Download or read book Extracorporeal Photopheresis written by Hildegard T. Greinix and published by Walter de Gruyter. This book was released on 2012-10-01 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.

Download or read book Extracorporeal Photochemotherapy written by Francis P. Gasparro and published by R. G. Landes. This book was released on 1994 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Download or read book Extracorporeal Photopheresis ECP written by Ontario Medical Advisory Secretariat and published by . This book was released on 2006 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Download or read book Extracorporeal Photopheresis ECP For Acute And Chronic Graft Versus Host Disease GVHD written by Carrillo Javier and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracorporeal photopheresis (ECP) for acute and chronic graft versus host disease (GVHD): a retrospective study.J. Carrillo Checa, M. Lu00f3pez Parra, O. Lu00f3pez Villar, A. Avendau00f1o Pita, D. Rivera Delgado, A. Martu00edn Lu00f3pez, E. Pu00e9rez Lu00f3pez, M. Cabrero Calvo, L. Vu00e1zquez Lu00f3pez, F. Su00e1nchez Guijo M.V. Mateos, M.D. Caballero Barrigon, L. Lu00f3pez Corral.Complejo Asistencial Universitario de Salamanca-IBSAL, Hematology, Salamanca, SpainKEY WORDS: GVHD, Extracorporeal Photopheresis, alloSCT.CONTEXT: GVHD is the most common complication after alloSCT. Steroids are the first line but more than 40% of these patients will not response.OBJECTIVE: Evaluate efficacy and safety of ECP for refractory GVHD.DESIGN: retrospective study of 84 patients treated with ECP between january-2010-april-2018 in our centre.PATIENTS: 84 patients with steroid-refractory acute/chronic GVHD after alloSCT. Patients who didnu00b4t complete 8 procedures were not evaluable.INTERVENTIONS: an integrated system of continue flow, processing a standard volumen. Patients with aGVHD received 2 consecutive sessions/week during 12 weeks, then 2 sessions/fortnight until stop steroids. Protocol for cGHVD was 2 sessions/fortnight during 12 weeks and 2 sessions/month during 3 months until stop steroids.MAIN OUTCOMES MEASURES: ORR, OS and security.RESULTS: -aGVHD(n=35): median age of 48 (11-71) and 65.7% men. Organ involved was skin (91.4%), gut (71.4%) and liver (40%). 15 patients present grade II, 3 grade III and 17 grade IV. ORR was 78.1% (CR:53.1%). All of patients with grade II-III responded, but only 10 of 17 patients with grade IV GVHD. Best organ response was skin (ORR:87.1%). Grade IV had and adverse outcome (median OS not reached VS 3 months, p=0.016) and CR after ECP was associated with favourable outcome (median OS not reached VS 6 months, p=0.061). With a median follow-up after ECP of 5 months (0-51), 51,4% live.-cGVHD(n=49):, median age of 55 (9-69) and 54% men. 24 had severe cGVHD. Principal organs involved were skin and mucosas. ORR was 69%(CR:24.4%). Responses of moderate was superior (80%). Best organ responses were oral (ORR:84%) and skin (ORR:80%). After a median follow-up of 29 months (3-96), OS after ECP at 2 years was 78.3%.- Security: 8 CMV reactivation and 2 fungical infections ocurring during ECP. Steroids could stop in majority of the patients. 6 GVHD reactivacion were observed during ECP, the majority respond with intensification.CONCLUSIONS: ECP is an effective and safe salvage therapy for GVHD, especially in grade II-III aGVHD and moderate cGVHD. Best organ responses are skin in aGVHD and skin and mucosa in cGVHD.

Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Download or read book New Approaches to Improve Extracorporeal Photopheresis for the Treatment of Graft versus host Disease written by and published by . This book was released on 2016 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Graft-versus-host disease (GvHD) is a severe complication occurring after hematopoietic stem cell transplantation (HSCT). It is caused by alloreactive T cells contained in the graft, and associated with severe morbidity and mortality. Glucocorticoids (GC) are the gold standard for first-line treatment of GvHD but once patients become steroid-refractory, they need to be treated with second-line therapies such as extracorporeal photopheresis (ECP). ECP is an immunomodulatory therapy currently used in the clinic for treating patients suffering acute GvHD (aGvHD) or chronic GvHD (cGvHD). During...

Download or read book Best Practices of Apheresis in Hematopoietic Cell Transplantation written by Syed A. Abutalib and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

Download or read book Cutaneous T Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.

Download or read book Inpatient Dermatology written by Misha Rosenbach and published by Springer. This book was released on 2018-11-03 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​ Inpatient Dermatology is a concise and portable resource that synthesizes the most essential material to help physicians with recognition, differential diagnosis, work-up, and treatment of dermatologic issues in the hospitalized patient. Complete with hundreds of clinical and pathologic images, this volume is both an inpatient dermatology atlas and a practical guide to day-one, initial work-up, and management plan for common and rare skin diseases that occur in the inpatient setting. Each chapter is a bulleted, easy-to-read reference that focuses on one specific inpatient dermatologic condition, with carefully curated clinical photographs and corresponding histopathologic images to aid readers in developing clinical-pathologic correlation for the dermatologic diseases encountered in the hospital. Before each subsection the editors share diagnostic pearls, explaining their approach to these challenging conditions. This book is structured to be useful to physicians, residents, and medical students. It spans dermatology, emergency medicine, internal medicine, infectious disease, and rheumatology. Inpatient Dermatology is the go-to guide for hospital-based skin diseases, making even the most complex inpatient dermatologic issues approachable and understandable for any clinician.

