Download or read book Fluoroquinolone Associated Disability FQAD Pathogenesis Diagnostics Therapy and Diagnostic Criteria written by Stefan Pieper and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients. Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability. This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.
Download or read book Fluoroquinolone Associated Disability FQAD Pathogenesis Diagnostics Therapy and Diagnostic Criteria written by Stefan Pieper and published by Springer Nature. This book was released on 2021-06-08 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients. Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability. This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.
Download or read book Cough Pathophysiology Diagnosis and Treatment written by Alessandro Zanasi and published by Springer Nature. This book was released on 2020-07-25 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored. Coughing is a common symptom, occurring in many clinical settings, and as such the book appeals a broad readership, including pulmonologists specialized in cough, general practitioners, internists, pediatricians and otorhinolaryngologists.
Download or read book Sj gren s Syndrome written by Manuel Ramos-Casals and published by Springer Science & Business Media. This book was released on 2011-11-16 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sjögren’s Syndrome: Diagnosis and Therapeutics provides a thorough, multisystemic overview of the clinical manifestations of Sjögren’s Syndrome. It contains chapters pertinent across the range of medical specialties that may encounter Sjögren’s Syndrome cases. Chapters are specialty-specific, for easy reference by the relevant medical specialist. In addition to being a diagnostic guide, Sjögren’s Syndrome: Diagnosis and Therapeutics includes a section on prognosis and outcomes of Sjögren’s Syndrome patients and provides an exhaustive therapeutic update, focused on new agents and experimental techniques. The inclusion of diagnostic/therapeutic algorithms illustrates the text with clinical photographs of the main organs involved and helps the reader to make guided diagnostic and therapeutic decisions through decision-based algorithms.
Download or read book Hormone Use and Abuse by Athletes written by Ezio Ghigo and published by Springer Science & Business Media. This book was released on 2010-10-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical activity exerts an important influence on the endocrine system, modulating synthesis and secretion of several hormones. Almost every organ and system in the body is affected by physical activity and exercise, mainly through the endocrine and neuroendocrine system. Mode, intensity, and duration of the exercise bout, age, gender and fitness level of the individual as well as environmental and psychological factors may affect the endocrine response to physical activity. On the other hand, several hormones are able to influence physical performance and body composition. Thus, a bi-univocal interrelationship between exercise and hormones exists. In this book new developments on metabolic and endocrine response to exercise are revised and introduce the "hot topic" of hormonal doping in sports. In the past decades, hormone abuse has become a widespread habit among professional and – most of all and more frequently – recreational athletes. A substantial part of this volume is devoted to the effects of exogenous hormones on performance. Anabolic steroids, growth hormone and erythropoietin properties, use and misuse in sports are widely described. Specific methods to detect hormone abuse are presented and discussed. The contributors to this volume are well-known experts and dedicated researchers in the fields of sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection. The purpose of this volume is to provide all professionals involved in sports medicine and endocrinology a state-of-the-art overview of the complex interactions between physical activity and the endocrine system and to focus on hormone abuse in sports at competitive and recreational level highlighting its negative consequences for long-term health.
Download or read book Orthobiologics written by Giuseppe Filardo and published by Springer Nature. This book was released on 2021-12-02 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
Download or read book MRI of the Temporomandibular Joint written by Tiziana Robba and published by Springer Nature. This book was released on 2019-11-01 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies. TMJ conditions are increasingly gaining attention, as the underlying diseases involved can vary considerably and be difficult to diagnose. Similarly, several imaging sub-specialties (e.g. dental radiology, neuroradiology, and musculoskeletal radiology) now find themselves dealing with the temporomandibular joints. The authors provide essential information on TMJ anatomy, dynamics, function and dysfunction. Correlations between clinical aspects and MRI findings are discussed and guidance for the correct interpretation of results is offered. Special findings that are helpful for differential diagnosis (arthritis, osteochondroma, synovial chondromatosis) are also examined. Given its extensive and varied coverage, the book offers a valuable asset for radiologists, dentists, gnathologists, maxillofacial surgeons, orthodontists and other professionals seeking a thorough overview of the subject
Download or read book Proteases Structure and Function written by Klaudia Brix and published by Springer Science & Business Media. This book was released on 2014-01-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.
