Download or read book Engineered Tissues Using Bioactive Hydrogels written by Di Huang and published by Frontiers Media SA. This book was released on 2022-08-22 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods in Bioengineering written by Francois Berthiaume and published by Artech House. This book was released on 2010-05 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is an emerging field that involves the combination of materials, cells, and other signals or growth factors to generate new tissue that can be used to repair or replace damaged tissues due to injury or disease. This groundbreaking volume presents the latest methods and protocols for systematically building tissues in 3D configuration outside the body, as well as providing techniques that modulate repair and regeneration processes that occur "in situ" (in their natural or original place).
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Hydrogels in Tissue Engineering written by Esmaiel Jabbari and published by MDPI. This book was released on 2018-08-24 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue " Hydrogels in Tissue Engineering" that was published in Gels
Download or read book Biomimetic biomaterials written by J. Zhu and published by Elsevier Inc. Chapters. This book was released on 2013-09-30 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are widely used in biomedical applications, especially tissue engineering. This chapter discusses recent progress in design and synthesis of biomimetic hydrogels as scaffolds for tissue engineering. An overview is given of the extracellular matrix (ECM) as a natural model for biomimetic modification of synthetic hydrogels, then bioactive molecules and approaches for preparing biomimetic hydrogels are described, followed by highlighting applications in bioengineering of various tissues. Finally, conclusions and perspectives are provided regarding biomimetic modification of hydrogels and challenges in developing biomimetic hydrogels as tissue-engineering scaffolds.
Download or read book Designing Cell responsive Hydrogels for Bioactive Tissue Engineering Constructs written by Derek R Jones and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-term viability of three-dimensional tissue engineered constructs remains a major hurdle due to challenges associated with mass transfer of oxygen, nutrients, and waste products. To address this shortcoming, this work focuses on designing cell-responsive materials to be utilized in a bioactive tissue engineered construct, with a particular emphasis on vasculogenesis. We hypothesized that highly tunable synthetic materials tailored with the appropriate bioactivity could allow for: cell attachment, cell mediated degradation, and growth factor release in vitro. To accomplish this, bio-inert PEG hydrogels were used as a scaffold substrate. To mimic the properties of the extracellular matrix (ECM), cell-adhesive peptide (CGRGDSP), enzyme-sensitive peptide (CGPQGIAGQC), and bi-functional peptide (CGPQGIAGQCGRGDSP) were incorporated into the hydrogel scaffold. This, in conjunction with multi-arm PEG acrylate and Michael Addition chemistry, allowed for the synthesis of bio-active hydrogels that could be synthesized free of cytotoxic photoinitiator, and had decoupled hydrogel properties for more appropriate comparison between formulations. The resulting hydrogels could bind cells as a function of cell adhesive peptide concentration and degrade as a function of collagenase. Separately, enzymatically degradable growth factor loaded nanoparticles were synthesized using a liposome template technique in conjunction with dehydration-rehydration loading. This allowed for a high concentration of growth factor to be loaded into nanoparticles, while simultaneously preventing the deactiviation of growth factor through extreme processing conditions. Moreover, through the incorporation of enzymatically degradable peptide (VPMSMRGG) into the backbone of these hydrogel nanoparticles, we alter the release profile of the growth factor both as a function of collagenase concentration as well as cell concentration. These bioactive constructs offer the increased ability for cells to manipulate their microenvironment, and show promise as materials to be used in vasculogenic tissue engineered constructs.
Download or read book Bioactive Hydrogels for Tissue Engineering written by Elsie Sarah Place and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hydrogels for Tissue Engineering and Regenerative Medicine written by J. Miguel Oliveira and published by Academic Press. This book was released on 2023-09-29 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field. Reviews the fundamentals and recent advances of hydrogels in tissue engineering and regenerative medicine applications Presents state-of-the-art methodologies for the synthesis and processing of different types of hydrogels Includes contributions by leading experts in engineering, the life sciences, microbiology and clinical medicine
Download or read book Biomaterial based Hydrogels written by Sougata Jana and published by Springer Nature. This book was released on with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Injectable Hydrogels for Regenerative Engineering written by Lakshmi S. Nair and published by World Scientific. This book was released on 2015-12-28 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Regenerative engineering, with its ability to foster novel therapeutic techniques and strategies, has emerged as the most versatile and innovative technology of the 21st century. The past few years have seen a significant interest in the development of injectable hydrogels as a delivery system to realize the dream of regenerative engineering. The book will explain synthetic approaches towards developing injectable hydrogels, and the clinical implications and applications of injectable hydrogels for engineering various tissues. Injectable Hydrogels for Regenerative Engineering is the first of its kind to bring together the fields of injectable hydrogels and regenerative engineering to give a perspective of the emerging therapeutic strategies for a wide audience."--
Download or read book Scaffolding In Tissue Engineering written by Peter X. Ma and published by CRC Press. This book was released on 2005-08-19 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.
