Download or read book Fibrous Proteins Coiled Coils Collagen and Elastomers written by David A.D. Parry and published by Gulf Professional Publishing. This book was released on 2005-05-06 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards. Reveals new structural and functional aspects of fibrous proteins Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry

Download or read book Fibrous Proteins Structures and Mechanisms written by David A.D. Parry and published by Springer. This book was released on 2017-01-18 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the β-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials.

Download or read book Fibrous Proteins written by Thomas Scheibel and published by CRC Press. This book was released on 2008-10-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibrous Proteins will give an overview over some of the most important fibrous proteins including amyloids, collagens, fibrin, flagella, intermediate filaments, microtubules, silks concerning structure and function and possible applications as biomaterials.While our knowledge on globular proteins has been increasing over the past decades, fibrillar

Download or read book Fibrous Proteins Muscle and Molecular Motors written by John M. Squire and published by Gulf Professional Publishing. This book was released on 2005-08-29 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Motors and Muscle is the second of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award-winning issue of Journal of Structural Biology. There are two major types of protein: Globular proteins which are often enzymes which speed up biochemical reactions and Fibrous proteins which often have more structural roles but can also have dynamic properties. Fibrous proteins are usually either elongated molecules which pack together to form long filaments, as in the case of the intermediate filaments in our hair and skin and as in collagen fibrils in tendons and bones or they are globular proteins which aggregate linearly to form long filaments, such as actin filaments or microtubules. Fibrous proteins act as molecular scaffolds in cells, they can be involved in transport of cell organelles or even on a visible scale as in our muscles. They provide the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. They are vital for life and represent a fascinating subset of the proteome. Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier's extensive researcher network. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/ *Allows a comparison to be made between unique but related structures. *Quality of the text and illustrations allows ready comprehension of key protein design features. *Identifies fibrous protein sequence features for analysis of the human genome. *Analyzes design principles for fibrous protein sequences thus leading potentially to development of new devices by nanofabrication.

Download or read book Nanostructured Polymer Composites for Biomedical Applications written by Sarat Kumar Swain and published by Elsevier. This book was released on 2019-06-15 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured Polymer Composites for Biomedical Applications addresses the challenges researchers face regarding the creation of nanostructured polymer composites that not only have superior performance and mechanical properties, but also have acceptable biological function. This book discusses current efforts to meet this challenge by discussing the multidisciplinary nature of nanostructured polymer composite biomaterials from various fields, including materials science, polymer science, biomedical engineering and biomedicine. This compilation of existing knowledge will lead to the generation of new terminology and definitions across individual disciplines. As such, this book will help researchers and engineers develop new products and devices for use in effective medical treatment. - Summarizes the most recent strategies to develop nanostructured polymer composite biomaterials for biomedicine - Outlines the major preparation and characterization techniques for a range of polymer nanocomposites used in biomedicine - Explores the design of new types of nanostructured polymer composites for applications in drug delivery, tissue engineering, gene therapy and bone replacement

Download or read book Tunable Hydrogels written by Antonina Lavrentieva and published by Springer Nature. This book was released on 2021-05-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.

Download or read book Nanobiotechnology II written by Chad A. Mirkin and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume on a burgeoning field retains the proven concept of the spectacularly successful first one, extending and supplementing it. Individual sections are each dedicated to nanoparticles, nanostructures and patterns, nanodevices and machines, and nanoanalytics. Essential reading for an entire generation of scientists, this authoritative survey defines one of the most important new scientific fields to have emerged for many decades.

Download or read book Biotechnology of Silk written by Tetsuo Asakura and published by Springer Science & Business Media. This book was released on 2013-10-21 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a snapshot of the current state of the art of research and development on the properties and characteristics of silk and their use in medicine and industry. The field encompasses backyard silk production from ancient time to industrial methods in the modern era and includes an example of efforts to maintain silk production on Madagascar. Once revered as worth its weight in gold, silk has captured the imagination from its mythical origins onwards. The latest methods in molecular biology have opened new descriptions of the underlying properties of silk. Advances in technological innovation have created silk production by microbes as the latest breakthrough in the saga of silk research and development. The application of silk to biomaterials is now very active on the basis of excellent properties of silks including recombinant silks for biomaterials and the accumulated structural information.

Download or read book Fundamentals of Multiscale Modeling of Structural Materials written by Wenjie Xia and published by Elsevier. This book was released on 2022-11-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Multiscale Modeling of Structural Materials provides a robust introduction to the computational tools, underlying theory, practical applications, and governing physical phenomena necessary to simulate and understand a wide-range of structural materials at multiple time and length scales. The book offers practical guidelines for modeling common structural materials with well-established techniques, outlining detailed modeling approaches for calculating and analyzing mechanical, thermal and transport properties of various structural materials such as metals, cement/concrete, polymers, composites, wood, thin films, and more.Computational approaches based on artificial intelligence and machine learning methods as complementary tools to the physics-based multiscale techniques are discussed as are modeling techniques for additively manufactured structural materials. Special attention is paid to how these methods can be used to develop the next generation of sustainable, resilient and environmentally-friendly structural materials, with a specific emphasis on bridging the atomistic and continuum modeling scales for these materials. - Synthesizes the latest cutting-edge computational multiscale modeling techniques for an array of structural materials - Emphasizes the foundations of the field and offers practical guidelines for modeling material systems with well-established techniques - Covers methods for calculating and analyzing mechanical, thermal and transport properties of various structural materials such as metals, cement/concrete, polymers, composites, wood, and more - Highlights underlying theory, emerging areas, future directions and various applications of the modeling methods covered - Discusses the integration of multiscale modeling and artificial intelligence

