Download or read book Formulation And Evaluation Of Multilayer Matrix Tablet written by Ghanshyam Yadav and published by LAP Lambert Academic Publishing. This book was released on 2014-03 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study is carried out to design controlled release multilayered matrix tablets of antihypertensive drug. The aim of this research work is to reduce the frequency of dosing, decreasing the required dose employed, providing uniform drug delivery, reduction of side effects and enhancement of patient compliance of antihypertensive drug. The purpose of study to formulate and evaluate multi-layer matrix tablets using hydrophilic polymer, namely xanthan gum and chitosan by the wet granulation. Captopril was choosen as a model drug because of its higher water solubility. From the results obtained, the hydrophilic polymer xanthan gum and chitosan used individually could not sufficiently produce controlled release so must be combined in various ratios for effective oral controlled release to be achieved of multilayer matrix tablet that complied with all parameters. This book is a good guide for students who want to learn about formulation technology of multilayer matrix tablets along with their various evaluation parameters. This book will also work as a reference material for researchers, those are planning or already doing their research in this direction.
Download or read book Matrix Tablet written by Nikhil Shrivastava and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hello readers I am very glad to present my another book for you. This book contains the all basic and advance information about MATRIX TABLETS. It contains Development of matrix tablets, methods of formulation, various evaluation methods as per standards(IP & USP). As we know about the matrix tablets, these are used for sustain release of drug which prolongs the duration of action of drug in body. the matrix system is created by using polymers and gums. in this formulation the guar gum is used and the active pharmaceutical ingredient is the popular antifungal drug Ciclopirox olamine. I think this is very useful for medical and pharmaceutical students because it is the study of Control Drug Delivery System.
Download or read book Hydrophilic Matrix Tablets for Oral Controlled Release written by Peter Timmins and published by Springer. This book was released on 2014-10-11 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
Download or read book Formulation and Evaluation of Extended Release Tablet of Divalproex written by Kunal Patel and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present study was aimed to develop an extended release matrix tablet of Divalproex sodium using hydrophilic polymer as release retarding agent. The formulation of Divalproex sodium matrix forming tablet was developed by using 2 factor 3 level full factorial design. The concentrations of HPMC K100M (10%, 12.5% & 15%), Eudragit L100 (10%, 12.5% & 15%) were selected as independent variables. The dependent variables selected were %drug released at 3hr, and %drug released at 12hr. As the drug has good flow property and compressibility, the direct compression method was employed to formulate the tablets. Tablets were evaluated for various physicochemical parameters. In vitro drug release study showed that batch F8 (HPMC K100M-15%, Eudragit L100-10%) was found to be optimized as it had almost identical dissolution profile with marketed product. Eudragit show synergism with HPMC K100M on drug release retardation and avoid the chances of burst release. The kinetic release treatment showed that Korsmeyer equation has shown of r2 = 0.988. Stability study of optimized batch F8 was conducted at accelerated conditions for one month and it was found to be stable.
Download or read book Modulation and Assessment of Controlled Released Matrix Tablet of Losartan Potassium written by Amit Khairnar and published by GRIN Verlag. This book was released on 2012-10-16 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wissenschaftliche Studie aus dem Jahr 2012 im Fachbereich Pharmazie, Institute of Pharmaceutical Education Boradi, Sprache: Deutsch, Abstract: Ideally, a drug should arrive rapidly at the site of action (receptor) in the optimum concentration, remain for the desired time, be excluded from other sites, and be rapidly removed when the goal is achieved. Generally, the time course of a dosage form (pharmacokinetics) in man is considered to be controlled by the chemical structure of the drug. Decreasing the rate of absorption and/or changing the dosage form provide a useful adjunct. When it is not feasible or desirable to modify the drug compound on a molecular level, often sought is a product that will require less frequent administration to obtain the required biological activity time profile. It may be desirable to decrease the absorption rate in order to obtain a more acceptable clinical response. The goal of designing sustained release matrix delivery systems is to reduce frequency of dosing or to increase the effectiveness of the drug by localizing at the site of action, reducing the dose required, or providing uniform drug delivery. Hence, designing a sustained release formulation for an antihypertensive drug may prolong therapeutic concentration of drug in the blood and decrease the frequency of dosing and also improve the patient compliance. So in the present study, attempts will be made to formulate a sustained release matrix tablets containing an antihypertensive drug. In December 1843, a patent was granted to the Englishman, William Brockedon for a machine to compress powders to form compacts. This very simple device consisted essentially a hole (or die) bored through which the powder was compressed between the two cylindrical punches; one was inserted into the base of die and at a fixed depth, the other was inserted at the top of die and struck with hammer. The invention was first used to produce compacts of potassium bicarbonate and caught the imagination of no. of pharmaceutical companies. Later, welcome in Britain was the first company to use the term “tablet” to describe the compressed dosage form.
Download or read book Formulation Evaluation of Anti hypertensive Controlled Release Matrix Tablets written by Rajan Kothari and published by Createspace Independent Publishing Platform. This book was released on 2018-03-24 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of hypertension with conventional dosage forms is not effective as the drugs do not reach the site of action in appropriate concentration and it also requires frequent dosing. Thus an effective and safe therapy for hypertension disorder using specific drug delivery system is a challenging task for the pharmaceutical technologists. Most commonly used the method of modulating the drug release is to include it in a matrix system. Because of their flexibility, hydrophilic polymer matrix systems are widely used in oral controlled drug delivery to obtain a desirable drug release profile, cost-effectiveness and broad regulatory acceptance. In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compared to other formulations. The short-term stability study proved no change in the formulation of ageing and it indicates good stability.
