Download or read book Electrophysiology of Isolated Mammalian CNS Preparations written by G. A. Kerkut and published by . This book was released on 1981 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurochemical Systems written by Abel Lajtha and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Receptor Methodologies Pt A written by Paul J. Marangos and published by Elsevier. This book was released on 2012-12-02 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Receptor Methodologies, Part A, General Methods and Concepts: Amines and Acetylcholine provides information pertinent to neurotransmitter and neuromodulator receptors in brain. This book explores the methodologies that can used to address several basic and clinical problems. Organized into two sections encompassing 18 chapters, this book starts with an overview of the receptor concept, which can be validated from indirect evidence obtained in studies of the quantitative aspects of drug antagonism. This text then examines the radioligand–receptor binding interactions. Other chapters consider immunocytochemistry, which has a primary role in determining the precise distribution of regulatory peptides to neural and endocrine elements of the diffuse neuroendocrine system. The final chapter discusses the use of the radioligand binding procedure for the study of muscarinic receptors, which has expanded the area of muscarinic receptor pharmacology. Biochemists, pharmacologists, physiologists, and researchers engaged in the fields of neurobiology and neuroscience will find this book extremely useful.
Download or read book Brain Plasticity Learning and Memory written by B. E. Will and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of the contributions presented at a conference held from August 30 to September 1, 1984 at the Universite Louis Pasteur, Strasbourg, France. This meeting was organized under the joint auspices of the European Brain and Behaviour Society (EBBS) and the Societe Fran~aise pour 1 'Etude du Comportement Animal (SFECA). The objective of this meeting was to bring together an international group of participants to evaluate and to report on recent research in three broad and overlapping fields within the general theme of the relationships between brain plasticity and learning and memory. These three fields are "developmental plasticity" "adaptive plasticity" and "restorative plas tici ty." Al though the boundaries between these fie Ids are a rna t ter of debate (see Introduction), they have been retained as the major sections of this volume, the arrangement of which roughly parallels that of the meeting. We believe and very much hope that the contents of this volume convey an internal consistency despite the diversity of the material presented.
Download or read book Brain Slices written by Raymond Dingledine and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: In little less than a decade brain slices have gained prominence among neurobiologists as appropriate tools to study cellular electrophysiolog ical aspects of mammalian brain function. The purpose of this volume is to present in some detail several inquiries in the brain sciences that have benefited greatly by the use of brain slices. The book is directed primarily toward advanced students and researchers wishing to evaluate the impact these in vitro preparations of the mammalian brain are having on neurobiology. The term brain slice has come to refer to thin (100-700 j. Lm) sections of a brain region prepared from adult mammals and maintained for many hours in vitro, for either electrophysiological or biochemical stud ies. In addition to good accessibility, slices feature relatively intact syn aptic connections that allow a variety of experiments not feasible with standard in vivo or tissue culture preparations. Certain electrophysiol ogical studies once practical only with invertebrate models are becoming routine with mammalian brain slices. The ability to perform both bio chemical and electro physiological experiments on the same piece of CNS tissue provides additional bright prospects for future research. Although most of the electrophysiological studies have dealt with hippocampal slices, it should be evident from this book that slice methodology is not limited to the hippocampus. The Appendix, "Brain Slice Methods," is a multiauthored treatment of the technical aspects of brain slice work, collected into one document.
Download or read book Neurotransmitter Actions in the Vertebrate Nervous System written by Michael Rogawski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intercellular communication via bioactive substances occurs in virtually all multicellular systems. Chemical neurotransmission in the vertebrate nervous system represents a form of signaling of this type. The biology of chemical neurotransmission is complex, involving transmitter synthesis, transport, and release by the presynaptic neuron; signal generation in the target tissue; and mechanisms for termination of the response. The focus of this book is on one aspect of this scheme: the diverse electrophysiological effects induced by different neurotransmitters on targets cells. In recent years, astonishing progress has been made in elucidating the specific physiological signals mediated by neurotransmitters in the verte brate nervous system, yet, in our view, this has not been adequately recog nized, perhaps because the new concepts have yet to filter into neuroscience textbooks. Nevertheless, the principles of neurotransmitter action are critical to advances in many areas of neuroscience, including molecular neurobiol ogy, neurochemistry, neuropharmacology, physiological psychology, and clinical neuroscience. It was the need for a sourcebook that prompted us to engage a group of neurophysiologists to prepare the chapters in this volume. However, there was an additional reason for this book: more and more it seemed that the field, if not yet having reached maturity, at least was ap proaching adolescence, with strengths in some areas and healthy conflicts in others. At this stage of development a textbook can help to define a field, clarify problems to be resolved, and identify areas for future investigation.
Download or read book Neurotoxicology written by Kenneth Blum and published by CRC Press. This book was released on 1985-07-30 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurobiology of Vertebrate Locomotion written by Sten Grillner and published by Springer. This book was released on 2016-01-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrophysiology and Microinjection written by P. Michael Conn and published by Elsevier. This book was released on 2016-07-02 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity is central to the functioning and nature of neural cells. Every effort has been made in this volume to provide representative examples of useful techniques that have made this area a productive component of the neurosciences. Convenient bench-top format**Methods presented for easy adaptation to new systems**Comprehensive protocols included for**Cell recording: from conscious and freely behaving animals, measurement of calcium currents, and multiple electrodes**Voltage clamping and voltammetry: apparatus and applications**Specific ion channels and receptors: expression in oocytes, single-cell secretion, purification of calcium channel drug receptors**Special electrodes and other equipment: movable electrodes, microelectrodes, multiple electrodes, en passant recording, microincubators for optical studies**Special preparations: multicompartment cell cultures, grease-gap methods, perforated path techniques, giant proteoliposomes for reconstitution studies, microinjection**Data analysis and reduction: digital filtering on a personal computer, filtering on a personal computer, fitting of single-channel dwell time distributions, discrimination of kinetic models, voltage noise analysis, list-oriented analysis of single-channel systems
Download or read book Neurotransmitter Interaction and Compartmentation written by H. F. Bradford and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Study Institute held in the Hotel Metropole Llandrindod Wells, Powys, Wales from July 26th to August 4th 1981 provided an excellent platform for presentation and appraisal of our current knowledge of neurotransmitter systems. The proceed ings comprise the present volume and these were arranged to allow study of the pathways and the interactions of specific transmitter systems, one with another, in the various sub-regions of the central nervous system. In addition several of the key factors involved in neurotransmitter release were highlighted. These include the structural and molecular organisation of the nerve terminal, its organelles (such as vesicles, neurotubules and synaptic densities) and the mechanisms involved in neurotransmitter release including the participation of calcium. The organisation of transmitter synthesis, storage and transport were discussed together with their linkage to other streams of metabolism, and the cellular compartmentation of these processes. In addition to the principal lectures given at the Institute, many part1c1pants presented short reports for discussion and these are all included in this volume. The success of the Study Institute was due to the careful planning of the scientific programme to allow a smooth flow and integration of the topics included and this is reflected in the organisation of this book. The programme committee members were, R. Balazs (London), H. F. Bradford (London,Director), J. B. Clark (London), J. E. Cremer (MRC, Carshalton), J. S. Kelly (London), L. Lim (London), M. J. Neal (London) and P. J. Roberts (Southampton).
Download or read book Preparations of Vertebrate Central Nervous System In Vitro written by Henrik Jahnsen and published by Wiley. This book was released on 1990-09-07 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents some of the latest in vitro techniques that can be used to study the vertebrate central nervous system--particularly the brain slice technique. The advent of this new era in neuroscience led to a number of difficult test limitations in the use of this technique, including problems associated with the study of properties in large three-dimensional neural networks and processes lasting longer than 18-24 hours. The authors present solutions to these problems and indicate how it is possible to push in vitro techniques toward their known limits. Invaluable, this work will serve as a stepping-stone to further research and development activity in the neuroscience field.
Download or read book Handbook of Psychopharmacology written by Leslie L. Iversen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 15 of Handbook of Psychopharmacology represents the first of a new series of volumes whose aim is to bring earlier sections of the work up to date by describing the latest developments in the field. It is now seven years since the first Handbook volumes on Basic Neuropharmacology were published, and there have been many important advances. As in many other areas in science, progress in this field has depended to a considerable extent on the availability of new experimental methods, and Volume 15 reviews some major recent developments, including new autoradiographic techniques that allow direct visualization of drug and transmitter receptors in the nervous system, and the pinpointing of the precise locations of the changes in brain metabolism elicited by various drug treatments. Volumes 16 and 17 will cover two of the most active areas for basic research in psychopharmacology at the moment: the characterization of drug and transmitter receptors in brain by radioligand binding techniques, and studies of the role of small peptides in brain function. The latter area, in particular, illustrates how rapidly progress continues to be made in basic research on the mechanisms of chemical communication within the nervous system. Seven years ago when the Handbook first appeared none of the opioid peptides (enkephalins and endorphins) had yet been identified. Since then a whole new area of basic biological research has focused on these substances, and in addition we know of more than thirty other neuropeptides with putative eNS transmitter functions.
Download or read book Excitatory Amino Acids and Epilepsy written by Robert Schwarcz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human epilepsy is a major public health problem affecting approximately 2 persons per 1000. It is particularly frequent in ohildren where convul sions may lead to brain damage and subsequent seizure activity in adulthood. Temporal lobe epilepsy (synonyms include limbic epilepsy. psychomotor epilepsy and complex partial epilepsy) is the most devastating form of epilepsy in the adult population since: a) it is often extremely resistant to currently available anticonvulsant drugs (i.e •• it is more resistant than tonico-clonic or grand mal seizures) and b) it includes loss of consciousness. thereby limiting performance of many normal functions and leaving the individual susceptible to bodily injury. It is also associated with nerve cell loss. in particular in the hippocampus and other structures of the temporal lobes. In order to promote an appropriate therapy it is essential to understand the etiology of seizures and its relationship to brain damage. Basic research on epilepsy also provides a very useful vehicle to learn about the way the brain functions under normal conditions. For instance. much of our present understanding of the mechanisms of action of GABA and benzo diazepines. control of neuronal activity. etc. has been derived from such stUdies.
Download or read book Cellular Mechanisms of Conditioning and Behavioral Plasticity written by D.L. Alkon and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: I would like first to thank Charles Woody and his organizing committee for arranging the symposium on the "Cellular Mechanisms of Conditioning and Behavioral Plasticity," which was also a satellite meeting of the International Union of Physiological Sciences 30th International Congress. The proceedings of this symposium are represented by the chapters that follow. During the 1970s, Dr. Woody and co-workers were able to carry out a remarkable series of microelectrode studies, both intracellular and extracellular, of cortical nerve cells during conditioning of the eye-blink response to sound in the intact waking cat. He demonstrated enduring changes in excitability and membrane resistance in pericruciate cortical cells during associative conditioning of the eye blink, changes that are facilitated by ACh and cGMP and reinforced by stimulation of the hypothalamus (the latter con firming the original studies of Voronin). These findings have been of considerable im portance in our attempt to understand the conditioning process at the cellular level.
Download or read book Amino Acids written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 1985-12-09 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neurosclentlsts, and those that are available often seem either out of date or limited m scope. This series is about the methods most widely used by modern-day neurosclentists and 1s wrltten by their colleagues who are practicing experts. Volume 1 will be useful to all neurosclentists since It concerns those procedures used routinely across the widest range of subdisciplines. Collecting these general techniques together m a single volume strikes us not only as a service, but will no doubt prove of exceptIona utilitarian value as well. Volumes 2 and 3 - scribe all current procedures for the analyses of amines and their metabolltes and of ammo aads, respectively. These collections will clearly be of value to all neuroscientlsts working m or contemplating research m these fields. Similar reasons exist for Volume 4 on receptor binding techniques since experimental - tails are provided for all types of llgand-receptor bmdmg, including chapters on general prmciples, drug discovery and - velopment, and a most useful appendix on computer programs for Scatchard, nonlinear, and competitive displacement analyses. Volume 5 provides procedures for the assessment of enzymes - volved m biogenic amme synthesis and catabolism. Volumes in the NELJROMETHODS series will be useful to neurochemists, -pharmacologists, -physiologists, -anatomlsts, psychopharmacologists, psychlatnsts, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal), in fact, everyone involved m the neurosclences, both basic and clinical.
Download or read book GABA in the Retina and Central Visual System written by and published by Elsevier. This book was released on 1992-04-21 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: GABA in the Retina and Central Visual System
Download or read book Developmental Neurobiology of Breathing written by Gabriel Haddad and published by CRC Press. This book was released on 1991-06-28 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph provides a comprehensive basis for understanding the complex interactions that take place between synaptic input, cellular properties, and the oscillatory output of a neural network, especially in the maturing or developing nervous system. Emphasis is placed on drawing a parallel betw
