Download or read book Experimental Epilepsy written by and published by Elsevier. This book was released on 1965-01-01 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Epilepsy

Download or read book Models of Seizures and Epilepsy written by Asla Pitkänen and published by Academic Press. This book was released on 2017-06-14 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Download or read book Introduction to Epilepsy written by Gonzalo Alarcón and published by Cambridge University Press. This book was released on 2012-04-26 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Download or read book Experimental Clinical Epilepsy and Related Comorbidities written by Mohd Farooq Shaikh and published by Frontiers Media SA. This book was released on 2020-12-02 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Experimental Models of Epilepsy and Related Comorbidities written by Mohd. Farooq Shaikh and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved in studying the disease and its comorbid effects. Various experimental models are used to understand the mechansims of disease and to discover newer antiepileptic drugs. These experimental models combines the input from behavioral, biochemical and molecular level including genetic.

Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Download or read book Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy written by Divya Vohora and published by Humana. This book was released on 2021-06-23 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.

Download or read book Seizures and Epilepsy written by Jerome Engel Jr and published by Oxford University Press. This book was released on 2013-01-31 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Download or read book Encyclopedia of Basic Epilepsy Research written by and published by Academic Press. This book was released on 2009-05-27 with total page 1853 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Download or read book Idiopathic Generalized Epilepsies written by Alain Malafosse and published by John Libbey Eurotext. This book was released on 1994 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Idiopathic generalised epilepsies are characterised by strong genetic factors and multiple clinical phenotypes; animal models of untreated epilepsies are relevant to some of the clinical syndromes found in humans. This volume is the first to confront human clinical, animal (experimental) as well as basic and applied genetic data. Main section headings: Current approaches; Familial neonatal and infantile convulsions; Absence seizures and absence epilepsy; Juvenile myoclonic epilepsy and related syndromes; Photosensitivity; Pathophysiology of convulsive seizures; Fundamental and therapeutic aspects.

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Download or read book Experimental Studies of Mental Defectives written by John Edward Wallace Wallin and published by . This book was released on 1912 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Intractable Epilepsy written by Dieter Schmidt (M.D.) and published by Lippincott Williams & Wilkins. This book was released on 1986 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuropharmacology Methods in Epilepsy Research written by Steven L. Peterson and published by CRC Press. This book was released on 2019-05-07 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

Download or read book Models of Experimental Epilepsy written by Francisco Sanchez and published by . This book was released on 1969 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Experimental Models of Epilepsy a Manual for the Laboratory Worker written by Dominick P. Purpura and published by . This book was released on 1972 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: