Download or read book Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs written by Rainer H. Müller and published by CRC Press. This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore possible new approaches for overcoming poorly soluble drugs - a challenge to drug formulation work and an increasing problem. Many newly developed drugs are poorly soluble, very often simultaneously in aqueous and in organic media. Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs aims to: review the possibilities, limitations and future perspectives of emulsions as drug carriers considering technology from other than the phamaceutical industry (i.e food industry). show the production technology of nanosuspensions, explain the special dissolution properties (i.e. increased saturation solubility) and increased dissolution velocity (theory), and cover the possible applications. present the theory of high pressure homogenization and high pressure extrusion in dispersion techniques, including examples of applications and size measurements in concentrated dispersions.

Download or read book Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs written by Rainer H. Müller and published by . This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanodispersions for Drug Delivery written by Raj K. Keservani and published by CRC Press. This book was released on 2018-09-24 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems. The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves. Key features: • Provides an overview of nanoemulsions for drug delivery • Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems • Presents information relevant to specific routes of applications of nanoemulsions • Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration • Explores nanomicellar approaches for drug delivery • Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery

Download or read book Drug Delivery Strategies for Poorly Water Soluble Drugs written by Dionysios Douroumis and published by John Wiley & Sons. This book was released on 2012-12-19 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.

Download or read book Formulating Poorly Water Soluble Drugs written by Robert O. Williams III and published by Springer Science & Business Media. This book was released on 2011-12-04 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.

Download or read book Pharmaceutical Emulsions and Suspensions written by Françoise Nielloud and published by CRC Press. This book was released on 2000-02-25 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility. This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs. Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents. Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions discusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more! Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.

Download or read book Nanoemulsions written by Seid Mahdi Jafari and published by Academic Press. This book was released on 2018-02-24 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. - Summarizes general aspects of food nanoemulsions and their formulation - Provides detailed information on the production, application, and characterization of food nanoemulsion - Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations - Explains preparation of nanoemulsions by both low- and high-energy methods

Download or read book Oral Lipid Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Download or read book Water Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2018-03-12 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Download or read book Encyclopedia of Colloid and Interface Science written by Tharwat Tadros and published by Springer. This book was released on 2013-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive reference relevant to all scientists and engineers in the field. This encyclopedia not only helps chemistry, materials science and physics researchers to understand the principles, but also provides practicing engineers with the necessary information for implementing practical applications, such as Food and agrochemicals Polymers and ceramics Cosmetics and detergents Paints and coatings Pharmaceuticals and drug delivery In addition, the encyclopedia is an important reference for industrial chemists and chemical engineers faced with a multitude of industrial systems of a colloidal nature. As wide as the range of applications that colloid and interface science has is the range of scientific disciplines that contribute to research and development in this field. These encompass chemistry, physics, biology and mathematics as well as nanoscience and nanotechnology. The encyclopedia provides easy-to-digest information for meeting these interdisciplinary challenges. While providing numerous concise definitions of key terms, the encyclopedia also features more than forty in-depth essays on topics ranging from Agrochemical Formulations to Zeta Potential. All entries are cross-referenced and include selected references to original literature as well as synonyms.

