Download or read book Exploiting Molecular Diversity written by Cambridge Healthtech Institute and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Diversity in Drug Design written by P.M. Dean and published by Springer Science & Business Media. This book was released on 1999-10-31 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry. Therefore, this book deals with algorithms that are involved in understanding chemical space and selection of diverse sets of structures. The algorithms also deal with the problem of focused diversity where chemical libraries are being created within a structured physical volume. Diversity is necessarily connected to combinational chemistry, although this book is limited to the application of diversity methods to combinational chemistry and does not deal with synthetic methods. It is this focus on algorithms and strategies for exploiting molecular diversity that makes it different from books on combinational chemistry. The intended readership of the book falls into two categories: those actively engaged in applying molecular diversity in the chemical industry and those in academia who are developing strategies to embrace, understand and accept the many problems thrown up by this new research field of molecular diversity.

Download or read book Exploiting Molecular Diversity written by Wendy A. Warr and published by . This book was released on 1996 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploiting Molecular Diversity written by Wendy A. Warr and published by . This book was released on 1995 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery; Intellectual property protection; Molecular structures; Measuring chemical diversity; DIVERSOMER technology; Chemical libraries, etc...

Download or read book Exploiting Molecular Diversity written by Cambridge Healthtech Institute and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploiting Chemical Diversity for Drug Discovery written by Paul A Bartlett and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the most useful biological information, this book provides a comprehensive overview of modern approaches to lead identification. Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, the biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines will value the comprehensive and up-to-date coverage.

Download or read book Advances in Molecular Diversity written by Chris L. Waller and published by . This book was released on 2002 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Diversity written by Kim D. Janda and published by . This book was released on 1996 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploiting Molecular Diversity of Enzymes Based on Phage Display Development of Novel Enzymatic Catalysts written by Pamela Sears and published by . This book was released on 1999 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: Barnase was successfully displayed on the surface of m13 phage as an N-terminal fusion with coat protein III. The successful display was verified by Western Blotting of purified phage. For selection of a thermostable barnase, the buried residues Ala11, Leu14, Leu20, Ala74, Ile88, Tyr90, and Ile96 were replaced randomly with Phe, Leu, Val, Ile, Ala, Pro, Gly, Ser, or Thr, giving a library of 2x10(exp 6) members. The transformation yield obtained (4x10(exp 6) allows sampling of all possible members. We are currently selecting the phage library on immobilized barstar (the femtomolar inhibitor of barnase) at elevated temperature. Barstar N7C, a mutant constructed in this lab, was linked via a disulfide to a chromatography support. This allows specific elution under mild reducing conditions. Barnase has also been successfully expressed on the surface of phage when attached to the C-terminus of an Fab light chain, with the heavy chain attached to the gene III protein. Again, western blotting analysis was used to verify the success of display. Replacement of the barnase gene with cDNA should allow the successful surface display of cDNA libraries on phage.

Download or read book Diversity in Barley Hordeum vulgare written by R. von Bothmer and published by Elsevier. This book was released on 2003-07-03 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic diversity is one of the main resources sustaining human life. Food security largely depends on the availability and utilization of this diversity, which is of strategic importance for countries and companies. Conservation and utilization of biodiversity is thus currently an urgent area of global debate and concern. Barley is a major crop in the world used for food, feed and malt, and with a wide religious and ethnic importance. The crop was domesticated in Neolithic time in SW Asia and spread rapidly under cultivation to new areas. Nowadays it is one of the most widespread and widely adapted crops grown under contrasting edaphic conditions. Adaptations to new environments, different agricultural practices and selection for different uses have further added to the complex diversity pattern. Is it at all possible to give a complete picture of the diversity in a crop or wild species? Are we, by adding new technologies, only revealing parts of the diversity? Do different sets of data show similar or conflicting pictures of genetic diversity? Will the large genome size reduce the role of barley as a model organism in these current sequencing days? Or, are there still major reasons to continue to work with this beautiful crop? The aim of this book is to cover the complex issue of diversification in time and space in a single crop: barley. Leading scientists from various fields describe the entire variation pattern in different sets of characters and an attempt is made for a synthesis to a holistic picture. The book proposes ways to use the achievements of diversity studies in future research and breeding programmes.

