Download or read book Enhanced Spectral Domain Optical Coherence Tomography for Pathological and Functional Studies written by Zhijia Yuan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spectral Domain Optical Coherence Tomography A Practical Guide written by Dacosta Shaun and published by JP Medical Ltd. This book was released on 2011-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Spectral Domain OCT is a practical guide to the investigation and diagnosis of retinal disease using the Topcon machine. Beginning with an overview of OCT, the book provides a step by step approach to image capture, analysis and interpretation. With the help of numerous case studies, OCT patterns in different types of retinal disease are presented as both 2D and 3D images. In addition, Spectral Domain OCT highlights features of the new Topcon 2000 machine with an enhanced speed of 27,000 A scans/second, improved software algorithms and extra facilities for anterior segment imaging.

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Download or read book Development of Spectral Domain Optical Coherence Tomography for in Vivo Functional Imaging of Biological Tissues written by Lin An and published by . This book was released on 2013 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15,000 OCT units that had been put into service in ophthalmic clinic by 2009, which represented approximately $1 billion market. The total amount paid by Medicare for OCT scans has increased from $1 billion per year in 2001 to $7 billion per year by 2008. The market size has kept growing in recent years. Reported in [2] by IBISWorld (an American research company), the OCT has achieved an annual growth rate of 27.4% since 2007. In 2012, the revenue is expected to be $478.4 million, which is 24.7% larger than last year. Despite the massive success, there are still several technical issues that need to be addressed, which could help the OCT technology to deliver even better imaging quality. In this thesis, we described several OCT technologies that can be used to double the imaging depth, realize functional vasculature imaging of biological tissue and increase the imaging speed of OCT system. Aim 1: Use of a scanner to introduce spatial frequency modulation to OCT spectral interferograms for in vivo full-range Fourier-domain optical coherence tomography. A novel method was developed that could easily introduce a modulation frequency onto the X-direction (i.e., B-scan) of the FDOCT scanning system, enabling full-range Fourier-domain Optical Coherence Tomography (frFDOCT). Compared to the conventional FDOCT system, the newly developed frFDOCT system can provide increased system sensitivity and deeper imaging depth. The previous technology that can achieve frFDOCT either needed multiple steps for data capturing, which is time consuming, or required additional components which increased the system's complexity. The newly developed method generates a modulation spatial frequency in the spectral interferogram by simply offsetting the probe beam at the X-scanner. In this way, the frFDOCT could be easily realized through applying a Hilbert transformation. Aim 2: Using optical micro-angiography to achieve in vivo volumetric imaging of vascular perfusion within human retina and choroids. Optical Micro-Angiography (OMAG) is a functional extension of FDOCT technology. It can achieve visualization of vasculature network of biological tissue. In order to apply the OMAG method to image vasculature map of human retina and choroid, a phase compensation algorithm was developed, which could minimize the motion artifacts generated by the movements of human eye and head. The original scanning protocol of OMAG method could only achieve ~2 mm x 2 mm scanning area on the retina, which is relatively small for clinical applications. To achieve large field of view of vasculature visualization of retina and choroid, multiple small areas of retina were sequentially scanned. After being processed, all the vasculature maps coming from small areas were stitched together to produce a vasculature map of the whole retina and choroid, which is comparable to Fluorescein Angiography. Aim 3: Developing ultrahigh sensitive optical micro-angiography to achieve micro vasculature imaging of biological tissue. Though the OMAG has been successfully applied for visualizing vasculature networks of different biological tissue, there are several problems that need to be solved, such as lower flow sensitivity, longer imaging time and so on. To improve the vasculature image quality, we developed ultrahigh sensitive OMAG (UHS-OMAG). Unlike conventional OMAG, UHS-OMAG applied the OMAG algorithm onto the slow direction of FDOCT scan (Y-direction). Because the time interval between adjacent B-frames is much longer than that between adjacent A-lines, UHS-OMAG can achieve much higher flow sensitivity compared to the conventional OMAG. In addition, the UHS-OMAG usually employed high frame rate (typically 300 frames per second) to achieve 3D scan, it cost much less time to finish one 3D scan compared to the traditional OMAG. However, when it was applied to visualize vasculature map of human tissue, the motion artifacts caused by the inevitable movements is still the biggest challenge. Based on the phase difference calculated from two adjacent B-frames, a new phase compensation algorithm was developed. The UHS-OMAG system was then applied onto human retina and skin to produce detailed micro vasculature networks. Aim 4: Developing ultrahigh speed Spectral Domain OCT system through sequentially controlling two high speed line scan CMOS cameras. Since the report of OCT technology, the imaging speed is always the hot topic along its development path. Though one branch of FDOCT technology, swept source OCT, can run at several megahertz, SSOCT is still not approved by FDA for human eye imaging. The development of spectral domain OCT is more attractive from a commercialization perspective. Two identical high speed line cameras were employed to build two home build high speed spectrometers. Through sequentially controlling the reading time period of two cameras, the imaging speed of the whole system could reach twice higher than the single camera system. The newly built 800 nm SDOCT system which can work at 500,000 Hz A-lines capturing speed was then used to achieve in vivo 3D imaging in both high speed and large field of view mode. In addition, through combining with the OMAG algorithm, the newly developed system is capable of providing detailed micro-vasculature imaging of human retina and optic nerve head.

