Download or read book EudraBook written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: 2015 marks the 50th anniversary of pharmaceutical legislation in the EU, which began with Directive 65/65 in 1965 in the wake of the Thalidomide disaster. The EU legal framework for medicinal products for human use guarantees high standards of quality and safety of medicinal products and intends to promote the functioning of the internal market, with measures which encourage innovation and competiveness in Europe. It is based on the principle that medicinal products may be placed on the market only following a marketing authorisation granted by the competent authorities. A large body of legislation has developed around this principle, with the progressive harmonisation of requirements for the granting of marketing authorisations since the 1960s, implemented across the whole European Economic Area. Nowadays, medicinal products may be either authorised centrally by the European Commission or nationally by Member States' competent authorities.^The European Medicines Agency, established in 1995, underpins the centralised authorisation procedure and supports coordination between national competent authorities. The Agency is the hub of a European medicines network comprising over 40 national regulatory authorities guaranteeing a constant exchange and flow of information regarding the scientific assessment of medicinal products in the EU. The EU legal framework is definitely not an area in which the law stands still. Quite the contrary, its history is marked by a constant ambition to improve its functioning or tackling shortcomings in order to guarantee the right balance between early access of patients to new medicines and high standards of quality and safety. Moreover, over the past 50 years science has developed. New technologies and further knowledge about diseases led to the introduction of new concepts or re-shaping of existing medical therapies that were subsequently mirrored in legislation.^The pharmaceutical sector is characterised by an abundance of guidelines intended to help and support the key players in the application of the EU legal framework. Still, the guidance documents would be nothing without the basic legislation on which they build. To understand the EU legal framework for medicinal products it is important to know the applicable provisions of the legislation itself. This E-Book is intended to support readers in this regard by putting together the most recent versions of the key legal instruments on medicinal products for human use. It provides a useful overview for stakeholders, especially the pharmaceutical industry, regulatory authorities, legal practitioners, but also interested citizens, patients and healthcare professionals.

Download or read book Patent Settlements in the Pharmaceutical Industry under US Antitrust and EU Competition Law written by Amalia Athanasiadou and published by Kluwer Law International B.V.. This book was released on 2018-08-14 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reverse payment settlements or “pay-for-delay agreements” between originators and generic drug manufacturers create heated debates regarding the balance between competition and intellectual property law. These settlements touch upon sensitive issues such as timely generic entry and access to affordable pharmaceuticals and also the need to preserve innovation incentives for originators and to strengthen the pipeline of life-saving pharmaceuticals. This book is one of the first to critically and comparatively analyse how such patent settlements and various other strategies employed by the pharmaceutical industry are scrutinised by both United States (US) and European courts and enforcement authorities, and to discuss the applicable legal tests and the main criteria used for their assessment. The book’s ultimate objective is to provide guidance to the pharmaceutical industry regarding the types of patent settlements, strategies and conduct which may be problematic from US antitrust and European Union (EU) competition law perspectives and to assist practitioners in structuring settlements which are both efficient and compliant. To this end, an exhaustive legal analysis of some of the most controversial issues regarding pharmaceutical patent settlements is provided, including: – the lengthy split among US Circuit Courts on the issue of pay-for-delay settlements, its resolution by the US Supreme Court in FTC v. Actavisand subsequent jurisprudence; – the decision of Lundbeck v. Commissionby the European General Court and the Servier decision of the European Commission; – the Roche/Novartisdecision of the European Court of Justice and the most important decisions by National Competition Authorities on pharma patent settlements in the EU; – an overview of other types of strategies such as product-hopping and product reformulations, no-authorised generic commitments, problematic side-deals, mechanisms affecting generic substitution; – the rejection of the “scope of the patent” test in both the US and the EU and the balancing of patent law and antitrust law considerations in the prevailing applicable tests; – the benefits of settlements and the main criteria for assessing their legitimacy under US antitrust and EU competition law. The analysis provides concrete examples of both illegitimate and legitimate settlements and strategies, emphasising on conduct that falls within a grey zone and on the circumstances and criteria under which such conduct could be deemed problematic from an antitrust perspective. This book will serve as a valuable guide for pharmaceutical companies wishing to minimise the risk of engaging in conduct that could potentially infringe US antitrust and EU competition law. It further aims to save courts and enforcement agencies and also practitioners and academics considerable time and resources by providing an exhaustive analysis of the relevant caselaw, with the ultimate goal to increase legal certainty on the most controversial aspects of patent settlements in the pharmaceutical industry.

Download or read book Handbook of Radiopharmaceuticals written by Michael R. Kilbourn and published by John Wiley & Sons. This book was released on 2021-04-12 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2 nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

Download or read book The Law of the European Union and the European Communities written by Pieter Jan Kuijper and published by Kluwer Law International B.V.. This book was released on 2018-09-28 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Law of the European Union is a complete reference work on all aspects of the law of the European Union, including the institutional framework, the Internal Market, Economic and Monetary Union and external policy and action. Completely revised and updated, with many newly written chapters, this fifth edition of the most thorough resource in its field provides the most comprehensive and systematic account available of the law of the European Union (EU). Written by a new team of experts in their respective areas of European law, its coverage incorporates and embraces many current, controversial, and emerging issues and provides detailed attention to historical development and legislative history of EU law. Topics that are constantly debated in European legal analysis and practice are touched on in ways that are both fundamental and enlightening, including the following: .powers and functions of the EU law institutions and relationship among them; .the principles of equality, loyalty, subsidiarity, and proportionality; .free movement of persons, goods, services, and capital; .mechanisms of constitutional change – treaty revisions, accession treaties, withdrawal agreements; .budgetary principles and procedures; .State aid rules; .effect of Union law in national legal systems; .coexistence of EU, European Convention of Human Rights (ECHR), and national fundamental rights law; .migration and asylum law; .liability of Member States for damage suffered by individuals; .competition law – cartels, abuse of dominant position, merger control; .social policy, equal pay, and equal treatment; .environmental policy, consumer protection, public health, cultural policy, education, and tourism; .nature of EU citizenship, its acquisition, and loss; and .law and policy of the EU’s external relations. The fifth edition embraces many new, ongoing, and emerging European legal issues. As in the previous editions, the presentation is notable for its attention to how the law relates to economic and political realities and how the various policy areas interact with each other and with the institutional framework. The many practitioners and scholars who have relied on the predecessors of this definitive work for years will welcome this extensively revised and updated edition. Those coming to the field for the first time will instantly recognize that they are in the presence of a masterwork that can always be turned to with profit and that helps in understanding the rationale underlying any EU law provision or principle.

Download or read book Evergreening Patent Exclusivity in Pharmaceutical Products written by Frantzeska Papadopoulou and published by Bloomsbury Publishing. This book was released on 2021-09-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyses 4 central pieces of EU pharmaceutical regulation: the Orphan Drugs Regulation, the Paediatric Regulation, the Supplementary Protection Certificate Regulation, and the ATMP (Advanced Therapy Medicinal Products) Regulation. These four regulatory instruments constitute focal points in the pharmaceutical industry's approach to modern business and legal strategy. Their central role is justified by the way these regulatory instruments interact with each other and with the patent system, and by the considerable impact they (as a whole) have for the evergreening of exclusive rights on pharmaceutical products. The book guides the reader through the latest case law and legislative developments and discusses how these influence strategic legal and business choices in the pharmaceutical industry. It brings to the forefront the often-overlooked significance of the legislative architecture of the EU pharmaceutical regulatory framework, and evaluates its results through the lens of the efficiency test. The book is an important resource for academics and practitioners interested in updated case law and an in-depth analysis of these four regulations. It is also important for those interested in legislative studies, evaluation of legislation and a critical approach to legislative architecture.

Download or read book The European Union As A Global Health Actor written by Thea Emmerling and published by World Scientific. This book was released on 2016-08-10 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a systematic collection of EU actors, EU policy and EU actions in global health. It answers key questions on governance of the EU and its policy processes. The book starts with an introduction to the EU as a global actor and continues to outline the historical development and the Treaty basis for health, including the Maastricht and Lisbon Treaties. It also discusses the Commission's global health communication and the subsequent Council Conclusions on global health. Both documents define EU values in global health and identify the future priorities for global health action in the EU. Four of the five priorities are then described from the perspective of a different country experience. The book also considers the opportunities for research and provides an overview of the political, legal and financial instruments available to the EU. It also explores the global health architecture and processes within which the EU is acting, namely at the WHO, in the different multilateral organizations, and in global public health international treaties and regulations. Finally, the book addresses the importance of policy coherence at a national level and provides critical viewpoint on the EU as a global health actor.The book will assist practitioners working in policy making and international negotiations affecting health, as well as students and researchers, to create a better understanding of the European Union, its role in global health, and the uniqueness and specificity of the EU as a global health actor. It provides an overview of how the EU can act in global health and outlines the intersections of health and other sectors, as well as the instruments available to the EU to act effectively at a global level. The collection of contributions in this form and from this health policy perspective are not yet found elsewhere on the market.

Download or read book Natural Products and Medicinal Properties of Carpathian Romanian Plants written by Adina-Elena Segneanu and published by CRC Press. This book was released on 2024-04-30 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: Romanian ethnomedicinal knowledge extends as far back as the 16th century to the Geto-Dacian priests who used medicinal plants and practiced integrated holistic medicine. The ethnomedicine continued in monasteries by monks who used cultivated medicinal plants and wild harvested plants. There are now over 800 species of medicinal plants in Romania. An earlier work last century entitled “Pharmaceutical Botany: the Culture and Harvest of Pharmaceutical Plants” by Grinţescu refers to approximately 500 Romanian healing plants, although most of them are not recognized in modern medicine. There is clear evidence of ethnomedicine in this important region, particularly those that are endangered. Features: • Provides an understanding of indigenous plant-derived natural medicines of Romania • Discusses selected plant families that are representative members of the most important medicinal plants in the region. • Includes discussions and critical views on the potential and challenges for further development of the selected plants in a modern setting • Details the important plants and organizes the chapters based on either taxonomy or medical use • Covers traditional and folk medicine of Romania.

Download or read book WHO Expert Committee on Specifications for Pharmaceutical Preparations written by and published by World Health Organization. This book was released on 2021-04-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Expert Committee on Specifications for Pharmaceutical Preparations works towards clear, independent and practical standards and guidelines for the quality assurance of medicines and provision of global regulatory tools. Standards are developed by the Expert Committee through worldwide consultation and an international consensus-building process. The following new guidance texts were adopted and recommended for use: Guidelines and guidance texts adopted by the Expert Committee on Specifications for Pharmaceutical Preparations; Points to consider when including Health Based Exposure Limits (HBELs) in cleaning validation; Good manufacturing practices: water for pharmaceutical use; Guideline on data integrity; WHO/United Nations Population Fund recommendations for condom storage and shipping temperatures; WHO/United Nations Population Fund guidance on testing of male latex condoms; WHO/United Nations Population Fund guidance on conducting post-market surveillance of condoms; WHO “Biowaiver List”: proposal to waive in vivo bioequivalence requirements for WHO Model List of Essential Medicines immediate-release, solid oral dosage forms; WHO Certification Scheme on the quality of pharmaceutical products moving in international commerce; Good reliance practices in the regulation of medical products: high-level principles and considerations; and Good regulatory practices in the regulations of medical products. All of the above are included in this report and recommended for implementation.

Download or read book Research Handbook on Global Health Law written by Gian Luca Burci and published by Edward Elgar Publishing. This book was released on 2018-11-30 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effect of Globalization on health has attracted the attention of scholars and policy makers across multiple disciplines. A key concern is the regulation of international health protection, and in particular the use of international health instruments and the complex interaction between international law and health considerations. For the first time, a group of law and policy scholars have analysed these issues, drawing on knowledge from their respective fields. The resulting book provides comprehensive coverage of contemporary issues in global health law and governance.

Download or read book Nutraceuticals in Veterinary Medicine written by Ramesh C. Gupta and published by Springer. This book was released on 2019-05-21 with total page 877 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, probiotics, synbiotics, enzymes and antibacterial alternatives (Section-II), applications of nutraceuticals in prevention and treatment of various diseases such as arthritis, periodontitis, diabetes, cognitive dysfunctions, mastitis, wounds, immune disorders, and cancer (Section-III), utilization of nutraceuticals in specific animal species (Section-IV), safety and toxicity evaluation of nutraceuticals and functional foods (Section-V), recent trends in nutraceutical research and product development (Section-VI), as well as regulatory aspects for nutraceuticals (Section-VII). The future of nutraceuticals and functional foods in veterinary medicine seems bright, as novel nutraceuticals will emerge and new uses of old agents will be discovered. International contributors to this book cover a variety of specialties in veterinary medicine, pharmacology, pharmacognosy, toxicology, chemistry, medicinal chemistry, biochemistry, physiology, nutrition, drug development, regulatory frameworks, and the nutraceutical industry. This is a highly informative and carefully presented book, providing scientific insight for academia, veterinarians, governmental and regulatory agencies with an interest in animal nutrition, complementary veterinary medicine, nutraceutical product development and research.

Download or read book Microsystems for Pharmatechnology written by Andreas Dietzel and published by Springer. This book was released on 2016-01-22 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

Download or read book Industrial Agents written by Paulo Leitão and published by Morgan Kaufmann. This book was released on 2015-03-13 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Industrial Agents explains how multi-agent systems improve collaborative networks to offer dynamic service changes, customization, improved quality and reliability, and flexible infrastructure. Learn how these platforms can offer distributed intelligent management and control functions with communication, cooperation and synchronization capabilities, and also provide for the behavior specifications of the smart components of the system. The book offers not only an introduction to industrial agents, but also clarifies and positions the vision, on-going efforts, example applications, assessment and roadmap applicable to multiple industries. This edited work is guided and co-authored by leaders of the IEEE Technical Committee on Industrial Agents who represent both academic and industry perspectives and share the latest research along with their hands-on experiences prototyping and deploying industrial agents in industrial scenarios. Learn how new scientific approaches and technologies aggregate resources such next generation intelligent systems, manual workplaces and information and material flow system Gain insight from experts presenting the latest academic and industry research on multi-agent systems Explore multiple case studies and example applications showing industrial agents in a variety of scenarios Understand implementations across the enterprise, from low-level control systems to autonomous and collaborative management units

Download or read book Trends and Innovations in Information Systems and Technologies written by Álvaro Rocha and published by Springer Nature. This book was released on 2020-05-18 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers selected papers presented at the 2020 World Conference on Information Systems and Technologies (WorldCIST’20), held in Budva, Montenegro, from April 7 to 10, 2020. WorldCIST provides a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences with and challenges regarding various aspects of modern information systems and technologies. The main topics covered are A) Information and Knowledge Management; B) Organizational Models and Information Systems; C) Software and Systems Modeling; D) Software Systems, Architectures, Applications and Tools; E) Multimedia Systems and Applications; F) Computer Networks, Mobility and Pervasive Systems; G) Intelligent and Decision Support Systems; H) Big Data Analytics and Applications; I) Human–Computer Interaction; J) Ethics, Computers & Security; K) Health Informatics; L) Information Technologies in Education; M) Information Technologies in Radiocommunications; and N) Technologies for Biomedical Applications.

Download or read book Business Modeling and Software Design written by Boris Shishkov and published by Springer. This book was released on 2018-06-29 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the proceedings of the 8th International Symposium on Business Modeling and Software Design, BMSD 2018, held in Vienna, Austria, in July 2018. The 14 full papers and 21 short papers selected for inclusion in this book deal with a large number of research topics: (i) Some topics concern Business Processes (BP), such as BP modeling / notations / visualizations, BP management, BP variability, BP contracting, BP interoperability, BP modeling within augmented reality, inter-enterprise collaborations, and so on; (ii) Other topics concern Software Design, such as software ecosystems, specification of context-aware software systems, service-oriented solutions and micro-service architectures, product variability, software development monitoring, and so on; (iii) Still other topics are crosscutting with regard to business modeling and software design, such as data analytics as well as information security and privacy; (iv) Other topics concern hot technology / innovation areas, such as blockchain technology and internet-of-things. Underlying with regard to all those topics is the BMSD’18 theme: Enterprise Engineering and Software Engineering - Processes and Systems for the Future.

Download or read book An Introduction to MultiAgent Systems written by Michael Wooldridge and published by John Wiley & Sons. This book was released on 2009-06-22 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of multi-agent systems (MAS) focuses on systems in which many intelligent agents interact with each other. These agents are considered to be autonomous entities such as software programs or robots. Their interactions can either be cooperative (for example as in an ant colony) or selfish (as in a free market economy). This book assumes only basic knowledge of algorithms and discrete maths, both of which are taught as standard in the first or second year of computer science degree programmes. A basic knowledge of artificial intelligence would useful to help understand some of the issues, but is not essential. The book’s main aims are: To introduce the student to the concept of agents and multi-agent systems, and the main applications for which they are appropriate To introduce the main issues surrounding the design of intelligent agents To introduce the main issues surrounding the design of a multi-agent society To introduce a number of typical applications for agent technology After reading the book the student should understand: The notion of an agent, how agents are distinct from other software paradigms (e.g. objects) and the characteristics of applications that lend themselves to agent-oriented software The key issues associated with constructing agents capable of intelligent autonomous action and the main approaches taken to developing such agents The key issues in designing societies of agents that can effectively cooperate in order to solve problems, including an understanding of the key types of multi-agent interactions possible in such systems The main application areas of agent-based systems

Download or read book Statistical Method from the Viewpoint of Quality Control written by Walter A. Shewhart and published by Courier Corporation. This book was released on 2012-07-31 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important text offers lucid explanation of how to regulate variables and maintain control over statistics in order to achieve quality control over manufactured products, crops and data. First inexpensive paperback edition.

Download or read book Basic QC Practices 4th Edition written by James O. Westgard and published by . This book was released on 2016-07 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: