Download or read book From Metabolite to Metabolism to Metabolon written by Earl R. Stadtman and published by Elsevier. This book was released on 2014-06-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday. The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well. Biochemists, cytologists, and cell biologists will find the book very insightful.
Download or read book From Metabolite to Metabolism to Metabolon written by Earl R. Stadtman and published by . This book was released on 1992 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Metabolite, to Metabolism, to Metabolon.
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Download or read book Phenylpropanoid Systems Biology and Biotechnology written by Igor Cesarino and published by Frontiers Media SA. This book was released on 2022-04-01 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plant Metabolic Engineering written by Vladimir Shulaev and published by Humana. This book was released on 2022-12-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at the latest techniques used by researchers to study various aspects of plant metabolic engineering. The chapters in this book cover topics such as bioinformatics tools used to discover new genes and pathways; heterologous expression of biosynthetic genes in plant and microbial systems; and omics technologies, such as transcriptomics, proteomics, metabolomics, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Plant Metabolic Engineering: Methods and Protocols is a valuable resource for biologists, chemists, biotechnologists, students, and broad cohorts of researchers who works in the fields of plant metabolism and metabolic engineering.
Download or read book Plant Metabolic Networks written by Jörg Schwender and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are the basis for human nutrition and of increasing interest for the chemical industry as a source of chemical feed stocks. Fuels derived from plant biomass will increasingly replace fossil fuels in the future. In order to increase crop productivity, design new plant products, and create new energy crops, there is need for methods of qualitative and quantitative analysis of metabolism which are able to guide the rational re-design of metabolic networks. In this book, recent advances in qualitative and quantitative analysis of metabolism are summarized to give an overview of the current state of knowledge. Principles of the analysis of network structure, flux analysis, and kinetic modeling are described. Analytical methods necessary to produce the data needed for metabolic flux analysis and for kinetic modeling are described. The analysis of larger metabolic networks is only possible by using computer assistance. Therefore each chapter of the book shall also describe software available for this purpose.
Download or read book Glossary of Biotechnology Terms Fourth Edition written by Kimball Nill and published by CRC Press. This book was released on 2005-11-16 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if you studied biotechnology in school, if you haven't stayed current, it's not likely you'll be able to speak the same language as today's biotech scientists. The same is even truer for nanotechnology where everything gets smaller and smaller, except the terminology required to navigate it. In the Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition, Kimball Nill continues to improve upon the reference that for over a decade has helped thousands of professionals, including scientists, attorneys, government workers, lobbyists, venture capitalists, and university tech transfer staff, to communicate successfully with those working on the cutting edge of modern science. Now in its fourth edition, Nill has taken the much appreciated step of adding nanotechnology to his glossary. Just by casually perusing the Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition you will learn a number of enlightening facts. Even those in related sciences will be surprised to discover what the language unveils. The Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition is a handy reference designed for people with little or no training in the biological and chemical sciences, as well as scientists communicating from other disciplines. Unlike other glossaries, this one is both informative and completely accessible. Instead of looking up one term to end up mired in equally difficult terminology, this intelligently designed volume follows what the author refers to as a Reference Chain that steadily leads you to simpler more common terminology, down to a level that anyone with a high school education will be able to understand. The definitions are written utilizing words that enable you to conceptualize the idea embodied in the term, with explanations based on analogy whenever possible. Consider this example: Suppose you just received a funding request, a faculty memo, or patent concern that refers to A-DNA, which happens to be the first definition in the Glossary. A-DNA A particular right-handed helical form of DNA (possessing 11 base pairs per turn), which is the form that DNA molecules exist in when they are partially dehydrated. A-form DNA is found in fibers at 75% relative humidity and requires the presence of sodium, potassium, or cesium as the counterion. Instead of lying flat, the bases are tilted with respect to the helical axis, and there are more base pairs per turn. The A-form is biologically interesting because it is probably very close to the conformation adopted by DNA-RNA hybrids or by RNA-RNA double-stranded regions. The reason is that the presence of the 2'2 hydroxyl group prevents RNA from lying in the B-form. See also B-DNA, DNA-RNA HYBRID, DEOXYRIBONUCLEIC ACID (DNA), BASE PAIR (bp) But then after looking at the above definition, you wonder what exactly is a DNA-RNA Hybrid? DNA-RNA Hybrid A double helix that consists of one chain of DNA hydrogen-bonded to a chain of RNA by means of complementary base pairs. See also HYBRIDIZATION (MOLECULAR GENETICS), HYBRIDIZATION (PLANT GENETICS), DOUBLE HELIX ...however while you've often heard mention of a double helix, you were never quite sure what that meant.... Double Helix The natural coiled conformation of two complementary, antiparallel DNA chains. This structure was first put forward by Watson and Crick in 1953. See also DEOXYRIBONUCLEIC ACID (DNA) And that might brings you to ask, Do you really actually know what DNA is? Deoxyribonucleic Acid (DNA) Discovered by Frederick Miescher in 1869, it is the chemical basis for genes. The chemical building blocks (molecules) of which genes (i.e., paired nucleotide units that code for a protein to be produced by a cell's machinery, such as its ribosomes) are constructed. Every inherited characteristic has its origin somewhere in the code of the organism's complement of DNA. The code is made up of subunits called nucleic acids. The sequence of the four nucleic acids is interpreted by certain molecular systems in order to produce the proteins required by an organism. The structure of the DNA molecule was elucidated in 1953.... The Glossary of Biotechnology and Nanobiotechnology Terms, Fourth Edition is packed with over 400 pages of exceptionally well-organized and cross-referenced terminology, making it an essential reference for anyone working directly or indirectly with those pioneering the frontiers of modern biology.
