Download or read book Explicating the relationship between Infections and Alzheimer s Disease AD Etiology especially Late onset AD LOAD written by Dr.H.K.Saboowala. and published by Dr.Hakim Saboowala. This book was released on 2020-09-23 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explicating the relationship between Infections and Alzheimer’s Disease (AD) Etiology, especially Late-onset AD (LOAD). Inflammation is a part of the first line of defense of the body against invasive pathogens and plays a crucial role in tissue regeneration and repair. A proper inflammatory response ensures the suitable resolution of inflammation and elimination of harmful stimuli, but when the inflammatory reactions are inappropriate it can lead to damage of the surrounding normal cells. The relationship between infections and Alzheimer’s Disease (AD) etiology, especially late-onset AD (LOAD) has been continuously debated over the past three decades. Among bacteria special attention is focused on spirochetes family and on periodontal pathogens such as Porphyromonas gingivalis or Treponema denticola that could cause chronic periodontitis and possibly contribute to the clinical onset of AD. Emerging evidence supports the hypothesis of the role of neurotropic viruses from the Herpesviridae family, especially Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), and Human herpesvirus 2 (HHV-2), in AD neuropathology. Recent investigations also indicate the association between Hepatitis C virus (HCV) infection and dementia. An attempt has been made to discuss whether infections could be a causative factor that promotes the progression of AD along with Preventive and therapeutic approaches to AD in the context of an infectious etiology of the disease and summarize recent investigations associating infectious agents and chronic inflammation with AD. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Download or read book Understanding Alzheimer s Disease written by Neal R. Cutler and published by Univ. Press of Mississippi. This book was released on 2010-02-11 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease has received growing attention in recent years because the affected population is growing quickly as life spans in America creep ever upward. As they near retirement, many Americans start to fear that any minor memory lapse-misplacing the keys or forgetting a name-might spell Alzheimer's. In reality such incidents are a normal part of the aging process. In Alzheimer's disease, such incidents progress to a point at which they interfere with normal daily activities on a regular basis, and memory loss becomes progressively more disabling. This book is written for anyone interested in learning more about Alzheimer's disease-people who have it, their families and caregivers, professionals who serve such people, teachers, and anyone with a general interest in the disease. An important feature of this book is clear explanation of the basic biology of the disease. Here is information about who gets the disease, how it is diagnosed, and what happens to people who have it. A large section is devoted to the subject of caring for affected individuals, including legal and financial planning advice and pointers for finding outside support services. Existing treatments are discussed along with suggestions for handling many symptoms without drugs. Understanding Alzheimer's Disease describes the most current knowledge of how and why it arises and gives information about the many avenues being explored in search of a cure. With its chapters on causes and on the search for treatments, this guide will be of interest to a wider section of the population than other books on the disease.
Download or read book Handbook of Infection and Alzheimer s Disease written by J. Miklossy and published by IOS Press. This book was released on 2017-03-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.
Download or read book Early Stages of Late Onset Alzheimer s Disease written by Lars G. Forssell and published by . This book was released on 1989 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apolipoprotein E and Alzheimer s Disease written by A.D. Roses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Download or read book Systems Level Analysis of Late Onset Alzheimer s Disease Across Four Brain Regions written by Katherine Pieri and published by . This book was released on 2020 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease (AD) is a neurodegenerative disease that causes loss of memory, among other cognitive functions and is the 6th leading cause of death in the United States. Late Onset Sporadic Alzheimer's Disease (LOAD) is the most common form of AD and yet still little is known about the disease and there is no cure. The disease is complex, with temporally distinct effects at different stages. Microarray data generated from 885 postmortem patient brain tissue samples (401 control samples, 484 AD samples) was used to study the effects of LOAD on four regions of the brain: the dorsolateral Prefrontal Cortex (PFC), Visual Cortex (VC), Cerebellum (CR) and the Middle Temporal Gyrus (MTG). Various methods were explored and selected to create an analysis pipeline. The use of gene set and transcription factor enrichment enabled functional class sorting that suggested key biological functions affected by AD in each region. Five main endotypes were identified and further analyzed: Cell Cycle (G1-S Phase), Inflammation, Dedifferentiation, Synaptic Signaling and Mitochondrial Metabolism. Custom gene sets were used to create protein-protein interaction networks in order to identify key TF and gene activity within each brain region, revealing that these five endotypes were preferentially enriched in the PFC and VC brain regions.
