Download or read book Endotoxemia and Endotoxin Shock written by C. Ronco and published by Karger Medical and Scientific Publishers. This book was released on 2010-06-02 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of endotoxin in the bloodstream is the consequence of an immunological response triggered by bacterial invasion of the host. This condition leads to altered cardiovascular function, lung dysfunction and acute kidney injury. Removing as much as possible of the circulating endotoxin is therefore imperative to mitigate its biological and clinical effects at the cellular, tissue and organ levels. The publication at hand summarizes the basic mechanisms, rationale and clinical results of a new therapeutic approach that promises to attain this goal: It consists of a specific hemoperfusion process that utilizes cartridges with immobilized polymixin B in an extracorporeal circuit.Containing contributions by renowned researchers, this book represents as a milestone in the field of extracorporeal therapies in sepsis. It will be a valuable reference work for both basic scientists and clinical professionals who want to keep abreast of current developments.
Download or read book Endotoxins Structure Function and Recognition written by Xiaoyuan Wang and published by Springer Science & Business Media. This book was released on 2010-06-30 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.
Download or read book Septic Shock Methods and Protocols written by Thomas J. Evans and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Septic shock remains a serious medical condition with high mortality. Despite many advances in intensive care medicine and antibiotic devel- ment, this has not changed appreciably in the last 20 years. Frustratingly, over the same period of time, enormous advances have been made in understa- ing the underlying pathogenic mechanisms of this condition. This has resulted in the development of several novel therapies for septic shock, which, despite excellent theoretical grounds for their efficacy, have failed in altering mort- ity attributable to sepsis. The reasons for these failures are multiple, but it is clear that further research is required aimed at increasing our understanding of the basic pat- physiological processes that occur following infection. Research into septic shock draws upon a number of different disciplines, ranging from molecular and cellular biology to physiological measurements on whole animals. Septic Shock Methods and Protocols is an attempt to draw together into one volume a number of protocols that are of use in the investigation of the mechanisms of septic shock. I have divided the book into five sections. The first deals with endotoxin, the lipopolysaccharide component of the Gram-negative cell m- brane that can mimic many of the features of septic shock. Gram-positive organisms are found increasingly as causes of septic shock, and several - pects of toxins produced from these bacteria are considered in the second s- tion.
Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
Download or read book Endotoxin and Sepsis written by Jack Levin and published by Wiley-Liss. This book was released on 1998-04-30 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Clinical and Biological Research, Volume 397 ENDOTOXIN AND SEPSIS Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy Proceedings of the Fourth Conference of the International Endotoxin Society Held in Nagoya, Japan, October 23-27, 1996 Jack Levin, Matthew Pollack, Takashi Yokochi, and Masayasu Nakano, Editors Recent breakthroughs in our understanding of the molecular biology of the human immune response have lead to important advances in the recognition and treatment of sepsis. Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy compiles the latest basic and clinical research on many aspects of sepsis, including sepsis/SIRS. It provides researchers and clinicians with an up-to-date overview of the critical data and concepts in this rapidly progressing field of inquiry. Featuring contributions by researchers and clinicians from around the world, this book presents papers covering a broad spectrum of specialized topics in the bacteriology, biochemistry, molecular and cellular interactions, pathophysiology, and pharmacodynamics of sepsis/SIRS. It also presents information on in vivo detection and potential new therapies that target sepsis and its cellular effects. Specific topics covered in Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy include: Enzymes essential to the biosynthesis of Lipid A and their importance in the design of a new generation of antibiotics Recent breakthroughs in the understanding of the role of CD-14 in cellular resistance to infection and its therapeutic implications The role of Interleukin 6 in endotoxin-induced inflammatory response The molecular mechanisms responsible for endotoxin tolerance Unique chemical and biological features of LPS, and natural and synthetic LPS control mechanisms. Endotoxin and Sepsis: Molecular Mechanisms of Pathogenesis, Host Resistance, and Therapy is must reading for laboratory and clinical microbiologists, immunologists, and other investigators studying bacterial endotoxins, and specialists in internal medicine. It will also be of interest to biotechnology and pharmaceutical researchers involved with the development of new drugs to combat sepsis.
