Download or read book Exact Approaches to Testing Problems Involving Nuisance Parameters written by Joseph D. Consiglio and published by . This book was released on 2014 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: We propose exact approaches for tests of hypotheses in the presence of at least one nuisance parameter. The procedures discussed are useful in situations where the available sample size is small, and procedures grounded in large-sample theory may not be applied without consequence. We present an exact test of monotone trend useful for dose-response studies in which the dose variable is qualitative in nature. Further approaches are developed to incorporate a quantitative predictor. Finally, we develop an exact test about the kappa coefficient in studies of inter-rater reliability, and exact tests for homogeneity of agreement across multiple studies.

Download or read book Exact Statistical Methods for Data Analysis written by Samaradasa Weerahandi and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now available in paperback, this book covers some recent developments in statistical inference. It provides methods applicable in problems involving nuisance parameters such as those encountered in comparing two exponential distributions or in ANOVA without the assumption of equal error variances. The generalized procedures are shown to be more powerful in detecting significant experimental results and in avoiding misleading conclusions.

Download or read book Exact Statistical Inference for Categorical Data written by Guogen Shan and published by Academic Press. This book was released on 2016-01-22 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exact Statistical Inference for Categorical Data discusses the way asymptotic approaches have been often used in practice to make statistical inference. This book introduces both conditional and unconditional exact approaches for the data in 2 by 2, or 2 by k contingency tables, and is an ideal reference for users who are interested in having the convenience of applying asymptotic approaches, with less computational time. In addition to the existing conditional exact inference, some efficient, unconditional exact approaches could be used in data analysis to improve the performance of the testing procedure. - Demonstrates how exact inference can be used to analyze data in 2 by 2 tables - Discusses the analysis of data in 2 by k tables using exact inference - Explains how exact inference can be used in genetics

Download or read book Biostatistical Methods written by John M. Lachin and published by John Wiley & Sons. This book was released on 2009-09-25 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of classical and modern methods of biostatistics Biostatistical Methods focuses on the assessment of risks and relative risks on the basis of clinical investigations. It develops basic concepts and derives biostatistical methods through both the application of classical mathematical statistical tools and more modern likelihood-based theories. The first half of the book presents methods for the analysis of single and multiple 2x2 tables for cross-sectional, prospective, and retrospective (case-control) sampling, with and without matching using fixed and two-stage random effects models. The text then moves on to present a more modern likelihood- or model-based approach, which includes unconditional and conditional logistic regression; the analysis of count data and the Poisson regression model; and the analysis of event time data, including the proportional hazards and multiplicative intensity models. The book contains a technical appendix that presents the core mathematical statistical theory used for the development of classical and modern statistical methods. Biostatistical Methods: The Assessment of Relative Risks: * Presents modern biostatistical methods that are generalizations of the classical methods discussed * Emphasizes derivations, not just cookbook methods * Provides copious reference citations for further reading * Includes extensive problem sets * Employs case studies to illustrate application of methods * Illustrates all methods using the Statistical Analysis System(r) (SAS) Supplemented with numerous graphs, charts, and tables as well as a Web site for larger data sets and exercises, Biostatistical Methods: The Assessment of Relative Risks is an excellent guide for graduate-level students in biostatistics and an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

Download or read book Design and Analysis of Non Inferiority Trials written by Mark D. Rothmann and published by CRC Press. This book was released on 2016-04-19 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority tr

Download or read book Biopharmaceutical Applied Statistics Symposium written by Karl E. Peace and published by Springer. This book was released on 2018-08-21 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter. The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the second of the 3-volume book series. The topics covered include: Statistical Approaches to the Meta-analysis of Randomized Clinical Trials, Collaborative Targeted Maximum Likelihood Estimation to Assess Causal Effects in Observational Studies, Generalized Tests in Clinical Trials, Discrete Time-to-event and Score-based Methods with Application to Composite Endpoint for Assessing Evidence of Disease Activity-Free , Imputing Missing Data Using a Surrogate Biomarker: Analyzing the Incidence of Endometrial Hyperplasia, Selected Statistical Issues in Patient-reported Outcomes, Network Meta-analysis, Detecting Safety Signals Among Adverse Events in Clinical Trials, Applied Meta-analysis Using R, Treatment of Missing Data in Comparative Effectiveness Research, Causal Estimands: A Common Language for Missing Data, Bayesian Subgroup Analysis with Examples, Statistical Methods in Diagnostic Devices, A Question-Based Approach to the Analysis of Safety Data, Analysis of Two-stage Adaptive Seamless Trial Design, and Multiplicity Problems in Clinical Trials – A Regulatory Perspective.

Download or read book Statistical Decision Theory and Related Topics V written by Shanti S. Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth Purdue International Symposium on Statistical Decision The was held at Purdue University during the period of ory and Related Topics June 14-19,1992. The symposium brought together many prominent leaders and younger researchers in statistical decision theory and related areas. The format of the Fifth Symposium was different from the previous symposia in that in addition to the 54 invited papers, there were 81 papers presented in contributed paper sessions. Of the 54 invited papers presented at the sym posium, 42 are collected in this volume. The papers are grouped into a total of six parts: Part 1 - Retrospective on Wald's Decision Theory and Sequential Analysis; Part 2 - Asymptotics and Nonparametrics; Part 3 - Bayesian Analysis; Part 4 - Decision Theory and Selection Procedures; Part 5 - Probability and Probabilistic Structures; and Part 6 - Sequential, Adaptive, and Filtering Problems. While many of the papers in the volume give the latest theoretical developments in these areas, a large number are either applied or creative review papers.

Download or read book Hilbert Space Methods in Probability and Statistical Inference written by Christopher G. Small and published by John Wiley & Sons. This book was released on 2011-09-15 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains how Hilbert space techniques cross the boundaries into the foundations of probability and statistics. Focuses on the theory of martingales stochastic integration, interpolation and density estimation. Includes a copious amount of problems and examples.