Download or read book Handbook of Infection and Alzheimer s Disease written by Judith Miklossy and published by . This book was released on 2017-03-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer's disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century.In recent years, evidence of the microbial origin of various chronic inflammatory disorders - including several neurodegenerative, neuropsychiatric and other systemic disorders - has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer's disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions.This handbook assembles and connects findings with regard to the infectious origin of Alzheimer's disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer's disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.
Download or read book Elucidating the Role of Cystatin C in Alzheimer s Disease Pathology written by Kristen Marcellus and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Alzheimer's disease (AD) is the most prevalent form of dementia and is a progressive neurodegenerative disease, characterized by extracellular amyloid-beta plaques, intracellular neurofibrillary tangles, and neuronal death. In Alzheimer's disease patients, atrophy occurs in regions of the brain involved in learning and memory, resulting in cognitive impairment. Late-onset AD (LOAD), 90-95% of cases, is a multifactorial disease, as seen by the many morphological changes in the brain. Familial AD is caused by mutations in the APP or presenilin (PSEN1 and PSEN2) genes. However, the cause of LOAD remains unknown. Several susceptibility genes have been identified and amongst these genes is cystatin C (CysC), a cysteine protease inhibitor. Meta-analysis studies have characterized CysC as a potential risk factor for LOAD. An allelic variant, allele B, has an alanine to threonine substitution in the signal peptide, which results in the switch of a nonpolar amino acid to a polar one, which alters the hydrophobicity profile of the signal sequence, causing impaired secretion of CysC. Furthermore, studies have revealed extremely CysC immunoreactive neurons, as well as activated glia in the cerebral cortex of AD patients. Also, in the most susceptible neurons, CysC protein accumulates in intracellular vesicles. In the brains of patients with AD, neuronal concentrations of CysC are elevated and co-localize with A[beta], depositing in extracellular A[beta] plaques. CysC has been implicated in many other processes, including apoptosis regulation, cell proliferation, mitogenic activity, and cell survival/prevention of cell death. The identification and characterization of novel disease mechanisms and treatment targets are important in the field of AD in order to better understand disease etiology and aid the development of potential therapeutics. We hypothesize that CysC is involved in AD pathology and plays a key role in the progression of the disease. The objective of this study is to characterize the effect of CysC on the pathological hallmarks of AD. The results demonstrate that cystatin C is upregulated in the neuronal areas most susceptible to AD pathogenesis, the frontal cortex and the hippocampus of the 3xTg-AD mouse model. Furthermore, CysC causes apoptosis and does not attenuate APP toxicity in neuroblastoma cells. Interestingly, CysC results in the hyperphosphorylation of tau at the PHF-1 site in vitro, which is mediated by GSK3[beta]. Additionally, Egr-1 regulates CysC in vivo, in both Egr-1 knockout and Egr-1 transgenic mice models. The results suggest that CysC may contribute to the pathology of AD. Further research into the mechanisms of CysC induction of apoptosis and tau phosphorylation may shed light on a possible therapeutic target through the inhibition of CysC. " --
Download or read book Systems Biology Approaches Prevention Diagnosis and Understanding Mechanisms of Complex Diseases written by Sanket Joshi and published by Springer Nature. This book was released on with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Alzheimer s Disease written by Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting and published by . This book was released on 1996 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."
Download or read book Neurodegeneration and Alzheimer s Disease written by Ralph N. Martins and published by John Wiley & Sons. This book was released on 2019-07-10 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
Download or read book Frontiers in Clinical Drug Research Alzheimer Disorders written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2018-11-02 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders.
Download or read book Advanced Understanding of Neurodegenerative Diseases written by Raymond Chuen-Chung Chang and published by BoD – Books on Demand. This book was released on 2011-12-16 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
Download or read book Epidemiology of Alzheimer s Disease From Gene to Prevention written by Richard Mayeux and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique devoted to Alzheimer's Disease and dedicated to the epidemiological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's Disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease.
Download or read book Neurological and Neuroscientific Evidence in Aged COVID 19 Patients written by Thomas Wisniewski and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurotoxicity of Metals written by Michael Aschner and published by Springer. This book was released on 2017-09-18 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.
Download or read book Infection Inflammation Cardiovascular diseases and Neurodegeneration written by Deng-Feng Zhang and published by Frontiers Media SA. This book was released on 2021-10-25 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
