Download or read book Bioinformatics for Geneticists written by Michael R. Barnes and published by John Wiley & Sons. This book was released on 2007-03-13 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise from the reviews: "Without reservation, I endorse this text as the best resource I've encountered that neatly introduces and summarizes many points I've learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity." CIRCGENETICS "This book may really help to get geneticists and bioinformaticians on 'speaking-terms'... contains some essential reading for almost any person working in the field of molecular genetics." EUROPEAN JOURNAL OF HUMAN GENETICS "... an excellent resource... this book should ensure that any researcher's skill base is maintained." GENETICAL RESEARCH “... one of the best available and most accessible texts on bioinformatics and genetics in the postgenome age... The writing is clear, with succinct subsections within each chapter....Without reservation, I endorse this text as the best resource I’ve encountered that neatly introduces and summarizes many points I’ve learned through years of experience. The gems of truth found in this book will serve well those who wish to apply bioinformatics in their daily work, as well as help them advise others in this capacity.” CIRCULATION: CARDIOVASCULAR GENETICS A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research. The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment. Hallmark Features of the Second Edition: Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics The only book specifically addressing the bioinformatics needs of geneticists More than 50% of chapters are completely new contributions Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.

Download or read book A Guide to Forensic DNA Profiling written by Scott Bader and published by John Wiley & Sons. This book was released on 2016-03-21 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court - report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.

Download or read book Parallel and Distributed Processing written by Jose Rolim and published by Springer Science & Business Media. This book was released on 1998-03-18 with total page 1194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of 10 international workshops held in conjunction with the merged 1998 IPPS/SPDP symposia, held in Orlando, Florida, US in March/April 1998. The volume comprises 118 revised full papers presenting cutting-edge research or work in progress. In accordance with the workshops covered, the papers are organized in topical sections on reconfigurable architectures, run-time systems for parallel programming, biologically inspired solutions to parallel processing problems, randomized parallel computing, solving combinatorial optimization problems in parallel, PC based networks of workstations, fault-tolerant parallel and distributed systems, formal methods for parallel programming, embedded HPC systems and applications, and parallel and distributed real-time systems.

Download or read book Autophagy in Health and Disease written by and published by Academic Press. This book was released on 2020-06-30 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more. - Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagy - Includes critical discussions of autophagy in the context of each major human disorder - Models autophagy-related human pathologies in lower eukaryotes

Download or read book Gene Drives at Tipping Points written by Arnim von Gleich and published by Springer Nature. This book was released on 2020-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.

Download or read book Pathology of Childhood and Adolescence written by Consolato M. Sergi and published by Springer Nature. This book was released on 2020-10-28 with total page 1617 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the full range of pathologic conditions encountered during childhood and youth, including tumors and tumor-like conditions of all organ systems, with direct links to developmental biology pathways and genetics. It provides a user-friendly road map to the main diagnostic criteria and combines an organ-related approach with an explanation of the diagnostic approaches to various specific diseases and syndromes, including sequential segmental analysis of congenital heart disease. More than 500 new full-color macro- and microphotographs using more than 500 multi-photographic panels are included to provide a realistic basis for comparison macroscopically and under the lens, and summarizing tables highlight key information in the concise form required for at-a-glance review. Pathologists will find the book very helpful when signing out complex and challenging cases, and it will also prove invaluable for exam preparation and continuing medical education.

Download or read book Gene Regulation Explored by Systems Biology in Livestock Science written by Andressa Oliveira De Lima and published by Frontiers Media SA. This book was released on 2022-04-27 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecules to Medicine with mTOR written by Kenneth Maiese and published by Academic Press. This book was released on 2016-02-21 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. - Covers the role of mTOR by internationally recognized expert contributors in the field. - Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. - Includes analysis of the role of mTOR and in both health and disease. - Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Download or read book Handbook Of Forensic Genetics Biodiversity And Heredity In Civil And Criminal Investigation written by Antonio Amorim and published by World Scientific. This book was released on 2016-08-30 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of genetics for the resolution of legal conflicts has recently been gaining a higher profile, largely as a result of scientific and technological advancements and the substantial broadening of applications. The theoretical framework underlying forensic genetics is the same irrespective of the materials and technology involved, however a great divide still exists in the manner and processes related to human and non-human analyses.This advanced handbook intends to overcome the historical barriers between the scientific fields of legal medicine, biodiversity and conservation, and food analysis by presenting a unifying, global perspective on the implications of genetic analyses on forensic affairs. This global perspective is presented in three parts: modes of inheritance and reproduction and taxonomic implications; current technological approaches and future perspectives; and a comprehensive systematization of the types of applications and organisms. Finally, a critical revision of the current investigative/expert systems and future perspectives is undertaken.This book provides a collection of international research, thereby constituting a reference platform for the forensic community and an advanced textbook for graduate students. It encompasses the theoretical bases of the field, and presents in the context of both perspectives of forensic action — probative and investigative — a comprehensive coverage of the current applications and technological state of the art.