Download or read book Molecular Diversity in Drug Design written by P.M. Dean and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of organic chemistry, Furthermore, all the molecules can be screened in the same short period. However, like any weapons of immense power, these techniques must be used with care, to achieve maximum impact. The costs of implementing and running high-throughput screening and combinatorial chemistry are high, as large dedicated facilities must be built and staffed. In addition, the sheer number of chemical leads generated may overwhelm the lead optimisation teams in a hail of friendly fire. Mother nature has not entirely surrendered, as the number of building blocks that could be used to build libraries would require more atoms than there are in the universe. In addition, the progress made by the Human Genome Project has uncovered many proteins with different functions but related binding sites, creating issues of selectivity. Advances in the new field of pharmacogenomics will produce more of these challenges. There is a real need to make hi- throughput screening and combinatorial chemistry into 'smart' weapons, so that their power is not dissipated. That is the challenge for modellers, computational chemists, cheminformaticians and IT experts. In this book, we have broken down this grand challenge into key tasks.

Download or read book Diversity Oriented Synthesis written by Andrea Trabocchi and published by John Wiley & Sons. This book was released on 2013-06-17 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.

Download or read book The 2nd European Conference on High Throughput Screening and on Exploiting Molecular Diversity written by and published by . This book was released on 1995 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Wheat Landraces written by Nusret Zencirci and published by Springer Nature. This book was released on 2021-09-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Landraces possess a very large genetic base in population structure and are dynamic populations of cultivated plants with historical origin, distinct identity, and without any formal crop improvement. They are often genetically diverse, locally adapted, and associated with traditional farming systems. Resistance genes to biotic and abiotic stress factors, which are especially diversified in landraces, are of great interest to plant breeders, faced with global climate challenge. In addition, gene pools made of different landraces grown in different ecological conditions can be used for wheat breeding to enhance quality; yield and other desirable agricultural parameters. An estimated 75% of the genetic diversity of crop plants was lost in the last century due to the replacement of high yielding modern varieties. There is, thus, an urgent need to preserve existing species, not only for posterity but also as a means to secure food supply for a rising world population. In this book, we provide an overview of wheat landraces with special attention to genetic diversities, conservation, and utilization.

Download or read book Advances in Breeding Techniques for Cereal Crops written by Frank Ordon and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recent Developments on Genus Chaetomium written by Ahmed M. Abdel-Azeem and published by Springer Nature. This book was released on 2019-12-27 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chaetomium genus was established by Gustav Kunze in 1817. According to Index Fungorum Partnership, there are 273 Chaetomium species accepted till now. Members of the genus Chaetomium are capable of colonizing various substrates and are well-known for their ability to degrade cellulose and to produce a variety of bioactive metabolites. More than 200 compounds have been reported from this genus. A huge number of new and bioactive secondary metabolites associated with unique and diverse structural types, such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, depsidones, xanthones, anthraquinones, chromones, and steroids, have been isolated and identified. Many of the compounds have been reported to possess significant biological activities, such as antitumor, antimalarial, cytotoxic, enzyme inhibitory, antimicrobial, phytotoxic, antirheumatoid and other activities. Chaetomium taxa are frequently reported to be cellulase and ligninase producers with the ability to degrade cellulosic and woody materials. This is the first, comprehensive volume covering Chaetomium genus in detail. It includes the latest research, methods, and applications, and was written by scholars working directly in the field. The book also contains informative illustrations and is fully referenced for further reading.

Download or read book The Genetics and Exploitation of Heterosis in Crops written by CIMMYT. and published by CIMMYT. This book was released on 1997 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: