Download or read book Fast Neutron Rad And High let Particles in Cancer Therapy written by R. Engenhart and published by . This book was released on 1998-07-17 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fast Neutrons and High LET Particles in Cancer Therapy written by Rita Engenhart-Cabillic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast neutron therapy was introduced in London in 1970. The book gives an overview of the developments of the past 28 years, assesses the results of fast neutron treatment, and reviews the compiled clinical data worldwide. The authors describe the radiobiological profile of the neutron beams and evaluate the neutron RBE for secondary cancer induction, they introduce heavy-ion therapy, which combines high physical selectivity with the biological advantages of high-LET radiation for some tumor types, and finally they describe the very recent developments in Boron Neutron Capture Therapy (BNCT).
Download or read book High LET Radiations in Clinical Radiotherapy written by G. W. Barendsen and published by Elsevier. This book was released on 2013-09-11 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-LET Radiations in Clinical Radiotherapy covers the proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and other High-LET Particles in Clinical Radiotherapy. The title presents papers that report the experiences in utilizing High-LET radiations in clinical radiotherapy. The coverage of the text includes observations on the reactions of normal and malignant tissues to a standard dose; and clinical observations of early and late normal tissue injury and tumor control in patients receiving fast neutron irradiation. The selection also covers results of fast neutron radiotherapy at Amsterdam; and results of clinical applications with fast neutrons in Edinburgh. The book will be of great use to students and practitioners of medical technology.
Download or read book The Physics and Radiobiology of Fast Neutron Beams written by David K. Bewley and published by CRC Press. This book was released on 1989-10-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over fifty years have passed since the first patient was treated with fast neutrons, but this form of therapy is still a matter of bitter dispute. Neutron generators have been installed in many countries and now patients can be treated with equipment that is technically similar to modern megavoltage x-ray equipment. The Physics and Radiobiology of Fast Neutron Beams presents a full discussion of the physical and radiobiological factors governing the production and use of fast neutron beams for therapy. The book discusses vastly improved neutron generators, advances in the standardization of dosimetric methods, and the specification of radiation quality. In addition, it explores nuclear methods of analysis, particularly neutron activation analysis in vivo. Influencing the place of radiotherapy with neutrons and other heavy particles, the radiobiological factors governing the treatment of cancer with radiation are examined. The author also studies the radiation hazard of neutrons, a matter of importance in the use of neutrons for chemical analysis in vivo. The Physics and Radiobiology of Fast Neutron Beams will be a valuable introduction to the subject for radiotherapists, medical physicists, radiographers, and radiobiologists new to the field. The book is also a useful summary of current knowledge for those already established in the use of fast neutrons for medical purposes.
Download or read book Heavy Particle Radiotherapy written by M Raju and published by Elsevier. This book was released on 2012-12-02 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heavy Particle Radiotherapy covers the significant advances in the application of radiotherapy to cancer treatment. This book is composed of eight chapters that focus on the performance of several heavy particles. The introductory chapters describe the radiobiological phenomena of interest in radiotherapy and their modifications with increasing linear energy transfer. The remaining chapters discuss the physical aspects, cellular effects, and radiotherapy potential of heavy particles, including neutrons, protons, helium and heavy ions, and negative pions.
Download or read book Nuclear Science Applictions Se written by Yosh Maruyama and published by CRC Press. This book was released on 1991 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Download or read book Radiation Risks and Radiation Therapy written by Eli Glatstein and published by . This book was released on 1983 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Download or read book Fast Neutrons and High LET Particles in Cancer Therapy written by Rita Engenhart-Cabillic and published by Springer. This book was released on 1998-05-28 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast neutron therapy was introduced in London in 1970. The book gives an overview of the developments of the past 28 years, assesses the results of fast neutron treatment, and reviews the compiled clinical data worldwide. The authors describe the radiobiological profile of the neutron beams and evaluate the neutron RBE for secondary cancer induction, they introduce heavy-ion therapy, which combines high physical selectivity with the biological advantages of high-LET radiation for some tumor types, and finally they describe the very recent developments in Boron Neutron Capture Therapy (BNCT).
Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer. This book was released on 2012-11-06 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Download or read book Advances in Nuclear Data and All particle Transport for Radiation Oncology written by and published by . This book was released on 1994 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast neutrons have been used to treat over 15,000 cancer patients worldwide and proton therapy is rapidly emerging as a treatment of choice for tumors around critical anatomical structures. Neutron therapy requires evaluated data to (approximately)70 MeV while proton therapy requires data to (approximately)250 MeV. Collaboration between Lawrence Livermore National Laboratory (LLNL) and the medical physics community has revealed limitations in nuclear cross section evaluations and radiation transport capabilities that have prevented neutron and proton radiation therapy centers from using Monte Carlo calculations to accurately predict dose in patients. These evaluations require energy- and angle-dependent cross sections for secondary neutrons, charged-particles and recoil nuclei. We are expanding the LLNL nuclear databases to higher energies for biologically important elements and have developed a three-dimensional, all-particle Monte Carlo radiation transport code that uses computer-assisted-tomography (CT) images as the input mesh. This code, called PEREGRINE calculates dose distributions in the human body and can be used as a tool to determine the dependence of dose on details of the evaluated nuclear data. In this paper, we will review the status of the nuclear data required for neutron and proton therapy, describe the capabilities of the PEREGRINE package, and show the effects of tissue inhomogeneities on dose distribution.
Download or read book Clinical Aspects of Neutron Capture Therapy written by R. Fairchild and published by Springer. This book was released on 1989-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Locher first suggested Boron Neutron Capture Therapy (BNCT) in 1936, this theoretically ideal system has intrigued investigators. Unfortunately, the first clinical trials between 1951-1961 were not successful. However, they served to implant firmly the seed of BNCT, the growth of which has been carefully nurtured at a number of locations world-wide. This fact is attested to by the ongoing clinical trials in Japan as well as by the presence of researchers from active groups in the ten countries represented at this Workshop. In 1983 and 1985, the first and second international biannual symposia on BNCT were held, in response to a resurgence of interest in this field. In 1986, the DOE sponsored a workshop on NCT, in large part directed toward evaluating the national effort and the various neutron sources available within the United States. It now seems likely, because of various factors including improved neutron beams and boron delivery systems which have made the modality more attractive, that clinical trials will be initiated in the United States within the next few years. This 1988 special workshop, interspersed between the biannual international symposia, represents an effort to seek ideas and advice on the clinical a~pects of BNCT, from all those diverse groups with a national commitment to this project. Our purpose is to facilitate our endeavor to incorporate the best procedures and techniques in the upcoming clinical trials.
Download or read book Nuclear Science Applications written by and published by . This book was released on 1984 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
