Download or read book Extracorporeal Photopheresis written by Hildegard T. Greinix and published by Walter de Gruyter. This book was released on 2012-10-01 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.

Download or read book Extracorporeal Photochemotherapy photopheresis written by Wendy Lynne Hurwitz and published by . This book was released on 1989 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Extracorporeal Photochemotherapy written by Francis P. Gasparro and published by R. G. Landes. This book was released on 1994 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Download or read book Extracorporeal Photopheresis written by and published by . This book was released on 2006 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Therapy in Pediatric Dermatology written by Joyce M.C. Teng and published by Springer. This book was released on 2016-12-15 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the need for comprehensive review of therapeutic options that are known to be efficacious in the management of cutaneous diseases in children. It summarizes evidence-based literature on clinical responses among pediatric patients, including age-appropriate management strategies. Included is review of the extraordinary developments in understanding of the genetics and pathogenesis of many cutaneous disorders during the past decade, the novel therapeutic options and repurposing of old drugs, and the management of some of the most challenging skin disorders. Therapy in Pediatric Dermatology: Management of Pediatric Skin Disease is a succinct, user-friendly, and up-to-date therapeutic dermatologic textbook for physicians who care for children with skin disorders. Each skin condition is discussed with investigative and treatment recommendations in mind and provided based on extensive review of the literature. This book will provide unbiased, yet concise, information that is valuable to practitioners who manage pediatric patients in their practices.

Download or read book Chronic Graft Versus Host Disease written by Georgia B. Vogelsang and published by Cambridge University Press. This book was released on 2009-04-20 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Download or read book Comprehensive Dermatologic Drug Therapy written by Stephen E. Wolverton and published by Elsevier Health Sciences. This book was released on 2019-12-14 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed with practical usability in mind, Comprehensive Dermatologic Drug Therapy, 4th Edition, helps you safely and effectively treat the skin disorders you’re likely to see in your practice. Dr. Stephen E. Wolverton and new associate editor Dr. Jashin J. Wu lead a team of global experts to bring you concise, complete guidance on today's full spectrum of topical, intralesional, and systemic drugs. You’ll prescribe with confidence thanks to expert coverage of which drugs to use, when to use them, and adverse effects to monitor. Includes new drug interaction tables, drug risk profiles, and FDA guidelines, as well as two new appendices that summarize chapter questions and summarize highest-risk drug interactions. Covers the best uses for new biologic therapeutics. Contains new chapters covering medical decision-making principles, PDE-4 and JAK inhibitors, interleukin 17 inhibitors, interleukin 23 inhibitors, additional biologic therapeutics, and hedgehog pathway inhibitors. Contains quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a highly detailed, disease-specific index, as well as purchase information for major drugs. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book.

Download or read book Best Practices of Apheresis in Hematopoietic Cell Transplantation written by Syed A. Abutalib and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.

Download or read book Cutaneous T Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.

Download or read book Clinical Principles of Transfusion Medicine written by Robert W Maitta and published by Elsevier Health Sciences. This book was released on 2018-02-05 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a concise overview of transfusion medicine, including best practices for specific clinical settings, this practical resource by Dr. Robert W. Maitta covers the key information you need to know. Holistic, multidisciplinary coverage and a succinct, easy-to-read format make it essential reading for transfusion specialists, as well as practitioners in other specialties whose patients undergo blood transfusions. Covers the latest advancements in transfusion therapies, hematopoietic stem cells, infectious and non-infectious complications of transfusions, and future directions in transfusion medicine. Discusses special populations, including organ transplant patients; pediatric, obstetric, and geriatric patients; and patients undergoing emergency care. Consolidates fundamental clinical concepts and current practice of transfusion medicine into one convenient resource.

Download or read book Extracorporeal Photopheresis ECP written by Ontario Medical Advisory Secretariat and published by . This book was released on 2006 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evidence Based Psoriasis written by Tina Bhutani and published by Springer. This book was released on 2018-06-30 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the multitude of new treatment options for psoriasis, including topicals, phototherapy, oral systemic therapy, and injectable biologics, the treatment of the disease has truly become an art. Evidence-Based Psoriasis passes on this art to practicing physicians in a very practical and easy-to-use format, focusing on mild, moderate, and severe psoriasis. Offering evidence-based information in a concise text, this book discusses new treatment options, including topicals, phototherapy, oral systemic therapy, and injectable biolgoics. This text also describes unique methods of use, such as sequential and combination therapy, and is written for practicing dermatologists, residents, and primary care physicians. Evidence-Based Psoriasis also includes high quality color photographs and tables for quick and easy reference.

