Download or read book Evaluating Synergy written by Ming Tan and published by Wiley. This book was released on 2024-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing the historical and statistical information necessary to choose an analysis method and successful drug combination, Evaluating Synergy provides a systematic introduction of statistical methods for optimally designing and analyzing combination studies in cancer, anti-viral, and other therapeutic areas. This practical guide provides scientists in translational research, data analysts, and statisticians in cancer research with a detailed discussion on the challenging case of three or multi-drug combinations. Numerous examples accompany a presentation that illustrates experimental design considerations for modern drug analysis.
Download or read book Synergy Value and Strategic Management written by Stefano Garzella and published by Springer. This book was released on 2016-08-29 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses synergy management, which poses an important challenge for firms, advisors and practitioners involved in mergers and acquisitions (M&A). Synergy plays a key role in M&A contexts, both in the decision-making process and, subsequently, in the integration phase. However, despite the fact that synergy value is commonly regarded as one of the key success factors in M&A, research shows that firms generally fail to achieve the expected synergy. The extant literature is characterized by a lack of comprehensive models of synergy management: the assessment of synergy value remains a “black box” for scholars and practitioners alike. The authors provide a comprehensive framework for synergy management by integrating findings from prior research and various disciplines. The framework highlights the main dimensions of synergy management in mergers and acquisitions, common pitfalls, and new models and tools for avoiding them. As such, the book enriches the M&A literature, offers new insights for scholars, and provides valuable guidelines for practitioners involved in synergy management.
Download or read book Drug Synergism and Dose Effect Data Analysis written by Ronald J. Tallarida and published by CRC Press. This book was released on 2000-07-21 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.
Download or read book Synergy for Clinical Excellence written by Roberta Kaplow and published by Jones & Bartlett Learning. This book was released on 2005 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference for nursing students in developing and implementing the competencies necessary in caring for critically ill patients. Includes sample test questions relevant to the model that will assist nursing students in preparing for certification through AACN.
Download or read book Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs written by John Oleynick and published by . This book was released on 2013 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug synergy occurs when two or more drugs are used in a combination therapy, and the total effect of the drugs is more than would be expected based on their individual effects. Although numerous methods exist for evaluating synergy between two drugs, few have been developed for three or more drugs, and most of them have some significant drawbacks. This dissertation extends a number of two-drug synergy methods to accommodate three or more drugs. First, the method of Plummer and Short [27] is extended to three or more drugs, which is an appropriate method for cases where only global synergy may be present. Next, the parametric method of Kong and Lee [19] is extended, which is appropriate for cases where local synergy may be present. Finally, the semiparametric method of Kong and Lee [20] is extended to three or more drugs, which is an appropriate method for cases where either local synergy may be present or where the model assumptions of the extended Plummer and Short method and the extended Kong and Lee methods are not met. For each method, synergy models are presented for the case of n drugs; the models are then implemented and evaluated using simulated data for the case of three drugs, and their goodness of fit is evaluated using simulations. When more than two drugs are used in a combination, there is an additional complexity not present in 2-drug synergy: determining whether any detected synergy is between all n drugs or only a subset of the drugs. All of the new methods presented in this dissertation are able to make that distinction.
Download or read book In Search of Synergy in Small Group Performance written by James R. Larson, Jr. and published by Psychology Press. This book was released on 2013-01-11 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume critically evaluates more than a century of empirical research on the effectiveness of small, task-performing groups, and offers a fresh look at the costs and benefits of collaborative work arrangements. The central question taken up by this book is whether -- and under what conditions -- interaction among group members leads to better performance than would otherwise be achieved simply by combining the separate efforts of an equal number of people who work independently. This question is considered with respect to a range of tasks (idea-generation, problem solving, judgment, and decision-making) and from several different process perspectives (learning and memory, motivation, and member diversity). As a framework for assessing the empirical literature, the book introduces the concept of 'synergy.' Synergy refers to an objective gain in performance that is attributable to group interaction. Further, it distinguishes between weak and strong synergy, which are performance gains of different magnitude. The book highlights the currently available empirical evidence for both weak and strong synergy, identifies the conditions that seem necessary to produce each, and suggests where the search for synergy might best be directed in the future. The book is at once a high-level introduction to the field, a review of the field's history, and a scholarly critique of the current state-of-the-art. As such, it is essential reading for graduate students, advanced undergraduate students, and researchers interested in group dynamics generally -- and small group performance in particular.