Download or read book Computer Aided Econometrics written by David E. A. Giles and published by CRC Press. This book was released on 2003-06-18 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing the impact of computer software and computational technology on econometric theory and development, this text presents recent advances in the application of computerized tools to econometric techniques and practices—focusing on current innovations in Monte Carlo simulation, computer-aided testing, model selection, and Bayesian methodology for improved econometric analyses.

Download or read book Bayesian Economics Through Numerical Methods written by Jeffrey H. Dorfman and published by Springer Science & Business Media. This book was released on 1997-07-31 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing researchers in economics, finance, and statistics with an up-to-date introduction to applying Bayesian techniques to empirical studies, this book covers the full range of the new numerical techniques which have been developed over the last thirty years. Notably, these are: Monte Carlo sampling, antithetic replication, importance sampling, and Gibbs sampling. The author covers both advances in theory and modern approaches to numerical and applied problems, and includes applications drawn from a variety of different fields within economics, while also providing a quick overview of the underlying statistical ideas of Bayesian thought. The result is a book which presents a roadmap of applied economic questions that can now be addressed empirically with Bayesian methods. Consequently, many researchers will find this a readily readable survey of this growing topic.

Download or read book Statistical Methods in Spatial Epidemiology written by Andrew B. Lawson and published by John Wiley & Sons. This book was released on 2013-07-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology. Updated to include a new emphasis on bio-terrorism and disease surveillance. Emphasizes the importance of space-time modelling and outlines the practical application of the method. Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software. Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques. This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.

Download or read book Statistical Hypothesis Testing in Context Volume 52 written by Michael P. Fay and published by Cambridge University Press. This book was released on 2022-05-05 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fay and Brittain present statistical hypothesis testing and compatible confidence intervals, focusing on application and proper interpretation. The emphasis is on equipping applied statisticians with enough tools - and advice on choosing among them - to find reasonable methods for almost any problem and enough theory to tackle new problems by modifying existing methods. After covering the basic mathematical theory and scientific principles, tests and confidence intervals are developed for specific types of data. Essential methods for applications are covered, such as general procedures for creating tests (e.g., likelihood ratio, bootstrap, permutation, testing from models), adjustments for multiple testing, clustering, stratification, causality, censoring, missing data, group sequential tests, and non-inferiority tests. New methods developed by the authors are included throughout, such as melded confidence intervals for comparing two samples and confidence intervals associated with Wilcoxon-Mann-Whitney tests and Kaplan-Meier estimates. Examples, exercises, and the R package asht support practical use.

Download or read book Numerical Methods in Finance written by Michèle Breton and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: GERAD celebrates this year its 25th anniversary. The Center was created in 1980 by a small group of professors and researchers of HEC Montreal, McGill University and of the Ecole Polytechnique de Montreal. GERAD's activities achieved sufficient scope to justify its conversion in June 1988 into a Joint Research Centre of HEC Montreal, the Ecole Polytechnique de Montreal and McGill University. In 1996, the U- versite du Quebec a Montreal joined these three institutions. GERAD has fifty members (professors), more than twenty research associates and post doctoral students and more than two hundreds master and Ph.D. students. GERAD is a multi-university center and a vital forum for the devel- ment of operations research. Its mission is defined around the following four complementarily objectives: • The original and expert contribution to all research fields in GERAD's area of expertise; • The dissemination of research results in the best scientific outlets as well as in the society in general; • The training of graduate students and post doctoral researchers; • The contribution to the economic community by solving important problems and providing transferable tools.

Download or read book Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials written by Meinhard Kieser and published by Springer Nature. This book was released on 2020-11-19 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided. The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable for beginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.

Download or read book A Companion to Theoretical Econometrics written by Badi H. Baltagi and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Companion to Theoretical Econometrics provides a comprehensive reference to the basics of econometrics. This companion focuses on the foundations of the field and at the same time integrates popular topics often encountered by practitioners. The chapters are written by international experts and provide up-to-date research in areas not usually covered by standard econometric texts. Focuses on the foundations of econometrics. Integrates real-world topics encountered by professionals and practitioners. Draws on up-to-date research in areas not covered by standard econometrics texts. Organized to provide clear, accessible information and point to further readings.

Download or read book Concepts of Nonparametric Theory written by J.W. Pratt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores both non parametric and general statistical ideas by developing non parametric procedures in simple situations. The major goal is to give the reader a thorough intuitive understanding of the concepts underlying nonparametric procedures and a full appreciation of the properties and operating characteristics of those procedures covered. This book differs from most statistics books by including considerable philosophical and methodological discussion. Special attention is given to discussion of the strengths and weaknesses of various statistical methods and approaches. Difficulties that often arise in applying statistical theory to real data also receive substantial attention. The approach throughout is more conceptual than mathematical. The "Theorem-Proof" format is avoided; generally, properties are "shown," rather than "proved." In most cases the ideas behind the proof of an im portant result are discussed intuitively in the text and formal details are left as an exercise for the reader. We feel that the reader will learn more from working such things out than from checking step-by-step a complete presen tation of all details.

Download or read book International Conference on Frontiers of Energy Environmental Materials and Civil Engineering FEEMCE 2013 written by Roger D. W. Zheng and published by DEStech Publications, Inc. This book was released on 2013-12-26 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of FEEMCE 2013 is to provide a platform for researchers, engineers, academicians as well as industrial professionals from all over the world to present their research results and development activities in Energy, Environmental Materials and Civil Engineering. This conference provides opportunities for the delegates to exchange new ideas and experiences face to face, to establish business or research relations and to find global partners for future collaboration.