Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Download or read book Pediatric Allergy Principles and Practice E Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.

Download or read book Finding a Path to Safety in Food Allergy written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-05-27 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.

Download or read book Eosinophilic Gastrointestinal Diseases written by Glenn T. Furuta and published by Clinics: Internal Medicine. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis", "Nutritional management of patients with food allergies and EGIDs", "Chemotactic factors role in EGIDs", "Biomarkers associated with allergic diseases", "Association of other allergic diseases with EGIDs" and much more!

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book An Epidemic of Absence written by Moises Velasquez-Manoff and published by Simon and Schuster. This book was released on 2013-09-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: A controversial, revisionist approach to autoimmune and allergic disorders considers the perspective that the human immune system has been disabled by twentieth-century hygiene and medical practices.

Download or read book Unraveling the Exposome written by Sonia Dagnino and published by Springer. This book was released on 2018-10-08 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Download or read book Immunotherapies for Allergic Disease written by Linda S. Cox and published by Elsevier Health Sciences. This book was released on 2019-11-19 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the use of current and novel immunotherapies for use in the management and treatment of allergic reactions and diseases. This concise resource by Dr. Linda Cox covers the full range of allergic disease, including aeroallergens, asthma, food allergies, atopic dermatitis, and stinging insects. With essential coverage of allergen immunotherapies in addition to key topics on emerging allergen-associated immunomodulators, this succinct, comprehensive reference consolidates today's available information on this timely topic into a single convenient resource. - Discusses timely topics such as food tolerance, allergy, and allergen unresponsiveness; biologics for COPD and pediatric asthma; and adherence and pharmacoeconomics. - Summarizes practical guidelines and recommendations for use of immunotherapies in clinical practice. - Provides insight into the background and history of immunotherapies as a treatment for allergic disease. - Includes developments on the horizon, including alternative immunotherapy routes and modified allergens.

Download or read book Biologics for the Treatment of Allergic Diseases An Issue of Immunology and Allergy Clinics of North America E Book written by Lanny J. Rosenwasser and published by Elsevier Health Sciences. This book was released on 2020-10-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Immunology and Allergy Clinics, guest edited by Dr. Lanny Rosenwasser, will provide up-to-date clinical concepts regarding Biologics for the Treatments of Allergic Conditions. Articles in this outstanding issue include: Allergic Rhinitis/CRS/Polyposis, Eosinophilic Asthma, Pediatric Asthma, Severe Asthma, ACOS/COPD, Food Allergy, Atopic Dermatitis, Chronic Urticaria, Anaphylaxis, Drug Allergy, Cell Disorders, Biologics and Immunotherapy, and much more.

Download or read book Pediatric Food Allergy written by Ruchi S. Gupta and published by Springer Nature. This book was released on 2020-03-02 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and practical, this book thoroughly addresses the full range of concerns related to food allergies in the pediatric patient. As food allergies in the pediatric population increase in number and severity, Pediatric Food Allergy: A Clinical Guide provides information on new guidelines and potential treatment options, as well as working to improve awareness, diagnosis, management and prevention practices. Written by experts in their respective fields, chapters are divided into five sections. Opening with an introduction and overview of particular concerns and issues specific to food allergy in the pediatric population, sections two and three address diagnosis and management of comorbid conditions in food allergy, along with development of food allergies and current prevention recommendations. Sections four and five cover food allergy management, prognosis, and therapeutic options with a look to future developments, while all sections include a discussion of epidemiology, differential diagnoses of other potential food-related diseases. In Pediatric Food Allergy: A Clinical Guide, pediatricians and allergists alike will find an invaluable resource as they work with this vulnerable patient population.

Download or read book The End of Food Allergy written by Kari Nadeau MD, PhD and published by Penguin. This book was released on 2020-09-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: A life-changing, research-based program that will end food allergies in children and adults forever. The problem of food allergy is exploding around us. But this book offers the first glimpse of hope with a powerful message: You can work with your family and your doctor to eliminate your food allergy forever. The trailblazing research of Dr. Kari Nadeau at Stanford University reveals that food allergy is not a life sentence, because the immune system can be retrained. Food allergies--from mild hives to life-threatening airway constriction--can be disrupted, slowed, and stopped. The key is a strategy called immunotherapy (IT)--the controlled, gradual reintroduction of an allergen into the body. With innovations that include state-of-the-art therapies targeting specific components of the immune system, Dr. Nadeau and her team have increased the speed and effectiveness of this treatment to a matter of months. New York Times bestselling author Sloan Barnett, the mother of two children with food allergies, provides a lay perspective that helps make Dr. Nadeau's research accessible for everyone. Together, they walk readers through every aspect of food allergy, including how to find the right treatment and how to manage the ongoing fear of allergens that haunts so many sufferers, to give us a clear, supportive plan to combat a major national and global health issue.

Download or read book Childhood Food Allergy Current Management Emerging Therapies and Prevention An Issue of Pediatric Clinics written by Ruchi Gupta and published by Elsevier Health Sciences. This book was released on 2016-01-07 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Gupta provides a comprehensive overview of the clinjical management of food allergy. Articles are devoted to epidemiology, pathophysiology, diagnosis, management, immunology, and treatments of food allergy. Current knowledge of the relationship between the gut microbiome and food allergy is also presented as well as eosiniphilic esophagitis and oral allergy synrome.

Download or read book Skin Barrier Function written by T. Agner and published by Karger Medical and Scientific Publishers. This book was released on 2016-02-04 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Download or read book Medical Pharmacology and Therapeutics E Book written by Derek G. Waller and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the pharmacology you need, from basic science pharmacology and pathophysiology, through to clinical pharmacology to therapeutics, in line with the integrated approach of new medical curricula. The first section covers the basic principles, and the rest is organised by body systems. The book ends with sections on toxicity and prescribing practice. Integrates basic science pharmacology, clinical pharmacology and therapeutics Brief review of pathophysiology of major diseases Case histories and multiple choice questions (and answers) Tabular presentation of all common drugs within each class Section on further reading Kinetics chapter simplified with more practical examples Includes more on genetic issues Drug tables made more concise to make information more accessible Fully updated to reflect current clinical practice

Download or read book Healing the New Childhood Epidemics Autism ADHD Asthma and Allergies written by Kenneth Bock and published by Ballantine Books. This book was released on 2008-04-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive program that targets all four of the 4-A epidemics: autism, ADHD, asthma, and allergies “An easy-to-read commonsense guide to beneficial biomedical treatments.”—Temple Grandin Doctors have generally overlooked the connections among the 4-A disorders. For years the medical establishment has considered autism medically untreatable and utterly incurable, and has limited ADHD treatment mainly to symptom suppression. Dr. Kenneth Bock, a leading medical innovator, along with his colleagues, have discovered a solution that goes to the root of the problem. They have found that modern toxins, nutritional deficiencies, metabolic imbalances, genetic vulnerabilities, and assaults on the immune and gastrointestinal systems trigger most of the symptoms of the 4-A disorders, resulting in frequent misdiagnosis and untold mysteries. Dr. Bock’s remarkable Healing Program is an innovative biomedical approach that has changed the lives of more than a thousand children. Drawn from medical research and based on years of clinical success, this program offers a safe, sensible solution that is individualized to each child to help remedy the root causes. Dr. Bock also shares the dramatic true stories of parents and children that will inspire you to change the life of your own child. Hope is at last within reach.

Download or read book Rickettsial Diseases written by Didier Raoult and published by CRC Press. This book was released on 2007-04-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only available reference to comprehensively discuss the common and unusual types of rickettsiosis in over twenty years, this book will offer the reader a full review on the bacteriology, transmission, and pathophysiology of these conditions. Written from experts in the field from Europe, USA, Africa, and Asia, specialists analyze specific patho