precisely defining the effect of the association of the rs1061170 SNP encoding Y402H in CFH on AMD risk; (ii) precisely defining the association of rs1061170 on risk of CHD events; and (iii) developing and validating a high throughput assay of circulating fH, to enable further evaluation of the nature of the association between CFH genotype and fH concentration, and fH concentration and disease; (iv) measuring fH in a population based sample to determine its non-genetic correlates and genetic determinants (v) measuring fH in case control studies of AMD and genotyping of SNPs in the CFH and related genes to determine the concordance of the genetic associations of fH and AMD. Methods: To address aims (i) and (ii), I conducted a systematic review of published studies investigating the effect of variants in CFH on AMD and CHD risk respectively, supplementing data with results from newly genotyped studies in both AMD and CHD. To address aim (iii) I developed and validated a high-throughput assay measuring circulating fH, which I used to undertake studies in aim (iv) in which I measured fH in a population based sample with an existing range of blood and lifestyle measures as well as anthropometric, cardiovascular, glycaemic, lipid, liver, renal, and inflammation markers. In addition to this genome wide information was also available on ~500,000 SNPs across the genome with additional imputation of un-typed SNPs, giving coverage of ~ 2 million markers across the genome. In order to achieve aim (v) I measured fH in case control studies of AMD, with additional genotyping of SNPs in the CFH and CFH related gene in order to attain a more high resolution signal of association in this genomic region for both fH concentration and AMD risk. Results: Data synthesis from published literature and newly genotyped studies, confirmed the strong association of the rs1061170 SNP with risk of AMD (per-allele odds ratio (OR) of 2.30, 99% CI 1.93, 2.73; p
Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.
Download or read book Oxford Textbook of Vasculitis written by Gene V. Ball and published by Oxford University Press, USA. This book was released on 2014 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of inflammatory syndromes and diseases that affect the blood vessels, this volume draws upon authors from all over the world to present informed discussions on all types of vasculitis and related conditions.
Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Download or read book Adrenomedullin written by Alfredo Martínez and published by IOS Press. This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.
Download or read book Structure and Function of the Central Part of Complement Factor H written by Christoph Schmidt and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