Download or read book Endotoxin Induced Shock a Multidisciplinary Approach in Critical Care written by Silvia De Rosa and published by Springer Nature. This book was released on 2023-01-12 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation. The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption. Each section includes •) brief pathophysiology; •) principles of management; •) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal. The book – written by international opinion leaders of this field – is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material.
Download or read book Endotoxin in Health and Disease written by Helmut Brade and published by CRC Press. This book was released on 2020-10-28 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Download or read book Handbook of Sepsis written by W. Joost Wiersinga and published by Springer. This book was released on 2018-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Download or read book Immune Response in the Critically Ill written by John C. Marshall and published by Springer Science & Business Media. This book was released on 2002-01-21 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.
Download or read book Sepsis written by Marijke van Oosten and published by . This book was released on 1998 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Aspects of Endotoxin Shock written by Richard Allan Proctor and published by Elsevier Science & Technology. This book was released on 1986 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Yearbook of Intensive Care and Emergency Medicine 2009 written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2009-06-09 with total page 989 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Download or read book Health Professionals for a New Century written by and published by Harvard School of Public Health, Frangois-Xavier Bagnoud Cen. This book was released on 2011 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: One hundred years ago a series of seminal documents, starting with the Flexner Report of 1910, sparked an enormous burst of energy to harness the power of science to transform higher education in health. Professional education, however, has not been able to keep pace with the challenges of the 21st century. A new generation of reforms is needed to meet the demands of health systems in an interdependent world. The report of the Commission on the Education of Health Professionals for the 21st Century, a global independent initiative consisting of 20 leaders from diverse disciplinary backgrounds and institutional affiliations, articulates a fresh vision and recommends renewed actions. Building on a rich legacy of educational reforms during the past century, the Commission's findings and recommendations adopt a global and multi-professional perspective using a systems approach to analyze education and health, with a focus on institutional and instructional reforms.
Download or read book Handbook of Mediators in Septic Shock written by Edmund A. Neugebauer and published by CRC Press. This book was released on 2019-07-23 with total page 799 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mediators in Septic Shock presents a comprehensive, systematic evaluation of the various putative mediators of septic shock through the use of meta-analysis. Experts of individual mediators have objectively evaluated the collective literature using classical Koch-Dale Criteria for causal relationships. A decision tree approach has been used to analyze the existing evidence for each of the four Koch-Dale Criteria for each individual mediator of septic shock. The book provides an integrated perspective that describes how these many mediators interact. It also covers how advances in mathematical modeling of complex realities are applied to the field of septic shock pathogenesis. CRC Handbook of Mediators in Septic Shock will be a useful reference for emergency room and intensive care physicians, trauma specialists, pathophysiologists, physiologists, biochemists, pharmacologists, and others interested in the topic. Features
Download or read book Gram Negative Bacterial Infections and Mode of Endotoxin Actions written by Bernhard Urbaschek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relevance of international symposia and congresses has been questioned with increasing frequency. All too often, presentations at such meetings are meaningful only for very few members of the audience; fundamental scientific principles and relationships between disciplines are not always taken into account. Under present conditions rapid sharing of new information is highly desirable. However, many journals do not lend themselves to speedy exchange of information, nor do many provide the opportunity for the publication of discussion by various specialists of problems arising from different disciplines. Symposia may lend themselves, perhaps more readily, to the identification of current knowledge and the exchange of thoughts between scientists from various fields. It was particularly opportune to have the present symposium held in Vienna, where as early as 1365 the University was founded and where the medical sciences have played a dominant role in the investigation of the nature of diseases. It was the aim of the organizer to provide in this city the opportunity for the exchange of information and of thoughts between scientists from different disciplines and different countries. One of the many current, important problems relates to the fundamental basis of the pathogenesis of gram-negative infections. Information on immune mechanisms against these infections is in adequate; the relative role of non-specific resistance and specific immunity has not been fully elucidated. Problems regarding active immunization and the effectiveness of passively administered immuno globulins still exist even today.
Download or read book Nephrology and Public Health Worldwide written by G.B. Silva Junior and published by Karger Medical and Scientific Publishers. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.
Download or read book Sepsis and Non infectious Systemic Inflammation written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2008-11-24 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.
