Download or read book Fibrocystic Diseases of the Liver written by Karen F. Murray and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there have been huge advances in the understanding of the genetic and molecular basis of the fibrocystic diseases. This volume provides a thorough review of fibrocyctic diseases that affect the liver. It contains in-depth discussions of the genetics, molecular biology, pathogenesis, histology, clinical presentations, complications of, treatment, and prognosis of the conditions affecting children and adults, and hence will be the gold-standard reference for these conditions. In addition, the histological features that distinguish these conditions from other potentially fibrosing hepatopathies are illustrated. Conditions with syndromic features involving the kidney or other organ systems are also reviewed. Thorough review of the clinical phenotypes, their presentations, treatment, potential complications of, and prognosis is discussed. Fibrocystic Diseases of the Liver will be an invaluable resource for hepatologists, gastroenterologists, nephrologists, and hepatic surgeons who care for children and adults with liver disease, as well as basic scientists in molecular genetics, hepatobiliary pathophysiology, hepatology and nephrology.

Download or read book Pediatric Hepatology and Liver Transplantation written by Lorenzo D'Antiga and published by Springer. This book was released on 2019-04-29 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Download or read book CONGENITAL FIBROCYSTIC LIVER DISEASE Imaging Features and Differential Diagnosis written by Elena Inchausti and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: LEARNING OBJETIVES:To understand the diseases that come from the abnormal embryological development of the ductal plate, known as fibropolicystic liver diseases.To illustrate the imaging findings of congenital fibrocystic liver diseases.To be able to differentiate each entity from other differential diagnosis. BACK GROUND:Ductal plate malformations, known as fibrocystic liver diseases, are a group of congenital disorders resulting from the abnormal embryogenesis of the biliary ductal system. These entities include congenital hepatic fibrosis, biliary hamartomas, autosomal dominant polycystic disease, Caroli disease, and cholecochal cyst. The hepatic lesions can be associated with renal anomalies, suggesting the expression of a common underlying genetic abnormality.IMAGING FINDINGS:The different types of fibrocystic liver disease demonstrate characteristic findings at ultrasound, computed tomography and magnetic resonance imaging. We present different cases of each entity including.-tCongenital hepatic fibrosis.-tBiliary hamartomas.-tAutosomal dominant polycystic disease.-tCaroli disease.-tCholedochal cysts.We also present other diseases that can mimic these entities, including early viral alcoholic cirrhosis, hepatic lymphoma or metastasis, when it comes to congenital hepatic fibrosis. In the case of Caroli disease differential diagnosis with the sclerosing colangitis must be done. CONCLUSION:Accurate diagnosis of fibrocystic liver diseases is important to indicate an appropriate clinical management, as they can be clinically silent or can cause signs and symptoms such as portal hypertension, infections or space-occupying masses.

Download or read book Diseases of the Liver and Biliary System in Children written by Deirdre A. Kelly and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extremely practical text, this new edition of Diseases of the Liver and Biliary System in Children covers the essentials of paediatric hepatology. The range of material is wide and has been revised and updated to include the latest advances. Many helpful algorithms and tables are included and the references at the end of each chapter have been carefully selected so as to provide the most up-to-date information available. A concluding section comprising some 100 carefully annotated plates, completes this text. Containing the contributions of 23 internationally acclaimed authorities, active both clinically and in research, the book provides an essential guide to the diagnosis and management of paediatric liver diseases, both common and uncommon for all those involved in the care of the child with liver disease. Diseases of the Liver and Biliary System in Children has become THE REFERENCE of choice for the paediatric gastroenterologist, hepatologist and surgeon.

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. - Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. - Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. - Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Download or read book Hepatic Cirrhosis Associated with Fibrocystic Disease of the Pancreas written by Reginald Webster and published by . This book was released on 1953 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Schiff s Diseases of the Liver written by Eugene R. Schiff and published by John Wiley & Sons. This book was released on 2011-10-19 with total page 2480 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 50 years covering 10 previous editions, Schiff's Diseases of the Liver has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world’s leading hepatology textbooks. Now fully revised and updated, it will serve as your first-stop reference for today’s demanding clinical situations. With a strong clinical focus, Schiff’s Diseases of the Liver covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include: An attractive full color design throughout Informative section overviews for each section Concise key concepts box in every chapter Treatment guidelines and management algorithms for every disease A full liver transplant section This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world’s leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including: Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format High-quality video clips of a variety of surgical procedures, all fully linked to the text 35 case studies featuring real-life clinical scenarios. Schiff’s Diseases of the Liver remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease.

