Download or read book Exploring Cancer Metabolic Reprogramming through Molecular Imaging written by Franca Podo and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inclusion of oncogene-driven reprogramming of energy metabolism within the list of cancer hallmarks (Hanahan and Weinberg, Cell 2000, 2011) has provided major impetus to further investigate the existence of a much wider metabolic rewiring in cancer cells, which not only includes deregulated cellular bioenergetics, but also encompasses multiple links with a more comprehensive network of altered biochemical pathways. This network is currently held responsible for redirecting carbon and phosphorus fluxes through the biosynthesis of nucleotides, amino acids, lipids and phospholipids and for the production of second messengers essential to cancer cells growth, survival and invasiveness in the hostile tumor environment. The capability to develop such a concerted rewiring of biochemical pathways is a versatile tool adopted by cancer cells to counteract the host defense and eventually resist the attack of anticancer treatments. Integrated efforts elucidating key mechanisms underlying this complex cancer metabolic reprogramming have led to the identification of new signatures of malignancy that are providing a strong foundation for improving cancer diagnosis and monitoring tumor response to therapy using appropriate molecular imaging approaches. In particular, the recent evolution of positron emission tomography (PET), magnetic resonance spectroscopy (MRS), spectroscopic imaging (MRSI), functional MR imaging (fMRI) and optical imaging technologies, combined with complementary cellular imaging approaches, have created new ways to explore and monitor the effects of metabolic reprogramming in cancer at clinical and preclinical levels. Thus, the progress of high-tech engineering and molecular imaging technologies, combined with new generation genomic, proteomic and phosphoproteomic methods, can significantly improve the clinical effectiveness of image-based interventions in cancer and provide novel insights to design and validate new targeted therapies. The Frontiers in Oncology Research Topic “Exploring Cancer Metabolic Reprogramming Through Molecular Imaging” focusses on current achievements, challenges and needs in the application of molecular imaging methods to explore cancer metabolic reprogramming, and evaluate its potential impact on clinical decisions and patient outcome. A series of reviews and perspective articles, along with original research contributions on humans and on preclinical models have been concertedly included in the Topic to build an open forum on perspectives, present needs and future challenges of this cutting-edge research area.

Download or read book Exploring the breast tumor microenvironment Association to metastasis novel risk factors and novel treatments and immunotherapies written by Jorge Morales-Montor and published by Frontiers Media SA. This book was released on 2023-01-10 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer associated fibroblasts CAFs based model reveals potential for predicting bladder cancer patients prognoses and immunotherapy responses written by Mengyuan Dong and published by OAE Publishing Inc.. This book was released on 2024-02-19 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aim: The purpose of this study is to enhance the understanding of bladder cancer and the role of cancer-associated fibroblasts (CAFs) in its progression. We aim to identify CAF-specific biomarkers and develop a prognostic prediction model based on CAFs, thereby contributing to the advancement of treatment strategies and the identification of prognostic and predictive biomarkers for bladder cancer. Method: We employed single-cell RNA sequencing to detect biomarkers for CAFs in bladder cancer cells. Bladder cancer cohorts were categorized into low- and high-CAF groups using the ssGSEA algorithm. The study also explored the association between CAF-related scores, immune-related cells, and immune checkpoint-related genes. Furthermore, we performed GSVA analysis to understand the biological features of CAFs and their link to various cancer-related pathways. Result: Ten genes were identified as CAF markers in bladder cancer cells. A significant difference was found with 2712 differentially expressed genes between low-CAF and high-CAF tissues. The CAFs-based prognostic prediction model included nine genes (ALDH1L2, AL450384.2, EMP1, LINC02362, WFIKKN1, GOLGA8A, POU5F1, AL354919.2, PTPRR), which are potentially crucial in predicting bladder cancer prognosis. The GSVA analysis revealed the involvement of several cancer-related pathways, such as WNT, toll-like receptor, TGF-beta, MAPK, and MTOR signaling pathways, in the CAFs-based prognostic model. Conclusion: This study highlights the significant role of CAFs in the progression and prognosis of bladder cancer. The identified CAF biomarkers and the constructed prognostic model provide valuable insights for future research and potential therapeutic targets. CAF-dependent pathways are promising for the development of new treatments and improving the prognosis of bladder cancer patients.