Download or read book Biomedical Applications of Hydrogels Handbook written by Raphael M. Ottenbrite and published by Springer Science & Business Media. This book was released on 2010-09-05 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are networks of polymer chains which can produce a colloidal gel containing over 99 per cent water. The superabsorbency and permeability of naturally occurring and synthetic hydrogels give this class of materials an amazing array of uses. These uses range from wound dressings and skin grafts to oxygen-permeable contact lenses to biodegradable delivery systems for drugs or pesticides and scaffolds for tissue engineering and regenerative medicine. Biomedical Applications of Hydrogels Handbook provides a comprehensive description of this diverse class of materials, covering both synthesis and properties and a broad range of research and commercial applications. The Handbook is divided into four sections: Stimuli-Sensitive Hydrogels, Hydrogels for Drug Delivery, Hydrogels for Tissue Engineering, and Hydrogels with Unique Properties. Key Features: Provides comprehensive coverage of the basic science and applications of a diverse class of materials Includes both naturally occurring and synthetic hydrogels Edited and written by world leaders in the field.
Download or read book Multifunctional Hydrogels for Biomedical Applications written by Ricardo A. Pires and published by John Wiley & Sons. This book was released on 2022-05-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
Download or read book Injectable Hydrogels for 3D Bioprinting written by Insup Noh and published by Royal Society of Chemistry. This book was released on 2021-07-30 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels represent one of the cornerstones in tissue engineering and regenerative medicine, due to their biocompatibility and physiologically relevant properties. These inherent characteristics mean that they can be widely exploited as bioinks in 3D bioprinting for tissue engineering applications as well as injectable gels for cell therapy and drug delivery purposes. The research in these fields is booming and this book provides the reader with a terrific introduction to the burgeoning field of injectable hydrogel design, bioprinting and tissue engineering. Edited by three leaders in the field, users of this book will learn about different classes of hydrogels, properties and synthesis strategies to produce bioinks. A section devoted to the key processing and design challenges at the hydrogel/3D bioprinting/tissue interface is also covered. The final section of the book closes with pertinent clinical applications. Tightly edited, the reader will find this book to be a coherent resource to learn from. It will appeal to those working across biomaterials science, chemical and biomedical engineering, tissue engineering and regenerative medicine.
Download or read book Smart Hydrogels in Tissue Engineering and Regenerative Medicine written by Xing Wang and published by Frontiers Media SA. This book was released on 2020-06-16 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multifunctional Bioactive Polymers for the Fabrication of Tissue Engineering Scaffolds and the Treatment of Tissue Ischemia written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomaterials and Bioactive Molecules to Drive Differentiation in Striated Muscle Tissue Engineering written by Valentina Di Felice and published by Frontiers Media SA. This book was released on 2016-05-18 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is an innovative, multidisciplinary approach which combines (bio)materials, cells and growth factors with the aim to obtain neo-organogenesis to repair or replenish damaged tissues and organs. The generation of engineered tissues and organs (e. g. skin and bladder) has entered into the clinical practice in response to the chronic lack of organ donors. In particular, for the skeletal and cardiac muscles the translational potential of tissue engineering approaches has clearly been shown, even though the construction of this tissue lags behind others given the hierarchical, highly organized architecture of striated muscles. Cardiovascular disease is the leading cause of death in the developed world, where the yearly incidence of Acute MI (AMI) is approx 2 million cases in Europe. Recovery from AMI and reperfusion is still less than ideal. Stem cell therapy may represent a valid treatment. However, delivery of stem cells alone to infarcted myocardium provides no structural support while the myocardium heals, and the injected stem cells do not properly integrate into the myocardium because they are not subjected to the mechanical forces that are known to drive myocardial cellular physiology. On the other hand, there are many clinical cases where the loss of skeletal muscle due to a traumatic injury, an aggressive tumour or prolonged denervation may be cured by the regeneration of this tissue. In vivo, stem or progenitor cells are sheltered in a specialized microenvironment (niche), which regulates their survival, proliferation and differentiation. The goal of this research topic is to highlight the available knowledge on biomaterials and bioactive molecules or a combination of them, which can be used successfully to differentiate stem or progenitor cells into beating cardiomyocytes or organized skeletal muscle in vivo. Innovations compared to the on-going trials may be: 1) the successful delivery of stem cells using sutural scaffolds instead of intracoronary or intramuscular injections; 2) protocols to use a limited number of autologous or allogeneic stem cells; 3) methods to drive their differentiation by modifying the chemical-physical properties of scaffolds or biomaterials, incorporating small molecules (i.e. miRNA) or growth factors; 4) methods to tailor the scaffolds to the elastic properties of the muscle; 5) studies which suggest how to realize scaffolds that optimize tissue functional integration, through the combination of the most up-to-date manufacturing technologies and use of bio-polymers with customized degradation properties.
