Download or read book Formulation and Evaluation of Mouth Dissolving Tablets written by Reshu Gupta and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within

Download or read book Formulation and Evaluation Mouth Dissolving Tablets of Tramadol HCL written by Raja Sridhar Rao Ponugoti and published by LAP Lambert Academic Publishing. This book was released on 2015-08-11 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to United States Pharmacopoeia, the orodispersible tablets may be defined as solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly within a matter of seconds when placed upon the tongue. This means that the tablets dissolve or disintegrate in the oral cavity without use of water. In this regard, the tablets need to improve disintegration time, dispersion time, drug release studies, bioavailability and patient compliance and also need to mask the bitter taste of the drug and to maintain the drug stable at accelerated condition i.e. 40 C/75% RH up to 6 months period as per ICH guidelines. Tramadol HCl is centrally acting synthetic opioid analgesic for the treatment of moderate to severe pain and is readily soluble in water. The half life of the drug is around 5.5 hours. The MDT's place a major role for rapid onset of action for geriatrics, pediatrics and the patients who have less access of water. The drug itself having bitter taste, so the present authors developed mouth dissolving tablets of tramadol HCl with the aim to mask the bitter taste of the drug, to minimize the disintegration time and improve the drug release rate."

Download or read book Formulation Evaluation and Optimization of Mouth Dissolving Tablets written by Amita Yadav and published by . This book was released on 2014-08-09 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Preparation and Evaluation of Mouth Dissolving Film of Metoclopramide Hcl written by Dhaneshwar Kumar Vishwakarma and published by LAP Lambert Academic Publishing. This book was released on 2011-08 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral drug delivery is the most widely utilized route of administration among the entire route that has been explored for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The conventional tablet seems to be most popular because of its ease of transportability and comparatively low manufacturing cost but poor patient compliance in case of pediatrics and geriatrics patients who experienced difficulties in swallowing, in response to this mouth dissolving drugs delivery system(MDDs) were developed as an alternative to tablet, cap & syrups. A variety of MDDs like mouth dissolving tablets and mouth dissolving film (MDFs) were commercialized. MDFs evolved over the past few years from by the confection and oral care market in the form of breath strips & became a novel & widely accepted form by consumers. It consist very thin oral strips, which release active ingredients immediately after uptake into oral cavity. Today MDFs are a proven & accepted technology for the systemic delivery of active pharmaceuticals ingredients

Download or read book Current Advances in Drug Delivery Through Fast Dissolving Disintegrating Dosage Forms written by Vikas Anand Saharan and published by Bentham Science Publishers. This book was released on 2017-05-11 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast Dissolving/Disintegrating Dosage Forms (FDDFs) have been commercially available since the late 1990s. FDDFs were initially available as orodispersible tablets, and later, as orodipsersible films for treating specific populations (pediatrics, geriatrics, and psychiatric patients). Granules, pellets and mini tablets are among latest additions to these dosage forms, which are still in the development pipeline. As drug delivery systems, FDDFs enable quicker onset of action, immediate drug delivery, and sometimes offer bioavailability benefits due to buccal/sublingual absorption. With time, FDDF have evolved to deliver drugs in a sustained and controlled manner. Their current market and application is increasing in demands with advances in age adapted dosage forms for different patients and changing regulatory requirements that warrant mandatory assessments of new drugs and drug products before commercial availability. This book presents detailed information about FDDFs from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.

Download or read book Fast dissolving tablets written by Dr.G.SANDHYARANI Guggilla and published by Lulu.com. This book was released on with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Formulation And Evaluation Of Nebivolol Hcl Fast Dissolving Tablets written by Vanitha Kondi and published by LAP Lambert Academic Publishing. This book was released on 2015-06-16 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of the present study was the formulation and evaluation of Nebivolol Hcl fast dissolving tablet by solid dispersions. Fast dissolving tablets are novel types of tablets that dissolve / disintegrate / disperse in saliva within few seconds without water.The major category of Nebivolol Hcl is in the treatment of hypertension, adrenergic beta-antagonist and vasodilator. It is a poorly soluble and require enhancement of solubility and dissolution rate in its formulation development.

Download or read book Formulation Evaluation of Fast Dissolving Tablets to Treat Migraine written by Piyush Agarwal and published by . This book was released on 2015-05-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Delivery to the Oral Cavity written by Tapash K. Ghosh and published by CRC Press. This book was released on 2005-02-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from recognized authorities in industry, academia, and government, this reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of intraoral drug delivery products-summarizing intraoral dosage forms in various stages of research, as well as products currently on the market.

