Download or read book Elegant Total Synthesis written by Karl J. Hale and published by Wiley-VCH Verlag GmbH. This book was released on 2013-02-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to other books on this topic, the editor has chosen a top selection of target molecules not previously covered, many of them taken from chemical biology and including syntheses from bioorganic chemistry. Inspiration not only for organic chemists but also bioorganic chemists in industry and academia to develop their own synthesis routes.
Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book The Total Synthesis of Natural Products Volume 7 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The appearance of the seventh volume of The Total Synthesis of Natural Products signals the continued health of the art and science of organic synthesis. This new volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macro-cyclic lactones. The Total Synthesis of Natural Products, Volume Seven forms an integral part of the invaluable working reference begun in Volumes One through Six, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.
Download or read book Classics in Total Synthesis III written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 2011-03-14 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
Download or read book Classics in Total Synthesis II written by K.C. Nicolaou and published by . This book was released on 2003 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis of Natural Products written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemistry's innovative breadth is especially noteworthy in the area of natural products synthesis. Since the early 1970s, this landmark chemical reference has been documenting the newest and most important of these, in a readily understood format, that clearly traces each of their synthetic routes. Volume Eight, the latest in the series, contains a long-awaited look at the synthesis of tri- and tetracyclic diterpenes, along with the synthesis of naturally occurring quinones. Recent interest in the biologically important polysaccharides has led to a detailed consideration of that compound class. Finally, this new volume contains a look at the strategies and methods specific to natural products containing the spiroketal functional group. The Total Synthesis of Natural Products, Volume Eight, continues the meticulous work of the series, providing chemists with an entirely up-to-date and convenient guide to the critical new syntheses essential to organic chemistry's continuing evolution.
Download or read book The Total Synthesis of Natural Products Volume 8 written by John ApSimon and published by John Wiley & Sons. This book was released on 1992-04-16 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemistry's innovative breadth is especially noteworthy in the area of natural products synthesis. Since the early 1970s, this landmark chemical reference has been documenting the newest and most important of these, in a readily understood format, that clearly traces each of their synthetic routes. Volume Eight, the latest in the series, contains a long-awaited look at the synthesis of tri- and tetracyclic diterpenes, along with the synthesis of naturally occurring quinones. Recent interest in the biologically important polysaccharides has led to a detailed consideration of that compound class. Finally, this new volume contains a look at the strategies and methods specific to natural products containing the spiroketal functional group. The Total Synthesis of Natural Products, Volume Eight, continues the meticulous work of the series, providing chemists with an entirely up-to-date and convenient guide to the critical new syntheses essential to organic chemistry's continuing evolution.
Download or read book The Total Synthesis of Natural Products Volume 6 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixth volume of The Total Synthesis of Natural Products continues editor John ApSimon's exploration of one of the most promising areas for the future development of organic chemistry: synthesis. ApSimon has compiled the first definitive reference source of successful synthetic approaches to a wide variety of natural products. This new volume considers the total synthesis of triterpenes, carbohydrates, aromatic steroids, pyrrole pigments and genes first reported during the period from 1972 through 1982 in this series. The Total Synthesis of Natural Products, Volume Six forms an integral part of the invaluable working reference begun in Volumes One through Five, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.
Download or read book Progress in Total Synthesis written by Sarah Danishefsky and published by Springer. This book was released on 2014-05-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series stemmed from a group of weekly seminars in our research group aimed at keeping its members abreast of recent developments in organic synthesis. The seminars tended to consist of several syntheses of natural products or related systems with particular emphasis on the general strategy inherent in the effort, new and interesting reactions which were utilized in the work, and specificity (or the lack of it) in arranging the relative stereochemistry of asymmetric centers and the geometry of double bonds. We found that natural products offered an attractive setting in which the larger science of organic chemistry could be put to crucial tests. A truly elegant synthesis is a major advance in that it epitomizes how an imaginative mastery of the course of organic reactions can achieve a sophisticated objective by an economy of operations. Indeed any successful synthesis of a reasonably complex product, however cumbersome and graceless, is an important event for those who delight in the problem-solving dimension of science.
Download or read book Progress in Total Synthesis written by Sarah Danishefsky and published by Springer. This book was released on 1971-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series stemmed from a group of weekly seminars in our research group aimed at keeping its members abreast of recent developments in organic synthesis. The seminars tended to consist of several syntheses of natural products or related systems with particular emphasis on the general strategy inherent in the effort, new and interesting reactions which were utilized in the work, and specificity (or the lack of it) in arranging the relative stereochemistry of asymmetric centers and the geometry of double bonds. We found that natural products offered an attractive setting in which the larger science of organic chemistry could be put to crucial tests. A truly elegant synthesis is a major advance in that it epitomizes how an imaginative mastery of the course of organic reactions can achieve a sophisticated objective by an economy of operations. Indeed any successful synthesis of a reasonably complex product, however cumbersome and graceless, is an important event for those who delight in the problem-solving dimension of science.
Download or read book Progress in Total Synthesis written by Sarah Danishefsky and published by Springer. This book was released on 2012-06-12 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series stemmed from a group of weekly seminars in our research group aimed at keeping its members abreast of recent developments in organic synthesis. The seminars tended to consist of several syntheses of natural products or related systems with particular emphasis on the general strategy inherent in the effort, new and interesting reactions which were utilized in the work, and specificity (or the lack of it) in arranging the relative stereochemistry of asymmetric centers and the geometry of double bonds. We found that natural products offered an attractive setting in which the larger science of organic chemistry could be put to crucial tests. A truly elegant synthesis is a major advance in that it epitomizes how an imaginative mastery of the course of organic reactions can achieve a sophisticated objective by an economy of operations. Indeed any successful synthesis of a reasonably complex product, however cumbersome and graceless, is an important event for those who delight in the problem-solving dimension of science.
Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-07-24 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
Download or read book The Way of Synthesis written by Tomas Hudlicky and published by Wiley-VCH. This book was released on 2007-09-04 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)
Download or read book More Dead Ends and Detours written by Miguel A. Sierra and published by John Wiley & Sons. This book was released on 2013-07-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity.
Download or read book The Total Synthesis of Natural Products Volume 1 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