Download or read book Synthetic Biology Part A written by Chris Voigt and published by Academic Press. This book was released on 2011-07-08 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology encompasses a variety of different approaches, methodologies and disciplines, and many different definitions exist. This Volume of Methods in Enzymology has been split into 2 Parts and covers topics such as Measuring and Engineering Central Dogma Processes, Mathematical and Computational Methods and Next-Generation DNA Assembly and Manipulation. - Encompasses a variety of different approaches, methodologies and disciplines - Split into 2 parts and covers topics such as measuring and engineering central dogma processes, mathematical and computational methods and next-generation DNA assembly and manipulation

Download or read book Principles of Evolution Systems Species and the History of Life written by Jonathan Bard and published by Garland Science. This book was released on 2016-09-12 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Evolution considers evolution in the context of systems biology, a contemporary approach for handling biological complexity. Evolution needs this systems perspective for three reasons. First, most activity in living organisms is driven by complex networks of proteins and this has direct implications, particularly for understanding evo-devo and for seeing how variation is initiated. Second, it provides the natural language for discussing phylogenetic trees. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity. Understanding evolution means, on the one hand, describing the history of life and, on the other, making sense of the principles that drove that history. The solution adopted here is to make the science of evolution the primary focus of the book and place the various parts of the history of life in the context of the research that unpicks it. This means that the history is widely distributed across the text. This concise textbook assumes that the reader has a fair amount of biological knowledge and gives equal weight to all the major themes of evolution: the fossil record, phylogenetics, evodevo, and speciation. Principles of Evolution will therefore be an interesting and thought-provoking read for honors-level undergraduates, and graduates working in the biological sciences.

Download or read book Plant Microbe Insect Interactions in Ecosystem Management and Agricultural Praxis written by Gero Benckiser and published by Frontiers Media SA. This book was released on 2019-04-03 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature’s high biomass productivity is based on biological N2 fixation (BNF) and biodiversity (Benckiser, 1997; Benckiser and Schnell, 2007). Although N2 makes up almost 80% of the atmosphere’s volume living organisms need it in only small quantities, presumably due to the paucity of natural ways of transforming this recalcitrant dinitrogen into reactive compounds. N shortage is commonly the most important limiting factor in crop production. The synthesis of ammonium from nitrogen and hydrogen, the Haber–Bosch (H-B) process, invented more than 100 years ago, became the holy grail of synthetic inorganic chemistry and removed the most ubiquitous limit on crop yields. H-B opened the way for the development and adoption of high-yielding cultivars, for monoculturing by organic and precision farming. With N over fertilization and pesticide application monoculturing farmers could approach Nature’s high biomass productivity by causing side effects the scientific world is investigating. This eBook presents the complexity the scientific world is facing in in understanding the soil-microbe-plant-animal cooperation, the millions of taxonomically, phylogenetically, and metabolically diverse above-below-ground species, involved in shaping the ever-changing biogeochemical process patterns being of great significance for food production networks and yield stability. Because ecosystem management and agricultural praxis are still largely conducted in isolation, the aim of this Frontiers’ eBook is to gather and interconnect plant-microbe-insect interaction research of various disciplines, studied with a broad spectrum of modern physical-chemical, biochemical, and molecular biological, agronomical techniques. The goal of this Research Topic was to gain a better understanding of microbe-plant-insect compositions, functioning, interactions, health, fitness, and productivity.

Download or read book Autophagy Biology and Diseases written by Zheng-Hong Qin and published by Springer Nature. This book was released on 2019-11-27 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Download or read book Insect Olfactory Proteins From Gene Identification to Functional Characterization written by Peng He and published by Frontiers Media SA. This book was released on 2020-01-06 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Anthropological Genetics written by Michael H. Crawford and published by Cambridge University Press. This book was released on 2007 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume detailing the effects of the molecular revolution on anthropological genetics and how it redefined the field.

Download or read book ICRDB Cancergram written by and published by . This book was released on 1985 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Using Forensic DNA Evidence at Trial written by Jane Moira Taupin and published by CRC Press. This book was released on 2018-09-03 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using Forensic DNA Evidence at Trial: A Case Study Approach covers the most common DNA analysis methods used in criminal trials today, including STR techniques, mitochondrial DNA, and Y-STRs. It presents some novel techniques—including familial testing and analyzing domestic animal hair—that have been recently introduced in unique cases, each of which is outlined in detail. It also illustrates special issues related to forensic DNA evidence by using court proceedings such as trials and appeals, commissions of inquiry, and government and laboratory reviews. With forensic DNA analysis becoming increasingly important at trial, the lively and sometimes bizarre cases presented in this book have been carefully chosen to highlight specific concepts, methods, and interpretations used in DNA analysis. Sections throughout examine the nature of expertise with a special focus on the role of subjectivity in the interpretation of forensic DNA evidence, emphasizing cognitive bias and extraneous context. Using both convictions and exonerations as examples, the book also discusses the strengths and limitations of DNA evidence and testing. The book is written in an accessible manner for the non-scientific reader, such that criminal lawyers, judges, and forensic experts will all understand the nature of analysis and application of DNA evidence in a variety of court cases. Extensive references—including notable trial proceedings, cross references of cases, and specific forensic statistics—round out the book and help to provide a complete understanding of forensic DNA analysis and its current usage in the courtroom.