Download or read book Engineering Synthetic Metabolons From Metabolic Modelling to Rational Design of Biosynthetic Devices written by Lars M. Voll and published by Frontiers Media SA. This book was released on 2016-07-19 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Download or read book Engineering Synthetic Metabolons From Metabolic Modelling to Rational Design of Biosynthetic Devices written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Download or read book Analytical Electrochemistry written by Joseph Wang and published by John Wiley & Sons. This book was released on 2004-03-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed guide to the principles, techniques, and instruments of electroanalytical chemistry-now expanded and revised Joseph Wang, internationally renowned authority on electroanalytical techniques, thoroughly revises his acclaimed book to reflect the rapid growth the field has experienced in recent years. He substantially expands the theoretical discussion while providing comprehensive coverage of the latest advances through late 1999, introducing such exciting new topics as self-assembled monolayers, DNA biosensors, lab-on-a-chip, detection for capillary electrophoresis, single molecule detection, and sol-gel surface modification. Along with numerous references from the current literature and new worked-out examples, Analytical Electrochemistry, Second Edition offers clear, reader-friendly explanations of the fundamental principles of electrochemical processes as well as important insight into the potential of electroanalysis for problem solving in a wide range of fields, from clinical diagnostics to environmental science. Key topics include: The basics of electrode reactions and the structure of the interfacial region Tools for elucidating electrode reactions and high-resolution surface characterization An overview of finite-current controlled potential techniques Electrochemical instrumentation and electrode materials Principles of potentiometric measurements and ion-selective electrodes Chemical sensors, including biosensors, gas sensors, solid-state devices, and sensor arrays

Download or read book Regenerated Organs written by Chandra P. Sharma and published by Academic Press. This book was released on 2021-01-13 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. Discusses recent advances in tissue and organ fabrication Provides translational-research aspects that are often lacking in existing literature Contains chapters that are multi-authored by international experts in the field

Download or read book Metabolic Engineering of Plant Secondary Metabolism written by R. Verpoorte and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant secondary metabolism is an economically important source of fine chemicals, such as drugs, insecticides, dyes, flavours, and fragrances. Moreover, important traits of plants such as taste, flavour, smell, colour, or resistance against pests and diseases are also related to secondary metabolites. The genetic modification of plants is feasible nowadays. What does the possibility of engineering plant secondary metabolite pathways mean? In this book, firstly a general introduction is given on plant secondary metabolism, followed by an overview of the possible approaches that could be used to alter secondary metabolite pathways. In a series of chapters from various authorities in the field, an overview is given of the state of the art for important groups of secondary metabolites. No books have been published on this topic so far. This book will thus be a unique source of information for all those involved with plants as chemical factories of fine chemicals and those involved with the quality of food and ornamental plants. It will be useful in teaching graduate courses in the field of metabolic engineering in plants.

Download or read book Life at the Speed of Light written by J. Craig Venter and published by Penguin. This book was released on 2014-09-30 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Venter instills awe for biology as it is, and as it might become in our hands.” —Publishers Weekly On May 20, 2010, headlines around the world announced one of the most extraordinary accomplishments in modern science: the creation of the world’s first synthetic lifeform. In Life at the Speed of Light, scientist J. Craig Venter, best known for sequencing the human genome, shares the dramatic account of how he led a team of researchers in this pioneering effort in synthetic genomics—and how that work will have a profound impact on our existence in the years to come. This is a fascinating and authoritative study that provides readers an opportunity to ponder afresh the age-old question “What is life?” at the dawn of a new era of biological engineering.

Download or read book 3D Printing in Medicine and Surgery written by Daniel J. Thomas and published by Woodhead Publishing. This book was released on 2020-08-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Printing in Medicine and Surgery: Applications in Healthcare is an advanced book on surgical and enhanced medical applications that can be achieved with 3D printing. It is an essential handbook for medical practitioners, giving access to a range of practical methods, while also focusing on applied knowledge. This comprehensive resource features practical experiments and processes for preparing 3D printable materials. Early chapters cover foundational knowledge and background reading, while later chapters discuss and review the current technologies used to engineer specific tissue types, experiments and methods, medical approaches and the challenges that lie ahead for future research. The book is an indispensable reference guide to the various methods used by current medical practitioners working at the forefront of 3D printing applications in medicine. Provides a detailed introduction and narrative on how 3-D printing can be used towards developing future medicine-based therapies Covers up-to-date methods across a range of application areas for the first time in book form Presents the only book on all current areas of 3D printing in medicine that is catered to a medical rather than engineering audience

Download or read book Climate Change Photosynthesis and Advanced Biofuels written by Ashwani Kumar and published by Springer Nature. This book was released on 2020-08-31 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of fossil fuels results in rising CO2 and other greenhouse gas (GHG) emissions, causing global temperature rise and climate change that will negatively impact human health, the food supply, and eventually worsen hunger and misery. Presently, fossil fuels meet 88% of the energy demand, resulting in rising CO2/GHG emissions at alarming rates. The increased use of biofuels would help to mitigate climate change. Efficiently designing methods for the production of biofuels and plant-derived high-value products requires a deeper understanding of photosynthetic processes as a prerequisite for applying novel biotechnologies. Accordingly, this book provides ample information and a wealth of illustrative examples. The book’s eighteen richly illustrated chapters are divided into three thematic parts. I: Photosynthesis and Biomass Production under Changing Conditions, II: Microalgae and Engineered Crops for Production of Biofuels and High-value Products, and III: Genetic Resources and Engineering Methods to Improve Crop Plants. Readers will find the latest information on the molecular basis of photosynthetic processes in plants (including the regulatory principles that allow plants to maintain homeostasis under changing conditions), stress resistance and synthetic pathways. In addition, the basic principles of important biotechnologies, as well as examples of specially designed crops capable of growing under stress conditions with improved productivity, are presented. The book sets the course for future research in the field of biofuel development and production and provides both general and specific information for students, teachers, academic researchers, industrial teams, and general readers who are interested in new developments concerning the production of biofuels with value-added properties.

Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Download or read book Microbial Metabolomics written by Edward E.K. Baidoo and published by Humana. This book was released on 2018-11-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume includes protocols that represent the breadth of microbial metabolomics approaches to both large-scale and small-scale experiments with intention of highlighting techniques that can be used for applications ranging from environmental microbiology to human disease. Utilizing mass spectrometry as their primary measurement tool, the chapters explore microbial metabolomics, metabolism and microbial physiology, metabolite sample preparation, current analytical techniques used to profile primary and secondary metabolites and lipids, as well as establishing data analysis workflows for targeted metabolomics, untargeted metabolomics, analysis of metabolic fluxes, and genome-scale models. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Metabolomics: Methods and Protocols serves as an ideal reference for both novice and advanced users and can be adapted to similar analytical platforms or customized to suit the needs of the researcher.

Download or read book Synthetic Biology of Cyanobacteria written by Weiwen Zhang and published by Springer. This book was released on 2018-08-08 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.

Download or read book Biotechnology of Isoprenoids written by Jens Schrader and published by Springer. This book was released on 2015-05-19 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Download or read book Terpenes written by Eberhard Breitmaier and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise overview of terpenes and their applications covers the structure, natural sources, biological and pharmacological effects, as well as selected total syntheses of the compound. This book includes a chapter on structure determination, as well as added information on biogenesis, polycyclic terpenes, gingkoloids and neo-hopanes. This title is an ideal introductory book for anybody starting work in this field.

Download or read book Bioreactor Engineering Research and Industrial Applications II written by Jie Bao and published by Springer. This book was released on 2015-11-26 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Download or read book Functional Metabolism written by Kenneth B. Storey and published by John Wiley & Sons. This book was released on 2005-02-25 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Download or read book Enzymatic Bioelectrocatalysis written by Kenji Kano and published by Springer Nature. This book was released on 2020-11-13 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the fundamental aspects of the electrochemistry and redox enzymes that underlie enzymatic bioelectrocatalysis, in which a redox enzyme reaction is coupled with an electrode reaction. Described here are the basic concept and theoretical aspects of bioelectrocatalysis and the various experimental techniques and materials used to study and characterize related problems. Also included are the various applications of bioelectrocatalysis to bioelectrochemical devices including biosensors, biofuel cells, and bioreactors. This book is a unique source of information in the area of enzymatic bioelectrocatalysis, approaching the subject from a cross-disciplinary point of view.