Download or read book Exploration of Salvinorin A Chemical Space written by Sarah Jane Hill and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The salvinorins serve as templates for next generation analgesics, antipruritics and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selectivity via complex polyoxygenated scaffolds that have frustrated deep-seated modification by synthesis. Here we describe a short asymmetric synthesis that relies on a sterically-confined organocatalyst to dissociate acidity from reactivity and effect Robinson annulation of an unactivated nucleophile / unstable electrophile pair. Combined with a cobalt-catalyzed polarized diene-alkyne cycloaddition, the route allows divergent access to a focused library of salvinorins. We appraise the synthesis by its generation of multiple analogs that exceed the potency, selectivity, stability and functional bias of salvinorin A itself.
Download or read book Progress in the Chemistry of Organic Natural Products 110 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2019-10-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
Download or read book Plant Toxins written by P. Gopalakrishnakone and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Kappa Opioid Receptor written by Lee-Yuan Liu-Chen and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Birkhäuser. This book was released on 2012-11-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Download or read book Salvia Divinorum written by J. D. Arthur and published by Simon and Schuster. This book was released on 2010-02-17 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: One man’s personal journey through the unparalleled trance states of salvia • Originally published as Peopled Darkness • Contains real-life descriptions of salvia-induced visionary experiences • Offers guidance for the responsible use of this psychoactive plant • Explores the shamanic awareness associated with salvia Salvia divinorum, which recently entered the visionary pharmacopoeia of the modern world, has been used for centuries in the shamanic practices of the Mazatec Indians of Oaxaca, Mexico, for healing and divination. A member of the Mint family, Salvia divinorum--“diviner’s sage”--offers a new doorway to the visionary pursuit of higher spiritual and meditative states. With repeated sessions using salvia over the course of several years, J. D. Arthur began returning each time to the same inner landscape where he found himself entering a unique state of thought-free, or “thoughtless,” awareness. There he accessed a mode of “dream language” that communicated an exquisite constellation of detailed meanings swiftly and flawlessly. His repeated immersion in these states of trance, as well as his analysis of their approach and withdrawal, led to a profound reassessment of the nature of normal perception and a reevaluation of what we refer to as the real world. With true-life descriptions of salvia-induced visionary states, this book offers a detailed experiential analysis for those interested in exploring salvia in their quest for higher knowledge.
Download or read book Extraterrestrial Languages written by Daniel Oberhaus and published by MIT Press. This book was released on 2024-05-07 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: If we send a message into space, will extraterrestrial beings receive it? Will they understand? The endlessly fascinating question of whether we are alone in the universe has always been accompanied by another, more complicated one: if there is extraterrestrial life, how would we communicate with it? In this book, Daniel Oberhaus leads readers on a quest for extraterrestrial communication. Exploring Earthlings' various attempts to reach out to non-Earthlings over the centuries, he poses some not entirely answerable questions: If we send a message into space, will extraterrestrial beings receive it? Will they understand? What languages will they (and we) speak? Is there not only a universal grammar (as Noam Chomsky has posited), but also a grammar of the universe? Oberhaus describes, among other things, a late-nineteenth-century idea to communicate with Martians via Morse code and mirrors; the emergence in the twentieth century of SETI (the search for extraterrestrial intelligence), CETI (communication with extraterrestrial intelligence), and finally METI (messaging extraterrestrial intelligence); the one-way space voyage of Ella, an artificial intelligence agent that can play cards, tell fortunes, and recite poetry; and the launching of a theremin concert for aliens. He considers media used in attempts at extraterrestrial communication, from microwave systems to plaques on spacecrafts to formal logic, and discusses attempts to formulate a language for our message, including the Astraglossa and two generations of Lincos (lingua cosmica). The chosen medium for interstellar communication reveals much about the technological sophistication of the civilization that sends it, Oberhaus observes, but even more interesting is the information embedded in the message itself. In Extraterrestrial Languages, he considers how philosophy, linguistics, mathematics, science, and art have informed the design or limited the effectiveness of our interstellar messaging.
Download or read book Plant Medicines Healing and Psychedelic Science written by Beatriz Caiuby Labate and published by Springer. This book was released on 2018-04-28 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about the intersections of three dimensions. The first is the way social scientists and historians treat the history of psychiatry and healing, especially as it intersects with psychedelics. The second encompasses a reflection on the substances themselves and their effects on bodies. The third addresses traditional healing, as it circles back to our understanding of drugs and psychiatry. The chapters explore how these dimensions are distinct, but deeply intertwined, themes that offer important insights into contemporary healing practices. The intended audience of the volume is large and diverse: neuroscientists, biologists, medical doctors, psychiatrists, psychologists; mental health professionals interested in the therapeutic application of psychedelic substances, or who work with substance abuse, depression, anxiety, and PTSD; patients and practitioners of complementary and alternative medicine; ethnobotanists and ethnopharmacologists; lawyers, criminologists, and other specialists in international law working on matters related to drug policy and human rights, as well as scholars of religious studies, anthropologists, sociologists, and historians; social scientists concerned both with the history of science, medicine, and technology, and concepts of health, illness, and healing. It has a potentially large international audience, especially considering the increasing interest in “psychedelic science” and the growing spread of the use of traditional psychoactives in the West.
Download or read book Heterocyclic Chemistry in Drug Discovery written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2013-04-26 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Download or read book Beyond Physicalism written by Edward F. Kelly and published by Rowman & Littlefield. This book was released on 2015-02-19 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of modern science has brought with it increasing acceptance among intellectual elites of a worldview that conflicts sharply both with everyday human experience and with beliefs widely shared among the world’s great cultural traditions. Most contemporary scientists and philosophers believe that reality is at bottom purely physical, and that human beings are nothing more than extremely complicated biological machines. On such views our everyday experiences of conscious decision-making, free will, and the self are illusory by-products of the grinding of our neural machinery. It follows that mind and personality are necessarily extinguished at death, and that there exists no deeper transpersonal or spiritual reality of any sort. Beyond Physicalism is the product of an unusual fellowship of scientists and humanities scholars who dispute these views. In their previous publication, Irreducible Mind, they argued that physicalism cannot accommodate various well-evidenced empirical phenomena including paranormal or psi phenomena, postmortem survival, and mystical experiences. In this new theory-oriented companion volume they go further by attempting to understand how the world must be constituted in order that these “rogue” phenomena can occur. Drawing upon empirical science, metaphysical philosophy, and the mystical traditions, the authors work toward an improved “big picture” of the general character of reality, one which strongly overlaps territory traditionally occupied by the world’s institutional religions, and which attempts to reconcile science and spirituality by finding a middle path between the polarized fundamentalisms, religious and scientific, that have dominated recent public discourse. Contributions by: Harald Atmanspacher, Loriliai Biernacki, Bernard Carr, Wolfgang Fach, Michael Grosso, Michael Murphy, David E. Presti, Gregory Shaw, Henry P. Stapp, Eric M. Weiss, and Ian Whicher
Download or read book Hypervalent Iodine Chemistry written by Viktor V. Zhdankin and published by John Wiley & Sons. This book was released on 2013-10-01 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypervalent Iodine Chemistry is the first comprehensive text covering all of the main aspects of the chemistry of organic and inorganic polyvalent iodine compounds, including applications in chemical research, medicine, and industry. Providing a comprehensive overview of the preparation, properties, and synthetic applications of this important class of reagents, the text is presented in the following way: The introductory chapter provides a historical background and describes the general classification of iodine compounds, nomenclature, hypervalent bonding, structural features, and the principles of reactivity of polyvalent iodine compounds. Chapter 2 gives a detailed description of the preparative methods and structural features of all known classes of organic and inorganic derivatives of polyvalent iodine. Chapter 3, the key chapter of the book, deals with the many applications of hypervalent iodine reagents in organic synthesis. Chapter 4 describes the most recent achievements in hypervalent iodine catalysis. Chapter 5 deals with recyclable polymer-supported and nonpolymeric hypervalent iodine reagents. Chapter 6 covers the "green" reactions of hypervalent iodine reagents under solvent-free conditions or in aqueous solutions. The final chapter provides an overview of the important practical applications of polyvalent iodine compounds in medicine and industry. This book is aimed at all chemists interested in iodine compounds, including academic and industrial researchers in inorganic, organic, physical, medicinal, and biological chemistry. It will be particularly useful to synthetic organic and inorganic chemists, including graduate and advanced undergraduate students. It comprehensively covers the green chemistry aspects of hypervalent iodine chemistry, making it especially useful for industrial chemists.
