Download or read book Estimating Causal Direct and Indirect Effects in the Presence of Post treatment Confounders written by Yasemin Kisbu Sakarya and published by . This book was released on 2013 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: In investigating mediating processes, researchers usually use randomized experiments and linear regression or structural equation modeling to determine if the treatment affects the hypothesized mediator and if the mediator affects the targeted outcome. However, randomizing the treatment will not yield accurate causal path estimates unless certain assumptions are satisfied. Since randomization of the mediator may not be plausible for most studies (i.e., the mediator status is not randomly assigned, but self-selected by participants), both the direct and indirect effects may be biased by confounding variables. The purpose of this dissertation is (1) to investigate the extent to which traditional mediation methods are affected by confounding variables and (2) to assess the statistical performance of several modern methods to address confounding variable effects in mediation analysis. This dissertation first reviewed the theoretical foundations of causal inference in statistical mediation analysis, modern statistical analysis for causal inference, and then described different methods to estimate causal direct and indirect effects in the presence of two post-treatment confounders. A large simulation study was designed to evaluate the extent to which ordinary regression and modern causal inference methods are able to obtain correct estimates of the direct and indirect effects when confounding variables that are present in the population are not included in the analysis. Five methods were compared in terms of bias, relative bias, mean square error, statistical power, Type I error rates, and confidence interval coverage to test how robust the methods are to the violation of the no unmeasured confounders assumption and confounder effect sizes. The methods explored were linear regression with adjustment, inverse propensity weighting, inverse propensity weighting with truncated weights, sequential g-estimation, and a doubly robust sequential g-estimation. Results showed that in estimating the direct and indirect effects, in general, sequential g-estimation performed the best in terms of bias, Type I error rates, power, and coverage across different confounder effect, direct effect, and sample sizes when all confounders were included in the estimation. When one of the two confounders were omitted from the estimation process, in general, none of the methods had acceptable relative bias in the simulation study. Omitting one of the confounders from estimation corresponded to the common case in mediation studies where no measure of a confounder is available but a confounder may affect the analysis. Failing to measure potential post-treatment confounder variables in a mediation model leads to biased estimates regardless of the analysis method used and emphasizes the importance of sensitivity analysis for causal mediation analysis.
Download or read book Targeted Learning written by Mark J. van der Laan and published by Springer Science & Business Media. This book was released on 2011-06-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book Dynamic Regression Models for Survival Data written by Torben Martinussen and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the aim of describing time-varying effects of explanatory variables. Use of the suggested models and methods is illustrated on real data examples, using the R-package timereg developed by the authors, which is applied throughout the book with worked examples for the data sets.
Download or read book Explanation in Causal Inference written by Tyler J. VanderWeele and published by Oxford University Press, USA. This book was released on 2015 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive examination of methods for mediation and interaction, VanderWeele's book is the first to approach this topic from the perspective of causal inference. Numerous software tools are provided, and the text is both accessible and easy to read, with examples drawn from diverse fields. The result is an essential reference for anyone conducting empirical research in the biomedical or social sciences.
Download or read book Statistical Causal Inferences and Their Applications in Public Health Research written by Hua He and published by Springer. This book was released on 2016-10-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles and presents new developments in statistical causal inference. The accompanying data and computer programs are publicly available so readers may replicate the model development and data analysis presented in each chapter. In this way, methodology is taught so that readers may implement it directly. The book brings together experts engaged in causal inference research to present and discuss recent issues in causal inference methodological development. This is also a timely look at causal inference applied to scenarios that range from clinical trials to mediation and public health research more broadly. In an academic setting, this book will serve as a reference and guide to a course in causal inference at the graduate level (Master's or Doctorate). It is particularly relevant for students pursuing degrees in statistics, biostatistics, and computational biology. Researchers and data analysts in public health and biomedical research will also find this book to be an important reference.
Download or read book Handbook of Structural Equation Modeling written by Rick H. Hoyle and published by Guilford Publications. This book was released on 2023-02-17 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This accessible volume presents both the mechanics of structural equation modeling (SEM) and specific SEM strategies and applications. The editor, along with an international group of contributors, and editorial advisory board are leading methodologists who have organized the book to move from simpler material to more statistically complex modeling approaches. Sections cover the foundations of SEM; statistical underpinnings, from assumptions to model modifications; steps in implementation, from data preparation through writing the SEM report; and basic and advanced applications, including new and emerging topics in SEM. Each chapter provides conceptually oriented descriptions, fully explicated analyses, and engaging examples that reveal modeling possibilities for use with readers' data. Many of the chapters also include access to data and syntax files at the companion website, allowing readers to try their hands at reproducing the authors' results"--
Download or read book Causal Inference in Statistics written by Judea Pearl and published by John Wiley & Sons. This book was released on 2016-01-25 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: CAUSAL INFERENCE IN STATISTICS A Primer Causality is central to the understanding and use of data. Without an understanding of cause–effect relationships, we cannot use data to answer questions as basic as "Does this treatment harm or help patients?" But though hundreds of introductory texts are available on statistical methods of data analysis, until now, no beginner-level book has been written about the exploding arsenal of methods that can tease causal information from data. Causal Inference in Statistics fills that gap. Using simple examples and plain language, the book lays out how to define causal parameters; the assumptions necessary to estimate causal parameters in a variety of situations; how to express those assumptions mathematically; whether those assumptions have testable implications; how to predict the effects of interventions; and how to reason counterfactually. These are the foundational tools that any student of statistics needs to acquire in order to use statistical methods to answer causal questions of interest. This book is accessible to anyone with an interest in interpreting data, from undergraduates, professors, researchers, or to the interested layperson. Examples are drawn from a wide variety of fields, including medicine, public policy, and law; a brief introduction to probability and statistics is provided for the uninitiated; and each chapter comes with study questions to reinforce the readers understanding.
