Download or read book Frontiers of Cellular Bioenergetics written by S. Papa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 827 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts; P. Nicholls. 2. The Mitochondrial Enzymes of Oxidative Phosphorylation; Y. Hatefi. 3. Proton Pumps of Respiratory Chain Enzymes; S. Papa, et al. 4. Uncoupling of Respiration and Phosphorylation; V.P. Skulachev. 5. Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans; M. Hartmut, et al. 6. The Structure of Crystalline Bovine Heart Cytochrome c Oxidase; S. Yoshikawa, et al. 7. Electron and Proton Transfer in.
Download or read book Bioenergetics of the Cell Quantitative Aspects written by Valdur A. Saks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.
Download or read book The Warburg Effect Regulation Under Siege The Intertwined Pathways in Health and Disease written by Concetta Bubici and published by Frontiers Media SA. This book was released on 2019-10-17 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Download or read book Bioenergetic Processes of Cyanobacteria written by Guenter A. Peschek and published by Springer Science & Business Media. This book was released on 2011-06-08 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is unique among a number of books on cyanobacteria because it focuses on the bioenergetics of these widespread organisms which are the evolutionary prerequisite for the development of all higher forms of life on our "blue" planet. The book primarily addresses questions of energy conversion by the fundamental bioenergetic processes: (oxygenic) photosynthesis, (aerobic) respiration, and (anaerobic) fermentation which uniquely occur together in these prokaryotic cells. Thermophilic cyanobacteria offer the most suitable material for high resolution structure analyses of Photosystem I and II and other electron transport complexes by X-ray crystallography (for example, at present the structure of Photosystem II at atomic resolution is only known for these organisms). These achievements during the last decade represent a milestone in our understanding of the complexes which are crucial for solar energy exploitation through photosynthetic water splitting. The present work represents an ambitious attempt to achieve the goal of a synoptic state-of-the-art picture by casting together the mosaics of detailed knowledge described by leading experts in the field. It contains 24 chapters written by 35 authors from Europe, USA, India and Japan. The book is aimed at reaching a broad audience ranging from students to experienced scientists. The editors wish all readers a pleasant and stimulating journey through the fascinating “world” of the bioenergetics of cyanobacteria and sincerely hope that this book will not only be of great value for the experts but also entice young people into this exciting research area with the aim to address successfully the challenging problems of high relevance that are still waiting for a satisfactory answer.
Download or read book Biological Inorganic Chemistry written by Ivano Bertini and published by University Science Books. This book was released on 2007 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.
Download or read book Stress Biology of Cyanobacteria written by Ashish Kumar Srivastava and published by CRC Press. This book was released on 2013-03-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: A significant component of many different ecosystems, cyanobacteria occupy almost every niche of the earth, including fresh and salt waters, rice fields, hot springs, arid deserts, and polar regions. Cyanobacteria, along with algae, produce nearly half the global oxygen, making assessment of their ecophysiologies important for understanding climate
Download or read book Searching for a Mechanism written by John N. Prebble and published by Oxford University Press, USA. This book was released on 2019-01-03 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "bioenergetics revolution" has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced into the field until Albert Szent-Gyorgyi published a small book under that title in 1957. Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies.
Download or read book AI in Biological and Biomedical Imaging written by Xin Gao and published by Frontiers Media SA. This book was released on 2022-01-17 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doctors Gao and Li hold patents related to artificial intelligence.
Download or read book Compact Handbook of Computational Biology written by A.K. Konopka and published by CRC Press. This book was released on 2004-08-30 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The assimilation of computational methods into the life sciences has played an important role in advancing biological research. From sequencing genomes to discovering motifs in large collections of functionally equivalent sequences of nucleic acids and proteins, the value of powerful computational tools has become abundantly clear. The Compact Hand
Download or read book Wandering in the Gardens of the Mind written by John Prebble and published by Oxford University Press. This book was released on 2003-02-27 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peter Mitchell, winner of the 1978 Nobel Prize for chemistry for his chemiosmotic theory, was a highly original scientist who revolutionized our understanding of cellular metabolism and bioenergetics. This is the only full biography of Mitchell, and it should be of considerable interest to biophysicists, biochemists, and physicians and researchers focusing on metabolism, as well as historians of medicine and biology.
Download or read book Machine Learning in Biomolecular Simulations written by Gennady Verkhivker and published by Frontiers Media SA. This book was released on 2019-10-21 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine learning methods such as neural networks, non-linear dimensionality reduction techniques, random forests and others meet in this research topic with biomolecular simulations. The authors of eight articles applied these methods to analyze simulation results, accelerate simulations or to make molecular mechanics force fields more accurate.
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1999 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Growth and Oncogenesis written by S. Papa and published by Birkhäuser. This book was released on 2013-03-11 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. This book comprises recent results on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolism pathways during oncogenesis.
Download or read book Machine Learning Methodologies To Study Molecular Interactions written by Elif Ozkirimli and published by Frontiers Media SA. This book was released on 2022-01-21 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Elif Ozkirimli is a full time employee of F. Hoffmann-La Roche AG, Switzerland and Dr. Artur Yakimovich is a full time employee of Roche Products Limited, UK. All other Topic Editors declare no competing interests with regards to the Research Topic.
Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Download or read book List of Journals Indexed in Index Medicus written by National Library of Medicine (U.S.) and published by . This book was released on 1977 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus.
Download or read book Epitranscriptomics The Novel RNA Frontier written by Giovanni Nigita and published by Frontiers Media SA. This book was released on 2019-01-31 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.