Download or read book Extracorporeal Photopheresis in Acute and Chronic Steroid refractory Graft versus host Disease an Evolving Treatment Landscape written by Hildegard Greinix and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Patients with steroid-refractory graft-versus-host disease (GvHD) are known to have a poor prognosis and for decades no approved drug has been available to treat this serious condition. Although ruxolitinib, a selective Janus kinase (JAK)1/2 inhibitor demonstrated significantly higher response rates in randomized trials compared to the best available therapy, and thus, is of benefit in both acute as well as chronic GvHD, there is an urgent medical need to improve results, such as durability of responses, response in eye, liver and lung manifestations and reduction of infectious complications. In this "Review" article we would like to offer strategies for improving treatment results in patients with steroid-refractory GvHD by combining ruxolitinib with extracorporeal photopheresis (ECP), a leukapheresis-based immunomodulatory treatment frequently applied in T-cell mediated immune disease including GvHD. Our article explores key published evidence supporting the clinical efficacy of both ruxolitinib and ECP in the treatment of GvHD and highlights their potentially complementary mechanisms of action

Download or read book Extracorporeal photopheresis written by and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition, a review of the Product Monographs of the methoxsalen products that have been approved in Canada showed that none of them have been approved for oral administration in combination with the UVAR XTS photophoresis system for "the palliative treatment of the skin manifestations of cutaneous T-cell Lymphoma". [...] In the United States, the UVAR XTS Photopheresis System is approved by the Food and Drug Administration (FDA) for "use in the ultraviolet-A (UVA) irradiation in the presence of the photoactive drug methoxsalen of extracorporeally circulating leukocyte-enriched blood in the palliative treatment of the skin manifestations of CTCL in persons who have not been responsive to other therapy." UVADEX is a [...] The wide range in reported responses to ECP appears to be due to the variability of the patients treated and the way in which the data were presented and analyzed. [...] The tradeoffs, taking into account the estimated size of the effect for the main outcome, the confidence limits around those estimates and the relative value placed on the outcome. [...] For refractory erythrodermic CTCL, the overall GRADE and strength of the recommendation is "weak" - the quality of the evidence is "low" (uncertainties due to methodological limitations in the study design in terms of study quality and directness), and the corresponding risk/uncertainty is increased due to an annual budget impact of approximately $1.5M Cdn (based on 30 patients) while the cost-eff.

Download or read book Therapy in Pediatric Dermatology written by Joyce M.C. Teng and published by Springer. This book was released on 2016-12-15 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the need for comprehensive review of therapeutic options that are known to be efficacious in the management of cutaneous diseases in children. It summarizes evidence-based literature on clinical responses among pediatric patients, including age-appropriate management strategies. Included is review of the extraordinary developments in understanding of the genetics and pathogenesis of many cutaneous disorders during the past decade, the novel therapeutic options and repurposing of old drugs, and the management of some of the most challenging skin disorders. Therapy in Pediatric Dermatology: Management of Pediatric Skin Disease is a succinct, user-friendly, and up-to-date therapeutic dermatologic textbook for physicians who care for children with skin disorders. Each skin condition is discussed with investigative and treatment recommendations in mind and provided based on extensive review of the literature. This book will provide unbiased, yet concise, information that is valuable to practitioners who manage pediatric patients in their practices.

Download or read book Practical Transfusion Medicine written by Michael F. Murphy and published by John Wiley & Sons. This book was released on 2013-07-03 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly Commended - 2010 BMA Medical Book Awards An essential, practical manual for all those working in transfusion medicine Concise and user-friendly guide to transfusion medicine Focuses on clinical aspects but also covers background science and organizational issues Complications encountered in transfusion are addressed throughout Highlights controversial issues and provides advice for everyday clinical questions in transfusion medicine This comprehensive guide to transfusion medicine takes a practical and didactic approach. The third edition of this text includes many new contributions and has expanded to seven sections. The first of these takes the reader systematically through the principles of transfusion medicine. The second deals with the complications which can arise in transfusion and is followed by a section on the practice of transfusion in blood centres and hospitals. The fourth section covers clinical transfusion practice and the fifth looks at alternatives to transfusion. Section six addresses cellular and tissue therapy and organ transplantation and the final section of the book examines the development of the evidence base for transfusion. As with previous editions; the final section includes a visionary chapter on future advances in the field. This new edition of Practical Transfusion Medicine benefits from even more international authorship than the previous two editions and is an invaluable resource for trainee doctors, scientists, technicians and other staff in haematology and transfusion and as a reference book for clinical staff in haematology and other disciplines faced with specific problems.

Download or read book Extracorporeal Photopheresis Versus Standard Treatment for Acute Graft versus host Disease After Haematopoietic Stem Cell Transplantation in Children and Adolescents written by Kathrin Buder and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Extracorporeal Photopheresis as an Option for Controlling CRS and GvHD After CD19 CAR T Cell Therapy written by Huixiu Han and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: