Download or read book Field Guidelines for Genetic Experimental Designs in High Throughput Sequencing written by Ana M. Aransay and published by Springer. This book was released on 2016-06-02 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: High throughput sequencing (HTS) technologies have conquered the genomics and epigenomics worlds. The applications of HTS methods are wide, and can be used to sequence everything from whole or partial genomes, transcriptomes, non-coding RNAs, ribosome profiling, to single-cell sequencing. Having such diversity of alternatives, there is a demand for information by research scientists without experience in HTS that need to choose the most suitable methodology or combination of platforms and to define their experimental designs to achieve their specific objectives. Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing aims to collect in a single volume all aspects that should be taken into account when HTS technologies are being incorporated into a research project and the reasons behind them. Moreover, examples of several successful strategies will be analyzed to make the point of the crucial features. This book will be of use to all scientist that are unfamiliar with HTS and want to incorporate such technologies to their research.
Download or read book Compositional Data Analysis written by Vera Pawlowsky-Glahn and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is difficult to imagine that the statistical analysis of compositional data has been a major issue of concern for more than 100 years. It is even more difficult to realize that so many statisticians and users of statistics are unaware of the particular problems affecting compositional data, as well as their solutions. The issue of ``spurious correlation'', as the situation was phrased by Karl Pearson back in 1897, affects all data that measures parts of some whole, such as percentages, proportions, ppm and ppb. Such measurements are present in all fields of science, ranging from geology, biology, environmental sciences, forensic sciences, medicine and hydrology. This book presents the history and development of compositional data analysis along with Aitchison's log-ratio approach. Compositional Data Analysis describes the state of the art both in theoretical fields as well as applications in the different fields of science. Key Features: Reflects the state-of-the-art in compositional data analysis. Gives an overview of the historical development of compositional data analysis, as well as basic concepts and procedures. Looks at advances in algebra and calculus on the simplex. Presents applications in different fields of science, including, genomics, ecology, biology, geochemistry, planetology, chemistry and economics. Explores connections to correspondence analysis and the Dirichlet distribution. Presents a summary of three available software packages for compositional data analysis. Supported by an accompanying website featuring R code. Applied scientists working on compositional data analysis in any field of science, both in academia and professionals will benefit from this book, along with graduate students in any field of science working with compositional data.
Download or read book Biotechnological Tools in Fisheries and Aquatic Health Management written by Bijay Kumar Behera and published by Springer Nature. This book was released on 2023-11-22 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is focused on SDG 14: life below water. This book covers all aspects of fish biotechnology and health management. A detailed description is provided of CRISPR Cas9 technology application in the development of superior variety of fish with better growth, disease resistance, etc., accompanied by numerous helpful photographs and schematic diagrams. In addition, recent developments in nanotechnology and its application in fisheries production enhancement have been discussed. Further, topics includes, probiotics, immunostimulants, fish genetic markers, bioremediation, metagenomics, transgenerational immune priming, application of cell culture in fisheries and nano-biosensor application on fish disease diagnosis, pollution monitoring, etc. are provided in details. . The book is helpful for researchers, teachers, students, farmers, and entrepreneurs in utilizing the knowledge on recent advancements in different aspects of fish genetics and biotechnology for future research and aquaculture production enhancement.
Download or read book Botanical Gardens and Their Role in Plant Conservation written by T. Pullaiah and published by CRC Press. This book was released on 2023-09-29 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approaching the contributions of a world-wide sector of scientific institutions to addressing the extinction crisis, Botanical Gardens and Their Role in Plant Conservation brings together a diversity of perspectives. There are more than 3,600 botanical gardens worldwide, where trees, shrubs, herbs, and other plants are studied and managed in collections. They are foremost among efforts to conserve the diversity of living plant species and ensure that crucial biodiversity is available for the future of humanity. This book is a showcase for plant conservation, restoration, biodiversity, and related scientific and educational work of botanical gardens around the world, featuring both thematic overview chapters and numerous case studies that illustrate the critical role these institutions play in fighting extinction and ensuring plant diversity is available for sustainable use. FEATURES A wide range of case studies derived from practical experience in a diversity of institutional, national, and biogeographical settings, Reviews of topics such as networking amongst institutions, the importance of global policy agreements such as the Convention on Biological Diversity and the Global Strategy for Plant Conservation, Profiles of botanical gardens contributions at the national level to conservation priorities, Real-world examples of programs in plant conservation for both critically endangered wild plant diversity and unique horticultural or cultural germplasm. Botanical Gardens and Their Role in Plant Conservation includes contributions from institutions from Africa, Asia, Australia, Europe, and the Americas, and institutions of all sizes and histories, from long-established national gardens to new gardens offering their perspectives on developing their roles in this vital undertaking.
Download or read book Toxicoepigenetics written by Shaun D. McCullough and published by Academic Press. This book was released on 2018-11-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. - Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology - Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds - Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications
Download or read book Microbial Metatranscriptomics Belowground written by Manoj Nath and published by Springer Nature. This book was released on 2021-06-02 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book emphasizes role of functional microbes in soil to improve fertility and plant health in agro-ecosystem. In this compendium main emphasis is on occurrence and distribution of microbial communities, In situ active microbial quorum in rhizosphere, metratranscriptomics for microflora- and fauna, and fnctional diversity in rhizosphere. The book also highlights the importance of PGPRs in rhizosphere, root endotrophic microbes, functional niche under biotic stress, functional niche under abiotic stress, functional root derived signals, as well as functional microbe derived signals. Approaches deployed in metatranscriptomics, and molecular Tools used in rhizosphere are also discussed in detail. The book presents content is useful for students, academicians, researchers working on soil rhizosphere and as a policy document on sustenance of agriculture.
