Download or read book Enzyme Synthesis and Degradation in Mammalian Systems written by Miloslav Rechcígl and published by . This book was released on 1971 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rechcigl Enzyme Synthesis and Degradation in Mammalian Systems written by M. ENZYME and published by . This book was released on 1971-01-01 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzyme Systhesis and Degradation in Mammalian Systems written by Rechigl, Miloslar and published by . This book was released on 1971 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Exocrine Pancreas written by Stephen Pandol and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
Download or read book Medical Biochemistry written by Antonio Blanco and published by Academic Press. This book was released on 2022-03-23 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. Integrates basic biochemistry principles with molecular biology and molecular physiology Illustrates basic biochemical concepts through medical and physiological examples Utilizes a systems approach to understanding biological phenomena Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries
Download or read book A Biochemical Approach to Nutrition written by R. Freedland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though the major emphasis of this book will be references to several basic texts are given at the to provide the nutritionist with a biochemical end of the introduction. approach to his experimental and practical To facilitate easy reference, the book has problems, it is hoped that the book will also be been divided into chapters according to the of use to the biochemist and physiologist to roles of the basic nutrients in metabolism. demonstrate how dietary nutrition manipula Within chapters, discussion will include such tion can be used as a powerful tool in solving topics as the effects of nutrients on metabolism, problems in both physiology and biochemistry. the fate of nutrien ts, the roles of various tissues There will be no attempt to write an all-encom and interaction of tissues in utilizing nutrients, passing treatise on the relationship between and the biochernical mechanisms involved. biochemistry and nutrition; rather, it is hoped Toward the end of the book, several example that the suggestions and partial answers offered problems will be presented, which we hope will here will provide the reader with a basis for provide the reader with the opportunity to approaching problems and designing experi form testable hypotheses and design experi ments.
Download or read book Intracellular Protein Degradation written by A.J. Rivett and published by Elsevier Science. This book was released on 1998-08-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells. In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria. Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by a variety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some of the known substrates for this pathway which include cell cycle and transcriptional regulators. The structure and functions of proteosomes and their regulatory components are described in the two subsequent chapters by Tanaka and Tanahashi and by Dubiel and Rechsteiner. Proteasomes were the first known example of threonine proteases. They are multisubunit complexes that, in addition to being responsible for the turnover of most short-lived nuclear and cytoplasmic protein, are also involved in antigen processing for presentation by the MHC class I pathway. Recent studies reviewed by McCracken and colleagues (chapter 6) lead to the exciting conclusion that some ER-associated proteins are degraded by cytosolic proteasomes. Lysosomes are responsible for the degradation of long-lived proteins and for the enhanced protein degradation observed under starvation conditions. In chapter 7 Knecht and colleagues review the lysosomal proteases and describe studies of the roles of lysosomes and the mechanisms for protein uptake into lysosomes. Methods of measuring the relative contribution of different proteolytic systems (e.g., ubiquitin-proteasome pathway, calcium-dependent proteases, lysosomes) to muscle protein degradation, and the conclusions from such studies, are reviewed by Attai and Taillinder in the following chapter. Finally, proteases play an important role in signaling apoptosis by catalyzing the limited cleavage of enzymes. Mason and Beyette review the role of the major players, caspases, which are both activated by and catalyze limite proteolysis, and also consider the involvement of other protoelytic enzymes in this pathway leading cell death.
Download or read book Industrial Enzyme Applications written by Andreas Vogel and published by John Wiley & Sons. This book was released on 2019-10-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a "must-read": It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.
Download or read book Modern Biooxidation written by Rolf D. Schmid and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap in the literature, leading expert editors and top international authors present the field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the application of different monooxygenases to applications in the pharmaceutical industry, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.