Download or read book Pharmaceutical Suspensions written by Alok K. Kulshreshtha and published by Springer Science & Business Media. This book was released on 2009-11-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Download or read book The Production and Stabilization of Pharmaceutical Nanosuspensions written by Francis S. Romanski and published by . This book was released on 2011 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: The production and stabilization of pharmaceutical nanosuspensions has been a recent focus of the pharmaceutical industry where it has been shown that nanosuspensions of poorly water-soluble drugs exhibit a greatly increased dissolution rate, and as a consequence, an increased in vivo bioavailability. Accordingly, the ability to manufacture stable pharmaceutical nanosuspensions in a fast, safe, and predictable manner would be highly advantageous. However, the small size is not without consequence; the prodigious amount of available surface area in combination with van der Waals forces quickly cause irreversible agglomeration, destroying the desired properties, and thus requiring the use of surfactants for any combination of steric, electrostatic, and kinetic stabilization. As a result, this work focused on two distinct methods for producing pharmaceutical nanosuspensions, as well as the important role that surfactants play in stabilization. In the first method, high pressure homogenization was used to mill suspensions by forcing them through a minute piston gap, where particles were subjected to a combination of shear, cavitation, and grinding. This technique was optimized for use by incorporating excipients for novel formulations in situ with the goal of producing capsules, films, and oral-suspensions. Alternatively, the shortcomings present in all accepted nano-sizing methodologies led to the development of the emulsion precipitation method. In this process, nanoparticles as small as 60 nm were produced by extracting drug nanoparticles from an O/W emulsion made from partially miscible components. It was found that formulations utilizing any one of five contrastive solvents could be used to create nanosuspensions based not on intrinsic drug properties, but rather on droplet size, solvent diffusion, and surfactant choice, rendering this technique arguably the most robust currently available. Finally, the recurrent issue of stability was addressed through a series of molecular dynamics simulations and corresponding experiments to elucidate the molecular phenomena present at the surfaces of nano-scale crystals. Several case studies measured the interfacial binding energy between a surfactant and a crystal surface, where strong interactions were indicative of a longer shelf-life, quenched growth rates, and predictable crystal morphologies. It is hoped, that the culmination of this work will greatly advance our ability to produce, stabilize, and deliver poorly-soluble drugs.

Download or read book Formulating Poorly Water Soluble Drugs written by Robert O. Williams III and published by Springer. This book was released on 2023-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.

Download or read book Physicochemical Principles of Pharmacy written by Alexander T Florence and published by Pharmaceutical Press. This book was released on 2015-12-01 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 6th edition of the established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.

Download or read book Novel Drug Delivery Technologies written by Ambikanandan Misra and published by Springer Nature. This book was released on 2020-02-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

Download or read book Pharmaceutical Emulsions written by Dipak Kumar Sarkar and published by John Wiley & Sons. This book was released on 2013-07-26 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Emulsions: A Drug Developer's Toolbag covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for its application. The author uses his extensive experience in both industry and academic experience to provide a concise, student friendly guide to the essential fundamentals of physical pharmacy. Divided into three clear sections, the text begins with Section A - Consideration for Product: Medicinal Formulation which includes a historical perspective, explanation of what is an emulsion, stability and instability, and manufacture. Section B - Forms, Use and Application follows, with chapters on creams and ointments, pastes and bases, colloids, transdermal, gels and implants. The final Section, Tests: Chemistry to control the quality, efficacy and fitness for purpose of the product includes chapters on physic-chemical properties, sizing and microscopy, rheology, QC and finally questions, calculations and dilemmas. Throughout the text there are numerous figures, diagrams and tables to engage the reader. This is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms as well as industry professionals

Download or read book Current Trends in Green Nano emulsions written by Azamal Husen and published by Springer Nature. This book was released on 2023-09-28 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a complete overview of current developments on the green synthesis and extraction of nano-emulsions for numerous uses in food, agriculture, biomedical, and cosmetics sectors. In the food and agriculture section, the book demonstrates the use of nano-emulsions to deliver nutraceuticals, coloring, and flavoring agents, in the development of biodegradable coating, improving the quality of packing films and enhancing the shelf life and nutritional value of foods. It also shows that nano-emulsions are very good for pesticides formulation where it enhances the solubility of poorly water-soluble pesticides, resulting in increased pesticide bioactivity compared to conventional pesticides. In the biomedicine applications section, the chapters show that nano-emulsion can dissolve hydrophobic drugs and is used as a drug delivery system for many cancers treatment such as lung cancer, breast cancer, prostate cancer, liver, and gastric cancer. Also, nano-emulsions are an excellent candidate for encapsulating drugs or imaging probes for targeted delivery and immunotherapy. This book caters to scientists, researchers, and students interested in nanotechnology, nanomedicine, environmental science, plant science, agriculture, chemistry, biotechnology, pharmacognosy, pharmaceuticals, industrial chemistry, and many other interdisciplinary subjects.