Download or read book What You Must Know About the Hidden Dangers of Antibiotics written by Jay S. Cohen and published by Square One Publishers, Inc.. This book was released on 2018-06-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the news about taking too many antibiotics is now common knowledge, there is another underlying danger that the public is not aware of. As beneficial as this class of drugs are, there is a widely prescribed family of antibiotics that is highly destructive. Called fluoroquinolones, they are better known under the names Cipro and Levaquin (as well as four others). What You Must Know About the Hidden Dangers of Antibiotics, has two main goals. The first is to expose the truly destructive capability of these drugs to cause serious, sometimes long term and permanent injuries. The capacity of these drugs for such damage has been attested to by the government’s own watchdog agency, the FDA. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to the book’s author, Dr. Jay Cohen, while many hundreds more have been ignored or dismissed by their own physicians. As this book will show, being brushed off and dismissed as simple side effects essentially allows these manufactures to hide these problems from public view. The second goal of this book is to provide other safer and effective remedies, solutions, and considerations that may help end the suffering experienced by patients suffering from these dangerous side effects--that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. To do this we explain how these dangerous antibiotics work, and particularly how they injure. By understanding the underlying problems, the alternatives offered in this book can help people potentially reduce their pain reduction, clear up persistent antibiotic-based health issues, and just as important, give them hope. Because so many doctors do not carefully read the FDA’s dire warnings about the risks these specific antibiotics pose, there is little likely patients will be know why they are having such serious reactions. With What You Must Know About the Hidden Dangers of Antibiotics, they may have the answer they are looking for.
Download or read book Androgen Deficiency and Testosterone Replacement written by Wayne J.G. Hellstrom and published by Springer Science & Business Media. This book was released on 2012-11-28 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.
Download or read book Leishmania and Leishmaniasis written by Awanish Kumar and published by Springer Science & Business Media. This book was released on 2013-09-13 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
Download or read book How We Can Halt the Cipro and Levaquin Catastrophe written by Jay Cohen and published by . This book was released on 2015-10-25 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the powerful, sometimes lifesaving, yet sometimes highly destructive antibiotics known as fluoroquinolones. Best known of these drugs are Cipro (ciprofloxacin) and Levaquin (levofloxacin), as well as four others. This book, How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History, has two main goals. The first goal is to alert patients and doctors of the truly destructive capability of these drugs to cause serious, sometimes long term, sometimes permanent injuries. The capacity of these drugs for such damage has been attested by the U.S. Food and Drug Administration and others many times and is by now incontrovertible. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to me, while many hundreds more have been ignored or dismissed by their doctors. This must stop. Ignoring these problems has only made the problem worse. My second goal in writing How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History is to stimulate the interest of government, the drug industry, medical institutions and all others for any and all ideas regarding remedies, solutions, and any other ideas that may help end the suffering experienced by patients with the Fluoroquinolone Toxicity Syndrome that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. As you will see, I have offered some ideas for therapies that may provide benefit to some of the injured. I think it is imperative that we follow a trail that may lead us to an understanding of how these drugs work and particularly how they injure, and most of all how we might help people heal, obtain pain reduction and hope. Thousands of lives, young and old, depend on the efforts that we make.
Download or read book Diagnostic and Therapeutic Applications of Exosomes in Cancer written by Mansoor M. Amiji and published by Academic Press. This book was released on 2018-05-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.
Download or read book Chronic Viral Hepatitis written by Raymond Steven Koff and published by Springer Science & Business Media. This book was released on 2002 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic viral hepatitis is the predominant liver disease in the US and physicians are encountering it on a daily basis in their practice. Often, it is the primary care physician and their co-workers who are being routinely asked about risk factors for hepatitis, to screen for markers of chronic viral hepatitis, to identify infected patients, to provide councselling and education and to begin the evaluation for therapeutic intervention. This book equips these practitioners with the necessary, and most up-to-date, information on viral hepatitis focusing on its diagnosis, management and treatment. The emphasis is on easy-access to medical "pearls", supported by numerous figures and illustrations, and especially algorithms. Also included is information about cost indications for consulting subspecialists as well as lists of key principles essential to the clinical practice of caring for patients infected with viral hepatitis.
Download or read book Platelets in Thrombotic and Non Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Download or read book Ciprofloxacin written by Perry D. Snyder and published by CreateSpace. This book was released on 2014-06-25 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book based on what I suffered as a result of being prescribed Ciprofloxacin for a simple gallbladder infection. This antibiotic is a dangerous poison along with others in it's class. Not only does it cause nerve pain and tendons to rupture, it can also cause chemical hepatitis. The later is what I got. I also ended up having a severe cause of pancreatitis that I wasn't supposed to have lived through.
Download or read book Perilous Pills written by Marilyn Beardsley Heise and published by . This book was released on 2020-05-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The shocking story behind the risks of taking fluoroquinolone antibiotics, their development by Big Pharma that promotes profits above safety, unreliable federal regulation, overuse in hospital settings ,errors in pharmacy dispensing, and over-prescribing by doctors. The author offers help on what to do to safely protect yourself and your loved ones.