Download or read book Causality written by Carlo Berzuini and published by John Wiley & Sons. This book was released on 2012-06-04 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state of the art volume on statistical causality Causality: Statistical Perspectives and Applications presents a wide-ranging collection of seminal contributions by renowned experts in the field, providing a thorough treatment of all aspects of statistical causality. It covers the various formalisms in current use, methods for applying them to specific problems, and the special requirements of a range of examples from medicine, biology and economics to political science. This book: Provides a clear account and comparison of formal languages, concepts and models for statistical causality. Addresses examples from medicine, biology, economics and political science to aid the reader's understanding. Is authored by leading experts in their field. Is written in an accessible style. Postgraduates, professional statisticians and researchers in academia and industry will benefit from this book.
Download or read book Data Analysis Using Regression and Multilevel Hierarchical Models written by Andrew Gelman and published by Cambridge University Press. This book was released on 2007 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2007, is for the applied researcher performing data analysis using linear and nonlinear regression and multilevel models.
Download or read book Introduction to Statistical Mediation Analysis written by David MacKinnon and published by Routledge. This book was released on 2012-10-02 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume introduces the statistical, methodological, and conceptual aspects of mediation analysis. Applications from health, social, and developmental psychology, sociology, communication, exercise science, and epidemiology are emphasized throughout. Single-mediator, multilevel, and longitudinal models are reviewed. The author's goal is to help the reader apply mediation analysis to their own data and understand its limitations. Each chapter features an overview, numerous worked examples, a summary, and exercises (with answers to the odd numbered questions). The accompanying CD contains outputs described in the book from SAS, SPSS, LISREL, EQS, MPLUS, and CALIS, and a program to simulate the model. The notation used is consistent with existing literature on mediation in psychology. The book opens with a review of the types of research questions the mediation model addresses. Part II describes the estimation of mediation effects including assumptions, statistical tests, and the construction of confidence limits. Advanced models including mediation in path analysis, longitudinal models, multilevel data, categorical variables, and mediation in the context of moderation are then described. The book closes with a discussion of the limits of mediation analysis, additional approaches to identifying mediating variables, and future directions. Introduction to Statistical Mediation Analysis is intended for researchers and advanced students in health, social, clinical, and developmental psychology as well as communication, public health, nursing, epidemiology, and sociology. Some exposure to a graduate level research methods or statistics course is assumed. The overview of mediation analysis and the guidelines for conducting a mediation analysis will be appreciated by all readers.
Download or read book Causality and Psychopathology written by American Psychopathological Association. Meeting and published by Oxford University Press. This book was released on 2011 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains contributions from leading scholars of causal thinking in epidemiology and psychopathology research. Based on presentations at the ground-breaking 2008 meeting of the American Psychopathological Association, the authors explore the meaning of causal statements that are made from statistical and experimental evidence; then, they suggest novel approaches to analyze these statements and thus make them more informative and medically rigorous.
Download or read book Regression and Mediation Analysis Using Mplus written by Bengt O. Muthen and published by . This book was released on 2016-07-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Elements of Causal Inference written by Jonas Peters and published by MIT Press. This book was released on 2017-11-29 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and self-contained introduction to causal inference, increasingly important in data science and machine learning. The mathematization of causality is a relatively recent development, and has become increasingly important in data science and machine learning. This book offers a self-contained and concise introduction to causal models and how to learn them from data. After explaining the need for causal models and discussing some of the principles underlying causal inference, the book teaches readers how to use causal models: how to compute intervention distributions, how to infer causal models from observational and interventional data, and how causal ideas could be exploited for classical machine learning problems. All of these topics are discussed first in terms of two variables and then in the more general multivariate case. The bivariate case turns out to be a particularly hard problem for causal learning because there are no conditional independences as used by classical methods for solving multivariate cases. The authors consider analyzing statistical asymmetries between cause and effect to be highly instructive, and they report on their decade of intensive research into this problem. The book is accessible to readers with a background in machine learning or statistics, and can be used in graduate courses or as a reference for researchers. The text includes code snippets that can be copied and pasted, exercises, and an appendix with a summary of the most important technical concepts.
