Download or read book Frontiers in Computational and Systems Biology written by Jianfeng Feng and published by Springer Science & Business Media. This book was released on 2010-06-14 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.

Download or read book The Life Sciences written by and published by National Academies. This book was released on 1970-01-01 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frontiers in Mathematical Biology written by Simon A. Levin and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a mathematical point of view, physiologically structured population models are an underdeveloped branch of the theory of infinite dimensional dynamical systems. We have called attention to four aspects: (i) A choice has to be made about the kind of equations one extracts from the predominantly verbal arguments about the basic assumptions, and subsequently uses as a starting point for a rigorous mathematical analysis. Though differential equations are easy to formulate (different mechanisms don't interact in infinites imal time intervals and so end up as separate terms in the equations) they may be hard to interpret rigorously as infinitesimal generators. Integral equations constitute an attractive alternative. (ii) The ability of physiologically structured population models to increase our un derstanding of the relation between mechanisms at the i-level and phenomena at the p-level will depend strongly on the development of dynamical systems lab facilities which are applicable to this class of models. (iii) Physiologically structured population models are ideally suited for the for mulation of evolutionary questions. Apart from the special case of age (see Charlesworth 1980, Yodzis 1989, Caswell 1989, and the references given there) hardly any theory exists at the moment. This will, hopefully, change rapidly in the coming years. Again the development of appropriate software may turn out to be crucial.

Download or read book Systems and Synthetic Biology written by Vikram Singh and published by Springer. This book was released on 2014-12-15 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Download or read book Frontiers of Biological Energetics written by P Dutton and published by Elsevier. This book was released on 2012-12-02 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers of Biological Energetics, Volume II: Electrons to Tissues contains most of the papers presented at the International Symposium on "Frontiers of Biological Energetics: Electrons to Tissues," held at the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania on July 20-21, 1978. The symposium provided a forum for discussing the common problems of biological energetics from different perspectives and from various levels of cellular organization. Comprised of 84 chapters, this volume begins with a section on electrons and oxygen and covers topics ranging from the chemical constitutions and subunit function of cytochrome oxidase polypeptides to the structure and function of copper atoms in cytochrome oxidase. The next section deals with structural-functional approaches to membrane energetics and includes chapters that explore rhodopsin and bacteriorhodopsin in model membranes; the mechanism of free energy utilization for active transport of calcium ions; and the regulation of cytoplasmic calcium by liver mitochodria. The final section focuses on nondestructive measurements of tissue function, paying particular attention to phosphorus nuclear magnetic resonance of diseased muscle and extracellular oxygen gradients in shock, among other topics. This book should be of interest to scientists from a variety of disciplines, including medicine and biology.

Download or read book Tissue Regeneration Where Nano structure Meets Biology written by Qing Liu and published by World Scientific. This book was released on 2014-01-03 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume presents the recent advances in tissue regeneration. The authors are all active researchers in their respective fields with extensive experiences. The focus of the book is on the use of stem cells and nano-structured biomaterials for tissue regeneration/tissue engineering. It includes the use of stem cells, naturally derived extracellular matrix (ECM), synthetic biomimetic nano-fibers, synthetic nano-structured ceramics and synthetic nano-structured polymer/ceramic composites that can help/promote tissue regeneration. Methods on how to produce these nano-structured biomaterials are also discussed in several chapters. Future challenges and perspectives in the field of regenerative medicine (tissue regeneration) are also discussed.

Download or read book New Frontiers and Applications of Synthetic Biology written by Vijai Singh and published by Academic Press. This book was released on 2022-01-12 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. - Offers basic understanding and knowledge in several aspects of synthetic biology - Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more - Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more

Download or read book Transport Equations in Biology written by Benoît Perthame and published by Springer Science & Business Media. This book was released on 2006-12-14 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents models written as partial differential equations and originating from various questions in population biology, such as physiologically structured equations, adaptive dynamics, and bacterial movement. Its purpose is to derive appropriate mathematical tools and qualitative properties of the solutions. The book further contains many original PDE problems originating in biosciences.

Download or read book Frontiers in Physicochemical Biology written by Institut de biologie physico-chimique and published by . This book was released on 1978 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Physicochemical Biology ...

Download or read book Prokaryotic Gene Expression written by Simon Baumberg and published by OUP Oxford. This book was released on 1999-05-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.