Download or read book Optimization of Multi functional 1310 Nm Spectral domain Optical Coherence Tomography SD OCT System and Three dimensional Volumetric OCT Image Registration written by Junze Liu and published by . This book was released on 2018 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a novel and promising imaging technique that has been widely applied in clinical practice and research. Currently advanced spectral-domain OCT is capable for fast generating three dimensional (3D) volumetric image and extracting multi-biological information that has potential uses in disease study. Based on a laboratory-built multi-functional spectral-domain OCT system with center wavelength of 1310 nm, the research goal in this thesis is to solve problems about proper optical characterization method of volumes of in vivo biological sample taken at different time points which requires appropriate 3D volume registration and alignment. In this thesis, system optimization is introduced in order to improve OCT signal-to-noise ratio (SNR) and image quality for better image registration performance. Details of a computational-efficient 3D volume alignment based on cross-correlation image registration is discussed. Optical characterization of post-traumatic epilepsy (PTE) is described as an example to demonstrate the feasibility of the OCT system and to evaluate the image post-processing method in actual neural disease research.

Download or read book Spectral Domain OCT written by Shaun Dacosta and published by Jaypee Brothers,Medical Publishers Pvt. Limited. This book was released on 2008-11-01 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Spectral Domain OCT is a practical guide to the investigation and diagnosis of retinal disease using the Topcon machine. Beginning with an overview of OCT, the book provides a step by step approach to image capture, analysis and interpretation. With the help of numerous case studies, OCT patterns in different types of retinal disease are presented as both 2D and 3D images. In addition, Spectral Domain OCT highlights features of the new Topcon 2000 machine with an enhanced speed of 27,000 A scans/second, improved software algorithms and extra facilities for anterior segment imaging.

Download or read book Clinical Applications of Optical Coherence Tomography Angiography written by Francesco Bandello and published by S. Karger AG (Switzerland). This book was released on 2020 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often introduced as a routine exam in clinical practice, granting the opportunity to non-invasively investigate retinal and choroidal circulation. In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas about OCTA"--

Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.

Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

Download or read book Optical Coherence Tomography in Age Related Macular Degeneration written by Gabriel Coscas and published by Springer Science & Business Media. This book was released on 2009-07-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid or even dramatic progress has been made in the field of AMD over recent years, leading to a constant revision of basic concepts. A wide range of fundus imaging modalities are now available, and this book explains the respective value of each technique. The information provided by OCT is presented logically by comparison with plain films, autofluorescence, fluorescein angiography, or indocyanine green angiography. Meticulous biomicroscopic examination of macular changes and the essential value of fluorescein angiography for the detection of anatomical alterations of the macula and for precise evaluation of lesions and their course by indocyanine green angiography have naturally led the author Gabriel Coscas to analyze the new data provided by OCT.