Download or read book Fragment based Approaches in Drug Discovery written by Wolfgang Jahnke and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Download or read book DMT Dialogues written by David Luke and published by Simon and Schuster. This book was released on 2018-08-14 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge explorations and discussions of DMT experiences and plant sentience from leading luminaries in the field of psychedelic research • Includes contributions from Rupert Sheldrake, Rick Strassman, Dennis McKenna, Graham Hancock, Jeremy Narby, Erik Davis, Peter Meyer, David Luke, and many others • Explores DMT beings, plant sentience, interspecies communication, discarnate consciousness, dialoguing with the divine, the pineal gland, the Amazonian shamanic perspective on Invisible Entities, and the science behind hallucinations Encounters with apparently sentient beings are reported by half of all first time users of the naturally occurring psychedelic DMT, yet the question of DMT beings and plant sentience, interspecies communication, discarnate consciousness, and perhaps even dialoguing with the divine has never been systematically explored. In September 2015, ten of the world’s leading luminaries noted for exploring the mysterious compound DMT (dimethyltryptamine) gathered with other researchers at Tyringham Hall in England to discuss the subject. Over three days, they pooled their expertise from a wide range of subjects--archaeology, anthropology, religious studies, psychology, neuroscience, chemistry, and psychopharmacology, to name a few--to explore the notion of “entheogenic plant sentience” and the role of DMT as a conduit between Spirit and Matter. Offering cutting-edge insights into this visionary domain, this book distills the potent exchange of ideas that occurred at Tyringham Hall, including presentations and discussions on DMT entities, the pineal gland, the possibility of DMT as a chemical messenger from an extraterrestrial civilization, the Amazonian shamanic perspective on Invisible Entities, morphic resonance, and the science behind hallucinations. Contributors to the talks and discussions include many leading thinkers in this field, including Rupert Sheldrake, Rick Strassman, Dennis McKenna, Graham Hancock, Jeremy Narby, Erik Davis, Ede Frecska, Luis Eduardo Luna, Bernard Carr, Robin Carhart-Harris, Graham St. John, David Luke, Andrew Gallimore, Peter Meyer, Jill Purce, William Rowlandson, Anton Bilton, Vimal Darpan, Santha Faiia, and Cosmo Feilding Mellen.
Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
Download or read book Insight Outlook written by Albert Hofmann and published by Green Dragon Books. This book was released on 1989 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Albert Hofmann, one of this century's greatest minds, offers a lifetime of insights, observations, and discussions. He leads us on an exploration of reality perception, where our newly discovered insights are drawn into intellectual meditation. Reality is approached as a combination of subjective and objective truths, which must be unified for ultimate awareness. This amazing book will expand your mind and lift you to a level where the material and spiritual aspects of your life exist in harmony.
Download or read book Clinical Handbook for the Management of Mood Disorders written by J. John Mann and published by Cambridge University Press. This book was released on 2013-05-09 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-stop evidence-based guide to the management of all types of mood disorders.
Download or read book Diterpenoids written by Brandon Jones and published by Nova Science Publishers. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diterpenoids are chemical compounds containing 20 carbon atoms and belong to the terpenoid class. They derive from geranylgeraniol, a C20 precursor, have a C20H32 basic structure, and are composed of four isoprene units. These features make diterpenoids different from simple terpenes, which possess only 10 carbon atoms. A diterpenoid molecule may also include alcohol, phenol, aldehyde, cheton, or acidic functional groups. These compounds are highly lipophilic, odorless, and may possess strong flavours. They are found mainly in fungi and in resins of higher-order plants, as typical products of plant metabolism. This book examines the types, functions and provides new research on diterpenoids.
