Download or read book Experimental Models of Parkinson s Disease with Levodopa induced Dyskinesias and Gait Dysfunction written by Xingxing Jin and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Levodopa Induced Dyskinesia in Parkinson s Disease written by Susan H. Fox and published by Springer. This book was released on 2014-10-08 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.
Download or read book Levodopa induced Dyskinesias in Parkinson s Disease Current Knowledge and Future Scenarios written by Antonio Cerasa and published by Frontiers Media SA. This book was released on 2015-05-13 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topic aims to pool the most recent advances in the phenomenology and pathophysiology of levodopa-induced dyskinesias. The papers in this eBook have strongly contributed to reduce the gaps in our knowledge of LIDs pathogenesis.
Download or read book Pathophysiology of Levodopa induced Dyskinesia in Animal Models of Parkinson s Disease written by Montague Adam Silverdale and published by . This book was released on 2003 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Symptoms of Parkinson s Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2011-09-22 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book about Parkinson's disease provides a detailed account of various aspects of this complicated neurological condition. Although most of the important motor and non-motor symptoms of Parkinson's disease have been discussed in this book, but in particular a detailed account has been provided about the most disabling symptoms such as dementia, depression, and other psychiatric as well as gastrointestinal symptoms. The mechanisms responsible for the development of these symptoms have also been discussed. Not only the clinicians may benefit from this book but also basic scientists can get enough information from the various chapters which have been written by well known faculty.
Download or read book Pathophysiology Pharmacology and Biochemistry of Dyskinesia written by Jonathan Brotchie and published by Academic Press. This book was released on 2011-09-19 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Download or read book Movement Disorders Advances in Research and Treatment 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Movement Disorders. The editors have built Movement Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Movement Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Movement Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Establishing Mechanisms of Levodopa induced Dyskinesias in Parkinson s Disease in Post mortem Human Brain Tissue written by Perdita Anne Cheshire and published by . This book was released on 2013 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson‘s disease (PD) is a progressive and disabling neurodegenerative disease,characterized by a loss of dopamine neurons in the midbrain. Treatment of the motorsymptoms of PD relies on replacing lost dopamine with dopaminergic drugs, inparticular the pro-drug levodopa (L-DOPA). Chronic L-DOPA treatment leads tounwanted side-effects in the form of abnormal, involuntary movements (dyskinesias), which represent a major barrier to effective symptomatic management of PD. Although pre-clinical animal models provide compelling evidence as to the underlying mechanisms of levodopa-induced dyskinesias (LID), this has repeatedly failed to translate into treatment optionsAnimal model data implicates both pre-synaptic and post-synaptic mechanisms of LID; namely that serotonin neurons cause LID by aberrantly releasing dopamine, and thatpost-synaptic dopamine receptors become hypersensitised to dopamine resulting indyskinetic movements. Correlative data from human studies is notably lacking, but is acritical step in improving research translation. The research presented in this thesis aimed to address this translational gap by compiling two cohorts of post-mortem human brain tissue from PD patients characterised on the basis of their clinical LID phenotype, which provided an unprecedented opportunity to explore the pathophysiology of LID in PD.Studies were designed to determine whether hypotheses generated from animal modelscould be validated in human tissue. The results of these studies do not support a central role for serotonin neurons in LID, nor was post-synaptic sensitisation of dopamine receptors supported as a mechanism of LID. Putative genetic risk factors for developing LID identified from cross-sectional living cohorts were also excluded in a pathologicallyconfirmed study. The failure to demonstrate pathological markers of LID identified from animal models in human tissue challenges the adequacy of current pre-clinical animal models of LID, demonstrates the value of autopsy studies, and may go some way to explain why effective treatment of LID has so far proved elusive. These findings have important implications for the development of anti-dyskinetic agents but also contribute to the understanding of PD as a whole.
