Download or read book Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System written by Anna Zampetaki and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Global Technology Revolution 2020 In Depth Analyses Bio Nano Materials Information Trends Drivers Barriers and Social Implications written by Richard Silberglitt and published by Rand Corporation. This book was released on 2002-08-30 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2020, areas of particular importance for technology trends will include biotechnology, nanotechnology, materials technology, and information technology. This report, the companion document to The Global Technology Revolution 2020, Executive Summary (Silberglitt et al., MG-475-NIC, 2006), assesses in detail a sample of 29 countries with respect to their ability to acquire and implement 16 key technology applications.
Download or read book Non coding RNAs in Head and Neck Squamous Cell Carcinoma Functional and Clinical Implications written by Wei Cao and published by Frontiers Media SA. This book was released on 2022-02-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Gastro Archeologist written by Jeremy Woodward and published by Springer. This book was released on 2022-02-18 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to understand common conditions such as coeliac disease and Crohn’s disease, one must view the gut in its evolutionary context. This is the novel approach to the gut and its diseases that is adopted in this book. The first part tells the story of the evolution of the gut itself – why it came about and how it has influenced the evolution of animals ever since. The second part focuses on the evolution of immunity and how the layers of immune mechanisms are retained in the gut, resembling the strata revealed in an archeological dig. The final part, ‘The Gastro-Archeologist’, ties the first two together and highlights how understanding the gut and immune system in their evolutionary context can help us understand diseases affecting them. Ambitious in its scope but telling a unique story from a refreshingly novel perspective, the book offers an informative and enjoyable read. As the story of the gut, immunity and disease unfolds, the author aims to endow readers with the same sense of awe and excitement that the subject evokes in him. Difficult concepts are illustrated using simple and colourful analogies, and the main content is supplemented with anecdotes and unusual and amusing facts throughout the book. The book is intended for anyone with an interest in the gut, its immunity and diseases, ranging from school and college biology and biomedical students, to professionals working in the field, and to patients suffering from intestinal diseases who want to understand more about their conditions.
Download or read book The World s Worst Problems written by Walter Dodds and published by Springer Nature. This book was released on 2019-12-02 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the worst problems currently facing humanity and those that may pose future threats. The problems are explained and approached through a scientific lens, and categorized based on data involving global mortality, vulnerability, and threat level. The book presents indices of problem severity to compare relative intensity of current and potential crises. The approach avoids emotional argument using mainly empirical evidence to support the classification of relative problem severity. The author discusses multiple global problems and ranks them. He also explores specific solutions to each problem, links problems to human behavior from a social science perspective, considers international cooperation, and finally pathways to solutions. The book discusses confirmation bias and why this necessitates a scientific approach to tackle problems. The moral assumption that each person has the same rights to life and minimal suffering, and that the natural world has a right to exist, forms the basis of ranking problems based on death, suffering, and harm to the natural world. A focus is given to potential disasters such as asteroid collisions and super-volcanic eruptions, which are then presented in chapters that address specific contemporary global issues including disease, hunger, nuclear weapons and climate change. Furthermore the author then ranks the problems based on an index of problem severity, considering what other people think the worst problems are. The relative economic costs to solve each of these problems, individual behavior in the face of these problems, how people could work together internationally to combat them, and a general pathway toward solutions form the basis of the final chapters. This work will appeal to a wide range of readers, students considering how they can help the world, and scientists and policy makers interested in global problem solving./div
Download or read book An Introduction to Nanoscience and Nanotechnology written by Alain Nouailhat and published by Wiley-ISTE. This book was released on 2008-01-14 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part of this book adapted from "Introduction aux nanosciences et aux nanotechnologies" published in France by Hermes Science/Lavoisier in 2006."
