Download or read book Engineering the Genetic Code written by Nediljko Budisa and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application. Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique. Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given. Essential reading for all molecular life scientists who want to stay ahead in their research.
Download or read book The Triplet Genetic Code written by Lynn E. H. Trainor and published by World Scientific. This book was released on 2001 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring to interested readers (professionals and laypersons alike) an appreciation and a basic understanding of what the genetic code is and why it has come to revolutionize thinking about living systems as a whole. The consequences of this revolution in molecular biology are so vast as to be almost incomprehensible. It seems important in a democratic society to have a citizenry well informed about the crucial issues of the day, such as genetic engineering and molecular medicine, which impact the social order and the ethos of society in such a profound way.This book discusses concisely the genetic code ? what it is and how it provides the key to molecular biology. The structures of DNA (as revealed by Watson and Crick) and of the various forms of RNA are described in some detail, and it is shown how these structures are marvellously adapted to the twin problems of inheritance of traits and faithful development of individual organisms. In this latter respect, the role of proteins as the ?molecules of life? is described and the central dogma of molecular biology (information flows from DNA to RNA to protein) elaborated. In addition, theories of the origin and development of the universal genetic code are reviewed briefly, and a perspective concerning the impact of molecular biology on the social ethos is presented.
Download or read book Triplet Genetic Code The Key To Living Organisms written by Lynn E H Trainor and published by World Scientific. This book was released on 2001-06-25 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring to interested readers (professionals and laypersons alike) an appreciation and a basic understanding of what the genetic code is and why it has come to revolutionize thinking about living systems as a whole. The consequences of this revolution in molecular biology are so vast as to be almost incomprehensible. It seems important in a democratic society to have a citizenry well informed about the crucial issues of the day, such as genetic engineering and molecular medicine, which impact the social order and the ethos of society in such a profound way.This book discusses concisely the genetic code — what it is and how it provides the key to molecular biology. The structures of DNA (as revealed by Watson and Crick) and of the various forms of RNA are described in some detail, and it is shown how these structures are marvellously adapted to the twin problems of inheritance of traits and faithful development of individual organisms. In this latter respect, the role of proteins as the “molecules of life” is described and the central dogma of molecular biology (information flows from DNA to RNA to protein) elaborated. In addition, theories of the origin and development of the universal genetic code are reviewed briefly, and a perspective concerning the impact of molecular biology on the social ethos is presented.
Download or read book The Origin and Evolution of the Genetic Code 100th Anniversary Year of the Birth of Francis Crick written by Koji Tamura and published by MDPI. This book was released on 2018-03-23 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick" that was published in Life
Download or read book Engineering the Genetic Code and Expanding the Genetic Code for in Vivo Incorporation of Noncanonical Amino Acids Into Biologically Active Ribosomal Peptides written by and published by . This book was released on 2015 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Genetic Engineering written by Robert Snedden and published by Capstone Classroom. This book was released on 2007-08-25 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looks at cells as life's building blocks, focusing on DNA and genetic engineering, discussing DNA as a cell's instruction manual, explaining how DNA is put together, and exploring some of the controversies surrounding genetic engineering and gene therapy.
Download or read book The Code of Life written by Alvin Silverstein and published by Courier Corporation. This book was released on 2004-01-01 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses chemical codes found in cells, their effects on the genes, and the role genes play in heredity.
Download or read book The Code Breaker written by Walter Isaacson and published by Simon and Schuster. This book was released on 2021-03-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.
Download or read book Ctrl Z Humanity Rewriting the Genetic Code written by Shu Chen Hou and published by Shu chen Hou. This book was released on with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embark on an extraordinary journey through the pages of "Ctrl+Z Humanity: Rewriting the Genetic Code" – a groundbreaking exploration that delves into the realms of genetic manipulation, synthetic organisms, and the profound possibilities of genetic medicine. This book is not just a collection of words; it's an odyssey of discovery, ethics, and inspiration that will reshape the way you perceive the power of genetics. 🧬 Unlock the Secrets: Dive into the fascinating world of genetics and unravel the mysteries that define life itself. From the intricacies of DNA to the frontiers of genetic manipulation, each page unveils a tapestry of knowledge that will leave you in awe. 🌱 Rewrite the Narrative: Explore the potential of synthetic organisms and de-extinction, where the boundaries of creation and conservation intertwine. Discover the ethical dilemmas that emerge when humans become architects of life, and contemplate the implications for biodiversity and ecosystems. 💉 Genetic Medicine Redefined: Immerse yourself in the revolution of personalized medicine, where genetic profiling leads to tailored treatments and disease prevention. Navigate the ethical considerations that guide the path to healing and wellbeing for individuals and societies alike. 🌌 Unveil the Future: Journey into the uncharted territories of genetic engineering and ponder the limitless horizons that beckon us. Contemplate the ethical complexities, technological limitations, and unforeseen consequences that shape the path ahead. 🌟 Be Part of the Conversation: "Ctrl+Z Humanity" isn't just a book; it's an invitation to join a global dialogue. Engage with the interplay of science, ethics, and policy-making that will determine the future of genetic innovation. Your voice matters in shaping the story of responsible genetic engineering. This book is more than an insight into genetics; it's an exploration of humanity's role as custodians of the genetic code. Whether you're a curious mind, a student of science, an advocate of ethics, or simply someone intrigued by the boundless possibilities of tomorrow, "Ctrl+Z Humanity" is your guide to understanding, contemplation, and inspiration. Embark on the Journey Today! Explore the book that has captivated minds and ignited conversations about the power and responsibility of genetic innovation. Order "Ctrl+Z Humanity: Rewriting the Genetic Code" and venture into the uncharted territories that define the future of life itself.