Download or read book Feminism and Evolutionary Biology written by Patricia Gowaty and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standing at the intersection of evolutionary biology and feminist theory is a large audience interested in the questions one field raises for the other. Have evolutionary biologists worked largely or strictly within a masculine paradigm, seeing males as evolving and females as merely reacting passively or carried along with the tide? Would our view of nature `red in tooth in claw' be different if women had played a larger role in the creation of evolutionary theory and through education in its transmission to younger generations? Is there any such thing as a feminist science or feminist methodology? For feminists, does any kind of biological determinism undermine their contention that gender roles purely constructed, not inherent in the human species? Does the study of animals have anything to say to those preoccupied with the evolution and behavior of humans? All these questions and many more are addressed by this book, whose contributing authors include leading scholars in both feminism and evolutionary biology. Bound to be controversial, this book is addressed to evolutionary biologists and to feminists and to the large number of people interested in women's studies.

Download or read book Python Programming for Biology written by Tim J. Stevens and published by Cambridge University Press. This book was released on 2015-02-12 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do you have a biological question that could be readily answered by computational techniques, but little experience in programming? Do you want to learn more about the core techniques used in computational biology and bioinformatics? Written in an accessible style, this guide provides a foundation for both newcomers to computer programming and those interested in learning more about computational biology. The chapters guide the reader through: a complete beginners' course to programming in Python, with an introduction to computing jargon; descriptions of core bioinformatics methods with working Python examples; scientific computing techniques, including image analysis, statistics and machine learning. This book also functions as a language reference written in straightforward English, covering the most common Python language elements and a glossary of computing and biological terms. This title will teach undergraduates, postgraduates and professionals working in the life sciences how to program with Python, a powerful, flexible and easy-to-use language.

Download or read book The Biology of Nitrogen Fixation written by Anton Quispel and published by . This book was released on 1974 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nitrogen-fixing organisms. Free-living heterotrophic nitrogen-fixing bacteria. Nitrogen-fixing bacteria in the rhizosphere. Nitrogen fixation in the phyllosphere. Photosynthetic bacteria. Blue-gree algae. Associations with blue-green algae. Root-nodule symbioses with rhizobium. Root-nodulesymbioses withactinomycete-like organisms. Development of root-nodule symbioses. Root-nodule morphogenesis. Formation and function of bacteroids. The endophytes of the root nodules in nonleguminous plants. Leghemoglobin. Environmental effects on nodulation and symbiotic nitrogen fixation. Putative nitrogen fixation in other symbioses. The nitrogen-fixing system. The enzyme system. Genetics of N2-fixing organisms.

Download or read book Science the Endless Frontier written by Vannevar Bush and published by Princeton University Press. This book was released on 2021-02-02 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science.

Download or read book New Frontiers for Metrology From Biology and Chemistry to Quantum and Data Science written by M.J.T. Milton and published by IOS Press. This book was released on 2021-12-22 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of standard and reliable measurements is essential in many areas of life, but nowhere is it of more crucial importance than in the world of science, and physics in particular. This book contains 20 contributions presented as part of Course 206 of the International School of Physics Enrico Fermi on New Frontiers for Metrology: From Biology and Chemistry to Quantum and Data Science, held in Varenna, Italy, from 4 -13 July 2019. The Course was the 7th in the Enrico Fermi series devoted to metrology, and followed a milestone in the history of measurement: the adoption of new definitions for the base units of the SI. During the Course, participants reviewed the decision and discussed how the new foundation for metrology is opening new possibilities for physics, with several of the lecturers reflecting on the implications for an easier exploration of the unification of quantum mechanics and gravity. A wide range of other topics were covered, from measuring color and appearance to atomic weights and radiation, and including the application of metrological principles to the management and interpretation of very large sets of scientific data and the application of metrology to biology. The book also contains a selection of posters from the best of those presented by students at the Course. Offering a fascinating exploration of the latest thinking on the subject of metrology, this book will be of interest to researchers and practitioners from many fields.

Download or read book New Frontiers in Chemical Biology written by Mark E. Bunnage and published by Royal Society of Chemistry. This book was released on 2011 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Download or read book Molecular Biology of Weed Control written by Jonathan Gressel and published by CRC Press. This book was released on 2002-03-28 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Weeds are rarely considered a priority despite the fact that all active farmers know that the majority of their variable costs and time are devoted to eradicating them. Even most crop losses due to pests can be traced directly back to weeds, which harbor the pests as secondary hosts. In the Molecular Biology of Weed Control, Jonathan Gressel focuses attention upon the tools of molecular biology that can be used effectively in the science of weed control. Always keeping his perspective congruent with that of the working farmer, Gressel explains how weed biologists and ecologists are beginning to use recently developed tools to control intransigent weed species in modern as well as less developed areas of the world. With his usual candor, Gressel evaluates past efforts, while also exploring future prospects for replacing chemical herbicides with genetic engineering, to improve a crop's ability to compete against its feral cousins for light, nutrients, and water. Like much of Gressel's work, this book should be mandatory reading for all agriculturists and plant scientists, so that they employ and encourage what is truly effective and efficient in meeting one of this century's most critical challenges: maximizing agricultural productivity.