Download or read book Industrial Microbiology and Biotechnology written by Pradeep Verma and published by Springer Nature. This book was released on 2023-07-08 with total page 751 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Book-Industrial Microbiology and Biotechnology covers various emerging concepts in microbial technology which have been developed to harness the potential of the microbes. The book examines the microbes-based products that have widespread applications in various domains i.e., agriculture, biorefinery, bioremediation, pharmaceutical, and medical sectors. It focusses on recent advances and emerging topics such as CRISPR technology, advanced topics of genomics, including functional genomics, metagenomics, metabolomics, and structural and system biology approaches for enhanced production of industrially relevant products. It further gives an insight into the advancement of genetic engineering with special emphasis on value-added products via microalgal systems and their techno-economics analysis and life cycle assessment. The book towards the end presents recent advancements in the use of microbes for the production of industrial relevant enzymes, amino acids, vitamins, and nutraceuticals, on vaccine development and their biomedical applications. The book is an essential source for researchers working in allied fields of microbiology, biotechnology, and bioengineering.
Download or read book The Development and Utilization of Novel Antibiotic Alternatives written by Wang Jiajun and published by Frontiers Media SA. This book was released on 2022-10-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Wastewater Treatment written by Maulin P. Shah and published by Elsevier. This book was released on 2021-01-30 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wastewater Treatment: Cutting-Edge Molecular Tools, Techniques and Applied Aspects reports new findings in existing molecular biology strategies, including their limitations, challenges and potential application to remove environmental pollutants through advancements made in cutting edge tools. In addition, the book introduces new trends and advances in environmental bioremediation with thorough discussions on recent developments in this field. - Describes the application of different omics tools in wastewater treatment plants (WWTPs) - Describes the role of microorganisms in WWTPs - Points out the reuse of treated wastewater through emerging technologies - Includes the recovery of resources from wastewater - Emphasizes the need for the use of cutting-edge molecular tools
Download or read book Hazardous Pollutants in Biological Treatment Systems written by Ferhan Çeçen and published by IWA Publishing. This book was released on 2017-11-15 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hazardous pollutants are a growing concern in treatment engineering. In the past, biological treatment was mainly used for the removal of bulk organic matter and the nutrients nitrogen and phosphorous. However, relatively recently the issue of hazardous pollutants, which are present at very low concentrations in wastewaters and waters but are very harmful to both ecosystems and humans, is becoming increasingly important. Today, treatment of hazardous pollutants in the water environment becomes a challenge as the water quality standards become stricter. Hazardous Pollutants in Biological Treatment Systems focuses entirely on hazardous pollutants in biological treatment and gives an elaborate insight into their fate and effects during biological treatment of wastewater and water. Currently, in commercial and industrial products and processes, thousands of chemicals are used that reach water. Many of those chemicals are carcinogens, mutagens, endocrine disruptors and toxicants. Therefore, water containing hazardous pollutants should be treated before discharged to the environment or consumed by humans. This book first addresses the characteristics, occurrence and origin of hazardous organic and inorganic pollutants. Then, it concentrates on the fate and effects of these pollutants in biological wastewater and drinking water treatment units. It also provides details about analysis of hazardous pollutants, experimental methodologies, computational tools used to assist experiments, evaluation of experimental data and examination of microbial ecology by molecular microbiology and genetic tools. Hazardous Pollutants in Biological Treatment Systems is an essential resource to the researcher or the practitioner who is already involved with hazardous pollutants and biological processes or intending to do so. The text will also be useful for professionals working in the field of water and wastewater treatment.
Download or read book Methods in Yeast Genetics written by David C. Amberg and published by CSHL Press. This book was released on 2005 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.
Download or read book The Statistical Analysis of Compositional Data written by John Aitchison and published by . This book was released on 2003 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1986, this text contains a new Foreword, extensive postscript detailing developments in the field since its first publication, and a selection of more recent literature references. The work provides a clear and systematic account of statistical methods designed to meet the special needs of the compositional data analyst. (Mathematics)
Download or read book Sample Size Calculations in Clinical Research written by Shein-Chung Chow and published by CRC Press. This book was released on 2017-08-15 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.
Download or read book Clinical Applications for Next Generation Sequencing written by Urszula Demkow and published by Academic Press. This book was released on 2015-09-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments. Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients. The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia. - Fills the gap between state-of-the-art technology and evidence-based practice - Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment - Promotes a practical tool that clinicians can apply directly to patient care - Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases - Presents evidence regarding the important role of NGS in current diagnostic strategies
Download or read book The New Science of Metagenomics written by National Research Council and published by National Academies Press. This book was released on 2007-06-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although we can't usually see them, microbes are essential for every part of human life-indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying-one at a time-the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.
Download or read book Marine Metagenomics written by Takashi Gojobori and published by Springer. This book was released on 2019-07-24 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state-of-art marine metagenome research and explains the method of marine metagenomic analysis in an easy-to-understand manner. Changes in the marine environment due to global warming and pollution have become a major global problem. Maintaining a healthy marine ecosystem requires advanced environmental monitoring and assessment systems. As such, the book presents a novel metagenomic monitoring method, which has been developed for comprehensive analyses of the DNA of microorganisms living in seawater to further our understanding of the dynamics of the marine environment. The book can be used as a primer for new researchers and as a manual on experimental methods.