Download or read book Ultraviolet Light in Human Health Diseases and Environment written by Shamim I. Ahmad and published by Springer. This book was released on 2017-11-08 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter. The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted. The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes. The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields. It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light.

Download or read book Dermatological Phototherapy and Photodiagnostic Methods written by Jean Krutmann and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the most up-to-date publication on photodiagnostic and phototherapeutic methods used in dermatology. Edited by international experts in the field, it offers comprehensive information on every aspect of Photodiagnostics and Phototherapy. The book focuses on the clinical aspects: detailed descriptions of photo- and photochemotherapy for the treatment of selected diseases as well as standardized test protocols for photodermatoses and for the diagnosis of skin tumors are presented. The clinically oriented chapters are supplemented by practical guidelines for phototherapy and information about basic principles of photobiology.

Download or read book Extracorporeal Photopheresis ECP For Acute And Chronic Graft Versus Host Disease GVHD written by Carrillo Javier and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracorporeal photopheresis (ECP) for acute and chronic graft versus host disease (GVHD): a retrospective study.J. Carrillo Checa, M. Lu00f3pez Parra, O. Lu00f3pez Villar, A. Avendau00f1o Pita, D. Rivera Delgado, A. Martu00edn Lu00f3pez, E. Pu00e9rez Lu00f3pez, M. Cabrero Calvo, L. Vu00e1zquez Lu00f3pez, F. Su00e1nchez Guijo M.V. Mateos, M.D. Caballero Barrigon, L. Lu00f3pez Corral.Complejo Asistencial Universitario de Salamanca-IBSAL, Hematology, Salamanca, SpainKEY WORDS: GVHD, Extracorporeal Photopheresis, alloSCT.CONTEXT: GVHD is the most common complication after alloSCT. Steroids are the first line but more than 40% of these patients will not response.OBJECTIVE: Evaluate efficacy and safety of ECP for refractory GVHD.DESIGN: retrospective study of 84 patients treated with ECP between january-2010-april-2018 in our centre.PATIENTS: 84 patients with steroid-refractory acute/chronic GVHD after alloSCT. Patients who didnu00b4t complete 8 procedures were not evaluable.INTERVENTIONS: an integrated system of continue flow, processing a standard volumen. Patients with aGVHD received 2 consecutive sessions/week during 12 weeks, then 2 sessions/fortnight until stop steroids. Protocol for cGHVD was 2 sessions/fortnight during 12 weeks and 2 sessions/month during 3 months until stop steroids.MAIN OUTCOMES MEASURES: ORR, OS and security.RESULTS: -aGVHD(n=35): median age of 48 (11-71) and 65.7% men. Organ involved was skin (91.4%), gut (71.4%) and liver (40%). 15 patients present grade II, 3 grade III and 17 grade IV. ORR was 78.1% (CR:53.1%). All of patients with grade II-III responded, but only 10 of 17 patients with grade IV GVHD. Best organ response was skin (ORR:87.1%). Grade IV had and adverse outcome (median OS not reached VS 3 months, p=0.016) and CR after ECP was associated with favourable outcome (median OS not reached VS 6 months, p=0.061). With a median follow-up after ECP of 5 months (0-51), 51,4% live.-cGVHD(n=49):, median age of 55 (9-69) and 54% men. 24 had severe cGVHD. Principal organs involved were skin and mucosas. ORR was 69%(CR:24.4%). Responses of moderate was superior (80%). Best organ responses were oral (ORR:84%) and skin (ORR:80%). After a median follow-up of 29 months (3-96), OS after ECP at 2 years was 78.3%.- Security: 8 CMV reactivation and 2 fungical infections ocurring during ECP. Steroids could stop in majority of the patients. 6 GVHD reactivacion were observed during ECP, the majority respond with intensification.CONCLUSIONS: ECP is an effective and safe salvage therapy for GVHD, especially in grade II-III aGVHD and moderate cGVHD. Best organ responses are skin in aGVHD and skin and mucosa in cGVHD.