Download or read book Drug Safety Data How to Analyze Summarize and Interpret to Determine Risk written by Michael J. Klepper and published by Jones & Bartlett Publishers. This book was released on 2010-09-15 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk was selected for The First Clinical Research Bookshelf - Essential reading for clinical research professionals by the Journal of Clinical Research Best Practices. Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk provides drug safety/pharmacovogilance professionals, pharmaceutical and clinical research scientists, statisticians, programmers, medical writers, and technicians with an accessible, practical framework for the analysis, summary and interpretation of drug safety data. The only guide of its kind, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is an invaluable reference for pre- and post-marketing risk assessment. With decades of pharmaceutical research and drug safety expertise, authors Dr. Klepper and Dr. Cobert discuss how quality planning, safety training, and data standardization result in significant cost, time, and resource savings. Through illustrative, step-by-step instruction, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is the definitive guide to drug safety data analysis and reporting. Key features include: * Step-by-step instruction on how to analyze, summarize and interpret safety data for mandatory governmental safety reports * Pragmatic tips...and mistakes to avoid * Simple explanations of what safety data are collected, and what the data mean * Practical approaches to determining a drug effect and understanding its clinical significance * Guidance for determining risk throughout the lifecycle of a drug, biologic or nutraceutical * Examples of user-friendly data displays that enhance safety signal identification * Ways to improve data quality and reduce the time, resources and costs involved in mandatory safety reporting * Relevant material for the required training of drug safety/pharmacovigilance professionals * SPECIAL FEATURE: Actual examples of an Integrated Analysis of Safety (IAS) -used in the preparation of the Integrated Summary of Safety (ISS) and the Summary of Clinical Safety (SCS) reports -, and the Periodic Safety Update Report (PSUR)
Download or read book Proteomic Profiling written by Anton Posch and published by Humana. This book was released on 2021-02-04 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed new edition presents the latest developments of the main pillars of protein analysis, namely sample preparation, separation, and characterization. Core areas in this volume are protocols for the analysis of post-translational modifications and protein interaction partners, followed by sophisticated procedures to enrich for extracellular vesicles and organelles, along with several types of protein immuno-assays complemented by various methods for the characterization of antibodies and host-cell protein analysis. Last but not least, a few standard sample preparation protocols and recent advances concerning immuno-chemical detection of proteins are included as well. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Proteomic Profiling: Methods and Protocols, Second Edition serves as an ideal reference for students of biochemistry, biomedicine, biology, and genomics and will be an invaluable source for the experienced, practicing scientist as well.
Download or read book On Edge written by Andrea Petersen and published by Crown. This book was released on 2017-05-16 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: A celebrated science and health reporter offers a wry, bracingly honest account of living with anxiety. A racing heart. Difficulty breathing. Overwhelming dread. Andrea Petersen was first diagnosed with an anxiety disorder at the age of twenty, but she later realized that she had been experiencing panic attacks since childhood. With time her symptoms multiplied. She agonized over every odd physical sensation. She developed fears of driving on highways, going to movie theaters, even licking envelopes. Although having a name for her condition was an enormous relief, it was only the beginning of a journey to understand and master it—one that took her from psychiatrists’ offices to yoga retreats to the Appalachian Trail. Woven into Petersen’s personal story is a fascinating look at the biology of anxiety and the groundbreaking research that might point the way to new treatments. She compares psychoactive drugs to non-drug treatments, including biofeedback and exposure therapy. And she explores the role that genetics and the environment play in mental illness, visiting top neuroscientists and tracing her family history—from her grandmother, who, plagued by paranoia, once tried to burn down her own house, to her young daughter, in whom Petersen sees shades of herself. Brave and empowering, this is essential reading for anyone who knows what it means to live on edge.
Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Download or read book A Walk Through the Dark written by Eva Piper and published by Thomas Nelson. This book was released on 2013-08-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: One day Eva Piper was an elementary school teacher, the mother of three, the beloved wife of a strong, protective husband. The next day she stood at the bedside of a broken man who could do nothing but moan in agony and turn his head away from her. Later she would learn that he had died and actually experienced heaven before being prayed back to life—a true miracle. Don Piper’s testimony, told in the New York Times bestseller 90 Minutes in Heaven, would one day bring hope to thousands. But all that was in the future. Despite family and friends who kept vigil with her, Eva Piper found herself essentially alone. Walking in the dark. And she had always hated the dark. Though it parallels that of her husband, Eva Piper’s account is quite different from his. It takes readers not to heavenly places but through a very earthly maze of hospital corridors, insurance forms, tiring commutes from home to workplace and hospital, and lonely hours of waiting and worrying. This is the story of a woman learning, step by darkened step, to go places she never thought she could go and growing into a person she never thought she could be. Packed with hard-earned wisdom about what it means to be a caregiver, to open yourself to the care of others, and to rest in God’s provision, this bookprovides a dependable source of light to help you walk through the dark.
Download or read book Decision making in a Fuzzy Environment written by Richard Bellman and published by . This book was released on 1970 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Paediatrics at a Glance written by Lawrence Miall and published by John Wiley & Sons. This book was released on 2016-04-29 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paediatrics at a Glance provides an introduction to paediatrics and the problems encountered in child health as they present in primary, community and secondary care, from birth through to adolescence. Thoroughly updated to reflect changes in understanding of childhood illness over the last 5 years, the 4th edition of this best-selling textbook diagrammatically summarises the main differential diagnoses for each presenting symptom, while accompanying text covers important disorders and conditions as well as management information. Paediatrics at a Glance: • Is an accessible, user-friendly guide to the entire paediatric curriculum • Features expanded coverage of psychological issues and ethics in child health • Includes more on advances in genetics, screening and therapy of childhood illness • Contains new videos of procedures and concepts on the companion website • Includes a brand new chapter on Palliative Care - an emerging area in the specialty • Features full colour artwork throughout • Includes a companion website at www.ataglanceseries.com/paediatrics featuring interactive self-assessment case studies, MCQs, videos of the procedures and concepts covered in the book, and links to online resources Paediatrics at a Glance is the ideal companion for anyone about to start a paediatric attachment or module and will appeal to medical students, junior doctors and GP trainees as well as nursing students and other health professionals.
Download or read book Out Of Control written by Kevin Kelly and published by Basic Books. This book was released on 2009-04-30 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Out of Control chronicles the dawn of a new era in which the machines and systems that drive our economy are so complex and autonomous as to be indistinguishable from living things.
Download or read book Cardiac Gene Therapy written by Kiyotake Ishikawa and published by Humana. This book was released on 2016-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides methodological information on cardiac gene delivery, from classic to state-of-the-art technologies and techniques. Efficient, cardiac-specific, and safe vectors, as well as refined vector delivery methods, are key for successful cardiac gene transfer and eventually for improving patients’ outcomes. Newer vectors and more efficient vector delivery methods have the potential to dramatically improve gene transduction efficacy, while novel gene manipulation techniques enforce the therapeutic power and broaden disease targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Gene Therapy: Methods and Protocols serves as a valuable tool for molecular biologists and physiologists in the cardiology field conducting cardiac gene transfer research, which will ultimately lead to further advancements in the vital field.
Download or read book The Pandemic Century written by Mark Honigsbaum and published by Oxford University Press. This book was released on 2019-03-09 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like sharks, epidemic diseases always lurk just beneath the surface. This fast-paced history of their effect on mankind prompts questions about the limits of scientific knowledge, the dangers of medical hubris, and how we should prepare as epidemics become ever more frequent. Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet, despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu and the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 'parrot fever' pandemic and the more recent SARS, Ebola, and Zika epidemics, the last 100 years have been marked by a succession of unanticipated pandemic alarms. Like man-eating sharks, predatory pathogens are always present in nature, waiting to strike; when one is seemingly vanquished, others appear in its place. These pandemics remind us of the limits of scientific knowledge, as well as the role that human behaviour and technologies play in the emergence and spread of microbial diseases.
Download or read book Skills for Successful School Leaders written by John Hoyle and published by . This book was released on 1990-01-01 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
