Download or read book Foundations of Pharmacokinetics written by Aldo Rescigno and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. It was not my intention to write a popular book; what distinguishes this one from many others on the same subject is its large use of algebra and calculus. For this I make no apologies; in fact a serious study of pharmacokinetics without the help of mathematics is, in my opinion, impossible. The exact definition of many pharmacokinetic quantities, even the most common, and the correct use of many equations, even the most simple, requires the constant use of mathematical language. On the other hand I have made a considerable effort to use only elementary algebra and elementary calculus, as commonly taught in most introductory university courses. For the few exceptions, when less common mathematical concepts were needed, I have supplied the necessary explanations in four appendices. The first three chapters are a general introduction to the scientific method. Chapters 4 to 12 show different specific methods to deal with pharmacokinetic pr- lems. There is considerable overlap among those chapters; this is intentional and its p- pose is to convince the reader that every problem can be solved in more than one way, including ways that were not mentioned in this book and that intelligent readers can find for their own pleasure. Chapters 13 to 17 show how different parameters of importance in pharmacokinetics can be exactly defined and measured.

Download or read book Pharmacology and Physiology for Anesthesia E Book written by Hugh C. Hemmings and published by Elsevier Health Sciences. This book was released on 2018-10-19 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology and physiology are the foundation of every anesthesia provider's training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. - Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. - Incorporates entirely new sections on Physics, Anatomy, and Imaging. - Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. - Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. - Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.

Download or read book Concepts in Clinical Pharmacokinetics written by William Spruill and published by ASHP. This book was released on 2014-04-11 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpu Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpufConcepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf

Download or read book Handbook of Basic Pharmacokinetics Including Clinical Applications written by Wolfgang A. Ritschel and published by . This book was released on 1992 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Pharmacokinetics written by John E. Murphy and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely-used textbook and reference. Clinical Pharmacokinetics, Sixth Edition includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. There is also a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book. The new edition includes everything you need to know about pharmacokinetics today: Drugs, dosing, and therapeutic. Drug concentration measurements. New chapter on the impact of pharmacogenomics. Neonatal, pediatric, obese, and geriatric dosing. Dosing in renal disease and creatinine clearance estimation. Drugs sorted by family and as single drugs. Written in a straightforward style, with numerous charts and lists, the sixth edition makes complicated dosing and monitoring information easy to find and understand. Whether you are a student or practitioner, it is a resource you will turn to for reliable guidance throughout your pharmacy career.

Download or read book Basic Principles of Drug Discovery and Development written by Benjamin E. Blass and published by Academic Press. This book was released on 2021-03-30 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Download or read book Drug like Properties Concepts Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Download or read book Modeling in Biopharmaceutics Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer Science & Business Media. This book was released on 2006-04-26 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Download or read book Fundamentals of Pharmacology written by Shane Bullock and published by Pearson Higher Education AU. This book was released on 2013-10-15 with total page 1249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Pharmacology 7e presents key scientific and clinical principles to facilitate a greater understanding of pharmacology. This wholly Australasian text provides comprehensive and current coverage of topics, written in a clear style with a reader-friendly full colour design.

Download or read book Basic and Applied Pharmacokinetics Self Assessment written by John E. Murphy and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To exercise the best possible judgment in patient care, medication plans should be selected for the maximum efficacy and safety for each individual patient. Be confident in your approach with ASHP's Basic & Applied Pharmacokinetics Self Assessment, a new resource from John E. Murphy, author of ASHP's Clinical Pharmacokinetics, Fifth Edition, which offers questions and exercises with answers and detailed solutions to help gauge your understanding.

Download or read book Advanced Pharmacology for Prescribers written by Brent Q. Luu, PharmD, BCPS, BCACP and published by Springer Publishing Company. This book was released on 2021-01-13 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivers the critical information primary care providers need to be thoroughly informed prescribers This unique resource—an evidence-based pharmacology text and reference for advanced practice students and clinicians—guides users in analyzing the pharmacological foundations of drug therapy and fosters the development of sound clinical judgment in determining the appropriate medication for every patient across the lifespan. Targeting the specific needs of APRN and PA students and clinicians, the text is a “bridge” between standard, lengthy pharmacology texts and quick pocket references that lack information regarding key pharmacotherapy principles. Featuring an applied therapeutic approach to major disorders and their pharmacologic treatment, the book examines how medications act on the body and visa versa, while teaching the rationale for using specific therapeutic agents or drug classes. Each chapter includes case studies that apply the concepts discussed, relevant diagnostic studies, applicable guidelines, genomics, and important lifespan considerations. Of special interest is a chapter on pharmacogenetics explaining the basic principles underlying our current understanding of genetic variations in response to pharmacotherapy and adverse drug reactions. Easily digestible chapters include objectives and review questions. Ancillary resources include an instructor manual with learning objectives, chapter summaries, and case studies; chapter PowerPoint slides; test bank; and image bank. Key Features: Delivers an applied, evidence-based foundation on the basic science underlying prescribing Targets the specific needs of APRN and PA students and professionals and related healthcare providers Provides clinical decision-making tools and principles to support sound prescribing judgment Focuses on synthesizing drugs to manage commonly occurring disorders Includes strategies for addressing the needs of specific populations throughout the lifespan Includes abundant case studies illuminating key concepts Includes a robust instructor manual with learning objectives, chapter summaries, and case studies; PowerPoint slides; test bank; and image bank. Purchase includes access to the eBook for use on most mobile devices or computers.

