Download or read book Eva Gaba written by Peabody Museum of Archaeology and Ethnology Library and published by . This book was released on 1963 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalogue Authors Eva Gaba written by Peabody Museum of Archaeology and Ethnology. Library and published by . This book was released on 1963 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Its outstanding feature is the inclusion of journal articles. For more than 50 years the periodicals have been indexed, as well as compilations such as Festschriften, and the proceedings of congresses.
Download or read book Glial Cells written by Peter R. Laming and published by Cambridge University Press. This book was released on 1998-06-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1998 book discusses how neurons and glial cells interact with each other to influence behaviour.
Download or read book Toxoplasma Gondii Host Interactions A Story of Immune Attack and Parasite Counterattack written by Jeroen P. J. Saeij and published by Frontiers Media SA. This book was released on 2020-08-10 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.
Download or read book Catalogue of the Library of the Peabody Museum of Archaeology and Ethnology written by and published by . This book was released on 1963 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book JIMD Reports Volume 43 written by Eva Morava and published by Springer. This book was released on 2019-01-07 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
Download or read book Biological Sciences written by Theodore Besterman and published by . This book was released on 1972 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classified bibliography of bibliographies in the biological sciences, largely retrospective. International scope. Citations are given in their original language. Approximate number of citations in each bibliography is indicated in brackets.
Download or read book The Glutamate GABA Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
Download or read book The International Who s who in Distance Learning written by and published by . This book was released on 1998 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book Spring Hippocampal Research Conference and Beyond written by Jochen C. Meier and published by Frontiers Media SA. This book was released on 2022-01-17 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroreceptor Mechanisms in Brain written by Shozo Kito and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers contained in this volume constitute a state of-the-art survey of the most advanced aspects of neurotransmitter recep tor mechanisms in the brain. lowe thanks for the great success of the symposium to Prof. Richard Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya Tohyama of Osaka University. I express my sincere gratitude to many friends for making this publication possible. I especially thank Dr. Rie Miyoshi, whose devoted efforts as secretary-general were vital to the success of the symposium. Dr. Miyoshi is currently an instructor in the Department of Pharmacology at Tokyo Women's Medical College. I would also like to acknowledge the excellent secretarial work of Misses Ritsuko Sato and Yuko Wakita.
Download or read book Neuroendocrinology written by and published by . This book was released on 1993 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book GABA and Endocrine Function written by Giorgio Racagni and published by Lippincott Williams & Wilkins. This book was released on 1986 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transmitters and Modulators in Health and Disease written by Seiji Shioda and published by Springer Science & Business Media. This book was released on 2009-07-25 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent international researchers contributed to this volume of reports advancing the study of brain function and morphology. Comprising investigations in several areas of neuroscience, the book includes research in neurodegenerative diseases and in neuroregeneration in adults. Described here are the effects of neuropeptides and biogenic amines on feeding, respiration, and other autonomic functions as well as on behavior. One chapter focuses on regulation of the blood brain barrier function by various neuropeptides, proteins, receptors, and transporters. Another is concerned with the modulation of higher brain functions by neuropeptides and biogenic monoamines. Yet another chapter presents research on ischemic neuronal damage and hippocampal neurogenesis in the adult mouse. Morphological or physiological techniques to study neuropeptides and neuromodulators influencing higher-order or brain-stem functions are given particular attention. The use of bio-imaging tools such as brain navigation systems and fMRIs with patients in a clinical setting creates new possibilities for investigation of human brain function and specialization of treatment.
Download or read book Building up the inhibitory synapse written by Enrico Cherubini and published by Frontiers E-books. This book was released on with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast inhibitory transmission exerts a powerful control on neuronal excitability and network oscillations thought to be associated with high cognitive functions. An alteration of inhibitory signaling is associated with major neurological and psychiatric disorders including epilepsy. Once released from presynaptic nerve terminals, GABA and glycine cross the synaptic cleft and bind to postsynaptic receptors localized in precise apposition to presynaptic release sites. The functional organization of inhibitory synapses consists in a dynamic process which relies on a number of highly specialized proteins that ensure the correct targeting, clustering, stabilization and subsequent fate of synaptic receptors. Among the proteins involved in this task, the tubulin-binding protein gephyrin plays a crucial role. Through its self-oligomerization properties, this protein forms hexagonal lattices that trap GABAA and glycine receptors and link them to the cytoskeleton. By directly interacting with cell-adhesion molecules of the neuroligin-neurexin families that connect presynaptic and postsynaptic neurons at synapses, gephyrin ensures a backward control of presynaptic signaling. In addition, changes in clusters size is dynamically regulated by lateral diffusion of neurotransmitter receptors between the synaptic and extrasynaptic compartments and by their interaction with synaptic scaffold proteins. The aim of this Research Topic (research articles and reviews) is to bring together experts on the cellular and molecular mechanisms regulating the appropriate assembly, location and function of pre and postsynaptic specializations at inhibitory synapses. A particular emphasis will be on the role of receptor trafficking in synaptic stabilization and plasticity.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