Download or read book Formulation and Evaluation of Fast Dissolving Oral Film written by Ronak Gokani and published by LAP Lambert Academic Publishing. This book was released on 2014-05-02 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present study, formulation of Fast dissolving film containing antihistaminic drug Desloratadine was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of allergy. The combination of drug with suitable polymers such as HPMC E-5 and HPMC E-15 helps in providing quick onset of action. The basic aim of this work is to produce immediate release action of drug from the film. Fast dissolving film was prepared by solvent casting method using PEG 400 as plasticizer. A full factorial design was used to study the effect of HPMC E-5 and HPMC E-15 on disintegration time, thickness and folding endurance of the film. The responses were analyzed using ANOVA and by the polynomial equation. All the formulations were then evaluated for disintegration time, weight variation, and drug content and dissolution studies. Stability study shows that there was no significant change in physical appearance, disintegration time, thickness, drug content and In vitro drug release of the formulation. Fast dissolving film is an innovative concept for quick release of the drug.

Download or read book Hot Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.

Download or read book Flavor Encapsulation written by Sara J. Risch and published by . This book was released on 1988 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a new book that offers complete coverage of the most current research in flavor encapsulation. Covers processes such as extrusion, coacervation, microencapsulation, and molecular inclusion, with special emphasis on spray drying. Discusses various substances, including maltodextrins, corn syrup solids, and alginates, as part of a matrix system for flavor encapsulation. Also discusses wall materials, including acacia gums, carbohydrate-derived polymers, lipophilic starches, protein-based materials, and more. Offers complete and practical coverage of the processes involved. Vital information for flavor researchers as well as those industries for which spray drying offers a promising new technology.

Download or read book The Formulation and Evaluation of Orally Disintegrating Tablets written by Stephanie M. Chillas and published by . This book was released on 2013 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orally disintegrating tablets are a vital tool in keeping our children and elderly population healthy. Their ease of use and accurate dosing allow higher patient compliance and more reliable therapeutic effects. Superdisintegrants are the fundamental element contained in orally disintegrating tablets and are responsible for their unique ability to quickly disintegrate and dissolve on the surface of the tongue without the use of any additional liquid. In order to determine the most effective type and optimal amount of superdisintegrants for orally disintegrating tablets manufactured by direct compression, the following tablet parameters were tested (based on the standard USP 30 methods): hardness, thickness, friability, disintegration time, and wetting time. Four superdisintegrants were tested, namely: Kollidon CL-SF®, Primojel®, Ac-Di-Sol®, and Polyplasdone XL®, and the most efficient superdisintegrant was selected based on the above mentioned studies. Polyplasdone XL® outperformed the other superdisintegrants in nearly all the concentrations and all of the testing parameters. The ideal concentration was 5% Polyplasdone XL® for the orally disintegrating tablets before the API, diphenhydramine HCl, was added. Various concentrations were analyzed using the aforementioned parameters and 10% Polyplasdone XL® was selected for the final formulation. Tablets were tested over eight weeks of accelerated stability testing at various temperatures to determine percent of diphenhydramine HCl released in dissolution, disintegration time, wetting time, hardness, thickness, and weight variation. The tablets remained stable and within the acceptable range of drug release (90%-110%) at the three temperatures analyzed. Additionally, tablets were analyzed at different levels of relative humidity for percent weight change and change in hardness. The final formulation of diphenhydramine HCl tablets was stable between 3-40°C and at 33% relative humidity or less for eight weeks.

Download or read book Drugs for Pregnant and Lactating Women E Book written by Carl P. Weiner and published by Elsevier Health Sciences. This book was released on 2018-10-17 with total page 1300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Logically organized and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, is your #1 resource for details on how virtually all of today’s drugs and herbal supplements interact with pregnancy and lactation. More than just a dosing manual, this unique title by Dr. Carl P. Weiner fully explains whether each drug is FDA-approved for use by expecting or nursing mothers, is known to be safe for use, or is known to pose a danger. With up-to-date coverage of nearly 2,000 substances, it provides the thorough details you need to choose the most effective course of treatment. Uses a consistent, easy-to-follow format for each substance: generic and trade name • class • indications • mechanism of action • dosage, with contraindications and cautions • maternal considerations • fetal considerations • drug interactions • breastfeeding safety • references • and summary information. Describes over-the-counter drugs and alternative medications as well as prescription drugs. Uses an eye-catching icon to highlight known teratogens. Includes international drug names to give this reference a global perspective. Features new letter thumb tabs for easier navigation. Includes dozens of new drugs and thorough updates throughout.

Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Download or read book Oral Controlled Release Formulation Design and Drug Delivery written by Hong Wen and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Download or read book Principles of Pharmacology written by David E. Golan and published by Lippincott Williams & Wilkins. This book was released on 2011-12-15 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty