Download or read book Facilitative Glucose Transporters in Articular Chondrocytes written by Ali Mobasheri and published by Springer Science & Business Media. This book was released on 2008-09-20 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Articular cartilage is a highly specialized avascular connective tissue. This multidisciplinary article reviews the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors.
Download or read book Mechanosensitive Ion Channels written by Andre Kamkin and published by Springer Science & Business Media. This book was released on 2007-10-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.
Download or read book Smart Nanocontainers written by Phuong Nguyen Tri and published by Elsevier. This book was released on 2019-11-08 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Nanocontainers explores the fundamental concepts and emerging applications of nanocontainers in biomedicine, pharmaceuticals and smart materials. In pharmaceuticals, nanocontainers have advantages over their micro-counterparts, including more efficient drug detoxification, higher intracellular uptake, better stability, less side effects and higher biocompatibility with tissue and cells. In materials science, such as coating technology, they help by making coatings smarter, stronger and more durable. This important reference will help anyone who wants to learn more on how nanocontainers are used to provide the controlled release of active agents, including their applications in smart coatings, corrosion, drug delivery, diagnosis, agri-food and gas storage. - Discusses how the molecular design of nanocarriers can be optimized to increase performance - Explores how nanocarriers are being used to produce a new generation of active coatings - Explains how nanocarriers are being used to deliver more effective nanoscale drug delivery
Download or read book Firestein Kelley s Textbook of Rheumatology E Book written by Gary S. Firestein and published by Elsevier Health Sciences. This book was released on 2024-07-24 with total page 3010 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment―including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.
Download or read book The Essentials of Charcot Neuroarthropathy written by Claude Pierre-Jerome and published by Elsevier. This book was released on 2022-05-11 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity. - Presents a clear differentiation of Charcot neuroarthropathy with other conditions such as osteoarthritis, gout, psoriasis, rheumatoid arthritis, the Madura foot, and others - Provides a state-of-art catalogue of all radiological features of Charcot neuroarthropathy with MRI - Describes the pre-and post-surgical procedures used for the management of Charcot neuroarthropathy and their socioeconomic impacts - Includes MRI color images of soft tissue damages for ease of understanding
Download or read book Genomics Proteomics and Metabolomics in Nutraceuticals and Functional Foods written by Debasis Bagchi and published by John Wiley & Sons. This book was released on 2015-09-25 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.
Download or read book Studies on Arthritis and Joint Disorders written by Maria Jose Alcaraz and published by Springer Science & Business Media. This book was released on 2013-02-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress”, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.
Download or read book Focus on Arthritis Research written by Frank H. Columbus and published by Nova Publishers. This book was released on 2004 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthritis is an inflammatory disease affecting the joints and surrounding tissues. As the disease develops it can cause severe pain and disability. The two most common types of arthritis are osteoarthritis and rheumatoid arthritis. Osteoarthritis (OA) is a painful, degenerative joint disease that often involves the hips, knees, neck, lower back, or the small joints of the hands. Treatment usually includes analgesics, topical creams, or non-steroidal anti-inflammatory medications (known as NSAIDs); appropriate exercises or physical therapy; joint splinting; or joint replacement surgery for seriously damaged larger joints, such as the knee or hip. Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that usually involves the hands, wrists, elbows, shoulders, knees, feet, or ankles. Focus on Arthritis Research brings together leading research in the field.
Download or read book Human Glucose Transporters in Health and Diseases written by Leszek Szablewski and published by Cambridge Scholars Publishing. This book was released on 2019-07-23 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucose transporters play an important role in the metabolism of both humans and animals. These membrane proteins mediate the transport of several substances, such as monosaccharides, inositols, vitamins, and iodide, across the plasma membrane. Disturbances in expression and function of these carrier proteins usually cause severe or even fatal outcomes. This book discusses a series of current issues regarding the correlations between the expression of these transporters and diseases, including the role of glucose transporters as a potential anticancer and antidiabetic therapeutic target. By presenting a clear review of the correlation between glucose transporter-health and disease, the book will serve to draw more biomedical scientists, physicians, pharmacologists, physiologists, and students to dedicate their research to the role of glucose transporters in human health and disease.
Download or read book Gout and Other Crystal Arthropathies written by Robert Terkeltaub and published by Elsevier Health Sciences. This book was released on 2011-09-01 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout and Other Crystal Arthropathies, by Dr. Robert Terkeltaub, presents the state-of-the-art, clinically-focused coverage you need to manage these increasingly prevalent diseases. Diagnose the full range of crystal arthropathies-including pseudogout, intercritical gout, hyperuricemia, and gouty arthritis-and treat your patients effectively with discussions of recently-approved drugs like Uloric and those currently under review, such as Kristexxa and Colcryst. With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and crystal-induced arthropathies. Access the fully searchable contents online at www.expertconsult.com. Stay current on recent developments such as uricosuric therapy and inhibitor therapy; gout flare prophylaxis and colchicines; ultrasound in the diagnosis of crystal deposition diseases; imaging of gout, CPPD, and hydroxyapatitie deposition diseases; and uricase therapy of gout. Manage the full range of crystal arthropathies with 25 clinically-focused chapters on pseudogout, intercritical gout, hyperuricemia, gouty arthritis, and more. Treat your patients effectively using the latest information on drug treatments, from the recently-approved Uloric to Kristexx and Colcryst, which are still under review. The tools to you need to diagnose, treat, and manage gout and other crystal arthropathies
Download or read book Gout written by David S. Newcombe and published by Springer Science & Business Media. This book was released on 2012-10-12 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout: Basic Science and Clinical Practice is a thoroughly researched comprehensive text which covers all important aspects of gout, including its genetics, pathophysiology, diagnosis, and management. Gout is probably the most common rheumatic disease after osteoarthritis and is becoming more common with the prevalence of the metabolic syndrome in the US, and in many other countries. Only about 10% of patients with gout are treated by rheumatologists and this often leads to inadequate diagnosis and treatment in general medical practice. Written by an expert in the field this book is valuable reference for rheumatologists and others in the medical profession who are interested in understanding and managing this important disease.
Download or read book Transactions of the Annual Meeting of the Orthopaedic Research Society written by Orthopaedic Research Society. Meeting and published by . This book was released on 2003 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consists of the transactions of the 22nd- annual meeting of the society.
Download or read book Diverse Roles of Integrin Receptors in Articular Cartilage written by Mehdi Shakibaei and published by Springer Science & Business Media. This book was released on 2008-05-14 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the expression and function of ß1-integrins in articular chondrocytes. The authors discuss their research and that of others involved in studying chondrocyte ECM adhesion and signal transduction.
Download or read book Melanin the Master Molecule written by Arturo Solís Herrera and published by Bentham Science Publishers. This book was released on 2018-06-04 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melanin is a biological molecule associated with pigmentation in humans and animals. However, melanin has been observed to have other functions such as neuroprotection and energy production. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. Nine chapters explain the intrinsic biochemistry of melanin, comparisons with conventional energy producing and respiratory biomolecules, the property of melanin to transform light energy into chemical energy through the dissociation of the water molecule, and the theories of melanin based energy production in the nervous system, the cell nucleus, muscles and the eye, and the role the role of melanin in the context of ageing. The authors also delve into the possibility of melanin being the key molecule needed to spark life since its water dissociating property through the absorption of light energy emulates the role of chlorophyll, but unlike the latter, it is not limited to the plant cell environment. Hence, melanin is referred to as the master molecule which can provide a missing link to the biochemical processes behind the origin of life. Melanin, the Master Molecule is an exciting reference for biochemists and laymen interested in the science of melanin and a new perspective on the origin of life as we know it.
Download or read book The Physiology of Inflammation The Final Common Pathway to Disease written by Alexandrina Ferreira Mendes and published by Frontiers Media SA. This book was released on 2019-02-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.
Download or read book Bone and Osteoarthritis written by Felix Bronner and published by Springer Science & Business Media. This book was released on 2007-09-26 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem.
Download or read book Intracellular Signalling Proteins written by and published by Academic Press. This book was released on 2019-04-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more. - Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms - Targeted to a very wide audience of specialists, researchers and students - Contains timely chapters written by well-renowned authorities in their field - Includes a number of high quality illustrations, figures and tables