Download or read book The Enzymes written by Paul D. Boyer and published by Academic Press. This book was released on 1976-06-28 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes
Download or read book Czechmate written by Miloslav Rechcígl and published by AuthorHouse. This book was released on 2011-03-15 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: These reminiscences are an intimate account of Mila Rechcgls saga, his fascinating life, his varied and successful professional career, and his highly visible public life, encompassing some fifty years, since the earliest childhood in a small hamlet in northeastern rural Bohemia to his government career in the Worlds Capital, Washington, DC and spending his retirement years in active scholarship and voluntary work for non-profit organizations. He views his life as a chess game, in which he confronts various challenges head-on, usually ending with a checkmate in his favor. He describes his idyllic youth at family mill, in an area known as Bohemian paradise, talks fondly of his parents and grandparents, the time he spent in a one-class rural school, followed by eight years in gymnasium in Mlada Boleslav, four during the Nazi occupation of Czechoslovakia and four in the post-War era under the communist threat. After successful escape from communist Czechoslovakia, he immigrates to America, spending his greenhorn years in New York City, working in a glass jewelry factory. He gets a scholarship, is accepted by a prestigious Ivy League school (Cornell) and with skimpy English manages getting his bachelors degree in biochemistry in two and half years, followed by Masters and Ph.D. Gets hired by the National Institutes of Health in Bethesda where he conducts some pioneering research on enzyme turnover and later is offered training in science policy and administration, leading to his appointment as Special Assistant for Nutrition and Health, and later is put in charge of research at the US State Departments Agency for International Development. Beyond the call of duty, he publishes numerous books and in his spare time, devotes energies to organizing an international Czechoslovak Society of Arts and Sciences into a first-class institution and does premier research on immigration history.
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Download or read book Principles of Metabolic Control in Mammalian Systems written by Herman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work we present the basic principles of metabolic control which we hope will serve as a foundation for the vast array of factual matter which the biochemist and the physician engaged in metabolic research must accumulate. Accordingly, we attempt to set forth these principles, along with sufficient explanation, so that the reader may apply them to the ever-expanding literature of biochemistry. If we are successful, this will provide a theoretical approach which can be applied to any given set of metabolic reactions. It is impossible to enumerate each and every biochemical reaction and pathway since such a work would be too unwieldy for efficient use. Rather, we hope our presentation of the principles of metabolic control will be sufficiently basic to be of lasting usefulness no matter how detailed biochemistry may become. We would like to be able to con dense biochemistry into a theoretical biology that will not only allow for the general treatment of any given reaction but will enable predic tions to be made as to the existence of necessary pathways and the con sequences of altered control. Such is not possible today, but this may be accomplished in the future. We believe it is now possible to institute the beginnings of such a theoretical biology.
Download or read book Regulation of Amino Acid Metabolism in Mammals written by Bernard Schepartz and published by W.B. Saunders Company. This book was released on 1973 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Lysosomes A Survey written by E. Holtzman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief monograph is intended chiefly for non-specialists and for others interested in a concise introduction to the field. The literature on lysosomes is growing so rapidly that any effort at exhaustive comprehensiveness would be foredoomed to failure. Fortunately, an extensive series of reviews has been published in the past few years (see especially DINGLE and FELL 1969; DINGLE 1972, 1973 a; HERS and VAN HoOF 1973) and the "history" of the organelles is brief enough that major contributors to all stages of that history are still available to provide first-hand discussions (e. g. , DE DUVE and WATTIAUX 1966; DE DUVE 1969; NOVIKOFF 1971, 1973; see also VAN FURTH for work on phago cytes and DE REUCK and CAMERON 1963 for useful reviews of early work). New York, N. Y. , September 1975 E. HOLTZMAN Contents I. General Considerations and Background 1. 1. Perspectives 1 1. 2. Definitions . 2 1. 2. 1. General Functional Categories 2 1. 2. 2. Outline of Lysosome Functioning in Phagocytes 3 1. 2. 3. Additional Terms: Heterophagy and Autophagy 4 1. 3. Characterization of Lysosomes . . . . . . . . . . 4 1. 3. 1. Basic Biochemical Characteristics of Lysosomes 5 1. 3. 1. 1. Key Features of Lysosomes 8 1. 3. 1. 2. The Lysosomal Enzymes . 8 1. 3. 1. 3. Digestion in Lysosomes 11 1. 3. 104. Lysosomal "Permeability" 13 1. 3. 2. Some Cytochemical and Morphological Characteristics 15 1. 3. 2. 1. Cytochemical Methods . . . . . . . . . . 16 1. 3. 2. 2. Cytochemical Studies of Exogenous Tracers .