Download or read book Cell Chemistry and Physiology written by Edward Bittar and published by Elsevier. This book was released on 1996-01-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of a 4-volume module that is an introduction to the study of cell chemistry and physiology. It is not intended to be encyclopedic in nature but rather a general survey of the subject with an emphasis on those topics that are central to an understanding of cell biology and those that are certain to become of increasing importance in the teaching of modern medicine. We have followed what appeared to as to be the logical divisions of the subject beginning with proteins. Allewell and her colleagues stress the point that proteins fold spontaneously to form complex three-dimensional structures and that some of them unfold with the help of proteins called chaperones. Michaelis-Menten kinetics are shown by Nelsestuen to describe the behaviour of enzymes in the test tube. The formalism is particularly useful in the search for agents of therapeutic value, as exemplified by methotrexate. Uptake by mammalian cells of substrates and their metabolic conversions are discussed by van der Vusse and Reneman. However, both Welch and Savageau expound the view that the cell is not simply a bagful of enzymes. The biologist is urged by Savageau to abandon Michaelis-Menten formalism and apply the Power Law. The biologist is also told that the approach to arriving at a theory of metabolic control would have to be one of successive approximations requiring the use of the computer. Information gained from comparative biochemistry is shown by Storey and Brooks to have shed new light on mechanisms of metabolic rate depression and freeze tolerance, and to be applicable to organ transplantation technology. We are reminded that enzyme adaptation is partly the result of the presence of a hydrating shell of vicinal water that stabilises conformation of the enzyme. Vicinal water, according to Drost-Hausen and Singleton, lies adjacent to most solids and protein interfaces. The kinks or breaks observed in the slope of the Arrhenius plot are attributed to structural changes in vicinal water. Regulation of cell volume is shown by Hempling to involve regulation of cell water. It could be that the osmo-receptor or volume detection system is a protein that links the cytoskeleton to specific K and C1 channels. Additionally, it is interesting that aquaporins, which are water channel-forming membrane proteins, are now known to exist in both renal and extra-renal tissues. One of the renal porins is affected by vasopressin. We then pass on to protein synthesis (Rattan) and other important topics including protein glycosylation (Hounsell), methylation (Clarke), ADP-ribosylation (Pearson) and prenylation (Gelb). Among the four types of lipids attached to membrane proteins are the prenyl groups. Ford and Gross in their chapter on lipobiology drive home the point that there is an accumulation of acyl carnitine and lysophospholipids during myocardial infarction.
Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Download or read book Basic Exercise Physiology written by Moran S. Saghiv and published by Springer Nature. This book was released on 2020-08-26 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the assessment of human performance and the role of different exercise modes both in a laboratory and clinical setting. Details of how to successfully perform basic laboratory procedures for exercise training in health and disease, as well as how to apply non-invasive measurements in exercise physiology are provided. Chapters cover how to appropriately use a range of measures in assessing pulmonary function, anaerobic function and oxygen uptake. Techniques for cardiopulmonary rehabilitation and the mechanisms associated with thermoregulation are also described. Interactive exercises enable readers to easily assimilate key concepts and develop a thorough understanding of the topic. Basic Exercise Physiology provides both trainees and professional healthcare staff interested in exercise physiology with a detailed and practically applicable resource on the topic.
Download or read book Genetics Meets Metabolomics written by Karsten Suhre and published by Springer Science & Business Media. This book was released on 2012-06-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
Download or read book Improvement of Crop Plants for Industrial End Uses written by P. Ranalli and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides concerns useful to promote an increase of the productivity of crops by using functional genomics. Fundamental thematics have been addressed: metabolic engineering, plant breeding tools, renewable biomass for energy generation, fibres and composites, and biopharmaceuticals. The gained know how is relevant to identify bottlenecks in the major production chains and to propose actions for moving these issues forward.
Download or read book Plant Natural Products written by Herwig O. Gutzeit and published by John Wiley & Sons. This book was released on 2014-05-05 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Im Gegensatz zu existierenden Fachbüchern, die sich entweder ausschließlich auf die pharmakologischen Eigenschaften von pflanzlichen Naturstoffen konzentrieren oder den Sekundärstoffwechsel von Pflanzen im Rahmen der allgemeinen Pflanzenwissenschaft behandeln, deckt dieses Lehrbuch sämtliche Aspekte in einem Band ab. Es überzeugt durch Modernität, enthält farbige Abbildungen, einen Fragen- und Antwortteil und bietet Zugang zu einer begleitenden Website. Darüber hinaus liefern die einleitenden Kapitel ausreichend Hintergrundinformationen zur Chemie und Biochemie pflanzlicher Naturstoffe und deren Einsatz in der Biotechnologie. Damit ist dieses Lehrbuch in jeder Hinsicht als eigenständiges Werk in entsprechenden Kursen einsetzbar.
Download or read book Advances in Metabolic Mechanisms of Aging and Its Related Diseases written by Katia Aquilano and published by Frontiers Media SA. This book was released on 2020-12-18 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Muscles as Molecular and Metabolic Machines written by Peter W. Hochachka and published by CRC Press. This book was released on 2019-06-04 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen? To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.
