Download or read book Focus on Homocysteine and the Vitamins written by Christina Bolander-Gouaille and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Download or read book Homocysteine written by Christina Bolander-Gouaille and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: While research on homocysteine and vitamins involved in its metabolism has focused on associations with cardiovascular disease, pregnancy complications and fetal malformations, recent research explores connections between homocysteine metabolism and neuropsychiatric disease, particularly cognitive decline and dementia. If homocysteine-lowering vitamin treatment can reduce the incidence or delay the onset of dementia, the impact would be significant. This book summarises current research, reviews the underlying biochemistry and surveys diagnostic aspects.
Download or read book Homocysteine and Vascular Disease written by K. Robinson and published by Springer Science & Business Media. This book was released on 2000-04-30 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art review provides an in-depth and critical summary of homocysteine from its molecular basis to clinical relevance and current clinical trials of folic acid and vitamin B6. Written by leading workers in the field, the book provides an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians and any others engaged in the field. It will also be useful to anyone involved in managing vascular patients or cardiac risk factors, as well as biochemists, pharmacologists, general physicians, cardiologists and clinical and basic researchers with an interest in preventive medicine.
Download or read book Focus on Homocysteine written by Christine Bolander-Gouaille and published by Springer. This book was released on 2013-03-09 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 8-10 years the research on homocysteine has become very active. Hundreds of articles are now published each year. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalized by treatment with folate and/or vitamines B 12 and B 6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialized journals. The author has realized the difficulties for the practitioner in keeping updated.
Download or read book The Homocysteine Revolution written by Kilmer S. McCully and published by McGraw Hill Professional. This book was released on 1999-02-22 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 30 years ago, a young Harvard pathologist offered the medical community a theory for the cause of one of today's biggest killers-- heart disease. It is called the Homocysteine Theory and is the medical breakthrough that inspired Andrew Weil to label Dr. McCully as a visionary medical pioneer well ahead of his time. This discovery has the potential to save millions, yet ironically destroyed Dr. McCully's medical career. Homocysteine, a byproduct of metabolism, has been discovered to be a better risk indicator of heart disease than high cholesterol. A simple B6 vitamin and folic acid play a major role in controlling homocysteine levels. This proven theory will change the way the medical establishment views and treats heart disease. Today, the medical community is beginning to accept Dr. McCully's findings transforming his story from medical heresy to legitimate medicine. Updated and revised, complete with a new introduction by Walter Wilett, this eye opening book combines Dr. McCully's personal story and scientific philosophy with a fascinating exposition of his discovery and a special program to make use of this information to improve overall health.
Download or read book Nutritional Management and Metabolic Aspects of Hyperhomocysteinemia written by Mostafa I. Waly and published by Springer Nature. This book was released on 2021-03-31 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form.
Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.
Download or read book Homocysteine in Health and Disease written by Ralph Carmel and published by Cambridge University Press. This book was released on 2001-07-19 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.
Download or read book Meta analysis of Total Plasma Homocysteine and Nutritional Status of B vitamins of Health and Diseased Adults written by Prodromos A. Prodromou and published by . This book was released on 1998 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Homocysteine Levels with B Vitamins in Reducing Atherosclerosis written by Jonathan Colino and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Hyperhomocysteinemia (HHcy) is associated with an increased risk for atherosclerotic disease (Stuhlinger & Stanger, 2005). Cardiac arrhythmias, myocardial infarction, coronary artery disease, and stroke are clinical manifestations of atherothrombotic disease and account for the over 800,000 mortalities in North America (Austin, Lentz, & Werstuck, 2004). The purpose of this evidence-based practice change was to focus on the reduction of homocysteine levels in the middle-aged population to reduce cardiovascular risk. Elevated homocysteine levels can successfully be treated with the use of B vitamins (Stuhlinger & Stanger, 2005). Participants were provided B complex vitamins and Hcy levels were compared pre-treatment and post-treatment. Outcomes have found that implications for screening homocysteine levels should be performed on patients that meet critieria. Keywords: homocysteine, coronary artery disease, vitamin B6, vitamin B12, folic acid, atherosclerosis" -- Abstract.
Download or read book Homocysteine B Vitamins and Adhesion Molecules in Sickle Cell Disease and Diabetes written by Maria Victoria Medina and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Homocysteine is a risk factor for vascular disease, though the mechanism by which homocysteine contributes to vascular disease has not been definitively established. Recent studies suggest that elevated blood levels of homocysteine cause endothelial injury. High levels of homocysteine have been shown to upregulate VCAM-1 expression and adhesion of monocytes to the endothelium in cultured endothelial cells, animals, and humans. Elevated expression of vascular adhesion molecules are often observed in sickle cell disease (SCD) and diabetes patients and may contribute to the vascular morbidity observed in these conditions. Elevated homocysteine is also observed in SCD and diabetes patients, and thus may contribute to vascular disease in these patients through mechanisms involving vascular adhesion molecules. The dissertation research presented in this thesis sought to elucidate mechanisms of homocysteine in vascular disease by exploring the associations between homocysteine, B vitamins, and adhesion molecules in patients with SCD and diabetes via three studies. The first study assessed associations between vitamin B6, homocysteine, and inflammatory markers in adult SCD patients. SCD patients had lower plasma pyridoxal-5'-phosphate (PLP) and higher plasma homocysteine, CRP and sVCAM-1 compared with age, sex, and ethnicity matched controls. No significant correlations were observed between homocysteine and these inflammatory markers. However, a significant inverse correlation was found between PLP and sVCAM-1 in the patients, which suggests that low B6 status may contribute to vascular complications in SCD patients through a VCAM-1-mediated mechanism. The second study assessed whether there was an association between homocysteine and markers of inflammation and endothelial dysfunction in diabetic patients. In a cross-sectional study, we found that mean plasma homocysteine, soluble sVCAM-1 and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations in Type 1 and Type 2 diabetic patients were significantly higher than in healthy controls. Although homocysteine did not correlate with either sICAM-1 or C-reactive protein (CRP), sVCAM-1 was directly correlated with homocysteine in all three groups. The last study sought to evaluate whether a multi B vitamin supplement could reduce homocysteine and inflammatory markers. B vitamin supplementation (folic acid, vitamin B12, vitamin B6, vitamin B2, and choline) was administered in a placebo-controlled, double-blind, randomized study to patients with Type 2 diabetes for three months. Although homocysteine concentrations modestly decreased in response to supplementation, there was no significant effect on sVCAM-1, sICAM-1, or CRP. Most of the subjects had homocysteine levels that were in the normal range prior to treatment. However, two patients had markedly elevated homocysteine concentrations and these two subjects had the highest baseline sVCAM-1 levels of the entire cohort. One subject responded to supplementation with a 50% decrease in homocysteine levels and a 16% reduction in sVCAM-1 concentration while the other patient, who was given the placebo, showed increases in both homocysteine (10%) and sVCAM-1 (17%) concentration. These findings indicate that lowering homocysteine levels when in the normal range does not affect markers of endothelial dysfunction or inflammation in patients with Type 2 diabetes. However, the findings do not rule out the possibility that supplementation with B vitamins may be effective for patients with diabetes who have markedly elevated homocysteine levels. Future studies that assess the efficacy of B vitamin supplementation in reducing markers of inflammation and thereby vascular disease in adult patients with SCD and diabetic patients who have elevated concentrations of homocysteine may be clinically beneficial.
Download or read book Homocysteine Metabolism From Basic Science to Clinical Medicine written by Ian Graham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Download or read book Homocysteine Ralated Vitamines and Neuropsychiatric Disdorders written by Steven Finch and published by Createspace Independent Publishing Platform. This book was released on 2017-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: While research on homocysteine and vitamins involved in its metabolism has focused on associations with cardiovascular disease, pregnancy complications and fetal malformations, recent research explores connections between homocysteine metabolism and neuropsychiatric disease, particularly cognitive decline and dementia. If homocysteine-lowering vitamin treatment can reduce the incidence or delay the onset of dementia, the impact would be significant. This book summarises current research, reviews the underlying biochemistry and surveys diagnostic aspects.
Download or read book Present Knowledge in Nutrition written by John W. Erdman, Jr. and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 2062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.
Download or read book Focus on Homocysteine written by Christina Bolander-Gouaille and published by . This book was released on 2014-01-15 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vitamins and Minerals written by Ruth Kava and published by Am Cncl on Science, Health. This book was released on 2000 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Portfolio Diet for Cardiovascular Disease Risk Reduction written by Wendy Jenkins and published by Academic Press. This book was released on 2019-03-15 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Portfolio Diet for Cardiovascular Disease Risk Reduction: An Evidence Based Approach to Lower Cholesterol through Plant Food Consumption examines the science of this new dietary technology to reduce serum cholesterol and aid in cardiovascular health. With a thorough examination into the scientific rationale for the use of this dietary approach, discussions are included on the experimental findings both for the diet and its 4 individual food components: nuts, legume proteins, viscous fibers, and plant-sterol-enriched foods. Referenced with data from the latest relevant publications and enhanced with practical details (including tips, dishes, and menus), the reader is enabled to meet the goals of serum cholesterol lowering and CVD risk reduction. Provides the scientific basis for the selection of the foods included in the Dietary Portfolio and the experimental evidence demonstrating cholesterol lowering and cardiovascular risk factor reduction Provides an understanding of the current guidelines for lowering cholesterol and other risk factors of cardiovascular disease, explaining how the Dietary Portfolio effects these components and compares to other diet based approaches Provides a holistic view of the Dietary Portfolio by investigating issues of sustainability and ethics in the food system Allows readers to acquire the skills to successfully construct a potent cholesterol-lowering diet Includes tips, palatable recipes and meal planning aids