Download or read book Tumor Suppressor Par 4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-08 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

Download or read book Research Methods in Biomineralization Science written by and published by Elsevier. This book was released on 2013-10-31 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Contains sections on such topics as and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure

Download or read book On Biomimetics written by Lilyana Pramatarova and published by BoD – Books on Demand. This book was released on 2011-08-29 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-mimicry is fundamental idea "How to mimic the Nature" by various methodologies as well as new ideas or suggestions on the creation of novel materials and functions. This book comprises seven sections on various perspectives of bio-mimicry in our life; Section 1 gives an overview of modeling of biomimetic materials; Section 2 presents a processing and design of biomaterials; Section 3 presents various aspects of design and application of biomimetic polymers and composites are discussed; Section 4 presents a general characterization of biomaterials; Section 5 proposes new examples for biomimetic systems; Section 6 summarizes chapters, concerning cells behavior through mimicry; Section 7 presents various applications of biomimetic materials are presented. Aimed at physicists, chemists and biologists interested in biomineralization, biochemistry, kinetics, solution chemistry. This book is also relevant to engineers and doctors interested in research and construction of biomimetic systems.

Download or read book Cardiovascular Thrombus written by On Topaz and published by Academic Press. This book was released on 2018-08-18 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practices as related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. The formation, identification and management of cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference connects between research, up-to-date clinical knowledge, and the technological tools available for diagnosis and management of thrombus in cardiovascular medicine. The book includes comprehensive descriptions and review of pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends. It is the perfect reference for basic science students and researchers in general and interventional cardiology, general and interventional radiology, vascular medicine specialists, and vascular, general and cardiac surgeons. Provides comprehensive presentation of the pathophysiology, clinical presentations and diagnosis of cardiovascular thrombosis Includes the most up-to-date information on the practical management of patients with thrombus related conditions Written by the leading experts in the field Describes the current and upcoming pharmacotherapy and technology available for thrombus research and treatment

Download or read book Handbook of Biopolymers and Biodegradable Plastics written by Sina Ebnesajjad and published by William Andrew. This book was released on 2012-09-19 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new Handbook provides engineers and scientists with the information and practical guidance needed to successfully design and manufacture products using biopolymers and biodegradable plastics. Biopolymers and biodegradable plastics are a hot issue across the plastics industry, and for many of the industry sectors that use plastic: from packaging to medical devices and from the construction industry to the automotive sector. This book brings together in one place a number of key biopolymer and biodegradable plastics topics-in chapters previously published as well as updated and new chapters-for a broad audience of engineers of and scientists, especially those designing with biopolymers and biodegradable plastics or evaluating the options for switching from traditional plastics to biopolymers. Topics covered include preparation, fabrication, applications and recycling (including biodegradability and compostability). Applications in key areas such as films, coatings, controlled release, and tissue engineering are discussed.

Download or read book Peptide Based Materials written by Timothy Deming and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

Download or read book Biomechanics of Injury written by Ronald F. Zernicke and published by Human Kinetics. This book was released on 2023-01-05 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of Injury, Third Edition, explains the biomechanical principles of injury and how injuries affect the normal function of human anatomy. With a clear, accessible writing style and nearly 400 full-color photos and anatomy illustrations, it guides readers through the mechanical concepts of injuries without a heavy emphasis on mathematics. Previously titled Biomechanics of Musculoskeletal Injury, this third edition expands coverage of injuries beyond those of the musculoskeletal system to include the head, neck, and spine. Joining noted biomechanists Ronald Zernicke and William Whiting is concussion expert and athletic trainer Steven Broglio, who offers insights on head trauma and other neurological injuries. Unique in its evaluation of and appreciation for the intricacies of injury mechanisms, Biomechanics of Injury, Third Edition, comprehensively examines these issues: The mechanical aspects of injury and the concept of injury as a stimulus for beneficial tissue adaptations The effects of injury on the normal function of the human anatomy and joint mechanics Mechanical parameters such as force, stress and strain, stiffness, and elasticity and their application to tissue mechanics and injury How connective tissues respond to mechanical loading and how those tissues are studied to quantify their mechanical behavior Factors such as age, gender, nutrition, and exercise, with an emphasis on how lifestyle choices might lessen the chance or severity of injury How the principles of mechanical load and overload, use and overuse, level and progression of injury, and the many contributory factors involved in injury combine to form a backdrop for viewing specific injuries Updated sidebars present a detailed analysis of anterior cruciate ligament injuries, rotator cuff pathologies, and concussion. In addition, the text discusses topics of current concern such as falls in older populations, throwing-related rotator cuff pathologies, and youth injuries from carrying backpacks. Biomechanics of Injury, Third Edition, also employs learning aids to help readers understand and retain information. Objectives at the start of each chapter highlight the main concepts. Key terms appear in bold in the text and are defined in the glossary. Key Points at the end of each chapter summarize central concepts. Questions to Consider appear at the end of each chapter to test readers’ understanding and ability to apply the information presented. Updated Suggested Readings are included at the end of each chapter for readers who wish to dive deeper into selected topics. Knowledge of the biological responses of tissues to mechanical loading improves our understanding of injury and its consequences. Biomechanics of Injury, Third Edition, will enable students and health professionals to reduce the likelihood that clients, patients, or athletes will experience painful and debilitating physical injury.

Download or read book Biomarkers of the Tumor Microenvironment written by Lars A. Akslen and published by Springer Nature. This book was released on 2022-07-12 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.