Download or read book Atlas of Inherited Retinal Diseases written by Stephen H. Tsang and published by Springer. This book was released on 2018-12-21 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.

Download or read book Handbook of Pediatric Retinal OCT and the Eye Brain Connection written by Cynthia A. Toth and published by Elsevier Health Sciences. This book was released on 2019-05-04 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) plays a vital role in pediatric retina diagnosis, often revealing unrecognized retinal disorders and connections to brain injury, disease, and delayed neurodevelopment. Handbook of Pediatric Retinal OCT and the Eye-Brain Connection provides authoritative, up-to-date guidance in this promising area, showing how to optimize imaging in young children and infants, how to accurately interpret these images, and how to identify links between these images and brain and developmental disorders. Illustrates optimal methods of OCT imaging of children and infants, how to avoid pitfalls, and how to recognize and avoid artifacts Explains how the OCT image may relate to brain disease and delayed neurodevelopment Features more than 200 high-quality images and scans that depict the full range of disease in infants and young children Provides guidance in identifying retinal layers and important abnormalities. Covers the structural features of the retina and optic nerve head in developmental, acquired, or inherited conditions that affect the eye and visual pathways Offers practical ways to set up imaging programs in the clinic, operating room, or neonatal nursery

Download or read book Optical Coherence Tomography in Neurologic Diseases written by Peter A. Calabresi and published by Cambridge University Press. This book was released on 2015-05-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.

Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.

Download or read book Diagnosis Treatment of Uveitis written by C Stephen Foster and published by JP Medical Ltd. This book was released on 2013-03-30 with total page 1326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uveitis is inflammation of the middle layer of the eye, which is known as the uvea or uveal tract. It is a complex condition with a variety of causes and clinical manifestations, including injury, infection or an underlying condition. This 1200pp second edition brings ophthalmologists fully up to date with the latest developments in diagnosing and treating uveitis. Beginning with the basic principles of the disease, its diagnosis and management, the following sections discuss the treatment of numerous different infectious, non infectious, masquerade and autoimmune syndromes. Basic science, differential diagnosis, pathology and clinical management are discussed for each condition. Written by specialists from the Massachusetts Eye Research and Surgery Institution (MERSI) and John A Moran Eye Center in the USA, this comprehensive new edition includes 699 colour images and illustrations. Key points Comprehensive, second edition bringing ophthalmologists fully up to date with diagnosis and treatment of uveitis Discusses different uveitis syndromes – infectious, non infectious, masquerade and autoimmune Authored by US ophthalmic specialists Includes 699 full colour images and illustrations First edition published in 2001 by Saunders

Download or read book Pathologic Myopia written by Richard F. Spaide and published by Springer Nature. This book was released on 2021-07-28 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathologic Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, myopic maculopathy within the posterior staphyloma. The first edition of Pathologic Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. This new edition is a timely update to the standard reference in the field, with new chapters on advanced refractive error correction, genetics, developing a classification system, and special surgical approaches for pathologic myopia. Complete with even more high-quality color images and informative tables, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.

Download or read book OCT Atlas written by Nagahisa Yoshimura and published by Springer. This book was released on 2014-06-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: OCT provided a great advantage over other diagnostic modalities, as it could noninvasively provide tomographic images of the retina of a living eye. As a result, a number of new findings in retinal diseases were made using the time-domain OCT. OCT has now become an essential medical equipment OCT has now become an essential medical equipment in ophthalmic care and quality textbooks describing the functionality of OCT are very important in the education of young ophthalmologists and eye care personnel. In this book are chosen high quality OCT images of rather common diseases as well as images of several rare diseases.