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Book Endocrine Disrupters and Metabolism

Download or read book Endocrine Disrupters and Metabolism written by Yann Gibert and published by Frontiers Media SA. This book was released on 2020-01-20 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies

Download or read book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer. This book was released on 2021-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies

Download or read book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2020-08-04 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Book Innovative Medicine

    Book Details:
  • Author : Kazuwa Nakao
  • Publisher : Springer
  • Release : 2015-10-13
  • ISBN : 4431556516
  • Pages : 330 pages

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Book Endocrine Disruption and Human Health

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Book Environmental Impacts on Reproductive Health and Fertility

Download or read book Environmental Impacts on Reproductive Health and Fertility written by Tracey J. Woodruff and published by Cambridge University Press. This book was released on 2010-01-28 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.

Book Environmental Endocrinology and Endocrine Disruptors

Download or read book Environmental Endocrinology and Endocrine Disruptors written by Rosario Pivonello and published by Springer Nature. This book was released on 2023-04-20 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.

Book Endocrine Disruption and Human Health

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2021-09-19 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Book Endocrine Disruptors and Puberty

    Book Details:
  • Author : Evanthia Diamanti-Kandarakis
  • Publisher : Springer Science & Business Media
  • Release : 2011-12-01
  • ISBN : 1607615614
  • Pages : 383 pages

Download or read book Endocrine Disruptors and Puberty written by Evanthia Diamanti-Kandarakis and published by Springer Science & Business Media. This book was released on 2011-12-01 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Book Sicker  Fatter  Poorer

Download or read book Sicker Fatter Poorer written by Leonardo Trasande and published by Houghton Mifflin. This book was released on 2019 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.

Book Endocrine Disruption

    Book Details:
  • Author : David O. Norris
  • Publisher : Oxford University Press
  • Release : 2006
  • ISBN : 0195137493
  • Pages : 492 pages

Download or read book Endocrine Disruption written by David O. Norris and published by Oxford University Press. This book was released on 2006 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the biological effects of the large number of compounds that have been recognized as endocrine disrupters. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the state of understanding for the field.

Book Trends in Elevated Triglyceride in Adults  United States  2001 2012

Download or read book Trends in Elevated Triglyceride in Adults United States 2001 2012 written by Margaret D. Carroll and published by . This book was released on 2015 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Treating Endocrine and Metabolic Disorders With Herbal Medicines

Download or read book Treating Endocrine and Metabolic Disorders With Herbal Medicines written by Hussain, Arif and published by IGI Global. This book was released on 2020-12-11 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The utilization of herbal medicine to treat endocrine and metabolic disorders has garnered much attention within the past few decades. Specifically, the popularity of using dietary supplements for the management of chronic disorders has drastically increased, with a wide variety of these products available over the counter. They represent an attractive adjuvant to traditional therapy for their lower toxicity and their easy accessibility. The identification of such dietary compounds has prompted researchers to explore the vast array of their beneficial effects. However, despite their widespread use, there is still limited data on the safety and efficacy of the products currently on the market. Current research on the side effects and safe usage of herbal medicines is necessary for providing optimal care and counseling for patients. Treating Endocrine and Metabolic Disorders With Herbal Medicines is a comprehensive reference book focused on spreading awareness on the safety, potential harmful effects, and rational use of herbal medicines. The chapters within explore and provide insight on the effectiveness, versatility, and side effects of various herbal medicines across a range of different diseases and conditions. While highlighting herbal medicine in areas such as diabetes, cancer, infertility, and endocrine disorders, this publication is ideally intended for clinical practitioners, pharmaceutical scientists, doctors, practitioners, stakeholders, researchers, academicians, and students interested in enhancing their knowledge and awareness in the field of complementary medicine.

Book Endocrine Disruptors  Brain  and Behavior

Download or read book Endocrine Disruptors Brain and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017-04-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Book Endocrine Disruption in Fish

    Book Details:
  • Author : David E. Kime
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 1461549434
  • Pages : 402 pages

Download or read book Endocrine Disruption in Fish written by David E. Kime and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Book The Endocrine Disruptors

Download or read book The Endocrine Disruptors written by Maria Marino and published by . This book was released on 2007-01-01 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, it has become evident that many chemicals present in the environment can mimic, antagonize or alter the physiological actions of endogenous hormones. These compounds have been termed endocrine disrupters (EDs) and defined as exogenous substances that cause adverse health effects in an intact organism or in its progeny, consequent to changes in endocrine function [1]. EDs, even when present in minute amounts (part per trillion), could interfere with the synthesis, secretion, transport, metabolism, binding, action, or elimination of natural hormones responsible for homeostasis maintenance, reproduction, and developmental processes [2]. Currently more than 100 chemicals have been identified as EDs. Within this heterogeneous group of molecules we find: (a) synthetic chemicals used in industry, agriculture, and consumer products; (b) synthetic chemicals used as pharmaceutical drugs; and (c) natural chemicals found in human and animal food. About half of these compounds are substituted with halogen groups, mostly chlorine and bromine, and include dioxins, polychlorinated biphenyls, organochlorine pesticides, methoxychlor, dieldrin, and hexachlorocyclohexane. EDs have long environmental half-life resulting in a continue increase of their global concentration in the environment and can be detected and may concentrate at great distances from where they are produced, used or released. EDs have very low water solubility and extremely high lipid solubility, leading to their bioaccumulation in adipose tissue. Exposure to EDs can occur from a number of different sources: humans and animals can be exposed involuntarily by drinking contaminated polluted water, breathing contaminated air, ingesting food, contacting contaminated soil or even in the workplace. Although endocrine disruption has only received high-profile attention for just over a decade [2], the phenomenon does have a longer historical background. In the early 1900s, pig farmers in the USA complained of fertility problems in swine herds fed on moldy grain [3], and concern was stimulated in the 1940s by reports of infertility in sheep grazing on certain clovers in Western Australia [4]. Over the following two decades, estrogenic actions were evidenced in birds [5] and in mammals [6] owing to the dissemination of the agrochemical orto-dichlorodiphenyltrichloroethane (DDT), at the same time masculinization of bivalves and gastropods[7], with concomitant declines in population, was found in the 1970s with the introduction of tributyltin into antifouling paints for the boats, while feminization of fishes was observed in UK rivers in the presence of estrogenic components in sewage effluent [8]. Also the occurrence of genital abnormalities in both male and female alligators in Lake Apopka (FL, USA) were observed as effect of a spill of the pesticide difocol in 1980. After these first observations the scientific community increased the awareness of the consequences of exposure to chemicals which can interfere with reproductive functions [9]. Endocrine disruption in wildlife is now acknowledged to be a widespread problem, much resulting from environmental pollution, and, in the case of aquatic forms of wildlife, from the continuous exposure to these chemicals in the water. Extrapolation of the results of these researches on wildlife resulted in concern that the same compounds could interfere with hormone action in humans. Handling hazardous substances and the risk of exposure to chemicals are a painful part of modern life, as technology and science progress. Moreover, exposure to chemicals present in foods, at home, and at work is an important risk factor for human health, especially since our scientific knowledge is still not sufficient to ensure proper prevention. Nowadays there is justifiable concern that endocrine disruption could be the underlying cause of increasing female and male reproductive problems, thus endocrine disruption is one of the topics receiving much attention throughout all sectors of the society, and the debate between pharmaceutical companies and public health organisms is increasing. Both parts will call for urgent need of more research. The scientific challenge for the future is to identify the relevant real-life sources of exposure of the human population to endocrine-disrupting compounds and to find the appropriate remediation actions. This can be done: (a) by assessing the impact on human health of long-term, low-dose exposure to such chemicals; (b) by understanding the synergistic effects of the copious number of chemicals to which humans and animals are exposed; (c) by defining the variety of underlying mechanisms at molecular, cellular and physiological level, (d) by exploiting new technologies addressed to the remediation of the environment polluted by the presence of EDs, and (e) by designing and developing new sensors or biosensors capable of determining their concentration in traces. The review presented in this book has been written under the sponsorship of the Interuniversitary Consortium National Institute of Biostructures and Biosystems (INBB) , constituted by 26 Public Italian Universities. INBB is stimulating the research on endocrine disruptors, by encouraging and coordinating joint research projects between its members and those of other Italian public scientific institutions. This book represents one of the results of the meeting The biological and clinical research on endocrine disruptors: current status and perspectives , held in Rome during 2005 from October 27 to 28 and organized by INBB and ISPESL (Istituto Superiore Prevenzione e Sicurezza del Lavoro). The first three chapters of this book review the EDs effects on natural population living in aquatic ecosystems where EDs, due to their lipophilicity, tend to concentrate in sediments and in food webs. The edible mussel Mytilus (Chapter 1), a marine bivalve that can accumulate large amounts of organic contaminants, represents a species of economical, ecological and public health-related interest. Amphibians (Chapter 2) are favourite models for studying various aspects of reproduction, development of the central nervous system and metamorphosis. Moreover, there is great concern about the EDs and the dramatic decline of wild amphibian populations. In Chapter 3 different species of fishes are considered as experimental models to analyze, by both genomic and proteomic approaches, the expression of key molecules involved in reproduction and in detoxification processes. The following two chapters focus on the EDs effects on thyroid functions and on the development of central mechanisms controlling reproduction. Wildlife observations in polluted areas clearly demonstrate a significant incidence of thyroid imbalance in several species. Several EDs are now known or suspected to be thyroid disruptors altering thyroid economy at multiple levels. These compounds may interfere with thyroid homeostasis through many mechanisms of action, at receptor level, in binding to transport proteins, in cellular uptake mechanisms or in modifying the metabolism of thyroid hormones. Chapter 4 offers a focus on endocrine disrupting activity of chemical compounds on thyroid function. The dimorphic control of reproductive functions depends on the ability of the central nervous system, particularly the hypothalamus, to respond properly to circulating reproductive hormones. This ability is acquired during a perinatal critical period, when the presence of different levels of sex steroid hormones in male and female fetuses/neonates induces a sex-specific morpho-functional development of the neuronal networks controlling reproduction. The perinatal stage is thus particularly sensitive to endogenous or exogenous substances that interfere with the activities of sex steroid hormones. Chapter 5 summarizes the current knowledge on the neuro-endocrine disrupting potential of the perinatal exposure to the major classes of EDs focusing the attention on animal studies aimed to identify the EDs action mechanisms and the resulting impairment of the reproductive behavior. Flavonoids are defined as naturally occurring molecules of plant origin, capable of acting as hormone mimetics or antagonists, but also as endocrine disruptors. Many of them have been marketed as dietary supplements or nutraceuticals with health claims, thus leading to significant increase in flavonoid consumption levels in the Western population. Even though several reports suggest for these compounds health-promoting effects in preventing age-related diseases such as atherosclerosis, hormone-dependent cancers, and osteoporosis, the mechanistic aspects of their activity have not been fully clarified and a wide consensus of the pros and cons of their use in humans has not been reached by the scientific community. Chapter 6 presents an overview of the state of the art of the knowledge on the molecular mechanisms underlying flavonoids estrogen-like activity. Feed additives represent a major issue for the safety of foods of animal origin, as they constitute the bulk of chemicals used in animal production. Feeds can also be a major vehicle for human dietary intake of persistent EDs (Chapter 7). Farm animals ingest these substances with food and drinking water and it is likely that the range of ingestion will increase in the future as growing amounts of sewage sludges are recycled onto agricultural land with an overall increase of environmental contamination exerting adverse effects on human health. Research on how the exposure to EDs affects human health in the work environment (Chapter 8) attracts increasing attention among international scientists. Certain workplaces pose particular problems as regards the potential risk connected to processes involving the use, manufacture and handling of these chemicals, and the type of job that puts workers at greatest risk of contact with them. Some EDCs represent occupational risk factors credibly capable of inducing hormone-dependent tumors. Occupational exposure to EDs is a highly complicated question: risk factors in the workplace must be identified; how they penetrate the body has to be established; confounding factors in everyday environments are numerous, and it is hard to make a definite diagnosis of their effects on human health. Owing to the harmful health effects of EDs, the attention of many scientists has been attracted towards the remediation of environment polluted by their presence and the design and development of sensors or biosensors capable of determining their concentration in traces. In Chapter 9 the experimental results concerning the enzymatic remediation of waters polluted by Bisphenol A (BPA), taken as a model of endocrine disruptors, is discussed in view of the potential application of the technology of non-isothermal bioreactors to the treatment of polluted waters. Also the functioning of a tyrosinase-based sensor able to measure the BPA concentration in traces is presented in the same chapter. These reviews emphasize that many environmental chemicals possess endocrine-disrupting properties, and that exposure to such chemicals can have adverse effects on health and reproduction even at very low concentrations. Great care should be used when attempting to apply these data to other species or real life situations. Indeed only a paucity of information is available on the metabolism and tissue distribution of these chemicals which may vary according to species physiology as well as to levels and duration of exposure. Furthermore, the possible interactions between single contaminants of the complex mixtures present in the environment may induce completely unpredictable effects, due to synergies or reciprocal inhibition effects, suggesting great caution in drawing conclusions. It is hoped that these reviews will serve to stimulate further research on EDs and human health. References 1.Report of the proceedings of the European workshop on the impact of endocrine disrupters on human health and wildlife. 1996, Weybridge, UK, report EUR17549 of the environment and climate change research programme of DGXII of the European commission. 2.Colborn T, vom Saal FS & Soto AM. Environ Health Perspectiv 1993, 101, 378 384. 3.McNutt SH, Purwin P & Murray C. J Amer Veterinary Medical Ass 1928, 73, 484. 4.Bennets H, Underwood EJ & Shier FL. Australian Veterinary Journal 1946, 22, 2 12. 5.Burlington H & Linderman VF. Proceedings of the Society for Experimental Biology and Medicine 1950, 74, 48 51. 6.Bitman J, Cecil HC, Harris SJ & Fries GF. Science 1968, 162, 371 372. 7.Matthiessen P. Pure and Applied Chemistry 2003, 75, 2197 2206. 8.Jobling S, Nolan M, Tyler CR et al. Environmental Science and Technology 1998, 32, 2498 2506. 9.Guillette Jr. LJ & Gunderson MP. Reproduction 2001, 122, 857 864.

Book Environmental Endocrinology

    Book Details:
  • Author : I. Assenmacher
  • Publisher : Springer Science & Business Media
  • Release : 2013-03-07
  • ISBN : 3642669816
  • Pages : 344 pages

Download or read book Environmental Endocrinology written by I. Assenmacher and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 11 to 15 July 1977 about 60 physiologists, endo crinologists, ecologists and other biologists from 14 countries convened at the University Montpellier for a symposium on Environmental Endocrinology. This meet ing was organized as a Satellite Symposium of the 27th International Congress of Physiological Sciences, Paris, 18-23 July 1977. This volume is a record of the com munications presented at the symposium. The objectives of the program were to examine the role of the endocrine system in a wide spectrum of adjustments and adaptations to changes in environmental conditions by various spe cies of animals, including man, and to promote an ex change of ideas among investigators who have approached these functions from diverse aspects. The diversity of the information and ideas communicated is great. Of necessity, they represent only an extremely modest se lection of the many facets of endocrine function in the interaction of animals with their environments. Be yond the usefulness of the communications individually, we hope that they collectively demonstrate the substan tial heuristic value of the concept of environmental endocrinology as it was perceived by the participants. We acknowledge gratefully the kindness and sympathy of Professor Jaques ROUZAUD, President of the University of Montpellier II, for his generous extension of the hospitality of the University to the Symposium. We are most grateful to Mrs. Monique VIEU who effected so well the secretarial organization of the Sympos.