Download or read book Etiology of Parkinson s Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Download or read book Balance Dysfunction in Parkinson s Disease written by Martina Mancini and published by Academic Press. This book was released on 2019-09-14 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control
Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cellular and Synaptic Mechanisms of Parkinsonism and Levodopa Induced Dyskinesia written by Michael B. Ryan and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is a neurodegenerative disease, in which the progressive loss of dopamine neurons is associated with prominent motor deficits, including a loss of voluntary movement. Although the mechanisms underlying PD are poorly understood, these motor deficits can be effectively treated pharmacologically through dopamine replacement therapy with the dopamine precursor, levodopa. However, while levodopa is highly effective, the majority of patients develop motor complications, including levodopa-induced dyskinesia (LID) after 5-10 years of treatment. The excessive, involuntary movements observed in LID, which are triggered by levodopa administration, limit its therapeutic use. In Chapter 1, I will discuss prominent theories and experimental evidence suggesting aberrant activity of neurons in the striatum, the primary input nucleus of the basal ganglia, plays a crucial role in the abnormal movements seen in both PD and LID. This will be focused on the two main cell-types in the striatum, whose activity is thought to underlie the generation and coordination of movement in health and disease: the direct and indirect pathway medium spiny neurons (dMSNs and iMSNs, respectively). However, the precise cellular and circuit mechanisms of striatal dysfunction in PD and LID, or how aberrant striatal activity relates to behavioral dysfunction, are poorly understood. To gain a better understanding of these circuit mechanisms, in Chapter 2, I use a mouse model of PD and LID combined with in vivo electrophysiological recordings of dMSNs and iMSNs. Using this approach, I identified the changes in striatal physiology that correlate with the abnormal movements seen in parkinsonism and LID. In particular, this work converges on a distinct subpopulation of dMSNs with aberrant levodopa-evoked activity. In Chapter 3, I investigate how the differential regulation of the intrinsic and synaptic properties of these LID-associated dMSNs shape their response to levodopa, using synaptic tracing, combined with in vivo and ex vivo electrophysiology experiments. Together, these studies elucidate the cellular and circuit dysfunction that arises following chronic changes in dopamine and shed light on how the heterogeneous properties of direct pathway neurons in LID contribute to the differential therapeutic and dyskinetic effects of levodopa.
Download or read book Non Motor Symptoms of Parkinson s Disease written by K. Ray Chaudhuri and published by Oxford University Press, USA. This book was released on 2014 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
Download or read book Deep Brain Stimulation for Parkinson s Disease written by Gordon H. Baltuch and published by CRC Press. This book was released on 2007-03-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's
Download or read book Principles and Practice of Movement Disorders E Book written by Joseph Jankovic and published by Elsevier Health Sciences. This book was released on 2011-04-01 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com.
Download or read book Rehabilitation in Movement Disorders written by Robert Iansek and published by Cambridge University Press. This book was released on 2013-05-23 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad overview of current rehabilitation approaches, emphasizing the need for interdisciplinary management and focussing on deliverable outcomes.
Download or read book Surgery for Parkinson s Disease written by Robert R. Goodman and published by Springer. This book was released on 2019-01-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deep brain stimulation for the treatment of patients with Parkinson’s disease was introduced in the 1990s. Initially performed only at academic centers, over the past decade it has become a widespread surgical procedure. A variety of surgical techniques are employed and innovations are introduced frequently. This book is an ideal source of information for the many practicing neurosurgeons who did not learn this surgery during their training but would now like to add it to their practice, as well as an excellent update on exciting new developments in surgery for Parkinson’s disease. This book is designed to provide practicing neurosurgeons with current knowledge on the practical aspects of surgical treatment of patients with Parkinson’s disease. It explains how to identify surgical candidates and determine the optimal surgery, describes the various surgical techniques that are currently employed, and offers insights into how to optimize deep brain stimulation therapy after implantation. The keys to avoidance of surgical complications are carefully elucidated. In addition, an overview is provided of potential advances on the near-term horizon, including closed-loop deep brain stimulation, gene therapy, and optogenetics. All topics are covered by experienced Parkinson’s disease surgeons, in a concise and digestable format. The book will be an ideal source of information for the many practicing neurosurgeons who would like to add deep brain stimulation to their practice, as well as an excellent update on new developments in surgery for Parkinson’s disease.
