Download or read book Engineering Synthetic Metabolons From Metabolic Modelling to Rational Design of Biosynthetic Devices written by Lars M. Voll and published by Frontiers Media SA. This book was released on 2016-07-19 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Download or read book Engineering Synthetic Metabolons From Metabolic Modelling to Rational Design of Biosynthetic Devices written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Download or read book Synthetic Biology of Cyanobacteria written by Weiwen Zhang and published by Springer. This book was released on 2018-08-08 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.

Download or read book Metabolic Engineering of Plant Secondary Metabolism written by R. Verpoorte and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant secondary metabolism is an economically important source of fine chemicals, such as drugs, insecticides, dyes, flavours, and fragrances. Moreover, important traits of plants such as taste, flavour, smell, colour, or resistance against pests and diseases are also related to secondary metabolites. The genetic modification of plants is feasible nowadays. What does the possibility of engineering plant secondary metabolite pathways mean? In this book, firstly a general introduction is given on plant secondary metabolism, followed by an overview of the possible approaches that could be used to alter secondary metabolite pathways. In a series of chapters from various authorities in the field, an overview is given of the state of the art for important groups of secondary metabolites. No books have been published on this topic so far. This book will thus be a unique source of information for all those involved with plants as chemical factories of fine chemicals and those involved with the quality of food and ornamental plants. It will be useful in teaching graduate courses in the field of metabolic engineering in plants.

Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Download or read book Analytical Electrochemistry written by Joseph Wang and published by John Wiley & Sons. This book was released on 2004-03-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed guide to the principles, techniques, and instruments of electroanalytical chemistry-now expanded and revised Joseph Wang, internationally renowned authority on electroanalytical techniques, thoroughly revises his acclaimed book to reflect the rapid growth the field has experienced in recent years. He substantially expands the theoretical discussion while providing comprehensive coverage of the latest advances through late 1999, introducing such exciting new topics as self-assembled monolayers, DNA biosensors, lab-on-a-chip, detection for capillary electrophoresis, single molecule detection, and sol-gel surface modification. Along with numerous references from the current literature and new worked-out examples, Analytical Electrochemistry, Second Edition offers clear, reader-friendly explanations of the fundamental principles of electrochemical processes as well as important insight into the potential of electroanalysis for problem solving in a wide range of fields, from clinical diagnostics to environmental science. Key topics include: The basics of electrode reactions and the structure of the interfacial region Tools for elucidating electrode reactions and high-resolution surface characterization An overview of finite-current controlled potential techniques Electrochemical instrumentation and electrode materials Principles of potentiometric measurements and ion-selective electrodes Chemical sensors, including biosensors, gas sensors, solid-state devices, and sensor arrays

Download or read book The Metabolic Pathway Engineering Handbook written by Christina Smolke and published by CRC Press. This book was released on 2009-07-28 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux thro

Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Download or read book Protein Engineering Protocols written by Kristian Müller and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein engineering is a fascinating mixture of molecular biology, protein structure analysis, computation, and biochemistry, with the goal of developing useful or valuable proteins. Protein Engineering Protocols will consider the two general, but not mutually exclusive, strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The s- ond strategy is known as directed evolution. In this case, random mutagenesis is applied to a protein, and selection or screening is used to pick out variants that have the desired qualities. By several rounds of mutation and selection, this method mimics natural evolution. An additional technique known as DNA shuffling mixes and matches pieces of successful variants to produce better results. This process mimics recombination that occurs naturally during sexual reproduction. The first section of Protein Engineering Protocols describes rational p- tein design strategies, including computational methods, the use of non-natural amino acids to expand the biological alphabet, as well as impressive examples for the generation of proteins with novel characteristics. Although procedures for the introduction of mutations have become routine, predicting and und- standing the effects of these mutations can be very challenging and requires profound knowledge of the system as well as protein structures in general.

Download or read book Climate Change Photosynthesis and Advanced Biofuels written by Ashwani Kumar and published by Springer Nature. This book was released on 2020-08-31 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of fossil fuels results in rising CO2 and other greenhouse gas (GHG) emissions, causing global temperature rise and climate change that will negatively impact human health, the food supply, and eventually worsen hunger and misery. Presently, fossil fuels meet 88% of the energy demand, resulting in rising CO2/GHG emissions at alarming rates. The increased use of biofuels would help to mitigate climate change. Efficiently designing methods for the production of biofuels and plant-derived high-value products requires a deeper understanding of photosynthetic processes as a prerequisite for applying novel biotechnologies. Accordingly, this book provides ample information and a wealth of illustrative examples. The book’s eighteen richly illustrated chapters are divided into three thematic parts. I: Photosynthesis and Biomass Production under Changing Conditions, II: Microalgae and Engineered Crops for Production of Biofuels and High-value Products, and III: Genetic Resources and Engineering Methods to Improve Crop Plants. Readers will find the latest information on the molecular basis of photosynthetic processes in plants (including the regulatory principles that allow plants to maintain homeostasis under changing conditions), stress resistance and synthetic pathways. In addition, the basic principles of important biotechnologies, as well as examples of specially designed crops capable of growing under stress conditions with improved productivity, are presented. The book sets the course for future research in the field of biofuel development and production and provides both general and specific information for students, teachers, academic researchers, industrial teams, and general readers who are interested in new developments concerning the production of biofuels with value-added properties.

Download or read book Methane Biocatalysis Paving the Way to Sustainability written by Marina G. Kalyuzhnaya and published by Springer. This book was released on 2018-06-20 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth insights into the most recent developments in different areas of microbial methane and methanol utilization, including novel fundamental discoveries in genomics and physiology, innovative strategies for metabolic engineering and new synthetic approaches for generation of feedstocks, chemicals and fuels from methane, and finally economics and the implementation of industrial biocatalysis using methane consuming bacteria. Methane, as natural gas or biogas, penetrates every area of human activity, from households to large industries and is often promoted as the cleanest fuel. However, one should not forget that this bundle of energy, carbon, and hydrogen comes with an exceptionally large environmental footprint. To meet goals of long-term sustainability and human well-being, all areas of energy, chemicals, agriculture, waste-management industries must go beyond short-term economic considerations and target both large and small methane emissions. The search for new environment-friendly approaches for methane capture and valorization is an ongoing journey. While it is not yet apparent which innovation might represent the best solution, it is evident that methane biocatalysis is one of the most promising paths. Microbes are gatekeepers of fugitive methane in Nature. Methane-consuming microbes are typically small in number but exceptionally big in their impact on the natural carbon cycle. They control and often completely eliminate methane emission from a variety of biological and geothermal sources. The tremendous potential of these microbial systems, is only now being implemented in human-made systems. The book addresses professors, researchers and graduate students from both academia and industry working in microbial biotechnology, molecular biology and chemical engineering.

Download or read book Magnetic Nanoparticles written by Evgeny Katz and published by MDPI. This book was released on 2020-03-05 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book covers all research areas related to magnetic nanoparticles, magnetic nanorods, and other magnetic nanospecies, their preparation, characterization, and various applications, specifically emphasizing biomedical applications. The chapters written by the leading experts cover different subareas of the science and technology related to various magnetic nanospecies—providing broad coverage of this multifaceted area and its applications. The different topics addressed in this book will be of great interest to the interdisciplinary community active in the area of nanoscience and nanotechnology. It is hoped that this collection and its various chapters will be important and beneficial for researchers and students working in various areas related to bionanotechnology, materials science, biosensor applications, medicine, and many others. Furthermore, this book is aimed at attracting young scientists and introducing them to this field, in addition to providing newcomers with an enormous collection of literature references.

Download or read book Enzymatic Bioelectrocatalysis written by Kenji Kano and published by Springer Nature. This book was released on 2020-11-13 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the fundamental aspects of the electrochemistry and redox enzymes that underlie enzymatic bioelectrocatalysis, in which a redox enzyme reaction is coupled with an electrode reaction. Described here are the basic concept and theoretical aspects of bioelectrocatalysis and the various experimental techniques and materials used to study and characterize related problems. Also included are the various applications of bioelectrocatalysis to bioelectrochemical devices including biosensors, biofuel cells, and bioreactors. This book is a unique source of information in the area of enzymatic bioelectrocatalysis, approaching the subject from a cross-disciplinary point of view.

Download or read book Synthetic Metabolic Pathways written by Michael Krogh Jensen and published by Humana Press. This book was released on 2017-11-24 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Download or read book Terpenes written by Eberhard Breitmaier and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise overview of terpenes and their applications covers the structure, natural sources, biological and pharmacological effects, as well as selected total syntheses of the compound. This book includes a chapter on structure determination, as well as added information on biogenesis, polycyclic terpenes, gingkoloids and neo-hopanes. This title is an ideal introductory book for anybody starting work in this field.

Download or read book A Primer for the Exercise and Nutrition Sciences written by Christopher B. Scott and published by Springer Science & Business Media. This book was released on 2009-01-09 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: What a journey writing this text has been. The lengthy voyage started well before the idea hatched of authoring a text that contained the word “thermodynamics”! I was informed by my good friend and sometimes colleague Dr. Jose Antonio that by including that word in the title, nutritionists and exercise physiologists might avoid the subject. But almost every step of my expedition was taken on a rather solid foundation of thermodynamics and as such the topic could not possibly be omitted from the title or the text of a book about bioenergetics and energy expenditure. I am not a physicist. In fact I ?rst went to college to become a football coach. That vocational choice began to deteriorate when taking the mandatory anatomy and physiology courses required of all physical education majors. This information was exciting; my interest in physical education began to wane. During sophomore year, I answered an advertisement in the school newspaper requesting research subjects.

Download or read book Medicinal Plant Biotechnology written by Rajesh Arora and published by CABI. This book was released on 2010 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the latest advances in the use of plants to produce medicinal drugs and vaccines, examines topics including plant tissue culture, secondary metabolite production, metabolomics and metabolic engineering, bioinformatics, molecular farming and future biotechnological directions.