Download or read book Enantioselective C C Bond Forming Reactions written by and published by Elsevier. This book was released on 2023-12-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enantioselective C-C Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to Chirality, Metal-catalyzed stereoselective C-C-bond forming reactions, Enantioselective C-C bond forming reactions promoted by organocatalysts based on unnatural amino acid derivatives, Enantioselective C-C bond formation in complex multicatalytic system, Gold-based multicatalytic systems for enantioselective C-C Bond forming reactions, Novel enzymatic tools for C-C bond formation through the development of new-to-nature biocatalysis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Catalysis serials Updated release includes the latest information in the field
Download or read book Enantioselective Catalytic Carbon carbon Bond forming Reactions written by Mark Stephen Taylor and published by . This book was released on 2005 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantioselective Organocatalyzed Reactions II written by Rainer Mahrwald and published by Springer Science & Business Media. This book was released on 2011-08-03 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes; d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.
Download or read book Enantioselective Organocatalyzed Reactions II written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book C H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Download or read book Catalytic Enantioselective Carbon phosphorus Bond Forming Reactions written by Pietro Butti and published by . This book was released on 2009 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of Nickel catalyzed C C Bond Forming Reactions and Catalytic Enantioselective Trifluoromethylthiolations written by Xiangqian Liu and published by . This book was released on 2016* with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book I Enantioselective Total Synthesis of Quinine and Quinidine written by Izzat Tiedje Raheem and published by . This book was released on 2007 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: II. Thiourea-catalyzed enantioselective C-C bond-forming reactions. The discovery, development, and mechanistic study of new thiourea-catalyzed asymmetric C-C bond-forming reactions are detailed.
Download or read book Enantioselective CpRu catalyzed Decarboxylative C C Bond Forming Reactions written by David Linder and published by . This book was released on 2008 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: La combinaison du précatalyseur stable à l'air [CpRu([eta]6-C10H8)] [PF6] avec des ligands de type pyridine-monooxazoline a permis de développer une nouvelle stratégie pour effectuer des réactions de substitution allyliques avec des conditions expérimentales simples. Cette famille de ligands est apparue particulièrement appropriée pour effectuer l'étude de réactions du type réarrangement de Carroll. Le mécanisme de cette réaction a été étudié et un cycle catalytique raisonnable en a découlé. Une stratégie de double activation par co-catalyse a donc été développée: l'utilisation synergique de sels de magnésium a permis d'effectuer ces réactions à température ambiante et donc de manière plus sélective.
Download or read book P stereogenic Ligands in Enantioselective Catalysis written by Arnald Grabulosa and published by Royal Society of Chemistry. This book was released on 2011 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: P-stereogenic ligands were among the first to be used in asymmetric catalysis but synthetic difficulties and prejudices have hampered their development. However, continuous screening for new chiral ligands means that they can no longer be ignored and this rigorous reference source reflects their renaissance.The book is filled with many examples from recent primary literature. The synthetic chemist will easily be able to follow the preparation methods which are accompanied by a description of the challenges and limitations. Those working in homogenous catalysis, and wanting to increase their repertoire of ligands, will be able to establish which have already been used in each reaction and their performance.This book provides comprehensive coverage of the application of P-stereogenic ligands in homogeneous catalysis. It begins with a brief chapter on generalities of P-stereogenic compounds: history, configurational stability, and interconversions among them.The book then goes on to describe the main preparative methods, from resolution of racemates to enantioselective catalysis, before focusing on the catalytic applications of P-stereogenic ligands. Chapter 7 describes the use of the ligands in catalytic hydrogenation and related reactions whereas chapter 8 deals with other reactions, mainly C-C bond forming reactions. The aim of these two final chapters is to give an outline of the usefulness of the ligands in homogeneous catalysis.
Download or read book Highly Stereoselective Carbon carbon Bond forming Reactions written by Jeff D. McGilvra and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book C H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-08-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Download or read book Asymmetric Catalysis of Carbon carbon Bond Forming Reactions Through Hydrogen Bonding written by Vijaya Bhasker Gondi and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of Novel Methods for the Formation of C C and C N Bonds written by Christopher Andre Kalnmals and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon and carbon-nitrogen bonds are some of the most common motifs in organic molecules and as a result, the invention of new methods for selectively forming these bonds is highly important. The first half of this thesis describes the discovery of two novel and unexpected carbon-carbon bond forming reactions, and also includes a review on the unique chemistry of geminal and vicinal bis(sulfones). The second half of this work deals with enantioselective carbon-nitrogen bond formation, and describes the development of two transition metal-catalyzed asymmetric allylic alkylation reactions. It also contains a review on annulative allylic alkylation reactions between dual electrophiles and dual nucleophiles and their applications in complex molecule synthesis.
Download or read book Asymmetric Catalysis of Carbon carbon Bond Forming Reactions written by Souvagya Biswas and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has established numerous methods for synthesis of complex molecules utilizing simple and abundant resources such as the use of CO2, H2O and N2 using sunlight as a source of energy. Even more impressive are the high chemo-, regio-, and stereoselectivites observed in these transformations with a wide variety of both prochiral and chiral substrates. However, methods for the enantioselective incorporation of feedstock materials such as CO, HCN, CO2 or simple alkenes into prochiral molecules are limited and remain an important challenge in the field. The hydrovinylation reaction (HV), where ethylene is added across a carbon-carbon double bond, has been known for nearly fifty years, starting with the works of Hata, Alderson and Wilke. During the past few years, through an approach that relied mostly on mechanistic insights and systematic examination of ligand effects, our group discovered a number of protocols for Ni(II)- and Co(II)-catalyzed enantioselective hydrovinylation (HV) reactions of vinylarenes, 1,3-dienes and strained olefins. While the Ni(II)-catalyzed hydrovinylation (HV) reaction is one of the most selective asymmetric catalyzed carbon-carbon bond forming reactions, its use has been limited to alkenes conjugated to an aromatic ring and strained alkenes. We recently found Co(II)-bisphosphine complexes show much improved regioselectivity with broader functional group compatibility in 1,3-dienes. By utilizing finely tuned catalysts derived from Co(II)-bisphosphine complexes and Me3Al or methylaluminoxane (MAO) acyclic (E) and (Z)-1,3-dienes were found to undergo efficient hydrovinylation giving mostly 1,4-hydrovinylation products in an atmosphere of ethylene. In order to expand the hydrovinylation chemistry, we turned our attention to one of the mostly widely used intermediates on organic chemistry, viz., silyl enol ethers. Trialkylsilyl enol ethers are exceptionally versatile intermediates often used as enolate surrogates for the synthesis of carbonyl compounds. Yet there are no reports of broadly applicable, catalytic methods for the synthesis of chiral silyl enol ethers carrying latent functionalities useful for synthetic operations beyond the many possible reactions of the enol ether moiety itself. The work presented herein reports a general procedure for highly catalytic (substrate : catalyst ratio up to 1000:1) and enantioselective (96% to 98% major enantiomer) synthesis of silyl enol ethers bearing a vinyl group at a chiral carbon at the beta-position. The reactions, run under ambient conditions, use trialkylsiloxy-1,3-dienes and ethylene (1 atmosphere) as precursors, and readily available (bis-phosphine)-cobalt(II) complexes as catalysts. Once we have established the HV reaction conditions of the siloxydienes, we turn our attention towards diastereoselective functionalization of the hydrovinylated products. Under optimized conditions, we are able to successfully utilize our 1,4-hydrovinylated products as reactive nucleophilic synthons for several electrophilic reactions keeping moderate to good diastereomeric ratios. The silyl enolates can be readily converted into novel enantiopure vinyl triflates, a class of highly versatile cross-coupling reagents, enabling the syntheses of other enantiomerically pure trisubstituted alkene intermediates not easily accessible by current methods.
Download or read book Enantioselective Reactions in Organic Chemistry written by Otakar Červinka and published by . This book was released on 1995 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantioselective Organocatalyzed Reactions I written by Rainer Mahrwald and published by Springer Science & Business Media. This book was released on 2011-08-03 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes; d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.