Download or read book Formulation and in Vitro Evaluation of Extended release Matrix Tablets Prepared Using Compression coating written by Tejasvi Vankayala and published by . This book was released on 2013 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluation of a Sustained Release Matrix Tablet Prepared by Coating Drug silica Adsorbate with Eudragit written by Deepak B. Mehta and published by . This book was released on 1985 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Formulation and Evaluation of Delayed Release Tablet written by Tushar Rukari and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present work emphasize on Esomeprazole magnesium is formulated as delayed release tablets to provide desired effect at certain time in maintained drug concentration without any unwanted effect with patient compliance also to improve it bioavailability by decreasing its expose to gastric acid. A delayed release dosage form is designed to release the drug from the dosage form at a time other than promptly after administration. UV spectrophotometric method has been developed for the estimation of Esomeprazole in pharmaceutical formulations. Then the tablets were prepared by wet granulation method rather than direct compression because of cohesive property of the drug. Optimized core tablet then subjected for enteric coating by selected base coat polymer cellulose derivative for preventing core tablet from moisture. The coated formulations were compared with marketed sample (ESOZ) for optimization. Dissolution results of tablets with enteric coating have shown release of Esomeprazole in simulated gastrointestinal fluid pH 1.2, but most of the drug released in pH 6.8 Phosphate buffer. At the end it was found that prepared formulation gave satisfactory results.
Download or read book Formulation Evaluation of Floating Matrix Tablets of Levofloxacin written by Narendar Dudhipala and published by . This book was released on 2012-09-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oral Controlled Release Formulation Design and Drug Delivery written by Hong Wen and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
Download or read book Tablet Shapes and in Vitro Evaluation of Coated Hydrophilic Matrix Tablets Novel Mupirocin Formulations Non acidic Enteric Coating of Omeprazole and Novel Hot melt Coating Process written by Manshiu Leung and published by . This book was released on 2002 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex shape, which were encapsulated with membrane controlling film. The hydrophilic tablet core contained hydroxypropyl methylcellulose (HPMC) 15 LV, pectin, and Avecil®. The membrane film coating solution was comprised of deionized water, Opadry®, Surelease® and talc. The combination of membrane film coating and tablet shape design was found to influence in vitro verapamil release profile towards the zero-order release demonstrated by the commercial Covera HS® (Pharmacia). An alternative formulation for the commercial Bactroban® (Smithkline Beacham) ointment 2% was developed. Both the texture and consistency of the new ointment were comparable to the Bactroban® ointment. The new and the commercial formulations were found to be equivalent in drug release by the Bauer-Kirby test. Mupirocin remained unstable in the new formulation. Mg2 was added to help stabilize mupirocin and was shown to complex with mupirocin by nuclear magnetic resonance (NMR). The modified formulation including Mg2+ however failed to stabilize mupirocin. The stability assay results showed an average of 67.2% mupirocin recovery along with 25.2% degradation products. A generic omeprazole formulation was developed, which was comprised of nonpareil core, omeprazole matrix layer, and an enteric locating layer of ammoniated hydroxypropyl methylcellulose phthalate (HPMCP) 55S. The new formulation was gastro-resistant in protecting against omeprazole degradation for up to 2 h, but failed to dissolve as rapidly as the commercial Prilosec® (Astra Merk) in simulated intestinal fluid. The addition of expotab® to the enteric coating layer failed to improve omeprazole dissolution rate. A novel hot-melt coating methodology utilizing direct blending technique has been developed. The processing steps for the direct blending hot-melt coating are: (a) Hot-melt system preparation; (b) Dispersion/dissolution of the active ingredient(s) in the hot-melt system; (c) Pre-heating of the coating substrate; and (d) Cooling and congealing of the hot-melt on substrate surface. Immunogenic effect was observed in mice administered with enteric-coated ragweed pollen extract (RPE) alpha fraction by the hot-melt coating encapsulation with direct blending method. The effect was not shown to be statistically significant.
Download or read book Pharmaceutical Formulation written by Geoffrey D Tovey and published by Royal Society of Chemistry. This book was released on 2018-06-25 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.
Download or read book Formulation Drug Release and Swelling Characteristic of HPMC polymethacrlate Based Controlled Release Matrix Tablet abstract written by Chiew Geok Ming and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Formulation and Evaluation of Mouth Dissolving Tablets written by Reshu Gupta and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within
Download or read book Adhesion Measurement Methods written by Robert Lacombe and published by CRC Press. This book was released on 2005-11-21 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adhesion Measurement Methods: Theory and Practice provides practical information on the most important measurement techniques, their unique advantages and disadvantages, and the selection of the proper method for a given application. It includes useful information and formulae on adhesion related matters such as driving force formulae for various m
Download or read book Design and in Vitro Evaluation of Sustained Release Dosage Forms written by Suneel Kumar Vasireddy and published by LAP Lambert Academic Publishing. This book was released on 2012-08-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metformin matrix and gastro retentive tablets formulations were prepared with different compositions. Finally, one optimized formula for each, matrix and gastro retentive, were selected and studied in detail. The effect of formulation variables namely, process of manufacturing, different excipients, different polymers, and concentration of polymer were studied. Metformin release was inversely proportional to the polymer concentration. Drug release from the developed formulations was independent of pH of the release medium but dependent on the agitational intensity, hardness of tablet, and surface area of tablet. Metformin release from both developed matrix and gastro retentive formulations follows first order. The manufacturing procedure was found to be reproducible and formulations were stable after one month of accelerated stability studies.