Download or read book Imaging of the Liver and Intra hepatic Biliary Tract written by Emilio Quaia and published by Springer Nature. This book was released on 2020-09-28 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

Download or read book Textbook of Pediatric Gastroenterology Hepatology and Nutrition written by Stefano Guandalini and published by Springer. This book was released on 2015-09-30 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional problems in the various pediatric ages. The second part of the book, Hepatology, is articulated in a series of chapters which present a comprehensive review of congenital and acquired disorders of the biliary tract and liver. This section also includes a critical analysis of available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice constitutes a much needed, innovative resource combining updated, reliable and comprehensive information with agile consultation for a streamlined approach to the care of children with such disorders.

Download or read book Diseases of the Liver and Biliary System in Children written by Deirdre A. Kelly and published by John Wiley & Sons. This book was released on 2017-01-04 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This market-leading book, with comprehensive coverage of the entire spectrum of liver disease in children, returns with 12 brand new chapters covering key areas in liver transplantation, viral hepatitis, and liver disease in infancy. Authored by the world’s leading hepatologists and pediatricians and expertly edited by Deirdre Kelly, it covers the entire topic from pathology to diagnosis and clinical management, and in all stages of childhood from the unborn baby through to infancy, and from childhood to the transition into adolescence. Hepatologists, pediatricians and gastroenterologists of all levels will find it an essential tool to consult time and time again

Download or read book 30 Day Journal and Tracker Reversing Liver Fibrocystic Disease and Polydactyly written by Health Formation and published by . This book was released on 2020-01-29 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: After relentlessly studying the teachings of legendary healers, such as Dr Arnold Ehret and Dr Robert Morse, we set out on a journey of healing ourselves and reversing our very own conditions. Within our group, we were suffering from a range of diverse diseases and conditions, including Heart Disease, Kidney Disease, Diabetes, a variety of Autoimmune Diseases and Leaky Gut. During our healing journeys, we formed a journal that we would use on a daily basis, and this helped us to incorporate all of the lessons and tips that we had learnt and refined along the way - in short, it acted as a check list. It was important to us to not miss out on any knowledge and practices that had served us well. This journal is designed to guide and support you through your own journey with the core healing protocols included within its theme. One of the key conclusions that we reached through our individual journeys was that whether you are a sufferer of Liver Fibrocystic Disease and Polydactyly, or any other condition, the same protocol that we used applies. However, dependant on the severity of your Liver Fibrocystic Disease and Polydactyly, you may need to follow the protocols for longer, using specific herbs in order to achieve positive results, but you can make your own adjustments as you learn more. The great news is that all information and resources are readily available for personal study and application. Dr Arnold Ehret's books can be downloaded freely if you search for "arnold ehret books pdf". Visit rawfigs.com for Dr Robert Morse videos which can be searched through by keywords via the search bar. With this journal and your newly acquired knowledge, we trust that you will also soon start to experience the positive results that we did, along with the many others that send us regular positive feedback. We wish you all the best. The Health Formation Team

Download or read book Benign Tumors of the Liver written by Luca Aldrighetti and published by Springer. This book was released on 2015-04-21 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis of benign liver tumors is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph examines the epidemiology, histopathology and genetics of these tumors and provides a systematic overview of their evolution and differential diagnosis. Care is taken to document surgical indications accurately, with a view to assisting in the avoidance of useless interventions. Open, laparoscopic and robotic surgical techniques are described and illustrated, emphasizing the optimization of intra- and postoperative management in order to avoid potential complications and degeneration. In these chapters, attention is drawn to the ways in which the surgical management of benign liver tumors differs from that of malignant tumors. The book concludes by examining the role of interventional radiology in patients with benign liver tumors.

Download or read book Kidney Development Disease Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Download or read book Sherlock s Diseases of the Liver and Biliary System written by James S. Dooley and published by John Wiley & Sons. This book was released on 2011-03-08 with total page 1536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Awarded first prize in the Internal Medicine category of the British Medical Association Book of the Year Awards, 2012 Following a Tradition of Excellence from reviews of previous editions: "the best source of synthesized clinical wisdom" —Gastroenterology "a tour de force in terms of knowledge and effort" —The New England Journal of Medicine "the foremost liver book in the world" —The Journal of the American Medical Association "beautifully produced" —Hepatology Over the past 56 years, thousands of physicians have depended on Diseases of the Liver and Biliary System. Its didactic and reliable clinical guidance was - and still is - beyond comparison. This brand-new edition, now named Sherlock's Diseases of the Liver and Biliary System, after the late Professor Dame Sheila Sherlock, continues to provide concise clinical guidance for all those treating patients with hepato-biliary disease. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, this book has been updated to reflect the advances that have been made in the last 10 years, providing didactic and reliable clinical guidance in hepatology from the world’s leading experts. A consistent chapter structure allows readers to access the information immediately, with summary boxes and key learning points throughout, and special emphasis on the latest in evidence-based clinical guidance. And for the first time, this edition now offers a free companion website providing the 680 full-color illustrations and figures in the book, for use in scientific presentations.