Download or read book Methods in Social Epidemiology written by J. Michael Oakes and published by John Wiley & Sons. This book was released on 2006-05-11 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social epidemiology is the study of how social interactions—social norms, laws, institutions, conventia, social conditions and behavior—affect the health of populations. This practical, comprehensive introduction to methods in social epidemiology is written by experts in the field. It is perfectly timed for the growth in interest among those in public health, community health, preventive medicine, sociology, political science, social work, and other areas of social research. Topics covered are: Introduction: Advancing Methods in Social Epidemiology The History of Methods of Social Epidemilogy to 1965 Indicators of Socioeconomic Position Measuring and Analyzing 'Race' Racism and Racial Discrimination Measuring Poverty Measuring Health Inequalities A Conceptual Framework for Measuring Segregation and its Association with Population Outcomes Measures of Residential Community Contexts Using Census Data to Approximate Neighborhood Effects Community-based Participatory Research: Rationale and Relevance for Social Epidemiology Network Methods in Social Epidemiology Identifying Social Interactions: A Review, Multilevel Studies Experimental Social Epidemiology: Controlled Community Trials Propensity Score Matching Methods for Social Epidemiology Natural Experiments and Instrumental Variable Analyses in Social Epidemiology and Using Causal Diagrams to Understand Common Problems in Social Epidemiology. "Publication of this highly informative textbook clearly reflects the coming of age of many social epidemiology methods, the importance of which rests on their potential contribution to significantly improving the effectiveness of the population-based approach to prevention. This book should be of great interest not only to more advanced epidemiology students but also to epidemiologists in general, particularly those concerned with health policy and the translation of epidemiologic findings into public health practice. The cause of achieving a ‘more complete’ epidemiology envisaged by the editors has been significantly advanced by this excellent textbook." —Moyses Szklo, professor of epidemiology and editor-in-chief, American Journal of Epidemiology, Johns Hopkins University "Social epidemiology is a comparatively new field of inquiry that seeks to describe and explain the social and geographic distribution of health and of the determinants of health. This book considers the major methodological challenges facing this important field. Its chapters, written by experts in a variety of disciplines, are most often authoritative, typically provocative, and often debatable, but always worth reading." —Stephen W. Raudenbush, Lewis-Sebring Distinguished Service Professor, Department of Sociology, University of Chicago "The roadmap for a new generation of social epidemiologists. The publication of this treatise is a significant event in the history of the discipline." —Ichiro Kawachi, professor of social epidemiology, Department of Society, Human Development, and Health, Harvard University "Methods in Social Epidemiology not only illuminates the difficult questions that future generations of social epidemiologists must ask, it also identifies the paths they must boldly travel in the pursuit of answers, if this exciting interdisciplinary science is to realize its full potential. This beautifully edited volume appears at just the right moment to exert a profound influence on the field." —Sherman A. James, Susan B. King Professor of Public Policy Studies, professor of Community and Family Medicine, professor of African-American Studies, Duke University
Download or read book Causal Analysis written by Martin Huber and published by MIT Press. This book was released on 2023-08-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and cutting-edge introduction to quantitative methods of causal analysis, including new trends in machine learning. Reasoning about cause and effect—the consequence of doing one thing versus another—is an integral part of our lives as human beings. In an increasingly digital and data-driven economy, the importance of sophisticated causal analysis only deepens. Presenting the most important quantitative methods for evaluating causal effects, this textbook provides graduate students and researchers with a clear and comprehensive introduction to the causal analysis of empirical data. Martin Huber’s accessible approach highlights the intuition and motivation behind various methods while also providing formal discussions of key concepts using statistical notation. Causal Analysis covers several methodological developments not covered in other texts, including new trends in machine learning, the evaluation of interaction or interference effects, and recent research designs such as bunching or kink designs. Most complete and cutting-edge introduction to causal analysis, including causal machine learning Clean presentation of rigorous material avoids extraneous detail and emphasizes conceptual analogies over statistical notation Supplies a range of applications and practical examples using R
Download or read book Handbook of Causal Analysis for Social Research written by Stephen L. Morgan and published by Springer Science & Business Media. This book was released on 2013-04-22 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: What constitutes a causal explanation, and must an explanation be causal? What warrants a causal inference, as opposed to a descriptive regularity? What techniques are available to detect when causal effects are present, and when can these techniques be used to identify the relative importance of these effects? What complications do the interactions of individuals create for these techniques? When can mixed methods of analysis be used to deepen causal accounts? Must causal claims include generative mechanisms, and how effective are empirical methods designed to discover them? The Handbook of Causal Analysis for Social Research tackles these questions with nineteen chapters from leading scholars in sociology, statistics, public health, computer science, and human development.
