Download or read book Exploring Natural Products for Developing Medicinal Leads written by Khuroo Mohd a and published by LAP Lambert Academic Publishing. This book was released on 2015-06-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has always been a valuable source of drugs and continues to deliver lead compounds despite the unprecedented opportunities afforded by medicinal chemistry. Mother Nature has provided a complete store house of remedies to cure most of the ailments of mankind. Natural products have been a rich source of therapeutic agents, which have inspired chemists and physicians for millennia. Their rich structural diversity and bioactivity has prompted synthetic chemists to prepare them in laboratory and many drugs used today are natural products or natural-product derivatives. Despite competition from other drug discovery methods, Natural Products (NP's) are still providing their fair share of new clinical candidates and drugs especially in the anticancer and antihypertensive therapeutic areas. Therefore, exploring, exploiting and modifying the secondary metabolites can be a rewarding exercise as has been well demonstrated by the development of new drugs based on natural product scaffold. The present work is thus an attempt towards extending the secondary metabolites of bioactive molecules for their higher potential and lesser toxicity.
Download or read book Herbal Medicine written by Iris F. F. Benzie and published by CRC Press. This book was released on 2011-03-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
Download or read book Natural Products and Drug Discovery written by Subhash C. Mandal and published by Elsevier. This book was released on 2018-02-16 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Download or read book Lead Compounds from Medicinal Plants for the Treatment of Cancer written by Christophe Wiart and published by Academic Press. This book was released on 2012-10-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kelley/DNA Repair in Cancer Therapy, 2012, 978-0-12-384999-1.
Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Download or read book Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases written by Christophe Wiart and published by Academic Press. This book was released on 2013-12-16 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration
Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Download or read book Inflammation and Natural Products written by Sreeraj Gopi and published by Academic Press. This book was released on 2021-01-19 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.446 pages Approx.446 pages
Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Download or read book Lead Generation Approaches in Drug Discovery written by Zoran Rankovic and published by Wiley. This book was released on 2010-04-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Download or read book Bioactive Natural Products written by Goutam Brahmachari and published by World Scientific. This book was released on 2012 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.
Download or read book Evidence Based Validation of Herbal Medicine written by Pulok K. Mukherjee and published by Elsevier. This book was released on 2022-07-12 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more
Download or read book Medicinal Plants and Natural Product Research written by Milan S. Stankovic and published by MDPI. This book was released on 2020-02-14 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled Medicinal Plants and Natural Product Research describes various aspects of ethnopharmacological uses of medicinal plants; extraction, isolation, and identification of bioactive compounds from medicinal plants; various aspects of biological activity such as antioxidant, antimicrobial, anticancer, immunomodulatory activity, etc., as well as characterization of plant secondary metabolites as active substances from medicinal plants.
Download or read book WHO Global Report on Traditional and Complementary Medicine 2019 written by World Health Organization and published by World Health Organization. This book was released on 2019-05-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
Download or read book Medicinal Plants and Fungi Recent Advances in Research and Development written by Dinesh Chandra Agrawal and published by Springer. This book was released on 2017-11-03 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi.
Download or read book Pharmacognosy written by Shagufta Perveen and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacognosy is a term derived from the Greek words for drug (pharmakon) and knowledge (gnosis). It is a field of study within Chemistry focused on natural products isolated from different sources and their biological activities. Research on natural products began more than a hundred years ago and has continued up to now with a plethora of research groups discovering new ideas and novel active constituents. This book compiles the latest research in the field and will be of interest to scientists, researchers, and students.
Download or read book Drug Discovery and Development written by Omboon Vallisuta and published by BoD – Books on Demand. This book was released on 2015-06-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