Download or read book Pathway Engineering of the Expanding Genetic Code written by John Christopher Anderson and published by . This book was released on 2003 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several projects focused on expanding the genetic code of Escherichia coli to include amino acids beyond the common twenty are described. These include the identification of extended codons, orthogonal pairs, and the engineering of amino acid metabolic pathways in E. coli . To incorporate multiple unnatural amino acids at distinct sites in a polypeptide, multiple noncoding codons are required. To this end efficiently-suppressed 4- and 5-base codons were identified using a selection strategy. To make use of these extended codons, three orthogonal aminoacyl-tRNA synthetase/suppressor tRNA pairs were engineered from archaebacteria. These systems do not cross-react with their E. coli homologs, but efficiently suppress UAG, AGGA, or UGA codons. Using a combination of saturation mutagenesis and genetic selection, several variants of the Pyrococcus horikoshii lysyl-tRNA synthetase were identified that permit the genetic encoding of homoglutamine in response to the codon AGGA in E. coli . In addition to adding new components to the translational machinery of E. coli , we have also added a biosynthetic pathways for p-aminophenylalanine providing the first example of an autonomous 21-amino acid organism that can biosynthesize an unnatural amino acid and incorporate it into protein with no media supplement. Finally, in an effort to incorporate [alpha]-hydroxy acids genetically into proteins we have identified strains deficient in their biotransformation to [alpha]-amino acids in E. coli . In combination with extended codons and orthogonal pairs, these strains set the stage for the evolution of a system that genetically encodes polyesters. The work described here not only allows us to generate proteins and possibly entire organisms with novel properties not restricted by the common twenty amino acids, it also provides an opportunity to explore basic mechanisms of translation.
Download or read book Evolution of the Genetic Code written by Shōzō Ōsawa and published by . This book was released on 1995 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic code was deciphered experimentally around 1966 and for a number of years scientists considered it to be "universal" for all forms of life. In 1981 researchers shocked the scientific community with the discovery that the code differed in mitochondria and certain other organisms, evidence that the genetic code was still evolving. This book discusses the distribution and origin of the non-universal codes and examines the possible mechanisms of code changes, making it essential reading for all those interested in evolutionary genetics.
Download or read book Genetic Engineering of Plants written by National Research Council and published by National Academies Press. This book was released on 1984-02-01 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book...is, in fact, a short text on the many practical problems...associated with translating the explosion in basic biotechnological research into the next Green Revolution," explains Economic Botany. The book is "a concise and accurate narrative, that also manages to be interesting and personal...a splendid little book." Biotechnology states, "Because of the clarity with which it is written, this thin volume makes a major contribution to improving public understanding of genetic engineering's potential for enlarging the world's food supply...and can be profitably read by practically anyone interested in application of molecular biology to improvement of productivity in agriculture."
Download or read book Regenesis written by George M Church and published by Basic Books. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Download or read book Genome Engineering Technologies to Change the Genetic Code written by Marc Joseph Lajoie and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: New technologies are making it possible to engineer organisms with fundamentally new and useful properties. In vivo genome engineering technologies capable of manipulating genomes from the nucleotide to the megabase scale were developed and applied to reassign the genetic code of Escherichia coli. Such genomically recoded organisms show promise for thwarting horizontal gene transfer with natural organisms, resisting viral infection, and expanding the chemical properties of proteins.
Download or read book Non Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Download or read book Genetic Code Engineering with Methionine Analogs for Synthetic Biotechnology written by Carlos Guillermo Acevedo Rocha and published by . This book was released on 2010 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Biology written by Lisa Bartee and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.