Download or read book OECD Reviews of Evaluation and Assessment in Education Synergies for Better Learning An International Perspective on Evaluation and Assessment written by OECD and published by OECD Publishing. This book was released on 2013-04-11 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides an international comparative analysis and policy advice to countries on how evaluation and assessment arrangements can be embedded within a consistent framework to improve the quality, equity and efficiency of school education.
Download or read book The Synergy Solution written by Mark Sirower and published by Harvard Business Press. This book was released on 2022-03-15 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new M&A bible. Few actions can change the value of a company—and its competitive future—as quickly and dramatically as an acquisition. Yet most companies fail to create shareholder value from these deals, and in many cases they destroy it. It doesn't have to be this way. In The Synergy Solution, Deloitte's Mark Sirower and Jeff Weirens show acquirers how to develop and execute an M&A strategy—end to end—that not only avoids the pitfalls that so many companies fall into but also creates real, long-term shareholder value. This strategy includes how to: Become a prepared "always on" acquirer Test the investment thesis and DCF valuation of a deal Plan for a successful Announcement Day, and properly communicate synergy promises to investors and other stakeholders Realize those promised synergies through integration planning and post-close execution Manage change and build a new, combined organization Sirower and Weirens provide invaluable background to those considering M&A, laying out the issues they have to consider, how to analyze them, and how to plan and execute the deal effectively. They also show those who have already started the process of M&A how to maximize their chances of success. There's an art and a science to getting mergers and acquisitions right, and this powerful book provides the insights and strategies acquirers need to find success at every stage of an often complex and perilous process.
Download or read book Synergy in Mergers Acquisitions written by Stefan Karenfort and published by BoD – Books on Demand. This book was released on 2011 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The creation of synergy, which is often illustrated as the "2+2=5-effect", is a dominant motive as well as a key success factor for Mergers & Acquisitions (M&A). Inadequate expectations with respect to the synergistic potential can however easily result in an overrated acquisition price. If the planned synergies later fail to materialize, it will be increasingly hard for the acquiring firm to achieve positive value gains for its shareholders. It is therefore vital to obtain a comprehensive understanding of the synergistic potential of a planned M&A project. This issue was addressed with a doctoral thesis investigating the underlying drivers of synergy realization, in particular the concept of business relatedness which describes the similarity of firm attributes, such as product-market presence, resource configuration and supply channel types. Using a quantitative hypothesis-testing survey design, more than 300 M&A consultants worldwide have been invited to evaluate past M&A transactions with respect to their synergistic effects. In contrast to earlier studies, the relatedness of the merging firms is established as a multi-dimensional concept considering various attributes of business relatedness simultaneously. The degree of relatedness is measured using managerial perceptions which is a comparatively new measurement approach transferred from diversification research to the field of M&A. The individual dimensions of relatedness show a different effectiveness concerning synergy realization providing further support to recent contributions which advocate a multi-dimensional conceptualization of business relatedness. The study identifies dimensions of business relatedness and their underlying drivers which are particularly relevant to predictions concerning the synergistic potential. The research project thus makes a valuable contribution to clarify the impact of relatedness on M&A performance and provides important implications for practitioners regarding the eval
Download or read book Synergy Management Standard Requirements written by Gerardus Blokdyk and published by 5starcooks. This book was released on 2018-11-25 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why is Synergy Management important for you now? Who will provide the final approval of Synergy Management deliverables? How did the Synergy Management manager receive input to the development of a Synergy Management improvement plan and the estimated completion dates/times of each activity? Who is the Synergy Management process owner? Are improvement team members fully trained on Synergy Management? Defining, designing, creating, and implementing a process to solve a challenge or meet an objective is the most valuable role... In EVERY group, company, organization and department. Unless you are talking a one-time, single-use project, there should be a process. Whether that process is managed and implemented by humans, AI, or a combination of the two, it needs to be designed by someone with a complex enough perspective to ask the right questions. Someone capable of asking the right questions and step back and say, 'What are we really trying to accomplish here? And is there a different way to look at it?' This Self-Assessment empowers people to do just that - whether their title is entrepreneur, manager, consultant, (Vice-)President, CxO etc... - they are the people who rule the future. They are the person who asks the right questions to make Synergy Management investments work better. This Synergy Management All-Inclusive Self-Assessment enables You to be that person. All the tools you need to an in-depth Synergy Management Self-Assessment. Featuring 669 new and updated case-based questions, organized into seven core areas of process design, this Self-Assessment will help you identify areas in which Synergy Management improvements can be made. In using the questions you will be better able to: - diagnose Synergy Management projects, initiatives, organizations, businesses and processes using accepted diagnostic standards and practices - implement evidence-based best practice strategies aligned with overall goals - integrate recent advances in Synergy Management and process design strategies into practice according to best practice guidelines Using a Self-Assessment tool known as the Synergy Management Scorecard, you will develop a clear picture of which Synergy Management areas need attention. Your purchase includes access details to the Synergy Management self-assessment dashboard download which gives you your dynamically prioritized projects-ready tool and shows your organization exactly what to do next. You will receive the following contents with New and Updated specific criteria: - The latest quick edition of the book in PDF - The latest complete edition of the book in PDF, which criteria correspond to the criteria in... - The Self-Assessment Excel Dashboard, and... - Example pre-filled Self-Assessment Excel Dashboard to get familiar with results generation ...plus an extra, special, resource that helps you with project managing. INCLUDES LIFETIME SELF ASSESSMENT UPDATES Every self assessment comes with Lifetime Updates and Lifetime Free Updated Books. Lifetime Updates is an industry-first feature which allows you to receive verified self assessment updates, ensuring you always have the most accurate information at your fingertips.
Download or read book The Disclosure of Synergy Value in Mergers and Acquisitions written by Raffaele Fiorentino and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior studies found that synergy is one of the most important motives of M&As. However, studies generally overlooked the investigation of the use and reporting of synergy value. The purpose of this study is to assess the disclosure practices and to analyse different factors behind the disclosure of synergy in M&A corporate reports. First of all, we defined the information needed to effectively assess the synergy value. The following empirical analysis was performed in two stages: analysis of the data obtained through content analysis of M&A reports; analysis of the factors that influence the disclosure of synergy using a dependency model. Several variables were introduced to represent the features of companies and deals. Companies usually report information regarding valuation models and synergy types. Information about synergy flows, timing and likelihood of achievement is seldom reported. The results show a significant relationship between the listing status, the involvement of strategic advisors and the disclosure on synergy value. The findings emphasize that the companies characterized by higher disclosure pressure typically disclose information needed to effectively assess the synergy value. Moreover, the results suggest that companies utilize information on synergy value as a mechanism to persuade external stakeholders on the effectiveness of M&As.
Download or read book The Synergy Trap written by Mark L. Sirower and published by Simon and Schuster. This book was released on 2010-05-11 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: With acquisition activity running into the trillions of dollars, it continues to be a favorite for corporate growth strategy, but creating shareholder value remains the most elusive outcome of these corporate strategies—after decades of research and billions of dollars paid in advisory fees, why do these major decisions continue to destroy value? Building on his groundbreaking research first cited in Business Week, Mark L. Sirower explains how companies often pay too much—and predictably never realize the promises of increased performance and competitiveness—in their quest to acquire other companies. Armed with extensive evidence, Sirower destroys the popular notion that the acquisition premium represents potential value. He provides the first formal and functional definition for synergy -- the specific increases in performance beyond those already expected for companies to achieve independently. Sirower's refreshing nuts-and-bolts analysis of the fundamentals behind acquisition performance cuts sharply through the existing folklore surrounding failed acquisitions, such as lack of "strategic fit" or corporate culture problems, and gives managers the tools to avoid predictable losses in acquisition decisions. Using several detailed examples of recent major acquisitions and through his masterful integration and extension of techniques from finance and business strategy, Sirower reveals: -The unique business gamble that acquisitions represent -The managerial challenges already embedded in current stock prices -The competitive conditions that must be met and the organizational cornerstones that must be in place for any possibility of synergy -The precise Required Performance Improvements (RPIs) implicitly embedded in acquisition premiums and the reasons why these RPIs normally dwarf realistic performance gains -The seductiveness and danger of sophisticated valuation models so often used by advisers The Synergy Trap is the first exposé of its kind to prove that the tendency of managers to succumb to the "up the ante" philosophy in acquisitions often leads to disastrous ends for their shareholders. Sirower shows that companies must meticulously plan—and account for huge uncertainties—before deciding to enter the acquisition game. To date, Sirower's work is the most comprehensive and rigorous, yet practical, analysis of the drivers of acquisition performance. This definitive book will become required reading for managers, corporate directors, consultants, investors, bankers, and academics involved in the mergers and acquisitions arena.