Download or read book Essentials of Antimicrobial Pharmacology written by Paul H. Axelsen and published by Springer Science & Business Media. This book was released on 2002 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many medical students and physicians, the task of quickly obtaining sufficient, accurate, and up-to-date information about the pharmacology of antimicrobials often involves consulting either lengthy textbooks or inadequate tabular guides. In Essentials of Antimicrobial Pharmacology: A Guide to Fundamentals for Practice, Dr. Axelsen superbly addresses this problem by concisely summarizing the essential medical data concerning the leading antimicrobials used in fighting infectious diseases and clearly illustrating their mechanisms of action. The agents described range from antibacterial and antifungal to antiparasitic and antiviral agents, and include immunomodulators and immunizing agents. For each drug discussed, the book allows rapid access to the essential facts concerning its structure and mechanism of action, the spectrum of its activity, its pharmacokinetics, its adverse effects, and its resistance. Background discussions explain the fundamentals of measuring antibiotic effect, administering antibiotics, distribution and elimination, sensitivity testing, and dose-response relationships. Essentials of Antimicrobial Pharmacology: A Guide to Fundamentals for Practice provides medical students, physicians, and allied health professionals with rapid access to the core principles of antimicrobial pharmacology, and a foundation for decisions about the use of antimicrobials in daily practice.

Download or read book Principles of Clinical Pharmacology written by Arthur J. Atkinson Jr. and published by Elsevier. This book was released on 2011-04-28 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. - Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy - Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course - Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study - Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry - Expanded coverage of pharmacogenetics - Expanded coverage of drug transporters and their role in interactions - Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions - A new chapter on drug discovery that focuses on oncologic agents - Inclusion of therapeutic antibodies in chapter on biotechnology products

Download or read book Systems Pharmacology and Pharmacodynamics written by Donald E. Mager and published by Springer. This book was released on 2016-11-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Download or read book Fundamentals of Pharmacology written by Ian Peate and published by John Wiley & Sons. This book was released on 2021-02-08 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: All registered nurses must have a thorough understanding and a strong knowledge of pharmacology, medicines administration, and the ability to recognise and react to the effects of medicines. Fundamentals of Pharmacology helps nursing and healthcare students develop the skills and confidence required to apply the fundamental principles of pharmacology and to offer safe, competent and compassionate care. Concentrating on the medicines that students are most likely to encounter in real-world practice, this textbook provides concise coverage of pharmacology, essential medicines management principles, legal and ethical issues, drug formulations, analgesics, immunisations, and much more. Clinically focused chapters feature defined learning outcomes, multiple-choice questions, practical examples, and full-colour illustrations to aid readers’ comprehension of the complexities of pharmacology and care provision. The book utilises a straightforward, student-friendly approach to present ‘must-have’ information, with contributions from experienced clinicians and academics. Describes how to use pharmaceutical and prescribing reference guides Stresses the role and importance of compassionate care throughout Contains a full range of pedagogical tools which enhance learning and recall Aligns with current NMC Standards and Proficiencies for Registered Nurses and Nursing Associates Supplemented and supported by a wealth of online extras and resources Fundamentals of Pharmacology is essential reading for all nursing students, trainee nursing associates, post-registration nurses taking ‘nurse prescribing’ or ‘non-medical prescribing’ modules, and newly qualified nurses and nursing associates looking to better understand pharmacology.

Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Download or read book New Trends in Pharmacokinetics written by Aldo Rescigno and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac cessible only partly through experimental techniques and, mostly through mathemati cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi gators to have better pictures of the systems they are studying. Mathematical models through computer simulation and statistical estimation, mostly due to easy access be cause of inexpensive yet powerful personal computers, are enabling us to investigate ultrastructures and their functional connectivity in more detail. As a consequence, new hypotheses are being formed and tested in various related fields. In clinical pharmacokinetics, mostly due to mathematical modeling, more accurate interspecies scaling of pharmacokinetic parameters and dosimetry can be done now-a-days. The concept of "a human is a bigger rat" does not necessarily fly as a consequence. Pharmacokinetic concepts are becoming powerful tools in meaningful carcinogenic and toxic risk extrapolation of different chemicals in humans. New dose delivery designs are being formulated using pharmacokinetic techniques for different pharmaceutical compounds. Investigations continue in the academia, research institutions, pharmaceutical, biotechnological, and agricultural industries in developmental and physiological aspects of different chemicals for the benefit of mankind. The idea of a school on "New Trends in Pharmacokinetics", from which the present pUblication was made possible, took shape over almost a year.