Download or read book Crosstalk between cancer associated fibroblasts and tumor cells in the tumor microenvironment An emerging target of anti cancer immunotherapy written by Bo Kong and published by Frontiers Media SA. This book was released on 2023-08-31 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reviews in genitourinary oncology written by Andrea Lancia and published by Frontiers Media SA. This book was released on 2023-05-04 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The tumor and microenvironment crosstalk in breast cancer From biology to therapeutic opportunity written by Marta Truffi and published by Frontiers Media SA. This book was released on 2024-01-19 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tumor microenvironment in cancer hallmarks and therapeutics written by Na Luo and published by Frontiers Media SA. This book was released on 2023-06-05 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Reviews in Breast Cancer 2023 written by Maria Rosaria De Miglio and published by Frontiers Media SA. This book was released on 2024-10-25 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Oncology is delighted to present the ‘Reviews in’ series of article collections. Reviews in Breast Cancer will publish high-quality review articles on key topics in the field. It aims to highlight recent advances in the field, whilst emphasizing important directions and new possibilities for future inquiries. The Reviews in Breast Cancer collection welcomes full-length, mini or systematic review papers. New articles will be added to this collection as they are published.

Download or read book Targeting the Microenvironment Niche in Solid and Hematologic Malignancies Basic and Translational Research written by Cirino Botta and published by Frontiers Media SA. This book was released on 2022-02-28 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transcriptome and Single Cell Sequencing Analyses to Classify Immune Subtypes Uncover Novel Biomarkers and Assess Immunotherapeutic Responses in Cancer written by Hongda Liu and published by Frontiers Media SA. This book was released on 2024-07-24 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the most recent projections of the International Agency for Research on Cancer (IARC), there would be around 19.3 million new cases of cancer and 10 million cancer-related deaths globally in 2022. Cancer research has never halted. In particular, research into the cancer immunological microenvironment is gaining popularity.

Download or read book Community series in novel insights into immunotherapy targeting tumor microenvironment in ovarian cancer volume I written by Xiao Liang and published by Frontiers Media SA. This book was released on with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Role of Epigenetic Regulators in the Initiation Progression and Metastasis of Cancer written by Ritu Kulshreshtha and published by Frontiers Media SA. This book was released on 2022-11-30 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Post Transcriptional and Post Translational Regulation of Cancer Metabolism written by Qinong Ye and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Multi Cloud Administration Guide written by Jeroen Mulder and published by Stylus Publishing, LLC. This book was released on 2024-08-08 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: As businesses increasingly adopt cloud-first strategies, managing workloads across multiple cloud platforms becomes a critical challenge. This comprehensive book provides practical solutions and in-depth knowledge to efficiently operate in a multi-cloud world. Learn to leverage frameworks from AWS, Azure, GCP, and Alibaba Cloud to maximize the benefits of multi-cloud environments. Understand cloud networking, software-defined networking, and microservices to optimize cloud connectivity. Develop a robust data strategy to ensure data quality, security, and integrity across multiple cloud platforms. Discover how automation and AI can help maintain compliance with governmental and industry regulations in the cloud. Designed for cloud architects, IT administrators, and technical managers, this book is also valuable for anyone looking to deepen their understanding of cloud technologies and multi-cloud strategies. FEATURES • Uses frameworks from AWS, Azure, GCP, and Alibaba Cloud to maximize the benefits of multi-cloud environments • Provides practical instructions and real-world examples for managing multi-cloud environments • Features insights into cloud-native technologies, serverless functions, and container orchestration with Kubernetes • Explores the details of multi-cloud connectivity, storage, compute, data management, security, and compliance • Includes companion files with code samples and color figures available for downloading

Download or read book Neoadjuvant treatment of pancreatic ductal adenocarcinoma present and future written by Ioannis M. Koukourakis and published by OAE Publishing Inc.. This book was released on 2022-09-18 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with a poor prognosis. Effective treatment with acceptable outcomes is yet to be found, with chemo- and radioresistance comprising major impediments towards this goal. Although upfront surgery is the established therapeutic approach for resectable and borderline resectable disease, neoadjuvant treatment has recently monopolized the interest in clinical trials. This also applies to locally advanced pancreatic adenocarcinomas that could potentially be rendered operable. Chemotherapy and chemoradiotherapy are the most utilized therapeutic modalities in the neoadjuvant setting, while immunotherapy and targeting agents have been gaining significant attention. This critical review focuses on the clinical experience gained from retrospective and phase II/III randomized trials, reporting on the outcomes of neoadjuvant chemotherapy and chemoradiotherapy for pancreatic adenocarcinoma. Moreover, the ongoing trials, including those that involve immunotherapy and targeting agents, are summarized.

Download or read book Enhanced biological mechanism study drug discovery and individualized medicine with single cell multiomics data and integrative analysis written by Panwen Wang and published by Frontiers Media SA. This book was released on 2023-07-20 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Novel Biomarkers for Predicting Response to Cancer Immunotherapy written by Jinghua Pan and published by Frontiers Media SA. This book was released on 2023-07-11 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.