Download or read book Elucidating the Interactions Between Chronic High fat Diet Treatment and GABAergic Inhibition in the Emotional Behavior of Mice written by Akshilkumar Patel and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Major Depressive Disorder (MDD) is a debilitating condition that affects 6.7% of American adults and poses a serious public health concern. Meta analyses of clinical studies have identified chronic, low-grade inflammation as a predisposing factor in the development of MDD. Obesity, along with a poor diet, contributes to inflammation, which is especially concerning given the high prevalence of obesity in the United States. Longitudinal studies have established a link between obesity and depression, indicating comorbidity among these two disorders. Unhealthy diets with an excessive caloric content, common in modern Western nations, are a risk factor in the development of obesity and may be the source of obesitys increasing pervasiveness. To better study obesity-induced inflammation in the context of mood disorders, high-fat diet (HFD) treatment provides a reliable method for generating animal models of obesity, particularly using rodents. These HFD models, compared to control diet (CD) treated mice, also display the characteristic phenotypes expected of a model of obesity, including chronic metabolic inflammation and insulin resistance.Neurobiological studies investigating the effects of HFD on the brain have found that rodents treated with HFD exhibit behavioral deficits in anxiety-like behavior, anhedonia, and memory. To further investigate these neurological effects of HFD, and their interactions with genetic and neurophysiological factors, the behavioral consequences of HFD treatment were examined in two different mutant mouse models with an altered ratio of neuronal excitation and inhibition (the E:I ratio). Altered E:I ratio is thought to underlie MDD, and imbalance in the E:I ratio has been shown to produce anxiety- and depression-related behavioral phenotypes in mice. The first model (2+/-) involves mice that are globally heterozygous for the 2 subunit of GABAA receptors. In this model, GABAergic inhibition is reduced, leading to an increased E:I ratio. The 2+/- model has consistently produced an anxious-depressive-like phenotype in behavioral assessments. This phenotype can be diminished by treatment with antidepressants, thus implicating increased E:I ratio in the onset of mood disorders. A second mouse model (SSTCre:2f/f) involves mice in which somatostatin-positive (SST+) interneurons were disinhibited by selectively deleting the 2 subunit of GABAA receptors in these cells. In this model, inhibitory transmission onto hippocampal pyramidal cells was increased by disinhibiting SST+ interneurons, thereby reducing the overall E:I ratio in these mice. Behaviorally, these mice exhibit robust anxiolytic and antidepressant-like phenotypes. Together, results from studies involving 2+/- and SSTCre:2f/f models suggest that an impaired E:I ratio underlies anxiety- and depression-related behavior. The hypothesis examined in the present study, which aims to investigate the interactions between HFD and altered E:I ratio on behavior, is that increasing the E:I ratio (2+/- model) will exacerbate HFD-induced anxiety- and depression-like behavior, including defects in locomotion, grooming, and memory, while reducing the E:I ratio (SSTCre:2f/f model) will reduce HFD-induced anxiety- and depression-like behavior, including defects in locomotion, grooming, and memory. The results show that HFD treatment led to reductions in locomotion and grooming behavior of both the WT control and 2+/- mutant mice in the OFT and SSPT, respectively. However, the effects of HFD on 2+/- mice were not larger than in WT mice, so only an overall diet effect was present. Results from tests assessing short-term working (Y-maze) and recognition (NOR) memory indicate that the effects of diet and genotype are nonadditive, and that HFD treatment and altered E:I ratio impair behavior via different mechanisms. SSTCre:2f/f mutant mice presented an anxiolytic phenotype and increased locomotion in the EPM, consistent with studies in the literature. Additionally, HFD treatment of SSTCre:2f/f mice reduced locomotion in the OFT and EPM, and also decreased grooming behavior in the SSPT. Overall, the behavioral results observed for CD-treated animals in these experiments did not reproduce all of the phenotypes of 2+/- and SSTCre:2f/f mice published in the literature, most likely because the genetic backgrounds of the mice analyzed here (C57BL/6J and mixed 129X1/SvJ/C57BL/6J, respectively) were different from the mice described in earlier studies. Due to these unexpected results, additional behavioral experiments will be needed to further assess possible interactions between HFD treatment and altered E:I balance on anxiety- and depression-related behavior.
Download or read book Mood and Anxiety Related Phenotypes in Mice written by Todd D. Gould and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.
Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Salt Sugar Fat written by Michael Moss and published by Signal. This book was released on 2013-02-26 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a Pulitzer Prize-winning investigative reporter at The New York Times comes the troubling story of the rise of the processed food industry -- and how it used salt, sugar, and fat to addict us. Salt Sugar Fat is a journey into the highly secretive world of the processed food giants, and the story of how they have deployed these three essential ingredients, over the past five decades, to dominate the North American diet. This is an eye-opening book that demonstrates how the makers of these foods have chosen, time and again, to double down on their efforts to increase consumption and profits, gambling that consumers and regulators would never figure them out. With meticulous original reporting, access to confidential files and memos, and numerous sources from deep inside the industry, it shows how these companies have pushed ahead, despite their own misgivings (never aired publicly). Salt Sugar Fat is the story of how we got here, and it will hold the food giants accountable for the social costs that keep climbing even as some of the industry's own say, "Enough already."
Download or read book Charney Nestler s Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press. This book was released on 2018 with total page 1025 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5(R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.
Download or read book Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes written by Wim E. Crusio and published by Cambridge University Press. This book was released on 2013-04-25 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Download or read book Processed Food Addiction written by Joan Ifland PhD and published by CRC Press. This book was released on 2017-12-22 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity and eating disorders have stubbornly refused to respond to treatment since the 1990’s. This book organizes the evidence for a possible answer, i.e., that the problem could be one of addiction to processed foods. In a Processed Food Addiction (PFA) model, concepts of abstinence, cue-avoidance, acceptance of lapses, and consequences all play a role in long-term recovery. Application of these concepts could provide new tools to health professionals and significantly improve outcomes. This book describes PFA recovery concepts in detail. The material bridges the research into practical steps that health professionals can employ in their practices. It contains an evidence-based chapter on concepts of abstinence from processed foods. It rigorously describes PFA pathology according to the DSM 5 Addiction Diagnostic Criteria. It applies the Addiction Severity Index to PFA so that health practitioners can orient themselves to diagnosing and assessing PFA. It contains ground-breaking insight into how to approach PFA in children. Because the book is evidence-based, practitioners can gain the confidence to put the controversy about food addiction to rest. Practitioners can begin to identify and effectively help their clients who are addicted to processed foods. This is a breakthrough volume in a field that could benefit from new approaches.
Download or read book Methods for Neural Ensemble Recordings written by Miguel A. L. Nicolelis and published by CRC Press. This book was released on 2007-12-03 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively updated and expanded, this second edition of a bestseller distills the current state-of-the-science and provides the nuts and bolts foundation of the methods involved in this rapidly growing science. With contributions from pioneering researchers, it includes microwire array design for chronic neural recordings, new surgical techniques for chronic implantation, microelectrode microstimulation of brain tissue, multielectrode recordings in the somatosensory system and during learning, as well as recordings from the central gustatory-reward pathways. It explores the use of Brain-Machine Interface to restore neurological function and proposes conceptual and technical approaches to human neural ensemble recordings in the future.
Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Download or read book Principles of Nutrigenetics and Nutrigenomics written by Raffaele De Caterina and published by Academic Press. This book was released on 2019-09-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. - Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics - Includes a valuable guide to ethics for genetic testing for nutritional advice - Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts - Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book
Download or read book Magnetoencephalography written by Selma Supek and published by Springer. This book was released on 2014-08-07 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetoencephalography (MEG) is an invaluable functional brain imaging technique that provides direct, real-time monitoring of neuronal activity necessary for gaining insight into dynamic cortical networks. Our intentions with this book are to cover the richness and transdisciplinary nature of the MEG field, make it more accessible to newcomers and experienced researchers and to stimulate growth in the MEG area. The book presents a comprehensive overview of MEG basics and the latest developments in methodological, empirical and clinical research, directed toward master and doctoral students, as well as researchers. There are three levels of contributions: 1) tutorials on instrumentation, measurements, modeling, and experimental design; 2) topical reviews providing extensive coverage of relevant research topics; and 3) short contributions on open, challenging issues, future developments and novel applications. The topics range from neuromagnetic measurements, signal processing and source localization techniques to dynamic functional networks underlying perception and cognition in both health and disease. Topical reviews cover, among others: development on SQUID-based and novel sensors, multi-modal integration (low field MRI and MEG; EEG and fMRI), Bayesian approaches to multi-modal integration, direct neuronal imaging, novel noise reduction methods, source-space functional analysis, decoding of brain states, dynamic brain connectivity, sensory-motor integration, MEG studies on perception and cognition, thalamocortical oscillations, fetal and neonatal MEG, pediatric MEG studies, cognitive development, clinical applications of MEG in epilepsy, pre-surgical mapping, stroke, schizophrenia, stuttering, traumatic brain injury, post-traumatic stress disorder, depression, autism, aging and neurodegeneration, MEG applications in cognitive neuropharmacology and an overview of the major open-source analysis tools.
Download or read book Conference Papers Index written by and published by . This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monthly. Papers presented at recent meeting held all over the world by scientific, technical, engineering and medical groups. Sources are meeting programs and abstract publications, as well as questionnaires. Arranged under 17 subject sections, 7 of direct interest to the life scientist. Full programs of meetings listed under sections. Entry gives citation number, paper title, name, mailing address, and any ordering number assigned. Quarterly and annual indexes to subjects, authors, and programs (not available in monthly issues).
Download or read book Taurine 10 written by Dong-Hee Lee and published by Springer. This book was released on 2017-08-28 with total page 1181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taurine 10 contains original articles and critical reviews based on the oral and poster presentations of XX International Taurine Meeting held in Seoul, Korea in May 2016. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.
Download or read book Nutrition and Traumatic Brain Injury written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.
Download or read book Gareth and Lynette Lancelot and Elaine the Passing of Arthur written by Houghton Mifflin Company and published by Wentworth Press. This book was released on 2019-03-16 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