Download or read book The Synergy Valuation Models written by Raffaele Fiorentino and published by . This book was released on 2014 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this paper is to examine the use and effectiveness of synergy valuation models in mergers and acquisitions (M&A). This paper advances the current debate on synergy and valuation models in accounting and finance studies. In particular, it answers the call for a detailed investigation of the failure rates of mergers and acquisitions, which have remained consistently high.Relevant literature is reviewed and critically assessed. An interpretive methodology is used to analyze empirical data from a questionnaire survey and interviews of M&A experts. M&A experts perceive net present value as the most frequently used and most appropriate valuation model. There is a strong consensus on the simultaneous use of multiple models as control models. The effectiveness of the synergy value depends more on the valuation path and the assessment process than on the models used. The strategic factors that are considered very relevant to generating reliable forecasts are, surprisingly, not adequately quantified. Indeed, there are several mismatches in valuation practices. This set of contributions is important for both scholars and practitioners. We highlight that the synergy assessment process and the effective use of synergy valuation models are critical points to cut the failure rate of mergers and acquisitions Our findings show the need to warn firms of the potential risks of inaccurate synergy estimations and, at the same time, suggest that an effective synergy assessment model have to be developed to increase the likelihood of M&A success. This is the first comprehensive investigation of synergy valuation models in M&A. The findings recommend that synergy valuation processes must rely on knowledge and experience from accounting as well as from other disciplines such as finance and management.
Download or read book Antibiotics in Laboratory Medicine written by Victor Lorian and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implement the most current science and practice in antimicrobial research. Now, find the newest approaches for evaluating the activity, mechanisms of action, and bacterial resistance to antibiotics with this completely updated, landmark reference. Turn to this comprehensive reference for groundbreaking evidence on the molecular link between chemical disinfectants, sterilants, and antibiotics. On the latest methods for detecting antibacterial resistance genes in the clinical laboratory, and antivirogram use to select the most active antiviral components against your patient's HIV.
Download or read book Food Synergy written by Elaine Magee and published by Rodale Books. This book was released on 2008-03-04 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few years, scientists have made dramatic new breakthroughs in harnessing the healing power of foods. In addition to discovering which "superfoods" offer maximum health benefits, they now know that some nutrients pack a special healing wallop when eaten together rather than alone. In more than 25 books and her nationally syndicated newspaper column "The Recipe Doctor," popular food writer Elaine Magee has demonstrated a special gift for translating the science behind nutrition into easy-to-understand advice. Here, whether she is highlighting the latest news on phytochemicals or explaining why new lab studies suggest that tomatoes and broccoli work together to reduce prostate growth better than either vegetable alone, she not only details the best foods to eat and why—but also shows how to utilize the most nutritious food combinations and turn them into tasty everyday meals the whole family will enjoy. The book features over 40 delicious recipes, a 2-week menu plan for weight loss, and all the information anyone needs to use food synergy to lower the risk of high blood pressure, cancer, diabetes, and stroke the natural, drug-free way.
Download or read book Fitting Models to Biological Data Using Linear and Nonlinear Regression written by Harvey Motulsky and published by Oxford University Press. This book was released on 2004-05-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.
Download or read book Synergy written by Ann A. Michel and published by . This book was released on 2017-04-04 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: An inclusive and collaborative paradigm of ministry affirming the work of both lay and clergy servants.
